50 replies to this topic

[dblch]

Hi guys, I'd love to share my current regimen and get any opinions you might have. It's convenient for me that so many cryonicists are informed about dietary supplements and life extension, so I'm excited to see what you think.

My regimen has been a little weird lately, in that I've been avoiding some supplements during radiation, but for the most part this is what I've been doing:

Vitamin D3, 5,000 IU twice daily
Melatonin, 40 mg nightly
Clomipramine 50 mg nightly , but in the process of escalating to 250 mg a night
Garlic, 2,000-4,000 mg daily
Flaxseed Oil, 1200 mg 2-3 times daily
Quercetin, 500 mg twice daily
Curcumin, 240 mg twice a day
Resveratrol, 200 mg nightly (this might be off, I don't have in front of me)
Milk Thistle Extract, 450 mg twice a day
Green Tea Extract, 1,000 mg daily
Dronabinol (synthetic THC), 10-20 mg throughout the day
-I also use the real stuff, inhaled via a vaporizer, 2 times a day (usually, but I sometimes I take breaks; I am the sort of person that actually finds it makes me a bit nervous)

Things that I've used in the past include:

Fish Oil (DHA), various doses
mirtazapine, 25mg (antidepressant)
Plerixafor (as a part of the trial at Dana-Farber, can't get this anymore)
Avastin (last dose 10mg/kg two Fridays ago)

There are several supplements I'm interested in, but don't have access to or have been considering but haven't made a decision about dosing yet. These primarily include:

DCA (working on getting access to this, it's available online)
Maitake Mushrooms
Berberine
Piperine (enhances bioavailability of Curcumin)
Viagra (really! it may open up the blood-brain-barrier, but I haven't been TOO into it since the BBB is impaired in GBM anyway). I'd love to talk about this more, though
Sulphoraphane
Borage Seed Oil in combo with Fish Oil - I've been hesitant to try this since I'm not too comfortable with the metabolic processes involved with Borage Seed + Fish Oil, in some cases the Borage Seed oil can cause increased proliferation of cancer cells. I need to think about this more.
Quinine (a cheap malaria drug that is hard to get in the States)
Accutane (needs script)
Perillyl Alcohol (non-toxic nasal spray, but needs script)
Metformin (needs script)
Cimetidine (needs script)
Mebendazole (not available in states)


Now, here's what I really need help accessing. Some of the drugs are simply not available in the states, and some are hard to get "off-label" but are otherwise safe. The one's that I'm desperate to get my hands on are:


Quinine (a cheap malaria drug that is hard to get in the States)
Accutane (needs script)
Perillyl Alcohol (non-toxic nasal spray, but needs script I am particularly desperate to try this)
Metformin (needs script)
Cimetidine (needs script)
Mebendazole (not available in states)

Is there anyone out there that can help? Any doctors willing to prescribe off-label? Anyone out of the states that could ship something over? (I will pay for all costs).

Another problem I've run into is the issue of what antidepressant is best. There's probably the most research out there for clomipramine, but I was doing mirtazipine for awhile with the rationale that it might overcome a roadblock associated with plerixafor/CXCR4 inhibition. I'm not on plerixafor anymore, but I was always curious if this was a better bet in a CXCR4 inhibition context to further inhibit CXCR4. I also don't know how to handle this info, and my neuro-oncologist on the plerixafor trial could't answer it for me, but it appears that chronic THC exposure causes overexpression rather than inhibition of the T cells in the CXCR4 line, by overexpressing CD4+ and CD8+. This are typically associated with cancer killing cells, but I've always worried that THC might be contraindicated with a CXCR4 inhibiting treatment. If anyone knows more about blocking CXCR4 or using mirtazapine, I'd be glad to get some more info. Mirtazapine might be even more effective when combined with the anti-fungal known as clotrimazole (needs script for pill version). Part of this mess is that it's hard to combine antidepressants with other antidepressants because the side effects can become dangerous (seizures, psychomotor deficits) so I have set my priorities carefully. Also, fun fact: mirtazipine gives me vivid hallucinations upon waking, probably because of the combined effect of mirtazipine's serotonergic action and this thing called "peduncular hallucinosis" that can be caused by (you guessed it) peduncle/brain stem lesions. Luckily I knew the hallucinations were not real, but it was bizarre to say the least.

Alright, sorry this update is so long, and I hope to answer any questions about my rationale in a separate thread. Hopefully others can find some use for me since so far I've really only been in the "help me please" corner thus far.

Let me know if you have any recommendations or venues to obtain the drugs I can't get currently.

Thanks for reading, and as always, thanks for all of the continued support/donations. I've gotten way more of I response than I thought was even possible; you guys are awesome.

Kim

[Shannon Vyff]

Here is one thread that has some useful information on supplements to effect cancer:

http://www.longecity...nts#entry471964

[Shannon Vyff]

If you do a search for brain tumor, GBM and glioblastoma here you find a lot of great advice from why fasting two days before radiation helps protect healthy cells to why ketogenic calorie restricted diets can help slow tumor growth. In addition some others who fought brain cancer talk about their regime as well as clinical trials and experimental methods they tried.

[tham]

" ...... instead of conquering her brain tumor with some of the best doctors and
researchers in the world, the tumor had returned and was growing, the experts
were shrinking the time she had left even further. "


http://venturist.inf...zi-charity.html


As I had hypothesized in another thread earlier, trying to knock out cancer with chemo
and radiation also knocks out our first-line anticancer genetic defense at the same time - p53.

Thus it is little wonder that when cancer relapses in many cases, it does so aggressively,
because the patient is left fighting the disease virtually defenseless. Second-line drugs
don't really work because it's like giving a knight a sharper sword with his armor taken off.


" Guardian of the Cell "

" Guardian of the Genome. "


http://www.rcsb.org/...otm.do?momID=31

http://www.hhmi.org/...cer/p53/01.html


http://www.dnatube.c...es-Guardian-p53


If most adult cells can be made into iPS cells in the absence of p53, then
almost any p53-lacking cells should also be an eligible candidate for cancer initiation
— a prediction that runs counter to the cancer stem cell hypothesis.


http://blogs.nature....genome_als.html

Edited by tham, 28 August 2012 - 09:38 PM.

[tham]

Scutellaria baicalensis, the ancient Chinese herb mentioned before with activity against
glioblastoma, has multiple anticancer flavonoids.

Wogonin
Scutallarein
Scutallarin
Baicalein
Baicalin
Chrysin
Apigenin
Luteolin


The main anticancer component is probably wogoinin.

Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways
in human glioblastoma cells.

http://www.ncbi.nlm....in glioblastoma



Scutallarein was found to the major anticancer component in BZL101, the extract
from Scutelleria barbata currently in trials against breast cancer.

Scutellaria barbata is another scullcap species with potent anticancer
activity used in Chinese medicine since ancient times.


BZL101 is actually a five-to-one boiled extract from the raw herb, which is much
similar to the traditional Chinese way of boiling a raw medicinal herb or herbal formula
from four bowls of water down to one.

http://www.ncbi.nlm....les/PMC3260194/



In Phase 2 trials, BZL101 virtually hauled back some terminal women from the
crutches of death.



" One patient was on BZL101 for 449 days and remains stable
for 700 + days. Independent radiology review identified
three patients with objective tumor regression (>0% and <30%). "

http://www.ncbi.nlm....pubmed/20054647


I don't have access to the full study, but if this brief writeup on the Phase 1B
trial is correct, the woman who was alive at over 700 days at the end of the trial
in January 2010, was still alive at 1,130 days in March 2011 :

http://www.curetoday...article_id/1672





Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis
in cancer cells by transcriptional suppression of Mcl-1

" Importantly, at doses lethal to tumor cells, wogonin showed no or little toxicity for
normal cells and had also no obvious toxicity in animals. "


http://www.ncbi.nlm....cles/PMC3199715


Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells,
and wogonin reverses it by down-regulating Nrf2-mediated cellular
defense response

MCF-7 is drug resistant breast cancer line, in this case against doxorubicin.

http://www.ncbi.nlm....ubmed/22593043/



Wogonin and related natural flavones overcome tumor necrosis factor-related
apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation
of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.

http://www.ncbi.nlm....pubmed/22086925



Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis
on human malignant brain tumor cells

http://www.biomedcen.../1472-6882/6/27

[tham]

Apigenin, one of the flavonids in Scutelleria baicalensis and barbata.

Apigenin, a casein kinase-2 inhibitor, activates p53 and blocks SIRT1.

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest
and sensitizes glioblastoma cells to TNF-alpha induced apoptosis
through SIRT1 inhibition

http://www.nature.co...dis201210a.html



Apigenin, EGCG, genistein activate cell death in glioblastoma cell lines.

Flavonoids Activated Caspases for Apoptosis in Human Glioblastoma
T98G and U87MG Cells But Not in Human Normal Astrocytes

http://www.ncbi.nlm....les/PMC3159962/



Wogonin can be ordered from China, but extremely expensive.

http://www.alibaba.c...rchText=WOGONIN



The wogonin content in Scutellaria baicalensis is tiny, about 0.4 per cent.

http://www.iherb.com...0-Vcaps/72?at=0



" Wogonin is the most active flavonoid of the Scutellaria baicalensis; it stimulates
malignant cells apoptosis (the process of programmed cell death), with no influence
over other cells’ apoptosis and, therefore, wogonin can be used in oncological practice,
both for tumour treatment and for metastasis prevention. In addition, wogonin has an
evident cardioprotective effect and it can be used as an effective adjunct for treatment
of myocardial infarction consequences and other diseases.

However, the wogonin concentration in plants is very low, and technologies of its
extraction are complex and expensive. The wogonin substance cannot be synthetisized. "

Edited by tham, 29 August 2012 - 04:47 PM.

[tham]

Link to the writeup above :


http://www.enterpris...m?bbs_id=168541

[tham]

Plum flower has a 5 to 1 extract of the major herbs.

Scutellaria baicalensis is actually one of the 50 fundamental herbs
in traditional Chinese medicine.

http://www.maxnature...qiexpobaro.html

[tham]

If there is one fruit you can eat more of, it is this Eastern prickly pear,
found throughout the eastern USA.

I'm not familiar with cactuses over there, but Opuntia humifusa looks like a cousin
of Opuntia ficus-indica, the Mexican prickly pear, commonly found as a supplement,
and which also has anticancer activity.

http://en.wikipedia....puntia_humifusa

http://www.wildflowe...p?id_plant=OPHU



Opuntia humifusa partitioned extracts inhibit the growth of U87MG human glioblastoma cells.

http://www.ncbi.nlm....ubmed/20814744/



Cactus pear: a natural product in cancer chemoprevention

http://www.nutrition.../content/4/1/25



Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity
of nine prickly pear (Opuntia spp.) juices.


http://www.ncbi.nlm....pubmed/19468836


Betanin, a betacyanin pigment purified from fruits of Opuntia ficus-indica
induces apoptosis in human chronic myeloid leukemia Cell line-K562.

http://www.ncbi.nlm....ubmed/17482444/

[Logic]

Are you posting here for Kim?
http://www.longecity...en-suggestions/

Edited by Logic, 30 August 2012 - 11:03 AM.

[tham]

Glioblastomas immediately bring to mind Burzynski's antineoplastons.

It doesn't work for all cases, but the feedback shows that it gives you a good
fighting chance, at least in survival extension.

You could consider using your charity fund for this treatment. Writing to
Burzynski explaining your situation might well obtain a discount or concession
from him.


This man, Paul Leverett, managed to make it to at least five years.

http://cancerguide.o...rett_story.html


This study was evidently about him.

Long-term survival and complete response of a patient with recurrent diffuse
intrinsic brain stem glioblastoma multiforme.

http://www.ncbi.nlm....pubmed/15312271



Targeted therapy with antineoplastons A10 and AS2-1 of high-grade, recurrent,
and progressive brainstem glioma.

http://www.ncbi.nlm....pubmed/16484713


Note that both the studies above were by Burzynski.


This Japanese study also looked good.

Quick response of advanced cancer to chemoradiation therapy with antineoplastons.

http://www.ncbi.nlm..../pubmed/9538158



The Mayo Clinic study was disappointing, though.

http://www.ncbi.nlm....pubmed/10069350



The Japanese also had impressive results with liver cancer and metastases.

" One showed massive coagulation necrosis of tumors after intra-arterial
infusion of antineoplaston A10 I and the other showed resolution of portal
vein tumor thrombosis with systemic infusion of antineoplaston A10. "

http://www.ncbi.nlm..../pubmed/9769368


Long-term survival following treatment with antineoplastons for colon cancer
with unresectable multiple liver metastases: report of a case.

http://www.ncbi.nlm....ubmed/12768372/

Edited by tham, 30 August 2012 - 11:14 PM.

[cesium]

Valproic Acid
http://www.ncbi.nlm....a valproic acid

cimetidine is available over the counter in the US
metformin & Mebendazole is available without a prescription from various online pharmacies, as is the above mentioned valproic acid (Depakote).

[cesium]

Indirubins from the Chinese herbal remedy Dang Gui Long Hui Wan
http://cancerres.aac...tent/71/16/5374

[tham]

Burzynski's response on the Mayo Clinic trial :

" ..... the formulations of antineoplastons were diluted and when the Mayo Clinic (1999)
determined the concentration of antineoplastons in blood, we realize that it was something
like 50 times lower than what it should be. "


http://www.cancerinf...interview2.html


Jessica Ressel, mentioned in Burzynski's patient group page. Not sure
if her glioma is actually a glioblastoma.

http://www.burzynskipatientgroup.org/






Anaplastic Astrocytoma.





Coming back to p53.


" The p53 tumor suppressor gene plays an important role in protecting cells from developing
undesirable proliferation. The mutant p53 gene or malfunctioning p53 protein found in more
than 50% of cancer cells impedes DNA repair or apoptosis induction. This may be why
some cancers gain resistance to chemotherapy and radiation and become more resistant
after frequent cancer treatments. A non-toxic p53 gene activator would induce cancer
cell apoptosis and help damaged cancer cells to recover. "

" Antineoplaston A10 and AS2-1 are chemically identified and synthesized antineoplastons
proven to inhibit cancer cell growth by arresting the cell cycle in the G1 phase and inhibiting
tumor growth by reducing mitosis. These agents are thought to be good candidates for
clinically easily applicable non-toxic p53 gene activators. Our cases of advanced cancer
responded well to combination treatment using chemotherapeutics and irradiation with
antineoplaston A10 and AS2-1 in clinical trials being conducted in Kurume University Hospital. "

A novel strategy for remission induction and maintenance in cancer therapy.

http://www.ncbi.nlm....ubmed/11748457/

Edited by tham, 31 August 2012 - 03:29 AM.

[tham]

Other glioblastoma survivors on antineoplastons.

[Matt]

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?
http://www.ncbi.nlm....pubmed/20412570

Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report.
http://www.ncbi.nlm....pubmed/20412570

Take AHCC -3-6g of AHCC per day. (highly effective at boosting immunity). Fast for 1-2 days before radiation and 24 hours after. (protects healthy cells and kills cancer cells more easily)

Edited by Matt, 31 August 2012 - 09:14 AM.

[tham]

Indirubins from the Chinese herbal remedy Dang Gui Long Hui Wan
http://cancerres.aac...tent/71/16/5374

Indirubin is found in Dyer's woad, Isatis tinctoria, sometimes wrongly listed as
Isatis indigotica, or Chinese woad.

http://www.longecity...post__p__472190


http://en.wikipedia....satis_tinctoria



Another name for Isatis indigotica is Isatis Pulverata (Qing Dai), one of the herbs
in Dang Gui Long Hui Wan.

http://catstcmnotes....Heat/Relieve To

http://www.superherb...duct.asp?PID=90


" Isatis indigotica is not the same as Isatis tinctoria. I. indigotica is native to
northern china, and supposedly has a slightly higher indigotin content. "

http://www.pfaf.org/...satis tinctoria

http://www.sandmount...ad_chinese.html



http://www.scienceda...10712143006.htm



Suppliers :

http://www.alibaba.c...otion-list.html

[tham]

Indirubin has poor absorption and bioavailabity.

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system

" Indirubin has poor water solubility, resulting in low oral bioavailability. Moreover,
ingestion often leads to irritation in the gastrointestinal tract. Thus, although indirubin
is a promising antitumor agent, its clinical use has been limited. "

http://www.ncbi.nlm....les/PMC3292421/



Here is another proprietary Chinese herbal formula from Taiwan with activity against cancer.
It includes Isatis pulverata (indigotica) and another well-known anticancer herb,
Oldenlandia diffusa, plus common immune boosters like cordyceps, ginseng,
astragalus and atractylodes.

Atractylodes has been used against breast, cervical, uterine and ovarian cancers.

" THL is an aqueous preparation of herbal mixture and consists mainly of extracts from
14 Chinese medicinal herbs: Cordyceps sinensis (CS), Oldenlandia diffusa (OD),
Indigo pulverata levis (IPL; also known as Indigo Naturalis), Polyporus umbellatus (PU),
Radix astragali (RA), Panax ginseng (PG), Solanum nigrum L. (SNL), Pogostemon cablin
(PC), Atractylodis macrocephalae rhizoma (AMR), Trichosanthes radix (TR), Clematis
radix (CR), Margarite (M), Ligustrum lucidum Ait (LLA), and Glycyrrhiza radix."


Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal
cocktail Tien-Hsien Liquid

http://www.biomedcen...471-2407/10/175


Safety and Efficacy of Tien-Hsien Liquid Practical in Patients with Refractory Metastatic
Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group,
Phase IIa Trial

http://www.hindawi.c...am/2012/803239/



Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro
and inhibits tumor growth in vivo

http://www.cmjournal...content/5/1/25/



The chinese herbal medicine Tien-Hsien liquid inhibits cell growth and induces
apoptosis in a wide variety of human cancer cells.

http://www.ncbi.nlm..../pubmed/1586549



Quite expensive too.

http://www.tienhsien.com/store.htm

[1kgcoffee]

You're going to want supplements that will cross the blood brain barrier. And because permeability will not be 100%, you may have to take higher doses. You probably aren't taking enough curcumin IMO. As for the resveratrol, I'm not sure you could afford the right dose, and there are better alternatives that cost less.

I can't find the study ATM, but tocotrienols have been found to protect healthy cells and induce apoptosis in cancerous following radiation treatment. They will also cross the BBB. Even without radiation they have an apoptotic effect on cancerous cells.
http://www.ncbi.nlm....pubmed/14712090
You're going to want delta/gamma form, completely free of tocopherols, such as this-http://www.iherb.com/A-C-Grace-Company-Unique-Tocotrienol-60-Softgels/12977 (I would take a few times more the recommended dose probably 400mg)

I will add more after my head clears.

(disclaimer: none of this is medical advice, always consult a physician, etc etc gotta cover my ass)

Another one I really like is AHCC, kinoko gold. Active ingredient contained in the medicinal mushrooms. As much you can afford

[tham]

Another name for Isatis indigotica is Isatis Pulverata (Qing Dai), one of the herbs
in Dang Gui Long Hui Wan.

http://catstcmnotes....Heat/Relieve To

http://www.superherb...duct.asp?PID=90

This is the correct link above .

http://catstcmnotes....y/qing dai.html

[tham]

Another fruit to eat more - mulberries.

Mulberry fruit (Moris fructus) extracts induce human glioma cell death in vitro through
ROS-dependent mitochondrial pathway and inhibits glioma tumor growth in vivo.

http://www.ncbi.nlm....ubmed/20358478/


http://www.aliexpres...holesalers.html

Edited by tham, 02 September 2012 - 01:59 AM.

[tham]

Angelica (tang kuei, dang gui), the common Chinese herb, has anticancer properties.

Angelica is one of the herbs in the Dang Gui Hui Long Wan and Tien-Hsien
formulas above.

Its activity against glioblastomas has been extensively studied in Taiwan.



The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo.

http://clincancerres.../11/9/3475.long


Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma.

http://www.ncbi.nlm....pubmed/17085958



Its main active compound appears to be butylidenephthalide (Bdph).


The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits
malignant brain tumor growth in vitro and in vivo.

http://www.ncbi.nlm....pubmed/16987298

http://onlinelibrary...06.04151.x/full


Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide
chemotherapy on glioblastoma multiform brain tumor.

http://www.ncbi.nlm....pubmed/18419761



Overexpression of the orphan receptor Nur77 and its translocation induced by PCH4
may inhibit malignant glioma cell growth and induce cell apoptosis.

http://www.ncbi.nlm....pubmed/21246566

Edited by tham, 02 September 2012 - 05:35 AM.

[tham]

However, Bdph's effects has been limited by the blood brain barrier. These
Taiwanese researchers have developed a novel delivery method to enhance
its effect dramatically using polymer wafer implants, and their work looks
groundbreaking because it targets telomerase locally in the brain.


Local interstitial delivery of z-butylidenephthalide by polymer wafers
against malignant human gliomas.

http://www.ncbi.nlm....pubmed/21565841



It may well be worthwhile contacting the study authors for information as to whether
their new treatment, while somewhat experimental, may be available for you now
due to the urgency of your condition.

Their new wafer is an improvement over the Gliadel wafer by Bristol-Myers
currently used to deliver carmustine (BCNU), so their work looks highly feasible
and safe. The Gliadel wafer apparently extends lifespan by only 2 months.

http://www.gliadel.com/


The corresponding author's email is given in the study's full text:

Tzyy-Wen Chiou
National Dong Hwa University, Taiwan.

http://neuro-oncolog...t/13/6/635.long

http://www.ncbi.nlm....les/PMC3107093/


The main author, Horng-Jyh Harn, is at the Department of Pathology,
China Medical University Hospital, Taiwan.

http://www2.cmu.edu....athology&Key=27

Edited by tham, 02 September 2012 - 06:07 AM.

[tham]

From the study :


" Compared with the clinical chemotherapeutic agent BCNU, Bdph inhibits the
proliferation of tumor cells more effectively ..... when GBM cells were treated
with Bdph, significant inhibitory effects on proliferation and cell cycle progression
were found, as was induction of apoptosis . These in vitro and in vivo anticancer
effects indicate that Bdph may function as a new anti–brain tumor drug. "

' Bdph-Wafers not only decreased the size of tumors but also kept its concentration
for 30 days. Thus far, there has been no brain edema, no delay in wound healing,
no CSF leakage, and no brain infection observed. Here, we propose an alternative
wafer-based compound for the treatment of human brain tumors. '



" Telomerase is widely expressed in 80%–90% of human cancers, but it is almost
undetectable in normal somatic cells. In human brain tissue, telomerase activity
is observed in 89% of glioblastomas and 45% of anaplastic astrocytomas, but it is
absent in normal brain tissue. In most cancers, the level of telomerase activity
generally correlates with the proliferation state of the cells. The presence of the
enzyme is required for unlimited proliferation (immortality), whereas its absence
almost always dictates a finite lifespan (senescence). This suggests that
telomerase activation is involved in the establishment of cellular immortality and
may therefore be a critical step in carcinogenesis. Therefore, inhibiting telomerase
activity may be a therapeutic strategy for selectively targeting malignant gliomas
and sparing normal brain tissue. "



" Although telomerase is absent from most human somatic tissue, telomerase is
expressed in adult germline tissues and in bone marrow hematopoietic cells.
The presence of this telomerase activity may result in unwanted adverse effects
if Bdph is systemically administered to treat malignant gliomas; this may pose a
particular problem for long-term treatment regimens. In an attempt to solve this
potential issue, we tested the local, controlled release of drugs bound to polymers.
Overall, targeting the telomerase gene using a local delivery system to produce
antitumor effects with drugs such as Bdph may result in a clinically applicable
therapy in the future. "


" The carmustine implant, a currently used local delivery Gliadel wafer, is an alkylating
agent that kills both tumor and normal cells. As a consequence, many adverse effects
are observed even with local application. Adverse reactions are both local and mild
(eg, nausea and vomiting) and systemic and aggravating (eg, infection, pulmonary
embolus, and hemorrhaging). In contrast, systemic administration of Bdph results in
only a mild hepatic impairment and slight hyperglycemia accompanying a 7.5 g/kg
median lethal dose (LD50). Their mild side effect is due to Bdph being a targeted drug.
The effector of Bdph is the orphan receptor Nurr77, which translocates from the
nucleus to the cytoplasm and leads to tumor apoptosis. "


" Finally, compared with the carmustine-Gliadel wafer, the Bdph-Wafer targets
telomerase and therefore is expected to have no significant toxicity on surrounding
normal brain cells. In addition, Bdph has a higher lethal dose than does carmustine
(7500 mg/kg vs. 83 mg/kg), which encourages us to test higher concentrations and
different formulations (such as glue or paste) as well as other biodegradable
polymers (such as poly(lactic-co-glycolic acid), chitosan, and hydrogel) to increase
the stability and local Bdph concentration. "

[mikey]

What about liposomal vitamin C and other lipsomal nutrients, like CoQ10 and glutathione?
Liposomes deliver vitamin C intracellularly better than IV.
Liposomes - 90% delivery. IV - 20%

There is a well-documented case of a man with leukemia having no cancer after taking liposomal vitamin C. You can read my article on it here - http://www.michaelmo...CureCancer.html

As well, I have a friend who has breast cancer, tumor size 6. She started 6 grams of LivOn Liposomal Vitamin C in March and the tumor has consistently been shrinking - the tumor was 3.5 when we spoke two weeks ago - she had added liposomal glutathione a few weeks before we spoke and it seemed to be accelerating the tumor shrinking.

I would think that combining liposomal vitamin C, glutathione, CoQ10, and resveratrol would really attack some types of cancer, since vitamin C does it by itself.

I'm surprised people aren't talking about liposomal nutrients here. Liposomal resveratrol is sold by several companies - LETSTALKHEALTH.com is one. And we can make DIY liposomal nutrients easily with an ultrasonic jewelry cleaner.

Here's my page on the formula that I like best (of two I know) for making DIY liposomal nutrients. http://www.michaelmo...eLiposomalC.pdf

[tham]

Horng-Jyh Harn's Bdph wafer is being sponsored and developed by this
Taiwanese biotechnology firm, EFBiotech.

http://www.efbiotech.com


I would suggest contacting them immediately to enquire whether you could fly
over there to have the wafer implanted, if you wish to do so.

The website's English translation does not work. Their videos are on Youtube.


http://translate.goo...otech.com/home/


http://translate.goo...1kFmynlgOQVztyw

http://translate.goo...06eGxwO23k5hVqg

http://translate.goo...mQvuuPwgo4_F_uA

http://translate.goo...WOz6Jc-HjZYYQSA


http://www.youtube.c...9DDstYjncb-40_g

[tunt01]

this seems interesting

http://www.scienceal...0409-23708.html.


Studies were also done in mice to determine whether antimiR-138 could effectively inhibit the growth of tumours. These experiments were conducted with a control drug as well, revealing that tumours continued to be present when mice were injected with the control, while injection with the antimiR-138 showed no tumour growth after nine months.

http://www.scienceda...20904121438.htm

Edited by prophets, 05 September 2012 - 03:26 PM.

[tham]

Where's Kim ?

[tham]

Chiou Tzyy-Wen, coauthor with Harn Horng-Jyh in the Bdph studies.

http://www.dlife.ndh...363,c8037-1.php




Butylidenephthalide Suppresses Human Telomerase Reverse Transcriptase (HERT)
in Human Glioblastomas

http://biotech.niu.e...le=附件æª"案



Angelica sinensis: A Chinese herb for brain cancer therapy

http://www.kaiser.co...ca sinensis.pdf



" Drug derived from Chinese herb aided brain tumor-stricken mice. "

http://www.fiercebio...mice/2012-04-13

http://focustaiwan.t...ID=201204130030

[tham]

The PDF file to the second study above is in Chinese and does
not load unless it is renamed.

Butylidenephthalide Suppresses Human Telomerase Reverse
Transcriptase (HERT) in Human Glioblastomas.

Attached Files

•  ANGELICA.PDF   903.13KB   6 downloads

Edited by tham, 06 September 2012 - 09:57 PM.