37 replies to this topic

[normalizing]

of course i know of alibaba but i never visit that site because i realized you have to buy huge amounts only and it costs so much individually. and to form a group buy is such a hassle. long process requiring patience and ability to form a reliable group. also, anything sourced from china, im not too excited :s

[Mind_Paralysis]

Well, then Smartpowders is your friend. It's much more expensive tho', but not that bad. You get a 100 grams for $16.

 

http://www.smartpowd...hylglycine.html

 

Otherwise, have a look over at this thread:
http://www.schizophr...essageID=472334

[Mnemonicsmoke]

Wondering if you guys were aware of 

 

 

Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment.

Tanabe M1, Takasu K, Yamaguchi S, Kodama D, Ono H.

Author information

 

Abstract

BACKGROUND:

Impaired excitatory and inhibitory balance in the spinal dorsal horn has a crucial role in the pathophysiology of chronic pain. The authors addressed the therapeutic impact of increasing spinal glycine applied exogenously or via blockade of glycine transporter 1 using its selective inhibitors sarcosine and N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine on neuropathic and inflammatory pain in mice.

METHODS:

Mice with thermal and mechanical hypersensitivity after partial ligation of the sciatic nerve (Seltzer model) or mice with mechanical hypersensitivity after streptozotocin injection received intrathecal injection of glycine, sarcosine, and N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine. These drugs were also intrathecally injected in mice to assess their effects on formalin-evoked nociceptive behaviors. The supraspinal effect of blockade of glycine transporter 1 was studied on tetanus-induced long-term potentiation of the Schaffer-collateral synapses in hippocampal slices prepared from Seltzer model mice.

RESULTS:

Glycine, sarcosine, and N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine ameliorated thermal and mechanical hypersensitivity in Seltzer model mice, and reduced mechanical hypersensitivity in streptozotocin-injected diabetic mice. Moreover, they selectively inhibited the second phase of formalin-evoked licking/biting behavior. In hippocampal slices prepared from Seltzer model mice, long-term potentiation was maintained at a significantly lower level than that in sham-treated mice. Such impairment of long-term potentiation was never observed when it was induced in the presence of N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine.

CONCLUSIONS:

An increase in endogenous glycine via glycine transporter 1 blockade not only results in a net inhibitory influence on pain transmission at the spinal level but also supraspinally relieves decreased synaptic efficacy presumably related to cognitive disturbance often described in patients with chronic pain.

I was a bit confused to hear people talk about it increasing pain, since I had that read that study and it seems its being investigated for its effects in reducing pain.

Edited by Mnemonicsmoke, 30 September 2014 - 03:26 PM.

[jaiho]

any further updates? I'm trying this. 700mg x 2 a day

 

[Sleepdealer]

@Furniture
Maybe the sarcosine isn't different, but your brain. Like you say, and from what I've read, sarcosine enhances the NMDA "processing". I read a study a week ago about a schizophrenic or schizotypal patient who became hypersexual, overstimulated, discomforted etc. after about 2 weeks of 2 g of sarcosine. When they lowered his dose to 1 g he turned out more okay. Try lowering your dose or take it with some days between each dose.

[GABAergic]

where do you buy sarcosine from? i got mine from relentless improvement but the caps are filled with crystal sugar it seems. is this how its suppose to feel/look ??