So no one's seen or heard of this?
I don't remember if they autopsied the long term tox rats, which were the ones that lived so long. I think they autopsied the acute tox rats, which got even higher doses. Here's the paper; it's probably in there.
Just reread it and it looks like they only autopsied the rats that were sacrificed after treatment for 7 days. Section 2.2.2 describes the grouping and partial bio-distribution of c60 was reported in section 4.2.2. At the end of section 4.2.2 they mention that "A complete biodistribution study including intestine, skin, bone and fatty tissue is in progress in our laboratory", which suggests that a further report might follow. Haven't seen any additional reports yet.
The only hints about causes of death were mention in section 3.3 of the report:
After five months of treatment (M15) one rat treated with water only exhibited some palpable tumours in the abdomen region. Due to the rapid development of tumours (about 4 cmof diameter) this rat died at M17. As rats are known to be sensitive to gavages, we decided to stop the treatment for all rats and to observe their behaviour and overall survival.
Also, mentioned later:
At the end of M25 the animals of the control groups showed signs of ulcerative dermatitis with ageing while C60-treated animals remained normal.
I couldn't find any info in the report on the cause of death of the c60/evoo treated rats. I think it has been observed in this forum that Wistar rats usually die of cancer suggesting that the c60/evoo treatment probably at least delayed that usual outcome. Hopefully, a repeat of the experiment will focus on that question.
Howard
Edited by hav, 19 October 2012 - 07:32 PM.