1569 replies to this topic

[HappyPhysicist]

I think overall my Dihexa experience has been underwhelming. My experimentation however is related to my ALS, not for any desire to improve cognitive abilities.

[jabowery]

It all sounds really good...has any one tried PQQ (10mg) + Fish Oil + CDP Choline (250mg) and then used the laser?
I be really interested in the results

Nothing like piling on confounding variables to render a new drug study virtually worthless!

[progress_]

I think overall my Dihexa experience has been underwhelming. My experimentation however is related to my ALS, not for any desire to improve cognitive abilities.

You are venturing into unknown territories with your experimentation.

- The effects of the drug on the nervous system might have to reach certain threshold levels before you can experience an improvement in your condition, leading to a "sudden onset" after days or weeks of no apparent effects.

- A regenerative effect on your nervous system might have a more gradual onset, yet simply require a longer exposure than what you've done so far to get anywhere.

If anything, please keep at it!

It would also be interesting to hear your current and future scores @ the working memory tests you've been doing. If anything they can be an indicator that something is happening.

Edited by progress_, 03 July 2013 - 12:52 AM.

[Xenix]

<p><p>Just did the memory test.

<a class="bbc_url" href="<a class="bbc_url" href="http://neutralx0.net...me/mini04.html" rel="nofollow external" title="External link">http://neutralx0.net...ini04.html"</a> rel="nofollow external" title="External link"><a class="bbc_url" href="http://neutralx0.net...04.html</a><br" rel="nofollow external" title="External link">http://neutralx0.net...html</a><br</a> />
Before my max memory items was 2 and I tried many times to get beyond 2, this time I did 10 and could have done more buy they have two coins that look very similar and that is why I stopped at 10.

I think I was able to remember more because the images were invoking strong memories of touch as I looked at them. I could easily think about how those images felt.
One odd thing I noticed after my first dose of dihexa was that evening I had incredibly vivid dreams in which I was having strong tactile sensations in my dream. I brushed it off as coincidence but after doing this memory test I am now convinced Dihexa is indeed causing additional neuronal connection in my brain, in particular it is allowing me to combine the senses. This is a very common tactic in memorization.
Wish I had this in college.</p><p>Unfortunately it does not seem to be helping my motor neurons. 

Well, that is some good news, I suppose. Can't really complain with enhanced cognition if nothing else (assuming Dihexa is behind this).

I also experienced greatly enhanced vividness in my dreams the first night I took Dihexa. I didn't experience that same vividness on the following days, though. I haven't been taking it lately because I started getting migraines -- I don't know if this was due to Dihexa or some pre-existing issues with my mental health. Either way, I will resume dosing tomorrow morning and try some memory tests.

Have you been taking Dihexa on an empty, or full stomach? I've been recommended to take it on an empty stomach in the mornings for maximum absorption. Just something for you to chew over.

P.S., what is your logic behind the olive oil?

[Elusive]

It all sounds really good...has any one tried PQQ (10mg) + Fish Oil + CDP Choline (250mg) and then used the laser?
I be really interested in the results

Nothing like piling on confounding variables to render a new drug study virtually worthless!

I am a little dyslexic...but anyways...
Thanks Blwjobwery

[Nattzor]

Few questions:

Does Dihexa release more BDNF or act like BDNF?
How is it taken?
Does it work the same way as NSI-189 (how does NSI-189 work? :P)?
Where have you guys ordered it from?

[therein]

Can anyone briefly tell me what's the status of this thread? Was there a group buy? Was it delivered? I know Xenix has tried it and had positive experiences. Is it just him or are other people also giving this a try?

[lostfalco]

It all sounds really good...has any one tried PQQ (10mg) + Fish Oil + CDP Choline (250mg) and then used the laser?
I be really interested in the results :)

It's funny you should mention this...I've been running 20mg PQQ http://www.amazon.co...-3&keywords=pqq + 300mg CoQ10 http://www.amazon.co...&keywords=c0q10 + laser + 5g D-Ribose for the past four days. So far, it's been profound. Clearheaded focus and mental energy for days. I think that there is a real possibility here for true enhancement well beyond what I am currently capable of. Keep in mind, of course, that I'm still on my usual stack so the substances are really piling on right now.

I used the one human PQQ + CoQ10 study for dosing.

There is an excellent 4 paragraph discussion of mitochondrial optimization on page 17 of 'Aging Matters Magazine' (Issue 2, 2013) by 'Smart Drugs' author himself Dr. Ward Dean. Here are his recommendations: 1. Increase Number of Mitochondria: PQQ, 2. Increase Mitochondrial Energy Producing Intermediates: D-Ribose (5g/day), Creatine (5g/day), CoQ10SR (100mg/day), NADH, and IAS's ATP-Boost (combo of ALCAR, ALA, and ATP).

My creatine is on the way, but I haven't decided about the NADH and ATP-Boost yet.

Edited by lostfalco, 04 July 2013 - 03:06 AM.

[lostfalco]

It all sounds really good...has any one tried PQQ (10mg) + Fish Oil + CDP Choline (250mg) and then used the laser?
I be really interested in the results :)

It's funny you should mention this...I've been running 20mg PQQ http://www.amazon.co...-3&keywords=pqq + 300mg CoQ10 http://www.amazon.co...&keywords=c0q10 + laser + 5g D-Ribose for the past four days. So far, it's been profound. Clearheaded focus and mental energy for days. I think that there is a real possibility here for true enhancement well beyond what I am currently capable of. Keep in mind, of course, that I'm still on my usual stack so the substances are really piling on right now.

I used the one human PQQ + CoQ10 study for dosing.

There is an excellent 4 paragraph discussion of mitochondrial optimization on page 17 of 'Aging Matters Magazine' (Issue 2, 2013) by 'Smart Drugs' author himself Dr. Ward Dean. Here are his recommendations: 1. Increase Number of Mitochondria: PQQ, 2. Increase Mitochondrial Energy Producing Intermediates: D-Ribose (5g/day), Creatine (5g/day), CoQ10SR (100mg/day), NADH, and IAS's ATP-Boost (combo of ALCAR, ALA, and ATP).

My creatine is on the way, but I haven't decided about the NADH and ATP-Boost yet.

Sorry, Dihexa thread! I don't mean to derail this discussion. I'll copy the above into my thread and get out of here.

Edited by lostfalco, 04 July 2013 - 03:05 AM.

[Elusive]

Thanks Falco
please provide a like here to your thread where i can keep in touch and exchange ideas

[Strangelove]

Well, recent studies (and a book, human experimentation with brain tumors starting to shrink...) http://www.amazon.co...ntion of cancer The research gives really positive results on brain cancer and a restricted calorie ketogenic diet (it seems effective for prevention also...) so an extra reason to try Dihexa even with (a possible) cancer risk...? What I meant to say... please someone find it and arrange a group buy!

[Glymo]

Hi, any news?

[Glymo]

Sorry about my english, I'm not a native speaker.

I'm determined to buy some Dihexa, take some tests, experiment with varius doses, and post here the process and the results daily.

Could someone help me out in the process?

My first step is to find a fiable lab in Europe that synthesize Dihexa for me at a price not too high (I'm a student). Any help will be appreciated. Thanks.

[Nattzor]

Sorry about my english, I'm not a native speaker.

I'm determined to buy some Dihexa, take some tests, experiment with varius doses, and post here the process and the results daily.

Could someone help me out in the process?

My first step is to find a fiable lab in Europe that synthesize Dihexa for me at a price not too high (I'm a student). Any help will be appreciated. Thanks.

Wont work that way. If you're just gonna synthesize a bit it'll cost more than you can afford. Try to get in the next group-buy instead.

[Glymo]

Wont work that way. If you're just gonna synthesize a bit it'll cost more than you can afford. Try to get in the next group-buy instead.

Thank you. Do you know where that groups are formed? There is another thread for that? Thanks.

[Nattzor]

Wont work that way. If you're just gonna synthesize a bit it'll cost more than you can afford. Try to get in the next group-buy instead.

Thank you. Do you know where that groups are formed? There is another thread for that? Thanks.

People create group-buys themself. I'd recommend for you to wait until a few more has tested (until the group-buy is done) and then do one yourself/join another one.

[Xenix]

Any updates, HP? I had to take a break from it for a while, I believe it was messing with my vision... my eyes were starting to become very irritated, dry and bloodshot. But I am uncertain whether or not this can be attributed 100% to Dihexa...

[HappyPhysicist]

I took it for two weeks but it didn't seem to be helping so discontinued.

[jabowery]

I took it for two weeks but it didn't seem to be helping so discontinued.

Earlier you wrote:

"Wish I had this in college. Unfortunately it does not seem to be helping my motor neurons."

Do you still wish you had it in college? In other words, is your disappointment primarily related to your failed expectations for ALS amelioration?

[hadora]

guys i have a doubt you had the real dihexa synthesized, someone told me earlier in this thread ( i think it's Erebus ) that you need not only the sequence but you need the peptide structure too which i don't find anywere
so how can you be sure that you got the real dihexa and not something completly unrelated ?

[Xenix]

guys i have a doubt you had the real dihexa synthesized, someone told me earlier in this thread ( i think it's Erebus ) that you need not only the sequence but you need the peptide structure too which i don't find anywere
so how can you be sure that you got the real dihexa and not something completly unrelated ?

Answer: we don't know for certain.

But, seeing as ***I*** have had the sequence synthesized by THREE different (and completely unrelated) companies who gave me almost the exact same MS analysis (one of which was confirmed by Erebus), I think it's safe to say that I must be close.

Also, HP's supplier (who is a different source again) produced a compound with almost the exact same MS analysis results as the THREE companies that synthesized my 'Dihexa'.

[Xenix]

Interesting update (since I checked the page last month) from the Michael J Fox Foundation on Dihexa:

FINAL OUTCOME
The goal of this project was to begin to evaluate the therapeutic potential of a small molecule activator of a growth factor, hepatocyte growth factor, which is known to protect nerve cells from damage, stimulate new connections among nerve cells, and induce the production of new neurons form stem cells. The hypothesis guiding the study was that the drug candidate Dihexa would be effective at restoring motor function that was lost in a standard pre-clinical model of Parkinson’s disease. The results of this study confirmed this hypothesis, demonstrating that Dihexa, given by abdominal injection or orally, completely restored lost motor function. Moreover, staining for tyrosine hydroxylase (TH), a marker for the dopamine neurons that were lost following chemical lesioning, returned to near normal after 34 days of treatment. Studies are still ongoing to determine whether this recovery of TH staining was due to the presence of new nerve cells and/or the expansion of the appendages of surviving neurons.

https://www.michaelj...hp?grant_id=993

Edited by Xenix, 04 August 2013 - 07:27 PM.

[megatron]

Let's get this group buy on its feet.

[Krabby]

Let's get this group buy on its feet.

I agree.

[researchist]

Let's get this group buy on its feet.

I agree.

I Concur!

[spookytooth]

Let's get this group buy on its feet.

I agree.

I Concur!

+1

[Strangelove]

"completely restored lost motor function"?

I am utterly and completely baffled! What they mean by this? You have a restoration in movement and neuron damage in 34 days?

Of cource this is not a human study?

Amazing, somewhat scary or the next nobel price in medicine.

[megatron]

OK, since this is very expensive, maybe we should look towards China for the manufacturing? I'll try to acquire a quote from T&W Group. Can someone with the authority try the Polish lab? Maybe Googoltorian would want to synthesize it? One of the most crucial questions we need to ask is: How much do we need? As I suspect with NSI-189, Dihexa is something that has to be taken over a quite long period of time to yield any noticeable effects. We shouldn't be talking about weeks, but rather months of usage. That's why I initially was disappointed with the amount of NSI-189 finally ordered. That trial seems to turn out just as I had expected; no effects shown. Therefore, I don't want this to turn out the same; that we order too little and have to wait an endless amount of months before we get the second batch. Also, remember that the inventors stated that the effects were greatly dose-dependent, so we have to take enough. Maybe Googoltorian would want to synt

How much do you guys want to acquire?

Edited by Megatrone, 31 August 2013 - 02:10 PM.

[Hebbeh]

[Xenix]

OK, I have been speaking with Science Guy's chemist (who synthesized NSI-189). He is willing to make a synthesis.

10grams of Dihexa will cost 5,000USD
OR 50g for 9,500
OR 100g for around 14k
OR 1kg for 27-30k

Considering how small a dosage is required (2mg/kg in rats orally), I think 50 grams would be more than enough - even after the HED is translated (25-40mg/dose). This stuff seems (from what I can reason) that it only really needs to be taken on one cycle, with hopefully permanent effects.

If we go with 50 grams (hopefully my maths is right here) 50 participants would pay $190USD for a gram... or 25 participants could get 2 grams for $380USD

Obviously the more that is sythesized the cheaper the price per gram will be -- but I am unsure of the demand -- and it would be a major hassle for the person who is packaging and sending out 50-100 samples... I'd just really like to start the ball rolling here...