1569 replies to this topic

[megatron]

Found a video from Dr. Harding presenting this compound, in case anyone wants to know a bit more.

 

http://vimeo.com/89795497

 

Thanks dude! Is MM-201 Dihexa?

Edited by Megatrone, 08 April 2014 - 04:45 PM.

[neuroatypicow]

that's impressive!

i for one am not ashamed to admit that my current rope hang skills are sadly lacking; i'm quite looking forward to significant improvements in this area.

[Adaptogen]

Found a video from Dr. Harding presenting this compound, in case anyone wants to know a bit more.

 

http://vimeo.com/89795497

 

awesome, the rope hang time clip at 17:52 is my favorite part

[formergenius]

Thanks dude! Is MM-201 Dihexa?

 

This study mentions both MM-201 and Dihexa, but I haven't read it, so I don't know whether they are synonymous. But perhaps you can extract that info from its context.

 

edit; Early in the video, he talks about how one of the earlier analogues reversed kainic acid induced hippocampal lesions (60-70% neuron loss). He also states that they were only active for 2-3 minutes. Now I'm curious; what does he mean by "reversed"? As in; the kainic acid induced 60-70% loss of neurons, after which the substance grew them back, and that within 3 minutes? What am I missing here?

Edited by formergenius, 09 April 2014 - 07:26 AM.

[foreseason]

Would Dihexa have any possible application in treating mood disorders?  Or is this simply cognitive enhancement?  Although I'm assuming there's some crossover between those two. 

 

Apologies if that's a stupid question.  I'm somewhat new to these forums . 

[Amorphous]

Would Dihexa have any possible application in treating mood disorders?  Or is this simply cognitive enhancement?  Although I'm assuming there's some crossover between those two. 

 

Apologies if that's a stupid question.  I'm somewhat new to these forums . 

 

That's a good point. I think Dr. Harding talked about the growth in the hippocampus area; in this case, would that be similar to NSI -189? Do they have the same MOA?

[formergenius]

While on the subject, take a look at this. Ketamine's anti-depressant effects appear to be mediated via its synaptogenic action. More articles supporting a synaptic theory of depression.

Edited by formergenius, 10 April 2014 - 04:19 AM.

[xks201]

Mood disorders can be caused by low bdnf.

[HappyShoe]

So, how do we let you know we want in, directly through the yahoo group? Should we also do the pay it square group as well?

Edited by HappyShoe, 11 April 2014 - 08:35 PM.

[xks201]

Pay via PayPal cjs2027@gmail.com
156 for us shipped
All non us 170 per gram

[HappyShoe]

Can I still get 2g for 306? Also do I check goods and services or friends and family?

Edited by HappyShoe, 11 April 2014 - 08:58 PM.

[xks201]

Friends and family. No fee that way. And yes if you are in the US. Add the shipping address in comments or via pm.

[Azz19]

Why is my membership approval for the yahoo group still pending? :(

[moomoo]

I would imagine that he means:

 

• The early analogue reserved kainic acid induced hippocampal lesions
• The early analogue was only active for 2-3 minutes

From that I'd assume that the drug had to be given almost continuously to reverse the lesions. There's nothing in what he says to assume that it reversed the lesions completely back to a previous state, but instead simply that the lesion damage started to be reversed and continued to do so when given the analogue.

 

 

 

 

Thanks dude! Is MM-201 Dihexa?

 

This study mentions both MM-201 and Dihexa, but I haven't read it, so I don't know whether they are synonymous. But perhaps you can extract that info from its context.

 

edit; Early in the video, he talks about how one of the earlier analogues reversed kainic acid induced hippocampal lesions (60-70% neuron loss). He also states that they were only active for 2-3 minutes. Now I'm curious; what does he mean by "reversed"? As in; the kainic acid induced 60-70% loss of neurons, after which the substance grew them back, and that within 3 minutes? What am I missing here?

 

 

Edited by moomoo, 14 April 2014 - 01:06 PM.

[xks201]

Why is my membership approval for the yahoo group still pending? :(

 

Just let 9 people in. cjs2027@gmail.com is the paypal email 

150/gram +

6 us shipping or

20 non us shipping

 

Buy still has some room. 

[Azz19]

Did you receive my payment? I sent you a PM but you haven't responded.
Payment sent from arran******@hotmail.com

[xks201]

Sorry - you didn't request a response in the PM and I didn't because I was inundated with NSI pms. Just replied to it though.

[Azz19]

Okay, many thanks.

[StevesPetRat]

Hi, I hope I did not miss the window on this compound. Just went to join group.

[xks201]

It is still open.

[Amorphous]

xks201, 

 

I didn't receive my confirmation of payment neither. 

Please confirm that. I am going to pm yountoo

[xks201]

Lol now I have multiple people who paid a month ago asking for confirmations. Guys I don't want to write out 100 confirmations. If you have a PayPal receipt I did receive it

[Azz19]

Lol, sorry for starting this off.

[HappyShoe]

I'd like a pony infused with Dihexa. =D

[xks201]

Me too. Haha

[StevesPetRat]

By the way, will this be packed in dry ice?

[Metagene]

Thanks dude! Is MM-201 Dihexa?

 
This study mentions both MM-201 and Dihexa, but I haven't read it, so I don't know whether they are synonymous. But perhaps you can extract that info from its context.
 
edit; Early in the video, he talks about how one of the earlier analogues reversed kainic acid induced hippocampal lesions (60-70% neuron loss). He also states that they were only active for 2-3 minutes. Now I'm curious; what does he mean by "reversed"? As in; the kainic acid induced 60-70% loss of neurons, after which the substance grew them back, and that within 3 minutes? What am I missing here?

From what I understand MM-201 is a direct AT4 agonist opposed to Dihexa's acting on HGF. Both improve rope hang times

Our laboratory has recently synthesized a metabolically stable AngIV analog that acts by way of the hepatocyte growth factor (HGF)/c-Met receptor system (133136) to overcome the motor dysfunctions that follow 6-OHDA-induced lesions of the substantia nigra pars compacta in the rat (unpublished results). This compound, called Dihexa, sig- nificantly improved both rope hang times and stride length over the course of a 48-day treatment period.

[HappyShoe]

what is the route of administration with dihexa? IN, IM, oral?

[VERITAS INCORRUPTUS]

what is the route of administration with dihexa? IN, IM, oral?

 

If I recall correctly, my interpretation was a derived estimated relative potency of injection being approximately 4-fold more potent than oral; therein placing oral bioavailability at a respectable ~25%, though the correlation is not exact.  I recall a dose given orally of 400% of that given via i.p. to foster significant improvement comparable to i.p., but in one model assay not to quite the degree of the comparative dose given i.p.  Hence my extrapolation was an oral bioavailability to likely require a  4-fold dose or slightly greater so as to confer an equitable effect.  

 

Obviously with most substances injection will confer superior potency, though such is surprising that a peptide (even a 'simple' tetrapeptide) maintains such a fair degree of oral bioavailability.  This was at the maximal dose assayed that showed significant effect.  From recall, said dosing was 2mg/kg p.o. in rats so the equitable oral dose for a 60kg animal would be approximately 20mg p.o. and 5mg i.m. - so research accordingly.

[amara bin]

Pay via PayPal cjs2027@gmail.com
156 for us shipped
All non us 170 per gram

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