8 votes
Posted 16 June 2014 - 01:59 PM
Got an update...synthesis isn't finished yet but there have been no flags on it so that is good. If it was flagged I suppose that would mean they would have to repeat a step. Thanks everyone for your patience. As of now I don't have an eta but I am assuming it will be a few more weeks before we can get it purity tested.
It may take a month or so longer than expected I'm not sure but I will keep everyone updated as soon as I get updates.
Any updates? It has been a month since you posted this one.
Posted 16 June 2014 - 09:55 PM
I'm certain he didn't even have the correct structure.
Yeah, iirc, the first structure everyone threw around was wrong, then someone mailed the creator and got the real deal. The mail was after the reddit guy had tried it.
Xenix 
Posted 12 July 2014 - 02:02 PM
I read those comments, a while back. I'm not sure he got a quality synth.
I'm certain he didn't even have the correct structure.
Agree
Xenix had a very wrong structure. I obtained the correct structure and other specifics directly from WSU.
Posted 16 July 2014 - 01:47 AM
Hey guys,
Long time lurker here.
I recently had a custom synth completed. I've been taking ~27mg daily for about 12 days now.
The compound has a half life of about 13 days in rats[1], which is probably lower than the human half life. The original researchers found that it completely reversed scopolamine induced memory damage after 8 or 9 days of use.
At any rate, I should probably be approaching maximum circulating levels within these next few days.
Keeping in mind placebo effects are always possible, here are some rambling subjective observations:
I didn't notice any major psycho-activity. No dissociation or excessive stimulation.
The most dramatic effects I've noticed are sensory. My sense of taste & smell are heightened, similar to the effects I've experienced from deprenyl and rasagiline. There is also a heightened contrast visually, not unlike what many people experience from extended racetam use.
I suspect it's moderately elevated my blood pressure, yet because of its high circulating half life and limited pre-dosing data, its difficult to quantify.
In addition, I no longer have daytime drowsiness. I'm alert all day without any caffeine, modafinil, etc...
I study very demanding material. I haven't noticed any kind of dramatic cognitive increase that couldn't be ascribed to placebo. That being said, when forced to recall old information, things do seem to 'click' more easily.
I'm anticipating the real effects to come with moderately sustained use. Neuronal growth is probably not going to happen overnight.
I have much more of this compound than i'll need. I'd love to send out around a weeks worth of this compound to a few reputable members (stateside please). I also have a small amount i'd like to sell if anyone is interested. I made a reddit post a couple weeks ago for that purpose. If someone wants to search for it you'll find HNMR & MS for the compound. (Can't post links, sorry!)
[1] Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents
P.S. Thanks sk_scientific. I've been keeping up with this thread, and you have been extraordinarily helpful in researching this compound. None of this would have been possible without you.
Edited by DHEXA, 16 July 2014 - 01:53 AM.
Posted 16 July 2014 - 02:57 AM
Hey guys,
Long time lurker here.
I recently had a custom synth completed. I've been taking ~27mg daily for about 12 days now.
The compound has a half life of about 13 days in rats[1], which is probably lower than the human half life. The original researchers found that it completely reversed scopolamine induced memory damage after 8 or 9 days of use.At any rate, I should probably be approaching maximum circulating levels within these next few days.
Keeping in mind placebo effects are always possible, here are some rambling subjective observations:
I didn't notice any major psycho-activity. No dissociation or excessive stimulation.The most dramatic effects I've noticed are sensory. My sense of taste & smell are heightened, similar to the effects I've experienced from deprenyl and rasagiline. There is also a heightened contrast visually, not unlike what many people experience from extended racetam use.
I suspect it's moderately elevated my blood pressure, yet because of its high circulating half life and limited pre-dosing data, its difficult to quantify.
In addition, I no longer have daytime drowsiness. I'm alert all day without any caffeine, modafinil, etc...
I study very demanding material. I haven't noticed any kind of dramatic cognitive increase that couldn't be ascribed to placebo. That being said, when forced to recall old information, things do seem to 'click' more easily.I'm anticipating the real effects to come with moderately sustained use. Neuronal growth is probably not going to happen overnight.
I have much more of this compound than i'll need. I'd love to send out around a weeks worth of this compound to a few reputable members (stateside please). I also have a small amount i'd like to sell if anyone is interested. I made a reddit post a couple weeks ago for that purpose. If someone wants to search for it you'll find HNMR & MS for the compound. (Can't post links, sorry!)
[1] Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents
P.S. Thanks sk_scientific. I've been keeping up with this thread, and you have been extraordinarily helpful in researching this compound. None of this would have been possible without you.
Thank you, my friend.
Also, I should say thank you to the ACTUAL academic researchers who developed this hopeful substance. I'm just a vessel of operation in a community.
Edited by sk_scientific, 16 July 2014 - 03:18 AM.
Posted 16 July 2014 - 07:40 AM
Hey guys,
Long time lurker here.
I recently had a custom synth completed. I've been taking ~27mg daily for about 12 days now.
The compound has a half life of about 13 days in rats[1], which is probably lower than the human half life. The original researchers found that it completely reversed scopolamine induced memory damage after 8 or 9 days of use.At any rate, I should probably be approaching maximum circulating levels within these next few days.
If someone wants to search for it you'll find HNMR & MS for the compound. (Can't post links, sorry!)
DHEXA, PM sent.
Since DHEXA cannot post links, I'm linking his spectra for him:
MS Spectrograph: http://i.imgur.com/7eaiXS2.png
H-NMR Spectrograph: http://i.imgur.com/GLoIMIJ.png
EDIT: Forgot that there are various drawings for different molecules out there for Dihexa, which would make analyzing a bit more difficult. Here is the correct structure also posted by DHEXA elsewhere: http://i.imgur.com/uzxT1aM.jpg
Edited by FW900, 16 July 2014 - 07:47 AM.
Posted 16 July 2014 - 09:02 AM
Dear Members,
I am considering whether to give this drug a try, if the opportunity presents itself. I know all the available information is there in the threads, the links, etc., and it's up to me to acquaint myself with all the research out there. I've read quite a bit of the discussion, but not all of it. My question to the more knowledgeable members of the forum is this: does this drug have any potential for alleviating MDD/anxiety/stress? Out of all the new drugs touted as promoting neurogenesis, and therefore of interest as both nootropics and anti-depressants, this drugs seems to have the least potential as an anti-depressant. Is my impression roughly accurate?
Edited by tolerant, 16 July 2014 - 09:03 AM.
Posted 16 July 2014 - 12:33 PM
Hey guys,
Long time lurker here.
I recently had a custom synth completed. I've been taking ~27mg daily for about 12 days now.
The compound has a half life of about 13 days in rats[1], which is probably lower than the human half life. The original researchers found that it completely reversed scopolamine induced memory damage after 8 or 9 days of use.At any rate, I should probably be approaching maximum circulating levels within these next few days.
Keeping in mind placebo effects are always possible, here are some rambling subjective observations:
I didn't notice any major psycho-activity. No dissociation or excessive stimulation.The most dramatic effects I've noticed are sensory. My sense of taste & smell are heightened, similar to the effects I've experienced from deprenyl and rasagiline. There is also a heightened contrast visually, not unlike what many people experience from extended racetam use.
I suspect it's moderately elevated my blood pressure, yet because of its high circulating half life and limited pre-dosing data, its difficult to quantify.
In addition, I no longer have daytime drowsiness. I'm alert all day without any caffeine, modafinil, etc...
I study very demanding material. I haven't noticed any kind of dramatic cognitive increase that couldn't be ascribed to placebo. That being said, when forced to recall old information, things do seem to 'click' more easily.I'm anticipating the real effects to come with moderately sustained use. Neuronal growth is probably not going to happen overnight.
I have much more of this compound than i'll need. I'd love to send out around a weeks worth of this compound to a few reputable members (stateside please). I also have a small amount i'd like to sell if anyone is interested. I made a reddit post a couple weeks ago for that purpose. If someone wants to search for it you'll find HNMR & MS for the compound. (Can't post links, sorry!)
[1] Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents
P.S. Thanks sk_scientific. I've been keeping up with this thread, and you have been extraordinarily helpful in researching this compound. None of this would have been possible without you.
I PMed you. How many days of dosing have you done before you noticed the absence of drowsiness? Glad to hear that the compound does indeed work rather quickly in humans.
Edited by xks201, 16 July 2014 - 12:34 PM.
Posted 16 July 2014 - 04:51 PM
Dear Members,
I am considering whether to give this drug a try, if the opportunity presents itself. I know all the available information is there in the threads, the links, etc., and it's up to me to acquaint myself with all the research out there. I've read quite a bit of the discussion, but not all of it. My question to the more knowledgeable members of the forum is this: does this drug have any potential for alleviating MDD/anxiety/stress? Out of all the new drugs touted as promoting neurogenesis, and therefore of interest as both nootropics and anti-depressants, this drugs seems to have the least potential as an anti-depressant. Is my impression roughly accurate?
That's an interesting question. I'm lucky enough to not suffer from either MDD or excessive anxiety so i can't give any empirical data.
Regarding depression specifically, I put very little value in the serotonergic models. The fact that "treatment resistant" depression exists is testament to our poor understanding of the disease.
One interesting study involving ketamine argues for a connection between neuronal growth / synaptogenesis with mood regulation.
-snip-
I PMed you. How many days of dosing have you done before you noticed the absence of drowsiness? Glad to hear that the compound does indeed work rather quickly in humans.
Even though my sleep is fairly constant with 7-8 hours a night, I've been prone to have a 2pm crash.
I first noticed it a couple of days into the regimen. I had a lingering feeling it could be placebo, but the effect seems to be building in a linear fashion. Like I told someone in a pm, the effect doesn't seem stimulatory. The only comparison I would make is to deep meditation - like a calm awareness of your surroundings. I haven't noticed any real sleep disturbances, but I've only taken morning doses.
I was initially concerned that it might produce a hypomanic/manic state, so i have a close friend monitoring me. As of yet, there have been no obvious signs - no delusions of grandeur, changes in spending habits, etc.
Edited by DHEXA, 16 July 2014 - 04:53 PM.
Posted 17 July 2014 - 12:13 AM
Edited by Nemo888, 17 July 2014 - 12:28 AM.
Posted 17 July 2014 - 12:37 AM
This one is outside my envelope of safety too. I try to stick to bioidentical compounds. My experiments went well though. The TB4 did seem to prove my personal hypothesis of neural/neuronal inflammation. Unless your medical prognosis is terrible and degenerative I would not see the point of taking this. The irony is that not seeing the risk involved may prove your need for it.
Good luck with this. If my condition had continued to worsen I may have been considering equally risky behavior. My experience using peptides for neuronal regeneration is that a month is ideal with a month to bounce back. I ate double meals often the month I was on and the cells continued to mature the following month. I slept more than usual too. I felt very relaxed and on day 24 began to dream again which was very unexpected. The changes continue to this day which is months later. Regeneration of your brain WAS impossible, but medicine always changes.
As always, you can count on me to report my findings. Your hesitation is sound and I wouldn't encourage you to take any of these compounds. We're all big boys here, we make and own our own decisions.
Posted 17 July 2014 - 01:26 AM
Dear Members,
I am considering whether to give this drug a try, if the opportunity presents itself. I know all the available information is there in the threads, the links, etc., and it's up to me to acquaint myself with all the research out there. I've read quite a bit of the discussion, but not all of it. My question to the more knowledgeable members of the forum is this: does this drug have any potential for alleviating MDD/anxiety/stress? Out of all the new drugs touted as promoting neurogenesis, and therefore of interest as both nootropics and anti-depressants, this drugs seems to have the least potential as an anti-depressant. Is my impression roughly accurate?
Some of the tests that are undertaken on rodents measure acute depression in the form of learned helplessness and some other criteria. When we're speaking on genetic predisposition, neurochemical, or pathological depression, it is hard to speculate. An educated speculation in my opinion is: it is quite likely based upon what we know of neurogenesis, spinogenesis and differentiation impacting cases of Major Depressive Disorder.
Mind you, MDD being impacted by these items is still a theory without a whole lot of research to back it, and we have to be careful with correlation, but the implications are present and it seems on the surface to be the case. And this is, to some degree, supported by what's being seen with NSI-189, though I believe that what's going on pharmacologically with NSI-189 and what is likely going to go on with Dihexa will be fairly different in action and impact.
Edited by sk_scientific, 17 July 2014 - 01:32 AM.
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