1569 replies to this topic

[xks201]

I wouldn't say it is that spooky it just feels like my depth perception (which was already very good) is even better. Like I said I used to race street bikes around tracks for fun and that requires pretty much the best depth perception you can possibly have. Now it feels better. Colors feel enhanced still. Not in a psychadelic type way- more so just an improvement in vision or spatial processing almost. 

[sparkk51]

 

Anyone making slightly dyslexic typos lately? I noticed I have been making them more often lately while I have no history of dyslexia at all.

 
Can you relate to Harding's weird moments in http://vimeo.com/89795497?

 

 

I saw the video a while back and dont feel like watching again. Are you saying he is also taking Dihexia?

[xks201]

What weird moments? Give me some time (second) examples from the vid.

[xks201]

Another thing is your stupidity tolerance for others goes to zero even a week after the last dose. You will realize someone has no idea what they are talking about very quickly when interacting if they dont.

[therein]

Another thing is your stupidity tolerance for others goes to zero even a week after the last dose. You will realize someone has no idea what they are talking about very quickly when interacting if they dont.

 

What's your dosage? How often do you take it and how long have you been taking it for?

[jabowery]

Another thing is your stupidity tolerance for others goes to zero even a week after the last dose. You will realize someone has no idea what they are talking about very quickly when interacting if they dont.

 

I've noticed irritability when taking ginkgo in large doses before meetings -- so I take care to compensate.  I might attribute it to others' stupidity but I've also thought it possible that the increased cerebral perfusion can result in burning up the glucose reserves.

[fairy]

I saw the video a while back and dont feel like watching again. Are you saying he is also taking Dihexia?

 
It's only a hypothesis.
 

What weird moments? Give me some time (second) examples from the vid.

 
From 19:00 to 19:10. This is the one I remember.

[sk_scientific]

I redosed this afternoon after about a week of cessation.  Visual acuity enhancement promptly returned, while the Dihexa was still under my tongue.

 

FYI.

[jabowery]

I redosed this afternoon after about a week of cessation.  Visual acuity enhancement promptly returned, while the Dihexa was still under my tongue.

 

FYI.

 

Are you taking your blood pressure frequently after dosing?  Is bp rise transient?  Are the visual effects transient?

[sk_scientific]

The blood pressure fluctuates and I believe that it's unrelated to the drug.  The enhanced vision seems only to be present while the drug has been recently ingested.

[sparkk51]

 

I saw the video a while back and dont feel like watching again. Are you saying he is also taking Dihexia?

 
It's only a hypothesis.
 

What weird moments? Give me some time (second) examples from the vid.

 
From 19:00 to 19:10. This is the one I remember.

 

 

He stutters for 10 seconds, and you attribute that to the Dihexia he is theoretically taking? That's some some comedy gold right there.

[sk_scientific]

As far as a lot of Professors go, Dr. Harding is a really nice man, and he's no dummy either.

[fairy]

I'm not making any personal judgement on Professor W. Harding. It was a petty observation based on what I thought peculiar at the time. Excuse me for my poor choice of words.

[medicineman]

That video is nothing short of inspiring. Dr. Harding is pretty much what my dream was of being before being coerced culturally and by my family to go into medicine. I remember in the middle of my schooling, I went to the doctor who was supervising my literature based research on therapeutics of MDMA, and I told him that medicinal chemistry and drug design was my dream. He basically closed that door for me, and told me I'm too late and it's not possible to backtrack.

He's no dummy is right

[Metagene]

so.... method of administration? any hope for transdermal? sublingual? nasal spray?


http://www.mysticpha....com/nasal.html

Intranasal is listed in the patent for a potential delivery method among other things.

The Deltafish looks amazing btw.

[medicineman]

so.... method of administration? any hope for transdermal? sublingual? nasal spray?


http://www.mysticpha....com/nasal.html

Intranasal is listed in the patent for a potential delivery method among other things.

The Deltafish looks amazing btw.

imagine how much more amazing it would be if loaded with 30mg dihexa per dose.

[sk_scientific]

Gentlemen, I apologize for slightly diverging off topic, however this is relevant food for thought and I think the 13 minutes that you spend watching this video will be worth your time.

 

http://www.ted.com/t...the_human_brain

[xks201]

Not sure what dick head marked sks link off topic but that was a very good presentation. I did not realize the brain used that much energy. That is amazing when you think about it that such a small fraction of the body could use majority of the energy when you consider physically it isn't doing the work of say muscles. It is not off topic because if we can figure out to minimize entropy ie. Enhance efficiency of just energy metabolism of the brain that could be the most powerful nootropic there is.

If our brains depend on energy that much then even relatively minor metabolic errors basically can mentally handicap people extremely. So much for the body mind dichotomy.

Edited by xks201, 03 August 2014 - 02:59 PM.

[sk_scientific]

Not sure what dick head marked sks link off topic but that was a very good presentation. I did not realize the brain used that much energy. That is amazing when you think about it that such a small fraction of the body could use majority of the energy when you consider physically it isn't doing the work of say muscles. It is not off topic because if we can figure out to minimize entropy ie. Enhance efficiency of just energy metabolism of the brain that could be the most powerful nootropic there is.

If our brains depend on energy that much then even relatively minor metabolic errors basically can mentally handicap people extremely. So much for the body mind dichotomy.

 

Cognitive deficits are often seen in chronic anorexics, but even more to the point, think of how one becomes cranky and irritable when hungry.  Food for thought.

[amara bin]

Not sure what dick head marked sks link off topic but that was a very good presentation. I did not realize the brain used that much energy. That is amazing when you think about it that such a small fraction of the body could use majority of the energy when you consider physically it isn't doing the work of say muscles. It is not off topic because if we can figure out to minimize entropy ie. Enhance efficiency of just energy metabolism of the brain that could be the most powerful nootropic there is.

If our brains depend on energy that much then even relatively minor metabolic errors basically can mentally handicap people extremely. So much for the body mind dichotomy.

Is so cute to see you guys becoming Gods
Xks...when do you think the compound will be available?

[jabowery]

...That is amazing when you think about it that such a small fraction of the body could use majority of the energy when you consider physically it isn't doing the work of say muscles....

 

Actually, the machine learning model I'm working with is based on Robert Hecht-Nielsen's "Confabulation Theory" in which the bulk of the mammalian brain is phylogenetically descended from muscles:  the thalamocortical modules.

 

This isn't entirely off-topic regarding Dihexa.  Notice the rope-hanging performance of the treated rats and its correlation with water-maze performance of those rats.

Edited by jabowery, 03 August 2014 - 05:45 PM.

[sk_scientific]

 

 

Actually, the machine learning model I'm working with is based on Robert Hecht-Nielsen's "Confabulation Theory" in which the bulk of the mammalian brain is phylogenetically descended from muscles:  the thalamocortical modules.

 

This isn't entirely off-topic regarding Dihexa.  Notice the rope-hanging performance of the treated rats and its correlation with water-maze performance of those rats.

 

 

Explain.

[jabowery]

 

 

 

Actually, the machine learning model I'm working with is based on Robert Hecht-Nielsen's "Confabulation Theory" in which the bulk of the mammalian brain is phylogenetically descended from muscles:  the thalamocortical modules.

 

This isn't entirely off-topic regarding Dihexa.  Notice the rope-hanging performance of the treated rats and its correlation with water-maze performance of those rats.

 

 

Explain.

 

 

Confabulation theory posits that coordination of thought has the same phylogenetic origin as the coordination of movement*.  What we're seeing in Dihexa appears to be the restoration of coordination of thought (as evidenced by the cognitive demands of the water maze learning rate) and coordination of movement (restoration of normal gait and superior rope hanging performance).  

 

*Quoting:

 

Confabulation theory (Hecht-Nielsen 2005, 2006a, 2006b, 2006c, 2007) (Figure 1) proposes that cognition is a phylogenetic outgrowth of movement and that cognition utilizes the same neural circuitry that was originally developed for movement.

Movement relies on the deliberate, smooth, properly sequenced and coordinated, graded, contractions of selected ensembles of discrete muscles. Therefore, the neural circuitry of movement was specialized for this purpose. Soon, a new design possibility emerged: the elaborate neuronal machinery of movement control could be applied to brain tissue itself. In particular, discrete brain structures, modules, emerged that could be controlled exactly like individual muscles (the physical arrangement of the neurons involved in a single module differs considerably across taxa, e.g., see [Karten 1991], although module function is strongly conserved). By manipulating these modules in properly coordinated 'movements' (thought processes), valuable information processing (cognition) could be carried out – thereby further enhancing animal competitive success and diversity.

Edited by jabowery, 03 August 2014 - 11:27 PM.

[sk_scientific]

And that, is why I am done.

 

Be careful around here kids.

Edited by sk_scientific, 04 August 2014 - 02:52 AM.

[therein]

And that, is why I am done.

 

Be careful around here kids.

 

What happened?

[Strangelove]

Not sure what dick head marked sks link off topic but that was a very good presentation. I did not realize the brain used that much energy. That is amazing when you think about it that such a small fraction of the body could use majority of the energy when you consider physically it isn't doing the work of say muscles. It is not off topic because if we can figure out to minimize entropy ie. Enhance efficiency of just energy metabolism of the brain that could be the most powerful nootropic there is.

If our brains depend on energy that much then even relatively minor metabolic errors basically can mentally handicap people extremely. So much for the body mind dichotomy.

 

Yes, that was a great presentation, I already knew the facts of what she presented, and I think members here should be more aware that energy metabolism of the brain at times can be more important than raw intelligence. People hugely underestimate were endurance in mental tasks can get you. Two of the most succesful people I know, seem to be "very awake" continuously pursuing their goals, for very long hours each day. One of them, a doctor that would go in medical school only by studying continuously for ten or more hours each and every day (seriously with no break at all, comparing to myself he is a kind of a freak). I do not think he is "particularly smart" being very original, or looking all the details of a situation / he is not having much of an emotional intelligence either, but after 30 years of working very long hours in a hospital, making sure ten of thousands of people have a positive impression of him (going out of his way being helpful) and taking extra time to send people (that were not patients of him, he was doing it pro bono) to see the right specialist, he was voted "governor" in my small "state" in my country, from his former patients their relatives and his good reputation. Having knowing him, he is not really extraordinary by any means apart his extraordinary mental endurance. 

 

I looked in the past how mental endurance is mediated and it seems mechanisms of a "safety break" exists in the brain, so it would put a limit of how much time you would spend in a task mentally, how many new neurons would grow and how many calories you would burn when you have them. The mechanism as far I know is unknown (expect a rise in cortisol, after mental extertion that is expected) but if we could hijack it somehow, the extra effort we would spend in a task would push our brains further growing new neurons.

 

I started a thread a while ago, but I had much brain fog to continue researching it.

 

http://www.longecity...-for-the-brain/

 

Xks201, I am sure you know what myostatin is, imagine if we could inhibit chemicals that exist in the brain that function with a similar logic for neurons, were this might led us? The brain is a "lazy bum" as Claude Messier of the University of Ottawa say in my link above, because as I understand it, needs a lot of energy in its resting state, thous making neurons expensive in the long term. Although reading ten hours would not use considerably much energy than say sleeping for ten hours, the neurons you will grow and new connections, by continously using your brain in its extreme, would get expensive in the long term. So having a neuronal myostatin inhibitor "analog for neurons" would help us not die from famine ten years from now due to too many neurons in our brains :P Maybe this is the opposite side of the coin than having a good amount of neurotrophic factors for growing new neurons.

Edited by Strangelove, 04 August 2014 - 02:04 PM.

[agora]

You're talking about GDF11 right? Teamtlr has what is supposedly a myostatin and GDF-11 inhibitor antibody they sell in ampules

[Strangelove]

Hey Lynfectious, a wiki part of what myostatin is.

 

Clinical significance[edit] Effect in humans[edit]

Myostatin is active in muscles used for movement (skeletal muscles) both before and after birth. It normally restrains muscle growth, ensuring that muscles do not grow too large. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has a pattern of inheritance known as incomplete autosomal dominance. People with a mutation in both copies of the MSTN gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) also have increased muscle bulk, but to a lesser degree.

In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother has a mutation in one copy of the gene.^{[14][15][16][17]}

An American boy born in 2005, Liam Hoekstra, was diagnosed with a clinically similar condition but with a somewhat different cause:^[18] his body produces a normal level of functional myostatin; but, because he is stronger and more muscular than most others his age, his doctor believes that a defect in his myostatin receptors prevents his muscle cells from responding normally to myostatin. Liam appeared on the television show World's Strongest Toddler.

A technique for detecting mutations in myostatin variants has been developed.^[19]

 

^{Having a knowledge of what myostatin does to muscle composition, I thought that something similar exists for neurons, and it does. What I am getting at is an alternative way for neural hypertrophy? An alternative logic for brain growth than neurotrophic factors.} 

^{All this is hypothetical and do not wish to derail the thread, check the link from my thread above if interested. Is not well put together being foggy at that time, but you will get the idea.}

[jabowery]

Its one of the greatest tragedies of civilization that our caloric intake has skyrocketed at the same time as our cognitive demands have skyrocketed but those calories are routed away from cognitive functions into life-threatening fat deposits.  I've long wondered why there wasn't more research into simply dealing with that misallocation of calories.  Its one reason I've taken cerebral perfusion via ginkgo seriously -- get the nutrients to the neurons.  It seems to help temporarily in large doses but then there is a rebound effect with irritability (as I said speculated, possibly due to readily available forms of glucose being burned up, with a hunger response).

 

You're on the right track, Strangelove.

 

The caloric intake and exercise of the rats in the dihexa trials were not reported AFAIK -- nor were their post-treatment neuron counts taken in the manner suggested by the TED talk by Neuroscientist Suzana Herculano-Houzel linked by sk_scientific above.

 

 

 

Not sure what dick head marked sks link off topic but that was a very good presentation. I did not realize the brain used that much energy. 

 

Yes, that was a great presentation, I already knew the facts of what she presented, and I think members here should be more aware that energy metabolism of the brain at times can be more important than raw intelligence. People hugely underestimate were endurance in mental tasks can get you. Two of the most succesful people I know, seem to be "very awake" continuously pursuing their goals, for very long hours each day. One of them, a doctor that would go in medical school only by studying continuously for ten or more hours each and every day (seriously with no break at all, comparing to myself he is a kind of a freak). I do not think he is "particularly smart" being very original, or looking all the details of a situation / he is not having much of an emotional intelligence either, but after 30 years of working very long hours in a hospital, making sure ten of thousands of people have a positive impression of him (going out of his way being helpful) and taking extra time to send people (that were not patients of him, he was doing it pro bono) to see the right specialist, he was voted "governor" in my small "state" in my country, from his former patients their relatives and his good reputation. Having knowing him, he is not really extraordinary by any means apart his extraordinary mental endurance. 

 

I looked in the past how mental endurance is mediated and it seems mechanisms of a "safety break" exists in the brain, so it would put a limit of how much time you would spend in a task mentally, how many new neurons would grow and how many calories you would burn when you have them. The mechanism as far I know is unknown (expect a rise in cortisol, after mental extertion that is expected) but if we could hijack it somehow, the extra effort we would spend in a task would push our brains further growing new neurons.

 

I started a thread a while ago, but I had much brain fog to continue researching it.

 

http://www.longecity...-for-the-brain/

 

Xks201, I am sure you know what myostatin is, imagine if we could inhibit chemicals that exist in the brain that function with a similar logic for neurons, were this might led us? The brain is a "lazy bum" as Claude Messier of the University of Ottawa say in my link above, because as I understand it, needs a lot of energy in its resting state, thous making neurons expensive in the long term. Although reading ten hours would not use considerably much energy than say sleeping for ten hours, the neurons you will grow and new connections, by continously using your brain in its extreme, would get expensive in the long term. So having a neuronal myostatin inhibitor "analog for neurons" would help us not die from famine ten years from now due to too many neurons in our brains :P Maybe this is the opposite side of the coin than having a good amount of neurotrophic factors for growing new neurons.

 

 

[jabowery]

 

And that, is why I am done.

 

Be careful around here kids.

 

What happened?

 

 

Whatever happened, if sk_scientific has stopped reporting the effects of dihexa here and others are as well I'm going to take up the slack and report dihexa's effects on me before suggesting to my wife that she start treatment with it.  We could go on all day about the ethical trade offs here but bottom line is I am responsible for potentially bringing this into her life.  With a second gram on the way I am less concerned about taking dihexa that she needs than I am concerned about aggravating her condition with an experimental substance.  I'll be acquiring a safety man.