1569 replies to this topic

[Flex]

Dihexa is the most powerful non-plus-ultra nootropic that I know. I cant imagine that it is so easy going.

I dont think of the "usual side-effects" but more about perhaps possible profound changes in the synaptic architecture.

 

Question: could this lead to a chaotic state of the synaptic architecture ?

 

I dont have any reference of this nor I´m a scientist, but I guess there is some agreement of the little knowledge about Dihexa, even among the Scientists.

Edited by Flex, 12 August 2014 - 04:13 PM.

[neuroatypicow]

i think we all are aware that even the primary effect of dihexa hasn't been confirmed in humans, let alone possible side effects. we're taking calculated risks, with the risk-benefit calculation worked out by each of us, using our own personal calculus. just like all the other nootropics discussed on this forum.

 

(and yes, it was difficult to restrain myself from typing cowculated, cowculation, and cowculus)

[jabowery]

Dihexa is the most powerful non-plus-ultra nootropic that I know. I cant imagine that it is so easy going.

I dont think of the "usual side-effects" but more about perhaps possible profound changes in the synaptic architecture.

 

Question: could this lead to a chaotic state of the synaptic architecture ?

 

I dont have any reference of this nor I´m a scientist, but I guess there is some agreement of the little knowledge about Dihexa, even among the Scientists.

 

All these risk are well worth considering but it is irrational to consider one quantity without considering commensurate quantities to form ratios which is, after all, the root word of "rational".

 

For instance, in my situation, I'm married to a woman who is at substantial risk of death -- not just ultimately as we all are nor even sooner than we all might be but -- due to suicide arising from catastrophic loss of quality of life.  So a pessimistic view is that there is the risk that Dihexa will do her damage on top of the risk of her existing condition.  However, if we view what is known to be of benefit in animal models, it is known to correct motor control and motor control is what is most damaging in her condition (think projectile vomit, choking (with danger of dying as frequently happens to HD victims), incontinence, falling and breaking bones, etc ALL of which have already happened to her not to mention the loss of her primary joy in life which is singing).  Moreover, waiting for clinical trials would be foolish for the simple reason that she has already been rejected from clinical trials for gene silencing of the Huntingtin gene because she is too far gone.  Yes, you read right:  They refuse to allow people who are at greatest risk of loss of life into clinical trials that mighty save their lives.  There are a variety of reasons for this but one that is in common is that as the condition worsens there are so many systems that go haywire that confounding variables interfere with analysis.  You see, clinical trials are not for the benefit of the participants -- they are for the benefit of the scientists who are attempting to assess the safety and effectiveness of the treatments. I am not such a scientist.  I am her husband and while I have my own self-interest to ethically contend with, I do also, unlike the clinical scientist, have her interest at heart due to its correlation with my own self-interest.  

 

I honestly don't give a good goddamn in Hell what people think of me and my ethics in this situation. 

 

I'm going to continue testing on myself for safety at least in near term effects.  After determining, in my sole judgement, that the risk is warranted, I'm going to advise her to start treatment and do so against the advice of her medical professionals who are legally bound to provide such negative advice.  They can try to throw me in jail if they want but it will more likely be my dead body they throw in the morgue, quite possibly with some unfortunate individuals tasked with taking me down.

Edited by jabowery, 12 August 2014 - 10:32 PM.

[Flex]

Sorry to hear that Jabowery

 

I really dont want to annoy or burden You with my opinion thats why I´m writing so seldom in this thread.

I have posted my concerns about 2 months ago regarding a possible cancer risk and thats it.

I´ve only gave a comment now because the post of xks seemed to me to suggesting that Dihexa is somewhat unproblematic.

 

Believe me I would even rob a bank to get it because I would need it, but its too hot for me.

also I´m aware that You are willed to take the possible risks, but I just got worried when it seems or somehow suggests that its 100% safe to someone who is not willed to take the risks.

 

As You see: if I would try to convince anybody, I would post far more times in this thread and "troll arround" so to say.

But I dont.

I´m just about those who are unaware to the risks.

Because I´m a bit sceptic that every buyer or prospect of Dihexa has read the whole thread, got well informed about possible side-effects and cowculated    the benefit/risk ratio.

 

So that was my intention to "share" my concerns.

 

Edit:

I cant understand the ethics of the Doctors as well.

Taking Ebola as an example if You have the chance for 90% to Die, Why not using something that may could help.

Its the patients decision to take that risk and I would decide to try any possible cure form me.

Edited by Flex, 12 August 2014 - 11:06 PM.

[drg]

A ship is safe in harbor, but that's not what ships are for.

 

True rebels hate their own rebellion. They know by experience that it is not a cool and glamorous lifestyle; it takes a courageous fool to say things that have not been said and to do things that have not been done.

 

Very few beings really seek knowledge in this world. Mortal or immortal, few really ask. On the contrary, they try to wring from the unknown the answers they have already shaped in their own minds -- justifications, confirmations, forms of consolation without which they can't go on. To really ask is to open the door to the whirlwind. The answer may annihilate the question and the questioner.

 

Fortune favours the bold.

 

ect ect

[pdxer]

This is a fascinating thread. I've read through it all in the past few days. I'm sure I'm not the only lurker who feels grateful for all the contributions, citations, analysis and experience reports posted by the members here.

I don't have an academic background in life sciences, so I'm not sure if this line of thought makes sense... but here it goes:

My take on the Dihexa research is that there has not been any work done on how the rat doses may translate to therapeutic human doses. From reading about animal research on nutraceuticals, my understanding is that animal studies tend to start with extremely high doses to determine biological activity.

When considering a (cautious) target blood level of Dihexa for humans, would it make sense to consider the range of BDNF in human blood? Does anyone know what the range is? Closest info I could find is 1-16 nanograms / ml (per the range of a BDNF testing protocol). If that's the case, the average adult doesn't much more than 80 micrograms (5000 ml * 16 ng) of BDNF circulating in their blood. At the half life discussed above, we're talking about 4 ug absorbed a day to maintain 80 ug after a loading phase.

Conditions like depression have been associated with lower BDNF (and presumably neurogenesis). To restore normal or higher (effective) neurogenesis to depressed patients, I wonder if it would make sense to permanently have them on a low dose of Dihexa (1-2 MG or less a day). While the ketamine / depression study showed an acute effect, it's unclear how long that effect would last.

For any of the experimenters out there, have you considered the possibility of staying on Dihexa permanently?

Pdxer

[tolerant]

jabowery, I'm sorry to hear about your situation, and I can assure you that there are a number of people on these forums for whom these drugs can virtually mean the difference between life and death (I wish I could phrase it to sound less pompous and dramatic, but sadly it's true), and not merely a hobby of enhancing their intelligence (which I don't frown upon, don't get me wrong).

Edited by tolerant, 13 August 2014 - 11:07 AM.

[xks201]

Well the purity testing did not pass. This does not mean necessarily that the entire synthesis has to be redone according to N. Hopefully just the last step. I will keep everyone updated.

[PWAIN]

Any idea about what level of purity was achieved and what the contaminant was?

 

Well the purity testing did not pass. This does not mean necessarily that the entire synthesis has to be redone according to N. Hopefully just the last step. I will keep everyone updated.

 

[jabowery]

Yesterday:

25mg Dihexa oral before breakfast

 

Cambridge sciences website was not responsive when I tried to take the 'Odd One Out' test at the usual time of day (evening).

 

Today:

 

I acquired a blood pulse oximeter to monitor apneatic events as I have had a recent change of CPAP pressure.  There were a few last night with a low SpO2 of 90% -- not too bad unless it is interfering with slow wave sleep, which is a good chance.  Unfortunately my Zeo headband is way old and there are no replacement electrodes on the market.

 

20mg Dihexa oral with coffee before breakfast

 

9pm 

http://www.cambridgebrainsciences.com/ odd one out test score:

(17+16+15+14+14+13)/6

= 14.833333

 

I'm not really interested in the slight decline in average score from last time (15) but I find the downward trend over today's 6 tests interesting.  Fatigue?

 

I'm a bit concerned about the news that Nyles7 synthesis didn't pass the purity test.  I may need to cut shorter than I would have liked my safety "food taster" role for Jan.

 

 

 

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+13+16+15+15+15)/6

= 15

 

This is a rather large score increase.  

 

The earlier puzzles in a test are the easier ones and an interesting phenomenon is that this time through I took longer on a few of the easier (earlier) puzzles than I did on prior days, leaving less time to solve the harder puzzles that come later in the test.  I don't have quantitative measures on this phenomenon unfortunately.  This wasn't a strong effect but I did notice it.

 

It would be interesting to see how it compares with the performance increases experienced by others taking the "odd one out" test.  Do others get slower on the earlier ones as they get better overall or is this just a fluke occurance for me on this test today?  It would also be interesting to see how much random variance there is in the difficulty of a series of these tests.  Is anyone familiar enough with that system to tell me where to look?

 

I hesitate to interject my subjective experience of taking this test.  I will say I didn't sleep as well last night as I did the night before.  I had to take multiple naps today.

 

20mg dihexa oral after dinner

 

 

 

Cambridge Brain Sciences "Odd One Out" test scores:

(13+14+12+15+15+14)/6

= 13.833333

 

Higher score possibly attributable to better setting on CPAP machine as well as training.

I did make a few mistakes this time, but made up for them by getting more right on the same run.  

 

Noticed muscle spasms with slight cramps in right lower bicep/tricep in the middle of the night last night.

I've been using my right arm a lot due to my left arm needing upcoming surgery.

Also possibly related to genetic cramping condition.

 

20mg dihexa oral after dinner

 

I'm increasing my rate of intake of dihexa due to the upcoming surgery which will introduce noise into measurements taken afterwards.  If there are ill effects I'd prefer to see them before surgery.  I'm going to stop prior to surgery and then start Jan after surgery if I don't notice ill effects prior to surgery.

 

PS:  If I had it to do over again, I'd probably choose a test with more sensitivity than "Odd One Out" to improvements on the high end.  The distribution of scores on that test have a steeply descending slope on the high side of the mode (it's skewed to the right quite a bit).  In other words, a little score improvement represents a substantially greater increase in difficulty on the high side than on the low side.  Perhaps a better statistical moment to look for than left-skewness would be lower kurtosis.

 

 

 Cambridge Brain Sciences "Odd One Out" test scores:

(12+15+13+15+12+15)/6
= 13.666667

 

(This increase is almost certainly entirely due to normal training and not due to the prior dihexa dose.  I learned that there was a penalty for guessing when stumped and little likelihood of additional correct choices after guessing.  I just stopped guessing when stumped.)

 

Then took 20mg dihexa orally* on empty stomach.

 

Again, mild short-lived increase in blood pressure.

 

*I shifted to oral since this is the most likely mode of administration for Jan.

 

Pre-dihexa Cambridge Brain Sciences "Odd One Out" test score skewed low with mode (mean and median) of 12 and high of 16.

 

10mg nasal insufflation.  Mild increase in blood pressure for several minutes then return to normal.  

 

Mild and immediate subjective effects will not be reported.

 

 

 

 

[xks201]

None of us have keeled over here I think it is safe jab. I notice extreme nootropic effects on day one of taking it, then it sort of tapered and seemed accumulative post day 1. 

[DHEXA]

Well the purity testing did not pass. This does not mean necessarily that the entire synthesis has to be redone according to N. Hopefully just the last step. I will keep everyone updated.

Can you post the spectra from the synthesis and/or subsequent analysis? MS and HNMR would be great for comparisons.

Edited by DHEXA, 14 August 2014 - 12:55 PM.

[Jbac]

Well the purity testing did not pass. This does not mean necessarily that the entire synthesis has to be redone according to N. Hopefully just the last step. I will keep everyone updated.

 

Why bother purifying it if the contaminants aren't toxic? Are they?

[xks201]

I just asked him for a copy of the results. I will get back to you guys with that information .

[jabowery]

A few severe apneatic events (SpO2<88%) -- probably obstructive rather than central so will raise CPAP pressure 10% tonight to see if it improves

Phone call woke me up after 6 hours of sleep.

 

I decided to continue the "food taster" role for Jan as she is still establishing a baseline learning rate with Singing Coach and it looks like the Nyles7 synthesis will eventually come through.

 

22mg dihexa oral with breakfast

 

2pm

Physician visit bp 100/74 -- borderline low

This not inconsistent with other physician visits

It is, however, very inconsistent with home bp meter

Sunbeam Model 7652 which consistently reports high normal to borderline hypertensive

Next physician's visit I'll calibrate

 

10:45pm

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+15+12+13+15+12)/6

= 13.833333

Lower score (still higher than initial 2 groups of tests).

Sleep debt?

 

Made 4 or 5 mistakes that counted negatively.

 

 

Yesterday:

25mg Dihexa oral before breakfast

 

Cambridge sciences website was not responsive when I tried to take the 'Odd One Out' test at the usual time of day (evening).

 

Today:

 

I acquired a blood pulse oximeter to monitor apneatic events as I have had a recent change of CPAP pressure.  There were a few last night with a low SpO2 of 90% -- not too bad unless it is interfering with slow wave sleep, which is a good chance.  Unfortunately my Zeo headband is way old and there are no replacement electrodes on the market.

 

20mg Dihexa oral with coffee before breakfast

 

9pm 

http://www.cambridgebrainsciences.com/ odd one out test score:

(17+16+15+14+14+13)/6

= 14.833333

 

I'm not really interested in the slight decline in average score from last time (15) but I find the downward trend over today's 6 tests interesting.  Fatigue?

 

I'm a bit concerned about the news that Nyles7 synthesis didn't pass the purity test.  I may need to cut shorter than I would have liked my safety "food taster" role for Jan.

 

 

 

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+13+16+15+15+15)/6

= 15

 

This is a rather large score increase.  

 

The earlier puzzles in a test are the easier ones and an interesting phenomenon is that this time through I took longer on a few of the easier (earlier) puzzles than I did on prior days, leaving less time to solve the harder puzzles that come later in the test.  I don't have quantitative measures on this phenomenon unfortunately.  This wasn't a strong effect but I did notice it.

 

It would be interesting to see how it compares with the performance increases experienced by others taking the "odd one out" test.  Do others get slower on the earlier ones as they get better overall or is this just a fluke occurance for me on this test today?  It would also be interesting to see how much random variance there is in the difficulty of a series of these tests.  Is anyone familiar enough with that system to tell me where to look?

 

I hesitate to interject my subjective experience of taking this test.  I will say I didn't sleep as well last night as I did the night before.  I had to take multiple naps today.

 

20mg dihexa oral after dinner

 

 

 

Cambridge Brain Sciences "Odd One Out" test scores:

(13+14+12+15+15+14)/6

= 13.833333

 

Higher score possibly attributable to better setting on CPAP machine as well as training.

I did make a few mistakes this time, but made up for them by getting more right on the same run.  

 

Noticed muscle spasms with slight cramps in right lower bicep/tricep in the middle of the night last night.

I've been using my right arm a lot due to my left arm needing upcoming surgery.

Also possibly related to genetic cramping condition.

 

20mg dihexa oral after dinner

 

I'm increasing my rate of intake of dihexa due to the upcoming surgery which will introduce noise into measurements taken afterwards.  If there are ill effects I'd prefer to see them before surgery.  I'm going to stop prior to surgery and then start Jan after surgery if I don't notice ill effects prior to surgery.

 

PS:  If I had it to do over again, I'd probably choose a test with more sensitivity than "Odd One Out" to improvements on the high end.  The distribution of scores on that test have a steeply descending slope on the high side of the mode (it's skewed to the right quite a bit).  In other words, a little score improvement represents a substantially greater increase in difficulty on the high side than on the low side.  Perhaps a better statistical moment to look for than left-skewness would be lower kurtosis.

 

 

 Cambridge Brain Sciences "Odd One Out" test scores:

(12+15+13+15+12+15)/6
= 13.666667

 

(This increase is almost certainly entirely due to normal training and not due to the prior dihexa dose.  I learned that there was a penalty for guessing when stumped and little likelihood of additional correct choices after guessing.  I just stopped guessing when stumped.)

 

Then took 20mg dihexa orally* on empty stomach.

 

Again, mild short-lived increase in blood pressure.

 

*I shifted to oral since this is the most likely mode of administration for Jan.

 

Pre-dihexa Cambridge Brain Sciences "Odd One Out" test score skewed low with mode (mean and median) of 12 and high of 16.

 

10mg nasal insufflation.  Mild increase in blood pressure for several minutes then return to normal.  

 

Mild and immediate subjective effects will not be reported.

 

 

 

 

 

[jabowery]

No severe apneatic events at 11cm CPAP (2 events went to SpO2=92)

 

21mg dihex oral with morning coffee

 

11am

http://www.cambridgebrainsciences.com/ odd one out test score:

(17+15+16+16+15+14)/6

= 15.5

 

7:45pm

Immediately after dinner, I took the test.  

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+16+16+16+16+14)/6

= 15.666667

 

This is the highest score so far and its consistent with earlier in the day. 

It appears a good night's sleep is really important -- not that that's too surprising.

 

 

 

 

A few severe apneatic events (SpO2<88%) -- probably obstructive rather than central so will raise CPAP pressure 10% tonight to see if it improves

Phone call woke me up after 6 hours of sleep.

 

I decided to continue the "food taster" role for Jan as she is still establishing a baseline learning rate with Singing Coach and it looks like the Nyles7 synthesis will eventually come through.

 

22mg dihexa oral with breakfast

 

2pm

Physician visit bp 100/74 -- borderline low

This not inconsistent with other physician visits

It is, however, very inconsistent with home bp meter

Sunbeam Model 7652 which consistently reports high normal to borderline hypertensive

Next physician's visit I'll calibrate

 

10:45pm

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+15+12+13+15+12)/6

= 13.833333

Lower score (still higher than initial 2 groups of tests).

Sleep debt?

 

Made 4 or 5 mistakes that counted negatively.

 

 

Yesterday:

25mg Dihexa oral before breakfast

 

Cambridge sciences website was not responsive when I tried to take the 'Odd One Out' test at the usual time of day (evening).

 

Today:

 

I acquired a blood pulse oximeter to monitor apneatic events as I have had a recent change of CPAP pressure.  There were a few last night with a low SpO2 of 90% -- not too bad unless it is interfering with slow wave sleep, which is a good chance.  Unfortunately my Zeo headband is way old and there are no replacement electrodes on the market.

 

20mg Dihexa oral with coffee before breakfast

 

9pm 

http://www.cambridgebrainsciences.com/ odd one out test score:

(17+16+15+14+14+13)/6

= 14.833333

 

I'm not really interested in the slight decline in average score from last time (15) but I find the downward trend over today's 6 tests interesting.  Fatigue?

 

I'm a bit concerned about the news that Nyles7 synthesis didn't pass the purity test.  I may need to cut shorter than I would have liked my safety "food taster" role for Jan.

 

 

 

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+13+16+15+15+15)/6

= 15

 

This is a rather large score increase.  

 

The earlier puzzles in a test are the easier ones and an interesting phenomenon is that this time through I took longer on a few of the easier (earlier) puzzles than I did on prior days, leaving less time to solve the harder puzzles that come later in the test.  I don't have quantitative measures on this phenomenon unfortunately.  This wasn't a strong effect but I did notice it.

 

It would be interesting to see how it compares with the performance increases experienced by others taking the "odd one out" test.  Do others get slower on the earlier ones as they get better overall or is this just a fluke occurance for me on this test today?  It would also be interesting to see how much random variance there is in the difficulty of a series of these tests.  Is anyone familiar enough with that system to tell me where to look?

 

I hesitate to interject my subjective experience of taking this test.  I will say I didn't sleep as well last night as I did the night before.  I had to take multiple naps today.

 

20mg dihexa oral after dinner

 

 

 

Cambridge Brain Sciences "Odd One Out" test scores:

(13+14+12+15+15+14)/6

= 13.833333

 

Higher score possibly attributable to better setting on CPAP machine as well as training.

I did make a few mistakes this time, but made up for them by getting more right on the same run.  

 

Noticed muscle spasms with slight cramps in right lower bicep/tricep in the middle of the night last night.

I've been using my right arm a lot due to my left arm needing upcoming surgery.

Also possibly related to genetic cramping condition.

 

20mg dihexa oral after dinner

 

I'm increasing my rate of intake of dihexa due to the upcoming surgery which will introduce noise into measurements taken afterwards.  If there are ill effects I'd prefer to see them before surgery.  I'm going to stop prior to surgery and then start Jan after surgery if I don't notice ill effects prior to surgery.

 

PS:  If I had it to do over again, I'd probably choose a test with more sensitivity than "Odd One Out" to improvements on the high end.  The distribution of scores on that test have a steeply descending slope on the high side of the mode (it's skewed to the right quite a bit).  In other words, a little score improvement represents a substantially greater increase in difficulty on the high side than on the low side.  Perhaps a better statistical moment to look for than left-skewness would be lower kurtosis.

 

 

 Cambridge Brain Sciences "Odd One Out" test scores:

(12+15+13+15+12+15)/6
= 13.666667

 

(This increase is almost certainly entirely due to normal training and not due to the prior dihexa dose.  I learned that there was a penalty for guessing when stumped and little likelihood of additional correct choices after guessing.  I just stopped guessing when stumped.)

 

Then took 20mg dihexa orally* on empty stomach.

 

Again, mild short-lived increase in blood pressure.

 

*I shifted to oral since this is the most likely mode of administration for Jan.

 

Pre-dihexa Cambridge Brain Sciences "Odd One Out" test score skewed low with mode (mean and median) of 12 and high of 16.

 

10mg nasal insufflation.  Mild increase in blood pressure for several minutes then return to normal.  

 

Mild and immediate subjective effects will not be reported.

 

 

 

 

 

 

[jabowery]

How not to orally administer Dihexa:

 

 

 

Note how the Dihexa is not only insoluble, but it floats in such a way that after the contents of the cup are consumed, the Dihexa sticks to the sides of the cup.

Edited by jabowery, 17 August 2014 - 10:00 PM.

[StevesPetRat]

I couldn't find a documented method of determining maximum concentration from half life - though i can't imagine it's that hard.

Because the half life is so much longer than the dosing interval, you can model the dosing as approximately continuous.
dA/dt = Q - Aln2/T
Where Q is the amount entering the bloodstream per day (presumably fixed, but it doesn't have to be), A is the amount in the bloodstream on day t, and T is the halflife. Peak concentration is a steady state, dA/dt = 0, at which time A = QT/ln2. I assumed the metabolism of dihexa is irreversible and that it is the main bioactive compound (i.e. a drug not a prodrug). Using DHEXA's Q = 20 mg/day and T ~ 40 days I get 1150 mg peak which agrees with the plot. Now, it looks like the oral bioavailability is on the order of 1% or less so the actual circulating amount should be reduced by that factor.

To whomever was speculating that the peripheral myelination was responsible for more reps at the gym: I really, really want that to be true, but it would almost certainly require more than a few days. Nerves heal slooooowly. With the increased BP some are reporting, isn't greater epinephrine production more plausible? It is an angiotensin analog, after all.

[xks201]

N emailed me and told me they are retesting for purity after modification of the synthesis. In any event I did request a copy of the results which he said they would provide when the second purity test is done. I will update you as I get updates. Thank you everyone for their patience. 

[xks201]

 

I couldn't find a documented method of determining maximum concentration from half life - though i can't imagine it's that hard.

Because the half life is so much longer than the dosing interval, you can model the dosing as approximately continuous.
dA/dt = Q - Aln2/T
Where Q is the amount entering the bloodstream per day (presumably fixed, but it doesn't have to be), A is the amount in the bloodstream on day t, and T is the halflife. Peak concentration is a steady state, dA/dt = 0, at which time A = QT/ln2. I assumed the metabolism of dihexa is irreversible and that it is the main bioactive compound (i.e. a drug not a prodrug). Using DHEXA's Q = 20 mg/day and T ~ 40 days I get 1150 mg peak which agrees with the plot. Now, it looks like the oral bioavailability is on the order of 1% or less so the actual circulating amount should be reduced by that factor.

To whomever was speculating that the peripheral myelination was responsible for more reps at the gym: I really, really want that to be true, but it would almost certainly require more than a few days. Nerves heal slooooowly. With the increased BP some are reporting, isn't greater epinephrine production more plausible? It is an angiotensin analog, after all.

 

Steve I speculated that it was increasing strength but I didn't know exactly the mechanism or speculate on it. There are probably one thousand ways this compound could be doing it. No one really knows. 

[PWAIN]

They should have some idea since the resultant product should be x% less than what they started with depending on the initial purity

 

N emailed me and told me they are retesting for purity after modification of the synthesis. In any event I did request a copy of the results which he said they would provide when the second purity test is done. I will update you as I get updates. Thank you everyone for their patience. 

 

Edited by PWAIN, 18 August 2014 - 05:23 AM.

[VERITAS INCORRUPTUS]

Took a look at this with some chem friends and it may not be as difficult as it all has been made out be.

Within conventional methods indeed purification is a royal BIT%H.

Hopefully they finally figured out some method for success here.

[jabowery]

Now, it looks like the oral bioavailability is on the order of 1% or less so the actual circulating amount should be reduced by that factor.

 

What is the cite for "1% or less" oral bioavailability?

 

That is such a low figure and Diheaxa is so hard to come by I may have to cease administration until I find a less profligate route.

[jabowery]

Thus far I have seen no indications of deleterious side effects from Dihexa.

 

I have slowed, if not suspended, further reports due to extingencies in Jan's condition that arose a few days ago.  They were serious enough that I decided to start her on Dihexa before I had intended, but the news, to me, that Dihexa is "1% or less" orally bioavailable has caused me to stop after 2 days pending a less profligate route of administration.  My surgery has been postponed and I'm also stopping my intake as well.  I may or may not start myself on it again depending on Dihexa's availability and my wife's needs.

 

I'll continue to occasionally take the "odd one out" test and Jan will continue to use "Singing Coach" with me recording her high scores and running averages.  I will continue to report the results of my tests as I get around to taking them.

 

 

No severe apneatic events at 11cm CPAP (2 events went to SpO2=92)

 

21mg dihex oral with morning coffee

 

11am

http://www.cambridgebrainsciences.com/ odd one out test score:

(17+15+16+16+15+14)/6

= 15.5

 

7:45pm

Immediately after dinner, I took the test.  

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+16+16+16+16+14)/6

= 15.666667

 

This is the highest score so far and its consistent with earlier in the day. 

It appears a good night's sleep is really important -- not that that's too surprising.

 

 

 

 

A few severe apneatic events (SpO2<88%) -- probably obstructive rather than central so will raise CPAP pressure 10% tonight to see if it improves

Phone call woke me up after 6 hours of sleep.

 

I decided to continue the "food taster" role for Jan as she is still establishing a baseline learning rate with Singing Coach and it looks like the Nyles7 synthesis will eventually come through.

 

22mg dihexa oral with breakfast

 

2pm

Physician visit bp 100/74 -- borderline low

This not inconsistent with other physician visits

It is, however, very inconsistent with home bp meter

Sunbeam Model 7652 which consistently reports high normal to borderline hypertensive

Next physician's visit I'll calibrate

 

10:45pm

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+15+12+13+15+12)/6

= 13.833333

Lower score (still higher than initial 2 groups of tests).

Sleep debt?

 

Made 4 or 5 mistakes that counted negatively.

 

 

Yesterday:

25mg Dihexa oral before breakfast

 

Cambridge sciences website was not responsive when I tried to take the 'Odd One Out' test at the usual time of day (evening).

 

Today:

 

I acquired a blood pulse oximeter to monitor apneatic events as I have had a recent change of CPAP pressure.  There were a few last night with a low SpO2 of 90% -- not too bad unless it is interfering with slow wave sleep, which is a good chance.  Unfortunately my Zeo headband is way old and there are no replacement electrodes on the market.

 

20mg Dihexa oral with coffee before breakfast

 

9pm 

http://www.cambridgebrainsciences.com/ odd one out test score:

(17+16+15+14+14+13)/6

= 14.833333

 

I'm not really interested in the slight decline in average score from last time (15) but I find the downward trend over today's 6 tests interesting.  Fatigue?

 

I'm a bit concerned about the news that Nyles7 synthesis didn't pass the purity test.  I may need to cut shorter than I would have liked my safety "food taster" role for Jan.

 

 

 

http://www.cambridgebrainsciences.com/ odd one out test score:

(16+13+16+15+15+15)/6

= 15

 

This is a rather large score increase.  

 

The earlier puzzles in a test are the easier ones and an interesting phenomenon is that this time through I took longer on a few of the easier (earlier) puzzles than I did on prior days, leaving less time to solve the harder puzzles that come later in the test.  I don't have quantitative measures on this phenomenon unfortunately.  This wasn't a strong effect but I did notice it.

 

It would be interesting to see how it compares with the performance increases experienced by others taking the "odd one out" test.  Do others get slower on the earlier ones as they get better overall or is this just a fluke occurance for me on this test today?  It would also be interesting to see how much random variance there is in the difficulty of a series of these tests.  Is anyone familiar enough with that system to tell me where to look?

 

I hesitate to interject my subjective experience of taking this test.  I will say I didn't sleep as well last night as I did the night before.  I had to take multiple naps today.

 

20mg dihexa oral after dinner

 

 

 

Cambridge Brain Sciences "Odd One Out" test scores:

(13+14+12+15+15+14)/6

= 13.833333

 

Higher score possibly attributable to better setting on CPAP machine as well as training.

I did make a few mistakes this time, but made up for them by getting more right on the same run.  

 

Noticed muscle spasms with slight cramps in right lower bicep/tricep in the middle of the night last night.

I've been using my right arm a lot due to my left arm needing upcoming surgery.

Also possibly related to genetic cramping condition.

 

20mg dihexa oral after dinner

 

I'm increasing my rate of intake of dihexa due to the upcoming surgery which will introduce noise into measurements taken afterwards.  If there are ill effects I'd prefer to see them before surgery.  I'm going to stop prior to surgery and then start Jan after surgery if I don't notice ill effects prior to surgery.

 

PS:  If I had it to do over again, I'd probably choose a test with more sensitivity than "Odd One Out" to improvements on the high end.  The distribution of scores on that test have a steeply descending slope on the high side of the mode (it's skewed to the right quite a bit).  In other words, a little score improvement represents a substantially greater increase in difficulty on the high side than on the low side.  Perhaps a better statistical moment to look for than left-skewness would be lower kurtosis.

 

 

 Cambridge Brain Sciences "Odd One Out" test scores:

(12+15+13+15+12+15)/6
= 13.666667

 

(This increase is almost certainly entirely due to normal training and not due to the prior dihexa dose.  I learned that there was a penalty for guessing when stumped and little likelihood of additional correct choices after guessing.  I just stopped guessing when stumped.)

 

Then took 20mg dihexa orally* on empty stomach.

 

Again, mild short-lived increase in blood pressure.

 

*I shifted to oral since this is the most likely mode of administration for Jan.

 

Pre-dihexa Cambridge Brain Sciences "Odd One Out" test score skewed low with mode (mean and median) of 12 and high of 16.

 

10mg nasal insufflation.  Mild increase in blood pressure for several minutes then return to normal.  

 

Mild and immediate subjective effects will not be reported.

 

 

 

 

 

 

 

Edited by jabowery, 18 August 2014 - 05:52 PM.

[megatron]

And if its oral bioavailability is under 1% how are we supposed to administer it then? If taken sublingually, does powder actually diffuse through the mucous membrane or does it have to be dissolved first? 

 

Edit: Wouldn't dissolving it in DMSO and taking it sublingually be a great way of administering it? 

Edited by Megatrone, 18 August 2014 - 09:32 PM.

[Azz19]

Even if oral bioavailability is under 1% we still know the oral dosage from the studies. Finding out that oral bioavailability is under 1% isn't going to magically change the dosage.
Though no one has even pointed us to anything that does state that it's under 1%.

[StevesPetRat]

Now, it looks like the oral bioavailability is on the order of 1% or less so the actual circulating amount should be reduced by that factor.

What is the cite for "1% or less" oral bioavailability?

That is such a low figure and Diheaxa is so hard to come by I may have to cease administration until I find a less profligate route.

FW900 posted some study about that 7 or 8 pages back. On my phone, too lazy to go back and find it. I might try eye drops. After what happened to a couple of those guys who snorted Cerebro, I'm skittish on the intranasal administration of peptides. On the other hand it's so potent I'm not sure it matters.

[jabowery]

 

 

Now, it looks like the oral bioavailability is on the order of 1% or less so the actual circulating amount should be reduced by that factor.

What is the cite for "1% or less" oral bioavailability?

That is such a low figure and Diheaxa is so hard to come by I may have to cease administration until I find a less profligate route.

FW900 posted some study about that 7 or 8 pages back. On my phone, too lazy to go back and find it. I might try eye drops. After what happened to a couple of those guys who snorted Cerebro, I'm skittish on the intranasal administration of peptides. On the other hand it's so potent I'm not sure it matters.

 

 

Found it here:

 

http://www.longecity...ndpost&p=676677

 

Thanks.

[jabowery]

 

 

 

Now, it looks like the oral bioavailability is on the order of 1% or less so the actual circulating amount should be reduced by that factor.

What is the cite for "1% or less" oral bioavailability?

That is such a low figure and Diheaxa is so hard to come by I may have to cease administration until I find a less profligate route.

FW900 posted some study about that 7 or 8 pages back. On my phone, too lazy to go back and find it. I might try eye drops. After what happened to a couple of those guys who snorted Cerebro, I'm skittish on the intranasal administration of peptides. On the other hand it's so potent I'm not sure it matters.

 

 

Found it here:

 

http://www.longecity...ndpost&p=676677

 

Thanks.

 

 

I'm looking into subcutaneous.  When you're dealing with a potential "unobtanium" of limited supply, it just plain makes no sense to say things like "its so powerful the route of administration doesn't matter".

[StevesPetRat]

I'm looking into subcutaneous. When you're dealing with a potential "unobtanium" of limited supply, it just plain makes no sense to say things like "its so powerful the route of administration doesn't matter".

Sure, it'd be great to increase the bioavailability. I don't think it's very water soluble, though; not sure what solvent you had in mind for subQ. How did the DMSO work out for DHEXA?