1569 replies to this topic

[X_Danny_X]

 

so this guy Christinelire,   increase his intelligence with just caffeine???     i dont normally agree with Lumnosity games in increasing intelligence since I think you just become good at playing a game,  not increasing intelligence.   The only true game that helped me increase intelligence is DUAL N BACK! 

 

 

Caffeine surely helped, but we don't have enough data to know how much. Moreover, he claims that he's observed a general enhancement in mental performance as he outlined above, entirely apart from his one great Lumosity session (with no further sessions since). Lumosity is marketed as a "brain gym", but I think its real value is as a relatively objective assessment of mental performance. And although there is certainly a training effect resulting in improvement in scores, this ceases to apply after a month or two. His scores seemed to be flat enough that a one-day jump to 1570 would have been very unlikely, caffeine or not.

 

So pending more data, we have no good grasp of dihexa's role here.

 

BTW the BBC actually did a study of brain games with Cambridge Brain Sciences (in this video) wherein they found that several weeks of training were barely better than browsing the Web in order to answer obscure questions for the same amount of time. So they claim to have debunked brain games as a vehicle for mental improvement. But what they actually debunked was the economic utility of brain games, because both experimental and control groups showed improvement on a variety of cognitive tests, albeit a small one. But with 11,430 participants, the small change appears to have high statistical significance. (The control group should probably have been required to watch made-for-TV dramas or some such vacuity.)

 

 

 

how you figure that a little improvement had a large impact?   i have been doing luminosity for a couple of years...i train hard and i had the same difficulty in learning new tasks.    the extra cognitive function or working memory that i was supposed to get was never really there.   

 

 

Dual N Back worked perfectly though...I did notice an increase processing speed and also thinking....if only it could help me in verbal/speech impediment...still searching for that....i heard the racetams helps with that....the weakest pariracetam but i have to take higher doses. 

[medicineman]

700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.

Too bad these doses are impractical from an economic perspective. Have we settled on any ideas on how we can increase bioavailability?

[jabowery]

700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.

 
While I agree that 700 mg is reckless, you did in fact do it so I think you deserve considerable gratitude. So is there any quantitative mental characterization data you can offer us while in this state, now that you've already taken this risk? Or even observations like feeling less creative despite being more focussed, or more linguistically competent at the expense of math competence, etc.
 
I think it's increasingly clear that dihexa has a short term effect which has nothing to do with synaptic population increase.

His recommendation that people not exceed 40mg (per day?) based on his experience indicates he hasn't "lost it" but DHEXA's request for a rationale for these high doses is reasonable.

[StevesPetRat]

700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.

Wild speculation: the angiotensin system is activated during injury, isn't it? You just gave yourself a near death experience... Or not. Who knows?

 

Any evidence of vasoconstrictive effects? AT-II can really mess up the kidneys.

[Amorphous]

 

700mg knocked me out and behaved sort of like a high dose of human growth hormone. I woke up now in a state of hyperfocus....tunnel focus. Feels like my brain is like ten times more capable than my body. This behaves very different at 700mg than even 50mg. It feels as if my brain is being rewired. I have zero trace of adhd which I have had severely for a while. I don't recommend anyone go over like 40mg until I figure out what exactly is happening here. It is extremely intense, almost like a psychedelic high without the hallucinations....how I described it to N is it feels like my brain is a one thousand pound paper weight over whatever train of thought I am having. It feels like an extreme parasympathetic stimulant. Not like a traditional stimulant....This is unlike anytjing I've seen before ...not even close. I'm not sure whether to rejoice or what at this moment as the hyperfocus Is ridiculous.

This was taken orally? So, you've taken 1200mg in one day?

 

 

1.2 g in a day!! Hope you will be still around to be able to ship our orders.   Please update us for any positive and negative effects as well.  

If possible, please try to objectively observe and measure your body conditions, such as blood pressure, temperature, mental status....etc. 

[resveratrol_guy]

how you figure that a little improvement had a large impact?   i have been doing luminosity for a couple of years...i train hard and i had the same difficulty in learning new tasks.    the extra cognitive function or working memory that i was supposed to get was never really there.   

 

 

Dual N Back worked perfectly though...I did notice an increase processing speed and also thinking....if only it could help me in verbal/speech impediment...still searching for that....i heard the racetams helps with that....the weakest pariracetam but i have to take higher doses. 

 

 

Sorry if I conveyed that somehow. I meant that the small change observed in response to brain training was nonetheless measured over thousands of people, so that gives me some confidence that it's not just noise. In other words, brain games do work to some modest extent at improving general cognitive function, but I wouldn't characterize it as a large impact. There may be very specific exceptions, such as Dual N-Back which allegedly improves working memory.

 

For the verbal issues, I see benefit from 500 mg Super Quercetin (includes bromelain and other stuff). You might post a question in the Nootropics section.

[medicineman]

it's obvious that you guys missed the rebuttal to Jaeggi et al and the failure to replicate the dual n back findings.

[xks201]

it's obvious that you guys missed the rebuttal to Jaeggi et al and the failure to replicate the dual n back findings.

English?

[medicineman]

it's obvious that you guys missed the rebuttal to Jaeggi et al and the failure to replicate the dual n back findings.

English?

Two studies attempting to replicate Jaeggi et als findings failed. There was no increase in working memory, nor any transfer following dual n back training. Dual n back is just another neuromyth.

Edited by medicineman, 25 September 2014 - 04:43 PM.

[arcticjoe]

whilst i'm all for people doing what they like with their own bodies, i cant help but feel a little uneasy about someone consuming ridiculous doses of a relatively unresearched chemical that has potential to induce tumor growth in your brain of all places. seriously xks, please be careful.

also, please consider the potential fall out to other group buys should you do yourself some major damage. fear mongering politicians hardly need any more ammo to restrict our chemical research freedom. 

[xks201]

If it's a myth then why worry about it? I think our prefrontal cortef could respond differently than a rat in one rat study given a rat test

[medicineman]

If it's a myth then why worry about it? I think our prefrontal cortef could respond differently than a rat in one rat study given a rat test

I am talking about dual n back improving working memory.

Dual n back is the myth. Not cognitive enhancement. I am a firm believer that drugs have the potential to greatly improve our cognition. Not dual n back though.

Are we talking about the same thing? I think you are imagining that I am being critical of dihexa? If that's the case, surely you'd know better. I have a lot of hope in that peptide (not dnb though)

Edited by medicineman, 25 September 2014 - 10:11 PM.

[xks201]

Yeah I misunderstood you.

[X_Danny_X]

i dont want to hijack this thread but Dual N Back has worked for me in terms of learning and multitasking.   so far nothing has worked before that.   also with the Jaggie,  they did say that Dual N Back did improved their group subjects intelligence/working memory...but the problem is with Dual N Back that they mentioned that there is no proof that the higher intelligence/working memory stays.....

 

http://www.nytimes.c...?pagewanted=all

 

..PERSONALLY for me,  what  i gained with Dual N Back has stayed...i havent lost it.

 

 

also people do tooooo much of Dual N Back...they overuse the application.   generally 10 minutes a day is enough for me....about 4 times a week....

[fairy]

@X_Danny_X: How much time for you to see any change? What have you gained precisely? I find DNB reports very interesting. I use Brainworkshop occasionally, without a fixed schedule so I can't tell if I can feel any transfer. I'm stuck now with poor results in Position, Color, Sound 3 Back. While I'm good at position and piano notes I suck at remembering color. I think DNB is one of the most exciting things out there.

[megatron]

Please, can we drop the DNB discussion? Yes, after having reached one's DNB plateau it can possibly be used as a measure to see if working memory has improved given the usage of some drug. However, as medicineman said, the follow-up studies failed to replicate the findings of the Jaeggi et al study. I can safely say that after having used DNB for two years (plateauing after 1 year), it does not improve working memory! DNB does shit! Like other brain-games it is completely useless for any other purpose than testing improvements due to alterations of neurochemistry through drugs or gene therapy. 

Edited by Megatrone, 26 September 2014 - 06:21 PM.

[tolerant]

I am the latest person to try DHEXA's Dihexa. I guess it's kind of cool to have taken Dihexa from the first-ever synthesis. And probably being the first person in Australia to have tried it, too. But of course all I really want is to get better from my condition which is diagnosed as MDD but in reality behaves like a severe anxiety disorder, perhaps through the pathway suggested in this post. I see from the latest posts in this thread that people are taking doses up to 700 mg, so it feels like my experience is not worth sharing. But I'll put it on record anyway. I took about 5 mg of Dihexa last night. I didn't feel anything from it either last night or this morning. The only thing that changed is that my sleep/wake cycle has been reset to normal (I was able to fall asleep and wake up at more normal hours), but I put it to taking two 2 mg tablets of Circadin, instead of the one tablet I have been taking for about the last 10 days and which was doing nothing in terms of helping me to reset my sleep/wake cycle. For the sake of completeness I will say that I took it while having a bad cold, but that's neither here nor there I suppose. I plan to proceed very slowly with this substance, both because it's so experimental and because of its extraordinarily long half-life. But I will report back if something of note happens.

Edited by tolerant, 27 September 2014 - 02:25 AM.

[xks201]

I took 700 or so. I don't recommend anyone else do that till we see what it does in me. I doubt anyone is gonna notice anything from under 30mg swallowed

[typ3z3r0]

And probably being the first person in Australia to have tried it, too.

 

Nope. I did before you. I haven't noticed any positives from it though. If anything, it may have caused me to be tired often. Haha.

[xks201]

 

And probably being the first person in Australia to have tried it, too.

 

Nope. I did before you. I haven't noticed any positives from it though. If anything, it may have caused me to be tired often. Haha.

 

What dose did you take for how long and what method of administration and source if you don't mind me asking? I say this because I have seen some different perceptible differences between mgs obviously and method of administration (especially with food).  If you take this with food the odds are you won't get any effects. I am very open to honest opinions here and looking forward to hearing from the rats from my batch. I am pretty blown away by dihexa myself. I think a lot of us probably have certain genetic mutations that would have to be undone to see the full effects of it. Some of us (if not half) I think will see amazing results given that we stay on it for the full duration of the sample. 

 

There is an ancillary or two we can add here to amplify the effect of dihexa I believe so that potentially permanent effects will manifest faster. I am currently testing that idea. 

Edited by xks201, 27 September 2014 - 12:54 PM.

[megatron]

 

 

And probably being the first person in Australia to have tried it, too.

 

Nope. I did before you. I haven't noticed any positives from it though. If anything, it may have caused me to be tired often. Haha.

 

What dose did you take for how long and what method of administration and source if you don't mind me asking? I say this because I have seen some different perceptible differences between mgs obviously and method of administration (especially with food).  If you take this with food the odds are you won't get any effects. I am very open to honest opinions here and looking forward to hearing from the rats from my batch. I am pretty blown away by dihexa myself. I think a lot of us probably have certain genetic mutations that would have to be undone to see the full effects of it. Some of us (if not half) I think will see amazing results given that we stay on it for the full duration of the sample. 

 

There is an ancillary or two we can add here to amplify the effect of dihexa I believe so that potentially permanent effects will manifest faster. I am currently testing that idea. 

 

You mean high-dosing early on, a loading phase like i.e. creatine? 

[X_Danny_X]

@X_Danny_X: How much time for you to see any change? What have you gained precisely? I find DNB reports very interesting. I use Brainworkshop occasionally, without a fixed schedule so I can't tell if I can feel any transfer. I'm stuck now with poor results in Position, Color, Sound 3 Back. While I'm good at position and piano notes I suck at remembering color. I think DNB is one of the most exciting things out there.

 

 

About 1 month.  

[xks201]

Exactly

And probably being the first person in Australia to have tried it, too.

Nope. I did before you. I haven't noticed any positives from it though. If anything, it may have caused me to be tired often. Haha.

What dose did you take for how long and what method of administration and source if you don't mind me asking? I say this because I have seen some different perceptible differences between mgs obviously and method of administration (especially with food). If you take this with food the odds are you won't get any effects. I am very open to honest opinions here and looking forward to hearing from the rats from my batch. I am pretty blown away by dihexa myself. I think a lot of us probably have certain genetic mutations that would have to be undone to see the full effects of it. Some of us (if not half) I think will see amazing results given that we stay on it for the full duration of the sample.

There is an ancillary or two we can add here to amplify the effect of dihexa I believe so that potentially permanent effects will manifest faster. I am currently testing that idea.

You mean high-dosing early on, a loading phase like i.e. creatine?

Exactly

Exactly

And probably being the first person in Australia to have tried it, too.

Nope. I did before you. I haven't noticed any positives from it though. If anything, it may have caused me to be tired often. Haha.

What dose did you take for how long and what method of administration and source if you don't mind me asking? I say this because I have seen some different perceptible differences between mgs obviously and method of administration (especially with food). If you take this with food the odds are you won't get any effects. I am very open to honest opinions here and looking forward to hearing from the rats from my batch. I am pretty blown away by dihexa myself. I think a lot of us probably have certain genetic mutations that would have to be undone to see the full effects of it. Some of us (if not half) I think will see amazing results given that we stay on it for the full duration of the sample.

There is an ancillary or two we can add here to amplify the effect of dihexa I believe so that potentially permanent effects will manifest faster. I am currently testing that idea.

You mean high-dosing early on, a loading phase like i.e. creatine?

[typ3z3r0]

I should've really recorded my dosing schedule, but I believe I snorted 40mg of dihexa daily for 14 days or close to that. The tiredness thing could've potentially been caused by other stuff though, like keto flu. I think I'll wait to see how other people go with dosing and then decide how much to try next time.

Edited by typ3z3r0, 28 September 2014 - 05:32 AM.

[medicineman]

I should've really recorded my dosing schedule, but I believe I snorted 40mg of dihexa daily for 14 days or close to that. The tiredness thing could've potentially been caused by other stuff though, like keto flu. I think I'll wait to see how other people go with dosing and then decide how much to try next time.

Snorting or rectal or sublingual, etc doesn't necessarily mean you got anything in your system (although oral and rectal are close, since they share the Gi system) . A lot of times, properties of certain chemicals, solvent, etc just doesn't go through a certain route. Only guarantees are needle routes, and they are obviously not feasible in this scenario.

Edited by medicineman, 28 September 2014 - 11:03 AM.

[xks201]

Good point. Good luck telling that to someone who randomly snorts new drugs.

[FW900]

 

I should've really recorded my dosing schedule, but I believe I snorted 40mg of dihexa daily for 14 days or close to that. The tiredness thing could've potentially been caused by other stuff though, like keto flu. I think I'll wait to see how other people go with dosing and then decide how much to try next time.

Snorting or rectal or sublingual, etc doesn't necessarily mean you got anything in your system (although oral and rectal are close, since they share the Gi system) . A lot of times, properties of certain chemicals, solvent, etc just doesn't go through a certain route. Only guarantees are needle routes, and they are obviously not feasible in this scenario.

 

 

Even oral administration does not mean you will get anything in your system. Insufflating or sublingual administration will eventually make it's way to the GI track in the event it is not absorbed by the nasal mucosa or capillaries under the tongue, (unless you sneeze or clean shortly afterwords) so ultimately, it does not matter.

 

There is no chance that everything will be absorbed by the nasal mucosa but this is not the only way drugs are transported to the brain when insufflating. As I said before, there is such a thing known as direct olfactory transfer, which is whenever a substance is directly in contact with olfactory neurons in the brain, it almost instantly gets absorbed, and even bypasses the blood brain barrier altogether.

 

Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting.

 

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

 

 

 

When dealing with an exotic substance, with one paper alluding to a low oral BA, it would make the most sense to try RoAs that will increase BA, which probably means insufflation is the best RoA there is next to injection.

 

xks201....These people are not "randomly snorting" new drugs. The people who are insufflating it (Jabowery, typ3z3r0), probably did so because they had an inkling of an understanding of basic drug metabolism, and realized that this would produce the most bang for the buck. It almost sounds as though you are insinuating that they are drug users who just snort things for the heck of it, which is insulting.

[medicineman]

I should've really recorded my dosing schedule, but I believe I snorted 40mg of dihexa daily for 14 days or close to that. The tiredness thing could've potentially been caused by other stuff though, like keto flu. I think I'll wait to see how other people go with dosing and then decide how much to try next time.

Snorting or rectal or sublingual, etc doesn't necessarily mean you got anything in your system (although oral and rectal are close, since they share the Gi system) . A lot of times, properties of certain chemicals, solvent, etc just doesn't go through a certain route. Only guarantees are needle routes, and they are obviously not feasible in this scenario.

Even oral administration does not mean you will get anything in your system. Insufflating or sublingual administration will eventually make it's way to the GI track in the event it is not absorbed by the nasal mucosa or capillaries under the tongue, (unless you sneeze or clean shortly afterwords) so ultimately, it does not matter.

There is no chance that everything will be absorbed by the nasal mucosa but this is not the only way drugs are transported to the brain when insufflating. As I said before, there is such a thing known as direct olfactory transfer, which is whenever a substance is directly in contact with olfactory neurons in the brain, it almost instantly gets absorbed, and even bypasses the blood brain barrier altogether.

Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting.

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease



When dealing with an exotic substance, with one paper alluding to a low oral BA, it would make the most sense to try RoAs that will increase BA, which probably means insufflation is the best RoA there is next to injection.

xks201....These people are not "randomly snorting" new drugs. The people who are insufflating it (Jabowery, typ3z3r0), probably did so because they had an inkling of an understanding of basic drug metabolism, and realized that this would produce the most bang for the buck. It almost sounds as though you are insinuating that they are drug users who just snort things for the heck of it, which is insulting.

but then, there's the risk of lung injury, etc.

I am considering per rectal administration. The only risk in pr administration over oral is that I may like it too much, but surely, I'll take that over lung injury.

[FW900]

but then, there's the risk of lung injury, etc.

I am considering per rectal administration. The only risk in pr administration over oral is that I may like it too much, but surely, I'll take that over lung injury.

 

 

Good point regarding possible lung damage but in diminutive quantities over a short period of time, it should not cause irreversible damage. The fears over lung injury from Insufflation mainly stem from recreational drug users crushing up pills. A pure substance, as long as it is not corrosive to membranes lining the nose/lung, should be fine for a limited trial.

 

I would advise you not to take it via rectal administration. Most people seem to forget that rectal administration is still subject, to a large extent,  first pass metabolism. A large portion of the blood supply in the region is connected to the portal vein which is connected to the liver.

 

Roughly 30-50+% of rectal administration will undergo first pass metabolism, which makes it not much different than taking it orally. On top of this, a lot of medications administered rectally, have similar BA figures to their oral BA.

[chairofgold]

Hey all. I've been reading up on this thread here and Dihexa looks promising. Does anyone know where to buy it and what is the cost? Thank you a lot if you can answer this question.

Edited by chairofgold, 28 September 2014 - 11:34 PM.