1569 replies to this topic

[Nemo888]

Some info on synapse density.

 

"In the brain, however, the researchers found that MHCI immune molecules are one of the only known factors that limit the density of synapses, ensuring that synapses form in the appropriate numbers necessary to support healthy brain function. MHCI limits synapse density by inhibiting insulin receptors, which regulate the body's sugar metabolism and, in the brain, promote synapse formation."

 

http://www.princeton...tion=topstories

http://www.jneurosci...ent/34/35/11844

[xks201]

Some info on synapse density.

 

"In the brain, however, the researchers found that MHCI immune molecules are one of the only known factors that limit the density of synapses, ensuring that synapses form in the appropriate numbers necessary to support healthy brain function. MHCI limits synapse density by inhibiting insulin receptors, which regulate the body's sugar metabolism and, in the brain, promote synapse formation."

 

http://www.princeton...tion=topstories

http://www.jneurosci...ent/34/35/11844

Wow great find. As I briefly mentioned weeks ago, I can drink like a fish with the help of this substance. Easily 2-3 times the amount I normally could before feeling even slightly intoxicated. 

[xks201]

I have actually also been researching limiting factors to synapse formation myself. It is nice to see we are on the right track here. 

[Amorphous]

Is there any compound comparable with losartan or lisinopril in term of cognitive and antihypertensive effect? I was thinking to take 7,8-dhf with dihexa, but it is a little harder to get. Any good suggestion?

[Nemo888]

Is there any compound comparable with losartan or lisinopril in term of cognitive and antihypertensive effect? I was thinking to take 7,8-dhf with dihexa, but it is a little harder to get. Any good suggestion?

Viagra, seriously. http://www.ncbi.nlm....ubmed/21627640/

[Amorphous]

When the little thing goes up so easily, I don't think I can think logically; thus, I don't see how it will improve cognitive function. Yes, sildenafil can be used for pulmonary hypertension. 

I was trying to look for something without prescription that are losartan or lisinopril-like compound.

[jabowery]

 

 

 

I think it bears reminding that more connections do not imply better mental performance. ... Computerized neural networks don't work that way...

 
The problem with too many synapses in artificial neural networks is a tendency toward "overfitting".  Overfitting is basically seeing every case as a special case to be memorized without generalization to other, not yet observed, cases.  Its rather like an autist that takes the maxim "All generalizations are false." so seriously, it can't learn anything useful because all it has is edetic (perfect sensory) memory.

 

... 
So then, should we really be hunting for performance improvements in areas where we already function best? This might make sense in light of Jan's improvement on Singing Coach, which differs wildly from the hyperfocus (eidetic) state reported by others.

 

That's been at the back of my mind, having been involved with the La Jolla aspect of the revival of artificial neural networks back in the mid to late 80s. I've had a lot of hands-on experience with heuristics for synaptic pruning as a way of achieving more effective learning rather than over-fitting so it just seemed natural that a disease like Huntington's which results in loss of brain mass, would be "over-pruned" and might be remediated by additional synapses.

I have to say, however, that Jan's recent stalling out in her improvements in Singing Coach scores, combined with her understandable frustration, makes me wonder what exactly is going on here. That the stalling out occurred before I ran out of Dihexa for her is one datum of interest. Another is that she didn't express frustration until a couple of days after I actually ceased dosing her due to the Dihexa running out.

 

 

Another dataum of interest:

 

The Medicare program that had nurses and therapists visiting her is discharging her due to lack of progress in HD during their surveillance of her condition and absence of critical need (ie: no high frequency of falls, etc.).

 

As always, we have no control-Jan for comparison so this doesn't mean the Dihexa did it but we can at least be reasonably assured that if Dihexa harmed her, it was so subtle that the Medicare team of specialists didn't detect it.

[xks201]

Well before dihexa was she appreciably improving?

[jabowery]

Well before dihexa was she appreciably improving?

 

No.

 

I cannot exclude the possibility that her discharge from the Medicare sub-program is due to improvement in her condition as measured objectively by that program's criterion.  I am in the process of obtaining the complete data set compiled during her treatment.  I really don't want to make any strong claims -- HD is such a devastating disease in so many ways that it is a terrible thing to give people false hope.  What I can say unequivocally is that I find no reason, other than limited supply, not to go ahead with your recommendation of a higher dose -- perhaps 100mg/day -- oral empty stomach if not H2O dilute DMSO dissolved dihexa sublingual -- starting with myself as "royal taster".

[Nemo888]

Jabowery,

 

Support of the cytoskelton in amyloid diseases may give you more success than Dihexa alone. Thymosin Beta 4 is bio-identical and there is nothing better for sequestering actin, the building block of the cytoskeleton. http://newscenter.be...lding-diseases/

 

TB4 is also cheap and readily available. 1mg/day is sufficient to produce results. Saunas are likely helpful as well.

 

[resveratrol_guy]

Jabowery,

 

Support of the cytoskelton in amyloid diseases may give you more success than Dihexa alone. Thymosin Beta 4 is bio-identical and there is nothing better for sequestering actin, the building block of the cytoskeleton. http://newscenter.be...lding-diseases/

 

TB4 is also cheap and readily available. 1mg/day is sufficient to produce results. Saunas are likely helpful as well.

 

TB4 is bioidentical to what? You mean that it sequesters actin like HSF-1? By "sequester", do you mean "isolate from stress" or what? Wikipedia says that TB4 "is also involved in cell proliferation, migration, and differentiation." Sounds like the classic stem cell dilemma: we want healing without growth.

 

But from that article (great find!) it sounds like we don't want to mess with HSF-1 because it increases lifespan and cancer. (In humans, it would probably be more of the latter because we actually live long enough for cancer to matter, unlike some simple organisms such as the worms in the experiment.) OTOH, it sounds like we want to upregulate pat-10 directly (how?), independent of HSF-1.

 

And wouldn't saunas be like the broken window theory of economics: do lots of damage so that after the fact we can see healing happening and think it beneficial, even though the net result is still negative?

 

But maybe TB4 is worth looking into. Flex is mystified as to why it hasn't received much attention, as he inquired about in this unanswered thread.

Edited by resveratrol_guy, 25 October 2014 - 12:57 PM.

[jabowery]

TB4 is also cheap and readily available. 1mg/day is sufficient to produce results. Saunas are likely helpful as well.

 

http://www.abcam.com...de-ab42291.html

 

Has TB4 at 100µg for $176.

 

That's cheap?

Edited by jabowery, 25 October 2014 - 08:17 PM.

[Flex]

 

TB4 is also cheap and readily available. 1mg/day is sufficient to produce results. Saunas are likely helpful as well.

 

http://www.abcam.com...de-ab42291.html

 

Has TB4 at 100µg for $176.

 

That's cheap?

 

 

In abcam or any other scientific supplier, is even destilled water expensiver than gold.

 

Here You go for 30 Dollar/ 5mg.

http://www.gencopept...sin-beta-4-5mg/

Although You have to choose carefully which Vendor sells actually quality stuff since bodybuilding/testo vendors arent allways trustful

so You can expect to be scammed & etc.

 

Therefore do some recherche for Forums or Databases like:

http://www.eroids.com/reviews/

Edited by Flex, 25 October 2014 - 08:43 PM.

[jabowery]

 

 

TB4 is also cheap and readily available. 1mg/day is sufficient to produce results. Saunas are likely helpful as well.

 

http://www.abcam.com...de-ab42291.html

 

Has TB4 at 100µg for $176.

 

That's cheap?

 

 

In abcam or any other scientific supplier, is even destilled water expensiver than gold.

 

Here You go for 30 Dollar/ 5mg.

http://www.gencopept...sin-beta-4-5mg/

Although You have to choose carefully which Vendor sells actually quality stuff since bodybuilding/testo vendors arent allways trustful

so You can expect to be scammed & etc.

 

Therefore do some recherche for Forums or Databases like:

http://www.eroids.com/reviews/

 

 

1mg/day is $6/day which is about our current food budget.  I suppose there will be more affordable sources if I look.

[Flex]

You´re welcome

[Nemo888]

Genco Peptides is good quality and reliable. http://www.gencopept...sin-beta-4-5mg/

With a 25% discount code 25CAX1.

 

[sk_scientific]

Digression, halt.

[sparkk51]

Dont you guys worry about the possible, negative long-term effects associated with consuming substances like this? Substances that increase the body's natural threshold for any hormone and do so with great potency. I don't think the atrophying effects of long-term steroid use are exclusive to steroids. I believe that concept can be applied to all hormones and drugs that increase them.

Edited by sparkk51, 30 October 2014 - 01:40 AM.

[xks201]

The other two thirds of it are shipping to n. I wanted accurate expensive scales so I'll have that thursday to weigh the first third. Sorry for the delay I just didn't want to screw it up after after waiting thus long. Bdnf isn't secreted from just a gland so the atrophy idea can't be compared. God help us the world is ending

Edited by xks201, 30 October 2014 - 02:43 AM.

[Strangelove]

Nemo, when you are worrying about non biodentical peptides, do you have any opinion on cerebrolysin? I have read half the huge thread and there is no worry at all that the growth factors are from pigs and not human, I thought that this would be the main concern (even over the unlikely case of prion contamination they discuss). I do not want to derail the thread, but if you read the unbelievable good reports from cerebrolysin, I only hope that Dihexa would be as good... Although it would be tiring to do IM injections every day, you also have to cycle cerebrolysin and its expensive too...

 

Xks have you tried cerebrolysin?

Edited by Strangelove, 30 October 2014 - 02:13 PM.

[di36]

any news on this?

[christallire]

I am curious if Dihexa has changed any of the Guinea Pigs alcohol consumption patterns.

 

,...has demonstrated that the level of a protein known as brain-derived neurotrophic factor, or BDNF, is increased in the brain when alcohol is consumed in moderation. In turn, experiments in Ron’s lab have shown, BDNF prevents the development of alcohol use disorders.

https://www.ucsf.edu...roblem-drinking

 

Heck, I was wondering about this too.

 

I ran out dihexa one or two months ago and i had no idea about ceasation of dihexa affecting drinking pattern.

 

Anyways, I'm experiencing this exactly opposite way and I think I have alcohol addiction now, been drinking everyday and currently at 18 day streak.

My memory is definitely degenerated.

 

FYI

Edited by christallire, 21 November 2014 - 08:32 AM.

[jabowery]

 

I am curious if Dihex

a has changed any of the Guinea Pigs alcohol consumption patterns.

 

,...has demonstrated that the level of a protein known as brain-derived neurotrophic factor, or BDNF, is increased in the brain when alcohol is consumed in moderation. In turn, experiments in Ron’s lab have shown, BDNF prevents the development of alcohol use disorders.

https://www.ucsf.edu...roblem-drinking

 

Heck, I was wondering about this too.

 

I ran out dihexa one or two months ago and i had no idea about ceasation of dihexa affecting drinking pattern.

 

Anyways, I'm experiencing this exactly opposite way and I think I have alcohol addiction now, been drinking everyday and currently at 18 day streak.

My memory is definitely degenerated.

 

FYI

 

We've seen no effect on alcohol consumption.

[DHEXA]

Has this study already been brought up? It was published recently.

http://jpet.aspetjou...351/2/390.short

Can anyone grab the full version?

 

 

I am curious if Dihexa has changed any of the Guinea Pigs alcohol consumption patterns.

 

,...has demonstrated that the level of a protein known as brain-derived neurotrophic factor, or BDNF, is increased in the brain when alcohol is consumed in moderation. In turn, experiments in Ron’s lab have shown, BDNF prevents the development of alcohol use disorders.

https://www.ucsf.edu...roblem-drinking

 

Heck, I was wondering about this too.

 

I ran out dihexa one or two months ago and i had no idea about ceasation of dihexa affecting drinking pattern.

 

Anyways, I'm experiencing this exactly opposite way and I think I have alcohol addiction now, been drinking everyday and currently at 18 day streak.

My memory is definitely degenerated.

 

FYI

 

That's troubling! I've never been fond of alcohol, dihexa didn't seem to change that for me. Do take care of yourself Christallire, alcohol abuse will do far more than impair your memory if you don't reign it in.
 

[jabowery]

 

Well before dihexa was she appreciably improving?

 

No.

 

I cannot exclude the possibility that her discharge from the Medicare sub-program is due to improvement in her condition as measured objectively by that program's criterion.  I am in the process of obtaining the complete data set compiled during her treatment.  I really don't want to make any strong claims -- HD is such a devastating disease in so many ways that it is a terrible thing to give people false hope.  What I can say unequivocally is that I find no reason, other than limited supply, not to go ahead with your recommendation of a higher dose -- perhaps 100mg/day -- oral empty stomach if not H2O dilute DMSO dissolved dihexa sublingual -- starting with myself as "royal taster".

 

 

Two items of interest:

 

1) We got her readmitted to the Medicare sub-program, but not on the basis of her Huntington's Disease symptoms -- rather on the basis that she had an allergic reaction that required an emergency room visit.  This was a skin condition I noticed while she was getting dressed for Halloween that looked very serious.  The criterion for readmission to the program is fairly liberal.  We appear to have isolated the allergen to either a new laundry soap or a new lotion.

 

2)  A physical therapist who had seen Jan over a year ago commented to me, after seeing her for the first time last Monday, that Jan's speech was more intelligible.  She did not know Jan had undergone any kind of treatment that might affect her neurology.  This confirms a suspicion that I've had but did not report due to my daily interaction with her and potential confirmation bias.

[resveratrol_guy]

 

2)  A physical therapist who had seen Jan over a year ago commented to me, after seeing her for the first time last Monday, that Jan's speech was more intelligible.  She did not know Jan had undergone any kind of treatment that might affect her neurology.  This confirms a suspicion that I've had but did not report due to my daily interaction with her and potential confirmation bias.

 

 

While speech recovery is part of the healing process in certain types of stroke, I don't think it should be expected in the normal course of neurodegenerative diseases affecting this function. Straight downhill is pretty much the prognosis, absent intervention. The question is, is this due to dihexa, Singing Coach (reinforcing speech quality indirectly via auditory pathways), or both, or something else? From a statistical perspective, I find this highly significant in light of the presumed lack of expectation for improvement on the part of the therapist. Do you have any details to add? And to be clear, did you ask the therapist about Jan's speech quality? I don't suppose you have any before/after audio recordings?

 

BTW this is a very quiet thread considering the magnitude of the experimentation at stake. It sounds to me like dihexa is largely a failure, but another interpretation would be that it's so successful at achieving hyperfocus that all the rats have gone back to their day jobs and pretty much forgotten about the trial.

 

Edited by resveratrol_guy, 29 November 2014 - 06:17 PM.

[sk_scientific]

Petty drama and personal opinions aside, if xks_201 is delivering on his promises there's not much more that we need to comment on.  If Nyles made good on his end, there's no reason for bad blood between anyone.  This was intended to be a group endeavor and things did not work out as originally planned, but if the deliverables arrive to those who invested in them, we need to regain a sense of community and turn our focus back on the process of discovery.

 

All the in-fighting, bitching, lambasting, whining and pompous dialogues should be cut from the community discourse going forward.

 

It will be appreciated that those who receive their lots report on the successful delivery of such and also their subjective and empirical results with the compound.

[formergenius]

Petty drama and personal opinions aside, if xks_201 is delivering on his promises there's not much more that we need to comment on.  If Nyles made good on his end, there's no reason for bad blood between anyone.  This was intended to be a group endeavor and things did not work out as originally planned, but if the deliverables arrive to those who invested in them, we need to regain a sense of community and turn our focus back on the process of discovery.

 

All the in-fighting, bitching, lambasting, whining and pompous dialogues should be cut from the community discourse going forward.

 

It will be appreciated that those who receive their lots report on the successful delivery of such and also their subjective and empirical results with the compound.

 

Concurred, if I receive what I payed for, albeit delayed, I don't really care about the drama in between, and would rather focus on results and implications. I just hope the aforementioned happens, and that it is legitimate.

[sk_scientific]

 

Petty drama and personal opinions aside, if xks_201 is delivering on his promises there's not much more that we need to comment on.  If Nyles made good on his end, there's no reason for bad blood between anyone.  This was intended to be a group endeavor and things did not work out as originally planned, but if the deliverables arrive to those who invested in them, we need to regain a sense of community and turn our focus back on the process of discovery.

 

All the in-fighting, bitching, lambasting, whining and pompous dialogues should be cut from the community discourse going forward.

 

It will be appreciated that those who receive their lots report on the successful delivery of such and also their subjective and empirical results with the compound.

 

Concurred, if I receive what I payed for, albeit delayed, I don't really care about the drama in between, and would rather focus on results and implications. I just hope the aforementioned happens, and that it is legitimate.

 

 

The proof will be in the pudding.

[jabowery]

 

 

2)  A physical therapist who had seen Jan over a year ago commented to me, after seeing her for the first time last Monday, that Jan's speech was more intelligible.  She did not know Jan had undergone any kind of treatment that might affect her neurology.  This confirms a suspicion that I've had but did not report due to my daily interaction with her and potential confirmation bias.

 

 

While speech recovery is part of the healing process in certain types of stroke, I don't think it should be expected in the normal course of neurodegenerative diseases affecting this function. Straight downhill is pretty much the prognosis, absent intervention. The question is, is this due to dihexa, Singing Coach (reinforcing speech quality indirectly via auditory pathways), or both, or something else? From a statistical perspective, I find this highly significant in light of the presumed lack of expectation for improvement on the part of the therapist. Do you have any details to add? And to be clear, did you ask the therapist about Jan's speech quality? I don't suppose you have any before/after audio recordings?

 

I will add the caveat that Jan's speech intelligibility fluctuates quite a bit, as do other symptoms, even throughout the day.  There is a significant possibility that the physical therapist's limited samples of Jan's speech a year ago were at the low end of her intelligibility then and then a year later were on the high end of Jan's intelligibility.  I don't have good objective measurements of her intelligibility through time despite having asked a speech therapist that saw Jan on a regular basis as part of the Medicare sub-program to please take objective measurements on a longitudinal basis.  This high frequency fluctuation in symptoms creates a pretty serious baseline noise in any measurements.  

 

Unfortunately, I don't have before/after audio recordings for the first course of Dihexa treatment.  I will take a series of voice recordings prior to the next course and hopefully have enough of a sample to give a sense of the statistical distribution.

 

I guess I should also state that her neurologist on her last appointment commented that he expected to see more decline than he saw.  However I was required by ethics to fully inform her neurologist of my intention to provide Jan with a course of Dihexa, prior to the treatment, knowing that he was required by ethics to strongly recommend against any such experimental treatment, which he did, but hoping that he would permit pre-treatment measurements to be made such as NMR, which he declined for what seemed to me to be defensible reasons of medical ethics (she would have to be put under general anesthesia to inhibit her movements).