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Dihexa: "it would take 10 million times as much BDNF to get as much new synapse formation as Dihexa."


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#1261 Flex

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Posted 03 January 2015 - 12:06 AM

I´m not a expert but nevertheless here are my 2 cents:

I guess the compound should have left the factory as sterile in a sterile packaging.

The next question would be whether the substance, the 1% remnants as well as the solvent are or arent supposed to inject.

 

I would rather use a injection filter even for IM. Otherwise You could wait untill it dissolves completly. I believe to read somewhere that scientist waited 1h for the dissolution,

but I may be mistaken !

 

You could ask this question in a nurse forum or something like that, if You dont get many responses.



#1262 StevesPetRat

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Posted 03 January 2015 - 12:08 AM

For non-aqueous injections, fixed oils of vegetable origin are used as vehicles. That comes from the USP.  I have read about a home-made prep of testosterone in oil on a BB site. I think Dihexa is pretty non-polar, hence the non-aqueous suggestion. I would try to find some solubility data on Dihexa, but I'm guessing its gonna be non-aqueous.


Oils for injection? Kinky. I guess maybe a pure MCT oil might be safe to inject... or just dangerous enough to make it exciting.
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#1263 Flex

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Posted 03 January 2015 - 12:10 AM

Woman who injected COOKING OIL into her own face after doctors refused to give her any more plastic surgery

http://www.dailymail...ic-surgery.html


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#1264 sk_scientific

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Posted 03 January 2015 - 01:05 AM

Any suggestions on a solvent to use for subQ / IM injections? HYPOTHETICALLY, of course, I would never use this substance on a human being or even a rodent. I just have a really weird fetish that involves fantasizing about injecting experimental nootropics in which every detail must be perfectly accurate or it doesn't do anything for me, y'know?

 

 

Really, really bad idea Steve.  You don't want to end up with tissue necrosis.  Plus, imagine that before packing xks was penis rubbing with other member's goods.


Edited by sk_scientific, 03 January 2015 - 01:06 AM.

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#1265 StevesPetRat

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Posted 03 January 2015 - 02:56 AM

Plus, imagine that before packing xks was penis rubbing with other member's goods.

But that's part of the thrill!

For those who are curious, the solubility of Dihexa in warm coconut oil appears to be low, at most 1 or 2 mg/ml. May try ethanol next.

#1266 JASOG888

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Posted 03 January 2015 - 03:05 AM

 

 May try ethanol next.

 

 

Ouch!
 


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#1267 Flex

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Posted 03 January 2015 - 04:11 PM

Steve, do Your self the favor and ask someone who is a professional.

As said, they may be in reddit or on other forums or here, altough they are just(!?) students

http://www.longecity...-a-med-student/

http://www.longecity...out-nootropics/



#1268 StevesPetRat

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Posted 03 January 2015 - 05:44 PM

Maybe I should have asked google.

Here's the chemical name:
N-hexanoic L-tyrosine L-isoleucine (6)aminohexanoic amide

The N- terminal is basic, tyrosine is polar but uncharged, isoleucine is non-polar, and "aminohexanoic acid" is used as an anti-fibrinolytic agent (i.e., pro-coagulant). So I guess it should be pretty much neutral, or maybe slightly soluble in acids. Gonna try getting some DMSO, methinks. I mean, hypothetically. And also hypothetically start taking some lumbrokinase and bromelain.

Will also ask on Reddit.

#1269 JASOG888

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Posted 03 January 2015 - 05:52 PM

DMSO looks to be a good choice for transdermal delivery.


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#1270 DHEXA

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Posted 04 January 2015 - 07:25 PM

It took quite a bit of agitation to get it all dissolved, but DMSO works well.



#1271 Hebbeh

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Posted 04 January 2015 - 07:37 PM

How do you know you've got dihexa "dissolved" in DMSO and that it hasn't either broken down into component molecules and/or reacted into a different molecule?


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#1272 DHEXA

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Posted 10 January 2015 - 01:46 PM

I'd expect a certain amount of degradation over time. I certainly wouldn't store it (or any compound for that matter) in DMSO long term. In the context of making a topical solution for immediate use, I don't think there would be an issue. This is just speculation on my part though.



#1273 sparkk51

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Posted 15 January 2015 - 06:06 AM

Do we know enough to reasonably assume that Dihexa has a mechanism of action different from that of Lion's Mane (NGF) to increase neuronal growth/maintenance? Would combining the two be a waste, or possibly dangerous? 


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#1274 ceridwen

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Posted 15 January 2015 - 10:40 PM

As far as I know 1 increases synapses permanently. The other increases neurons temporarily
They might have a synergistic effect.

#1275 welbi

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Posted 16 January 2015 - 02:51 PM

Do you think it's worth taking Dihexa? It looks promising, but we know very little about it. Someone on the forum have benefited from it?



#1276 sk_scientific

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Posted 16 January 2015 - 04:53 PM

Do you think it's worth taking Dihexa? It looks promising, but we know very little about it. Someone on the forum have benefited from it?

 

I am beginning to see subtle, but important improvements in my general cognition.  Also, I seem to be learning a little quicker.  I have been taking 40 mgs a day for a couple of weeks.  The effects are not profound like an usual allopathic drug, or one which has neurotransmitter subreceptor site action.  But my ability to think, process information and concentrate seems improved.


Edited by sk_scientific, 16 January 2015 - 04:53 PM.

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#1277 drg

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Posted 23 January 2015 - 02:30 AM

Have taken dihexa for 3 days... 60, 40, 40mg... no noticeable effects. I might do what xks did and take a large amount at once so i can actually 'feel' the effects rather than a gradual improvement. And also see if it is worth continuing on a more long term basis.



#1278 JASOG888

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Posted 23 January 2015 - 03:48 AM

Personally, I'm going to wait until the third week of my next Cerebrolysin cycle before I try more Dihexa. My first experience with Dihexa was about a week after a Cerebrolysin cycle and the effects were pretty intense. A couple weeks later, not very intense.



#1279 Xenix

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Posted 23 January 2015 - 05:56 AM

With such a long half-life, would it really be necessary to dose daily while using Dihexa? When I get more Dihexa I plan on taking it every second day.
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#1280 Amorphous

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Posted 24 January 2015 - 07:23 AM

Have taken dihexa for 3 days... 60, 40, 40mg... no noticeable effects. I might do what xks did and take a large amount at once so i can actually 'feel' the effects rather than a gradual improvement. And also see if it is worth continuing on a more long term basis.

 

Please don't take the way xks did. He simply wasted it. His 500mg might just allow 5mg (<1%) to get inside his blood stream. Please try the following first:

 

DMSO is one way to make dihexa more absorbable. I've never tried DMSO. Does DMSO actually dissolve it or just disperse it? I am currently using coconut oil to disperse and mechanically break down the particle size and make the size distribution more even. For hydrophobic drug, I understand that there are several ways that can improves drug absorption. The most important 3 that we can easily do are 1) an acidic environment 2) fat or oil content 3) drug particle size and size distributions. I think the arrangement of significance are 3>2>1. 

 

I am suspecting it may allow about >25-50% (6.25-12.5mg of my usual 25mg) get into the body; whereas DMSO may seem like 100% absorption, but actually I feel like the absorption or effect is less than that of using coconut oil or mct oil. It seems like the dihexa is somehow inhibited or destroyed by the DSMO when mixing them (?). 

The way I do it is to break down the powder as much as possible while the powder is in MCT oil. I use a stick to break the large powder into smaller one on a spoon containing the dihexa and mct oil. After the larger particles breaking down into smaller one, the mct oil will turn milky - it is about time to swallow it. 

It may seem tedious to do the above, but remember we only have to do it once a week.


Edited by Amorphous, 24 January 2015 - 07:33 AM.


#1281 StevesPetRat

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Posted 24 January 2015 - 08:38 AM

The way I do it is to break down the powder as much as possible while the powder is in MCT oil. I use a stick to break the large powder into smaller one on a spoon containing the dihexa and mct oil. After the larger particles breaking down into smaller one, the mct oil will turn milky - it is about time to swallow it. 
It may seem tedious to do the above, but remember we only have to do it once a week.

FWIW I also have had the most pronounced effect so far from "dissolving" it in coconut oil. I've got a bottle of d-limonene coming since that's supposedly a good solvent and a few people are already trying DMSO.

#1282 JASOG888

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Posted 24 January 2015 - 03:29 PM

Be careful with the limonene. It will dissolve some plastics.


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#1283 killahbeatz

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Posted 24 January 2015 - 05:15 PM

Has anyone tried it sublingually



#1284 StevesPetRat

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Posted 24 January 2015 - 05:19 PM

Has anyone tried it sublingually

Yeah, barely any absorbs that way, probably because it's so poorly water soluble.

#1285 megatron

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Posted 24 January 2015 - 07:52 PM

 

Has anyone tried it sublingually

Yeah, barely any absorbs that way, probably because it's so poorly water soluble.

 

 

I used to take it dissolved in DMSO sublingually, didn't notice shit though. 


Edited by Megatrone, 24 January 2015 - 07:53 PM.


#1286 Amorphous

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Posted 25 January 2015 - 03:07 AM

 

 

Has anyone tried it sublingually

Yeah, barely any absorbs that way, probably because it's so poorly water soluble.

 

 

I used to take it dissolved in DMSO sublingually, didn't notice shit though. 

 

 

Are you still take it and how?


 

 

Has anyone tried it sublingually

Yeah, barely any absorbs that way, probably because it's so poorly water soluble.

 

 

I used to take it dissolved in DMSO sublingually, didn't notice shit though. 

 

 

Are you still take it and how?



#1287 drg

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Posted 27 January 2015 - 07:43 PM

Been on it a few more days. Took a dose of 200mg didn't notice much, at least no positive effects. Once I read about dissolving the Dihexa I began doing that. My appetite has increased. Unfortunately no improvement, socially, fatigue, at sports / video games. I will wait till I finish it all to write another experience. I haven't noticed much so far.

Have taken dihexa for 3 days... 60, 40, 40mg... no noticeable effects. I might do what xks did and take a large amount at once so i can actually 'feel' the effects rather than a gradual improvement. And also see if it is worth continuing on a more long term basis.



#1288 meatsauce

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Posted 29 January 2015 - 07:07 PM

I just took 30mg mostly dissolved in mct oil. An hour later I feel something going on in my head. It feels like a kind of energy or light pressure.



#1289 Plasticperson

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Posted 01 February 2015 - 03:00 PM

Someone should try dihexa with piperine mixed in fat. If any of you have a sonicator or even a jewelry cleaner I woukd recommend to try dihexa in a liposomal solution

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#1290 lurker1

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Posted 01 February 2015 - 09:07 PM

I'm surprized so few have used Dihexa topically in DMSO. That would seem like a no-brainer to try. That ROA would approach the efficiency of injection. Taking it orally is clearly an inferior way to take it; for the rats, it took 4x as much to produce the same effects as injection. So why are people taking it orally?






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