It looks like you consider all telomerase activating agents as pro cancer and vice versa - why ? Am I miss something ?
Oh boy! Now thats a big can of worms you are opening Andy.
I dont think I could put it better than this:
http://www.anti-agin...inhibit-the-expression-of-telomerase/
So it seems to me that nature is cleverer than we give it credit for and that substances that de-activate telomerase in cancer cells have the opposite effect in healthy cells....?
Every single paper that Vince cited in his review was looking at cells in vitro, where they are inevitably given doses that are far larger, and of far longer magnitude than could
ever be achieved in a human. For many compounds, such as resveratrol, the result you see with a given cell is dose dependent- at high dose you see one thing, while at low dose you see the opposite. The vast majority of in vitro results have no relevance at all to humans taking anything close to normal doses.
I have seen at least anecdotal evidence that resveratrol has anti-cancer properties at very high doses, but you'd better be taking
a lot. (10+ grams/day? maybe more.)
Here's a paper looking at hepatic cancer in humans, but it's only a safety/PK study, no clinical results. They use a specially formulated version of resveratrol that is a lot more bioavailable than plain resveratrol. There are some promising hints of an increase in an apoptosis marker.