10 replies to this topic

[Nickotin]

As the title says, I have a rare condition and I'm looking for some nootropic advice. Here is a quick description of MdD.

Mal de debarquement (or Mal de débarquement) syndrome (MdDS, or disembarkment syndrome) is a rare condition usually occurring after a cruise, aircraft flight, or other sustained motion event. It has only recently received attention and very little scientific research has been conducted. The phrase "mal de débarquement" is French for "disembarkation sickness".
Symptoms most frequently reported include a persistent sensation of motion usually described as rocking, swaying, or bobbing; difficulty maintaining balance; extreme fatigue; and difficulty concentrating ("brain fog"). Other common symptoms include dizziness, visual disturbances (such as seeing motion, inability to focus etc.), headaches and/or migraine headaches, confusion, and anxiety. Many patients also describe ear symptoms such as hyperacusis, tinnitus, "fullness", pain, or even decreased hearing. Cognitive impairment ("brain fog") includes an inability to recall words, short term memory loss, and an inability to multi-task.
Interestingly, the condition often abates when the patient is in motion such as in a car, train, plane, or boat. Symptoms are increased by stress, lack of sleep, crowds, flickering lights, loud sounds, fast or sudden movements, enclosed areas or busy patterns.

I've also attached a relevant study of MdD. It provides some evidence that MdD is a vestibular hallucination. An interesting thing is the change in the (EEG) brain wave activity going from symptomatic to asymptomatic. The follow observations were made: "the EEG while having MdD symptoms indicated a significantly decreased alpha-activity current source density (8-12 Hz) at the precentral gyrus (Brodmann area 6) of the left frontal lobe (Fig. 1A) and increased beta-2 activity (19-21 Hz) at the parahippocampal gyrus (Brodmann areas 27, 30, 35, and 36) of the right mesial temporal region (Fig. 1B). In contrast, the delta, theta, and lower beta bands did not differ significantly between the EEGs."

So far I've had very positive results with (zen) meditation, and I assume that it has something to do with the brain wave activity. I've also started a nootropic regimen that is as follows:

Piracetam 2.4g BID
Fish oil 1g BID
CDPCholine 250mg BID
Picamilon 150mg morning
Multivitamin
Creatine
Gold Standard whey loaded with various Aminos

Please help with recommendations on what I could possibly change/add/subtract. I would appreciate it and so would a lot of other people who have this disease. Thanks in advance!

Attached Files

•  MdD.pdf   1.3MB   7 downloads

[trance]

Maybe a low dose of melatonin before sleep would benefit immensely ...

[Raptor87]

Also you need to see a doctor for checking your ears. It might be crystal build up which affects your senses. Trust me on this one.

http://en.wikipedia....itional_vertigo

[protoject]

Agreed with brainfog! I dont have this disorder but I have experienced temporary versions of it. When i was a kid I went to the theme park on rollercoaster rides and what not, then we went to my parent's friends house to sleep, and I kept feeling like I was flying around on a roller coaster! It made me not able to sleep and very anxious and feeling like i was going to throw up. So Strange. Anyway. Considering the alpha-wave thing, try theanine. Theanine seriously boosts alpha waves. Maybe it'll help? Though I'm not sure if the decrease in alpha-waves is the cause of the problem, nor am I sure that your alpha waves are particularly unbalanced, it seems that it's possible considering your meditation.

[Nickotin]

Agreed with brainfog! I dont have this disorder but I have experienced temporary versions of it. When i was a kid I went to the theme park on rollercoaster rides and what not, then we went to my parent's friends house to sleep, and I kept feeling like I was flying around on a roller coaster! It made me not able to sleep and very anxious and feeling like i was going to throw up. So Strange. Anyway. Considering the alpha-wave thing, try theanine. Theanine seriously boosts alpha waves. Maybe it'll help? Though I'm not sure if the decrease in alpha-waves is the cause of the problem, nor am I sure that your alpha waves are particularly unbalanced, it seems that it's possible considering your meditation.

I wish it were as simple as BPPV. That's part of the diagnosis; ruling out every form of known vestibular disturbances. This is classified as a neurological condition and evidence points towards it being a "vestibular hallucination" from a section of the brain that remembers the motion event.

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[Mr. Pink]

i always get the disembarkment syndrome after being on a boat or a train for a few days. i never knew it was a rare neurological disease as I think my parents get it too. but it always just goes away after a few days on its own. how long have you been deeling with it? does benadryl or dramamine help?

[Nickotin]

i always get the disembarkment syndrome after being on a boat or a train for a few days. i never knew it was a rare neurological disease as I think my parents get it too. but it always just goes away after a few days on its own. how long have you been deeling with it? does benadryl or dramamine help?

I've been dealing with this for the last 12 years, although the symptoms remain in remission for about 60-70% of the time. I can go months feeling great and then months feeling like I'm constantly rocking. It's not a rotational vertigo but more like a phantom motion with severe brain fog and fatigue. Some people never recover from being symptomatic. I've found that nothing help accept high dose niacin and meditation. I was experimenting with niacin and gaba when I stumbled across picamilon. That was last week. This week I'm a total nootropics Guinea pig. :D

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[Mr. Pink]

i always get the disembarkment syndrome after being on a boat or a train for a few days. i never knew it was a rare neurological disease as I think my parents get it too. but it always just goes away after a few days on its own. how long have you been deeling with it? does benadryl or dramamine help?

I've been dealing with this for the last 12 years, although the symptoms remain in remission for about 60-70% of the time. I can go months feeling great and then months feeling like I'm constantly rocking. It's not a rotational vertigo but more like a phantom motion with severe brain fog and fatigue. Some people never recover from being symptomatic. I've found that nothing help accept high dose niacin and meditation. I was experimenting with niacin and gaba when I stumbled across picamilon. That was last week. This week I'm a total nootropics Guinea pig. :D

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that's interesting about the niacin. I have a chronic ear pressure thing in one of my ears (unrelated to mdb), and the only thing that relieves it is niacin. caffeine and other nootropics seem to make it worse (at least in some part of the time i feel their effects - i.e., during the comedown).

[Nickotin]

i always get the disembarkment syndrome after being on a boat or a train for a few days. i never knew it was a rare neurological disease as I think my parents get it too. but it always just goes away after a few days on its own. how long have you been deeling with it? does benadryl or dramamine help?

I've been dealing with this for the last 12 years, although the symptoms remain in remission for about 60-70% of the time. I can go months feeling great and then months feeling like I'm constantly rocking. It's not a rotational vertigo but more like a phantom motion with severe brain fog and fatigue. Some people never recover from being symptomatic. I've found that nothing help accept high dose niacin and meditation. I was experimenting with niacin and gaba when I stumbled across picamilon. That was last week. This week I'm a total nootropics Guinea pig. :D

Sent from my Galaxy Nexus using Tapatalk 2

that's interesting about the niacin. I have a chronic ear pressure thing in one of my ears (unrelated to mdb), and the only thing that relieves it is niacin. caffeine and other nootropics seem to make it worse (at least in some part of the time i feel their effects - i.e., during the comedown).

Have you tried picamilon? It's GABA fused to niacin which passes through the BBB.

Sent from my Galaxy Nexus using Tapatalk 2

[Mr. Pink]

i always get the disembarkment syndrome after being on a boat or a train for a few days. i never knew it was a rare neurological disease as I think my parents get it too. but it always just goes away after a few days on its own. how long have you been deeling with it? does benadryl or dramamine help?

I've been dealing with this for the last 12 years, although the symptoms remain in remission for about 60-70% of the time. I can go months feeling great and then months feeling like I'm constantly rocking. It's not a rotational vertigo but more like a phantom motion with severe brain fog and fatigue. Some people never recover from being symptomatic. I've found that nothing help accept high dose niacin and meditation. I was experimenting with niacin and gaba when I stumbled across picamilon. That was last week. This week I'm a total nootropics Guinea pig. :D

Sent from my Galaxy Nexus using Tapatalk 2

that's interesting about the niacin. I have a chronic ear pressure thing in one of my ears (unrelated to mdb), and the only thing that relieves it is niacin. caffeine and other nootropics seem to make it worse (at least in some part of the time i feel their effects - i.e., during the comedown).

Have you tried picamilon? It's GABA fused to niacin which passes through the BBB.

Sent from my Galaxy Nexus using Tapatalk 2

i've read about it, but I don't think it's for me. I used theanine which is anxiolytic through increasing GABA and I don't really notice a nootropic benefit. also not even taking niacin very much anymore. my ear thing is a very mild problem. i find i get better nootropic effects from things that increase my norepinephrine rather than lower it. my main problems are memory and motivation. even though i do have generalized anxiety, i get more complacent and my memory gets duller when i relax. it's weird how memory is tied to emotions.

[Nickotin]

i always get the disembarkment syndrome after being on a boat or a train for a few days. i never knew it was a rare neurological disease as I think my parents get it too. but it always just goes away after a few days on its own. how long have you been deeling with it? does benadryl or dramamine help?

I've been dealing with this for the last 12 years, although the symptoms remain in remission for about 60-70% of the time. I can go months feeling great and then months feeling like I'm constantly rocking. It's not a rotational vertigo but more like a phantom motion with severe brain fog and fatigue. Some people never recover from being symptomatic. I've found that nothing help accept high dose niacin and meditation. I was experimenting with niacin and gaba when I stumbled across picamilon. That was last week. This week I'm a total nootropics Guinea pig. :D

Sent from my Galaxy Nexus using Tapatalk 2

that's interesting about the niacin. I have a chronic ear pressure thing in one of my ears (unrelated to mdb), and the only thing that relieves it is niacin. caffeine and other nootropics seem to make it worse (at least in some part of the time i feel their effects - i.e., during the comedown).

Have you tried picamilon? It's GABA fused to niacin which passes through the BBB.

Sent from my Galaxy Nexus using Tapatalk 2

i've read about it, but I don't think it's for me. I used theanine which is anxiolytic through increasing GABA and I don't really notice a nootropic benefit. also not even taking niacin very much anymore. my ear thing is a very mild problem. i find i get better nootropic effects from things that increase my norepinephrine rather than lower it. my main problems are memory and motivation. even though i do have generalized anxiety, i get more complacent and my memory gets duller when i relax. it's weird how memory is tied to emotions.

I'm on my second day with picamilon, and unlike theanine it can have both an anxiolytic and energentic effect at high doses. I took 150mg in the AM and another 100mg at lunch. I've never experienced a calm energy like this before. All I can say is it's very cool and my theanine is going to the back of the cabinet. :D