54 replies to this topic

[renfr]

Fun topic, but this discussion will most likely lead to nowhere.

And so did it happen!

[focus83]

Fun topic, but this discussion will most likely lead to nowhere.

And so did it happen!

;-) Turned out to be a lively discussion, but what I meant was that a discussion solely about drugs that could kill fear will be a dead end since there is none.

[noos]

I found opposite ,Modafinil induce increase in fear .nicotine not increase in fear ,both vascular restrictors .why Modafinil increase in fear so much ?

Creatine help a lot for fear .

Can high testosterone help lower fear to zero?

Creatine reduces fear? How interesting, never heard that. How do you use it?
Modafinil fos some reduces social fear

[SuperjackDid_]

I don't know but i take with piracetam and it help a lot in confident and less fear .

[Sasha_]

Surprised no one already mentionned Noopept. It does work in my experience, although side effects build up within three days of takin it and I then become actually more anxious, so not a long term solution.

Panax Ginseng works, seems to elevate testosterone, lowers stress response and mildly stimulates the mind, which allows me to deal more successfully with minor challenges and confrontations, consequently making me more confident, which I believe elevates
testosterone, and allows for some kind of a positive loop.

[Alphatrial]

I read something about Beta Alanine.

[Alphatrial]

http://www.ergo-log....ineanxiety.html

Don't know if it works.. but there's one way to find out right...

[focus83]

We are getting slightly off topic here. The OP asked about drugs that KILL fear. Neither Ginseng, Beta Alanine, Noopept, Creatine, Piracetam nor any other such supplements or low impact drugs come close to KILLING fear. Now everybody posts stuff that has ever been linked to anxiolysis, no matter how mild. Certainly interesting, but that's not what this particular thread is about... Let's keep this thread a little more concise, please.

[focus83]

I think it would also be interesting to know what kind of anxiolytic drugs with novel mechanism of actions are currently in the pipeline of pharma companies? Admittedly, I have nothing to contribute here :-P
But maybe others?

[NeuroNootropic]

I found opposite ,Modafinil induce increase in fear .nicotine not increase in fear ,both vascular restrictors .why Modafinil increase in fear so much ?

Creatine help a lot for fear .

Can high testosterone help lower fear to zero?

Creatine reduces fear? How interesting, never heard that. How do you use it?
Modafinil fos some reduces social fear

I'm not sure how creatine reduces fear, but it increases DHT, which is more potent than testosterone: http://www.ncbi.nlm....pubmed/19741313

Anyway, I have relatively low testosterone for someone my age (19). My total testosterone is less than 400 ng/dl yet I experience no fear. I can still get startled, but watching horror movies or playing scary games does nothing for me. I'm pretty sure this is related to my dysthmia since I barely laugh at what would otherwise be funny things. My emotions are numb. Even now that I'm taking Wellbutrin, which is suppose to increase anxiety/fear, I still am emotionally numb.

I think SSRIs would be a good way to kill fear since they increase serotonin levels, which is known to reduce anxiety. A lot of people taking SSRIs feel like zombies. Maybe 5-HTP would kill fear while leaving your other emotions in tact.

[Mr Kebab]

alprazolam (xanax) kills fear better than anything I have experienced before. Accepting that the primary centre for fear is the amygdala, benzos (and in particular Xanax), suppress amygdala activity more than just about anything than maybe barbs. Propranolol does not affect the fear centre of the brain directly, only decreasing the physical effects of adrenalin. However, Propranolol (and other beta blockers) can reduce fear by short circuiting the feedback loop between physical and mental symptoms.

[AdamI]

Anyone tried Anti FAAH to reduce fear/eliminate it? Seems easy to buy, soo thought maybe someone here has tried it. Maybe I'm in the wrong thread if soo let me know, and I'll check that thread out.

http://www.eurekaler...u-wab060812.php
"With altered brain chemistry, fear is more easily overcome"

Earlier studies had suggested that blocking the FAAH enzyme could decrease fear and anxiety by increasing endocannabinoids.


http://io9.com/59179...ke-you-fearless
"Could a single pill make you fearless?"

[Turnbuckle]

Fun topic, but this discussion will most likely lead to nowhere.

And so did it happen!

;-) Turned out to be a lively discussion, but what I meant was that a discussion solely about drugs that could kill fear will be a dead end since there is none.

I pointed to the drug in post 23 as did ricca91 in posts 6 & 8. Have you tried it?

Edited by Turnbuckle, 06 February 2013 - 01:11 PM.

[AdamI]

Post 23 u talk about And D-Cycloserine and proponal or what ever it spells. Thats not Anti FAAH enzyme? or is it?

[Turnbuckle]

Post 23 u talk about And D-Cycloserine and proponal or what ever it spells. Thats not Anti FAAH enzyme? or is it?

That's a quote from ricca. I have no experience with cycloserine, but I do with propranolol. It's a beta blocker that keeps the heart from racing. It breaks the feed back loop where anxiety gets the heart racing and the racing heart increases the sense of anxiety.

[vapaatyyli]

http://www.dailymail...ists-claim.html

High doses of turmeric, might do something.

[musicman4534]

Hey, we're talking about this right now actually in a few HDAC inhibitor threads, and we just organized a group buy for vorinostat, an HDAC inhibitor that has shown to be able to extinguish fears and anxieties as well as improve memory, learning, and aid in addiction cessation.

 

HDAC Inhibitor discussion thread

 

Vorinostat Group Buy

 

CL-994 thread where the first couple small vorinostat group buys happened, and where a couple very well written experience reports are.

[gamesguru]

Propanolol, which is excellent at controlling situational anxiety, may be the closest option available today.  But its prolonged use is hardly recommended in erudite circles.

 

In terms of erasing negative memories associated with traumatic experience, Vorinostat, methylene blue, and Benadryl may be more effective than mediation combined with exercise (which works well on its own).

[RonBurgandy]

Increasing androgen levels either by natural production or replacement via TRT. From experience, whenever my testosterone levels are measurable >1000 ng/dl I've noticed fear is greatly diminished under a variety of circumstances.

 

Think about our ancestors that played on the battlefields, I can assure you they on average had higher levels of testosterone.

[p3x888]

I know this isn't directly related to the thread as a supplement, but there is a cure to behavioral based fear. More exposure to what we fear. Naval Special Warfare (SEALs) found this out in developing the BUDs course. They investigated why the drop out rate was so high (other than the obvious reasons) and started to focus on the mental aspects of the training. They developed a series of skill sets to be taught to recruits to help them overcome their fears and build mental strength. One of these was constant exposure to the thing the student feared the most. By using the skills they learned, being exposed over and over became easier until it was very bearable. So sales, public speaking, talking to girls, its all the same. Keep doing it. Don't mind the failures, get up and keep going. Again, I know this is slightly off topic but maybe it would be useful to someone.

[Mind_Paralysis]

Acetaminophen, a ka Paracetamol.

 

It's also the only compound which MIGHT work against the fear of death - it decreases existential fear. I already have a thread about it, look it up.

 

The reason it works is Endocannabinoid modulation - which I believe has already been brought up, but through a different target.

 

The active metabolite of Paracetamol diminishes pain through a similar way as CANNABIS - but WITHOUT the cognitive side-effects.

It does this by being more selective - it's an SCRI - Selective Cannabinoid Reuptake Inhibitor.

 

 

 

Increasing androgen levels either by natural production or replacement via TRT. From experience, whenever my testosterone levels are measurable >1000 ng/dl I've noticed fear is greatly diminished under a variety of circumstances.

 

Think about our ancestors that played on the battlefields, I can assure you they on average had higher levels of testosterone.

 

Perhaps, but this is an utterly useless suggestion for a woman.

 

I take it that I don't need to point out any of the number of health-issues which such increased androgen-levels will cause for a woman?
 

[PeaceAndProsperity]

Wasn't there something about a lot of school shooters in America having taken drugs like xanax and supposedly the "fear killing" effect is what allowed them to do what they did? Or something

[jack black]

Wasn't there something about a lot of school shooters in America having taken drugs like xanax and supposedly the "fear killing" effect is what allowed them to do what they did? Or something

No, i think its the other way around.
Those are mentally sick people who happened to take drugs (that clearly didn't work well). Crazy people do that without drugs too.

[Madman]

I stumbled on the curcumin fear killing effect by accident a few years ago with 99% curcumin extract with piperine at v high dosage, 2 - 3 tsp per day , breakfast, lunch and dinner, it wiped it out so effectively I was actually behaving abnormally for a while without realizing it as there was no base line amount of fear to keep me behaving normally similar to the effect long term valium has on behaviour or alcohol, less self control but with no fear its a little different behaving fearless seems very odd in day to day events.

 

I have since changed in the last year to normal non extracted turmeric at 2 tsp per day and notice a fear killing effect but my behavior is normal as its not so pronounced and feels more balanced with the other compounds assisting present in the full spectrum turmeric.

 

In addition to the above, I second the testosterone effect on fear response, I'm currently on TRT with an anti estrogen, however without strong estrogen control in some people  fear would be a problem as its related to emotion which estrogen in normal to higher levels brings, before TRT my test levels were low and estrogen levels at the high end which resulted in a high daily level of fear, anxiety and stress.

 

On-top of the above, raising serotonin levels with 5-htp 

 

magnesium and calcium

 

The neuro peptide "Selank" which had profound anti anxiety and fear reducing effects on me with the above compounds.

 

These helped me control fear and anxiety successfully, I'm not a doctor so take what I say with a pinch of salt.

Edited by Madman, 27 December 2016 - 09:52 PM.

[jack black]

 

The fear or 'fight-or-flight' response is mediated by the agonism of beta-adrenoreceptors. Hence the spike in sympathomimetic activity and the ensuing adrenaline rush one experiences when exposed to a perceptibly 'dangerous' or 'frightening' stimulus.

As such, beta-blockers are the answer to the OP's question.

As I said above, beta blockers will help with many (not all) of the physical manifestations of anxiety, but do little or nothing for the mental part. Propranolol is an exception here because it crosses the blood brain barrier and influences GABA levels amonst other things. However, this is not nearly enough to talk about fear elimination here.

 

 

really?

 

 

Furthermore, central effects such as tranquilizing influences are used for the treatment of conditions such as anxiety. Several different mechanisms of action could be responsible for these CNS effects: Centrally mediated specific actions on centrally located beta-adrenergic receptors, known to exist downstream from, and at the terminals of, 'vigilance-enhancing' central noradrenergic pathways. Centrally mediated specific actions on centrally located receptors of the non-adrenergic type; an affinity of some beta-blockers towards 5-HT-receptors is well documented. Centrally mediated non-specific actions on centrally located neurones, owing to the membrane-stabilizing effects of beta-blockers

https://www.ncbi.nlm.../pubmed/2865151

 

 

Propranolol is being investigated as a potential treatment for PTSD.^[19][20] Propranolol works to inhibit the actions of norepinephrine, a neurotransmitter that enhances memory consolidation. Individuals given propranolol immediately after trauma experienced fewer stress-related symptoms and lower rates of PTSD than respective control groups who did not receive the drug.^[21] Due to the fact that memories and their emotional content are reconsolidated in the hours after they are recalled/re-experienced, propranolol can also diminish the emotional impact of already formed memories; for this reason, it is also being studied in the treatment of specific phobias, such as arachnophobia, dental fear, and social phobia.^[22]

^[...]

In addition to blockade of adrenergic receptors, propranolol has weak inhibitory effects on the norepinephrine transporter and/or weakly stimulates norepinephrine release (i.e., the concentration of norepinephrine is increased in the synapse).^[41][42] Since propranolol blocks β-adrenoceptors, the increase in synaptic norepinephrine only results in α-adrenoceptor activation, with the α₁-adrenoceptor being particularly important for effects observed in animal models.^[41][42] Therefore, it can be looked upon as a weak indirect α₁-adrenoceptor agonist in addition to potent β-adrenoceptor antagonist.^[41][42] In addition to its effects on the adrenergic system, there is evidence that indicates that propranolol may function as an antagonist of certain serotonin receptors, namely the 5-HT_1A and 5-HT_1B receptors.^[43][44]

https://en.wikipedia...iki/Propranolol

 

i know this is an old thread, but i hate to see unopposed nonsense posted here.