20 replies to this topic

[panhedonic]

I'd like to start a discussion with people who either take or are planning to take Selegiline long-term. (over a year)

I'm taking 4mg/day (dep-pro) for 3 months now, with good results, and since I plan to keep taking it, I'd like to hear the experiences of whoever has taken it for over a year.

Does it still work for you? did you have to change your dose? do you notice any side-effects? What do you combine it with? What do you take it for in the first place?

Thanks

[spookytooth]

what are your results so far?

[Geoffrey]

Selegiline was great for me at the beginning, and worked for about two months (I started with one tablet daily, quickly reducing to every other day, then every three days, then down to one a week). But after the first two months the experience went quickly downhill. I started getting weird headaches which would make the whole of the back of my head and neck stiff and painful. Choline had no effect, or even made it worse. I reduced the dosage to half a pill a week, but I would find myself being virtually knocked out for a day and a half after taking it. I reduced to a quarter per week, but even that was distinctly unpleasant for about 12 hours after taking the dose. So now I'm off it altogether. I can't explain why such tiny doses ended up having such a bad effect on me, especially after the euphoria and huge sense of wellbeing that I got when I first started on one pill per day... I did combine with racetams in small doses, but never on the same day as taking the selegiline dose.

[Tubemode]

Wanted to stay on it. BP issues got in the way.

[panhedonic]

To me what it did is almost totally eliminated recurrent negative thinking that I had. Not sure if I should call it OCD, but certainly there are similarities. I feel better in general, but also taking a lot other supplements.

I take 5mg/day dep-pro, sublingual (which amounts to who knows how much buccal)

Anybody has been taking it for over 1 year?

[alecnevsky]

How's the sleep on this? Does it promote more REM rather than Deep sleep?

[Hope47]

I am going to give it a try.Does it helps in study/mood lifting.How much dose to take for first time

[crusader]

brainjuice-


can you give an updated review of your selegiline trial?

is it still helping you? side effects?

[jadamgo]

I took it for a year and a half, at doses ranging from 5mg/day to 10mg/day (all sublingual) for depression. It worked great for the melancholic/atypical side of the depression, improving and stabilizing my mood, restoring pleasure lost to consummatory anhedonia, and making it easier to break out of negative thought patterns.

It didn't do anything for the fatigue, anticipatory anhedonia, or lack of motivation. I later found that those symptoms were caused by seasonal affective disorder, and I had both melancholic depression AND seasonal affective disorder and the selegiline was only treating the melancholic depression. Bright light therapy was needed (and still is) to treat the seasonal affective disorder. But that's just me, and it's pretty rare for someone to have two separate mood disorders at the same time.

BTW brainjuice, I wouldn't call recurrent negative thinking "OCD" unless it was linked to the classic "have intrusive anxious thoughts -> try to suppress them, fail -> feel bad -> do ritual to relieve discomfort -> repeat" pattern that typifies OCD. Recurrent negative thinking is a huge feature of both clinical depression, where it's called rumination, and generalized anxiety disorder, where it's called uncontrolled worrying.

Edited by jadamgo, 23 February 2013 - 02:51 AM.

[panhedonic]

I can't be as specific as jadamgo, (thanks for the OCD clarification) but I can say that after about 5 months it still keeps me away from negative thinking and moreover, the emotional response to negative thinking, including high anxiety and sometimes panic (a very mental version of panic, that would start with thoughts and derive in a wreck of an emotional state, which would drain my energy for days and leave me in the most horrible state) Needless to say, I'm thrilled that these "guests" haven't come for a while now.

My energy, libido also seem higher. Didn't work for my irritability (seems the same, not higher than usual, though) Also, I bought a wrist blood pressure monitor and started to check my pressure. To my surprise, it's low.

I still have the question of whether my 5mg/day sublingual doses are still selective or both MAOb and MAOa.... maybe the fact that cheese or wine have no ill effect on me answers that question?

Also, who has taken Selegiline for LONG TERM? I don't seem to remember anybody here, except for one guy that took it for 16 years (and is in his 70's)

[riloal]

BUMP, panhedonic, are you still on selegine? Anyone here is on selegine long term? thanks

[panhedonic]

Yes, same dose, same effects as far as I can tell. No sides.

[fntms]

Wanted to stay on it. BP issues got in the way.

Same here, lower bp is a known side effect. Rasagiline also lowers bp in the long run but not as quickly apparently...

[NeuroGeneration]

Hey panhedonic, just wondering if you're still using selegiline, and if you are, how are the effects? If not, why did you stop?

[panhedonic]

Sorry for a late reply. I'm still using it and I am doing well. I like the effects, which I have described many times (please refer to my earlier posts)

[NeuroGeneration]

Yes, I've seen them. Thanks for sharing.

[NeuroNootropic]

Sorry for a late reply. I'm still using it and I am doing well. I like the effects, which I have described many times (please refer to my earlier posts)

 

Have you noticed an increase in motivation or decrease in anhedonia? I've taken Selegiline in the past at 5 mg everyday for a month and it increased motivation a little bit, but made me as tired as a hibernating bear. Every night I would sleep for more than 12 hours and wake up just dead tired. It also affected my emotions and while my emotions aren't exactly that of a normal person at baseline, Selegiline seems to worsen my condition and make me almost zombified. Laughter is also changed and becomes an artificial feeling and forced. Have you noticed this?

[panhedonic]

Neuro, haven't noticed any of that. My baseline motivation was very high and it's still the same. I didn't have anhedonia, but rather intrusive, negative thoughts and a self-defeating tendency which I think Selegiline helped a lot with. I might have called it anhedonia at some point, but it's not what it was. 

 

If anything, your effects seem the opposite from what I've gotten. 

[NeuroGeneration]

I've had anhedonia, no libido and defeatist thoughts.

 

1 drop of sublingual selegiline & 1 dopa mucuna (NOW brand) 6 days/week, and I'm a new man. Everything is up to the levels of my teens / early 20's (which was very high), minus the cockiness and lack of humility.

 

I tried 5 drops last spring, and they made me very tired – I needed naps during the day. This level doesn't seem to do that to me.

[crusader]

Neurogeneration-

1 drop of selegiline is how many mg's?

You say everything is up to your teen levels/early 20's? Are you just talking about libido or happiness, quality of life, etc..


Any blood pressure side effects?

[NeuroGeneration]

1 drop = 1mg.

 

Perhaps teen years is a bit of an exaggeration, but definitely early 20's; I'm 30 now.

 

Libido stands out most, because that's a primal urge. Other aspects are more influenced by life's lessons, if you know what I mean. For example, in my 20's I thought I could take over the world and had the drive to do so. Now, I know I can't take over the world, but still - or should I say, have regained - the drive to see how much I can get away with!

 

I haven't kept track of blood pressure, but no symptoms. Keep in mind, I am very healthy (diet and exercise). Also, from what I understand, 1mg is very low when it comes to MAOI.

Edited by NeuroGeneration, 31 March 2015 - 11:26 PM.