80 replies to this topic

[anagram]

on an unrelated note, I have found a use for lycopene other than supplementing. Today, out of curiosity, I found out that the aroma of roses was from the degradation of carotenoids. pretty soon I was engaged in making a deodorant for my self as I was tired of the chemically smelling deoderants that have saturated the market.

I added some lycopene into a container with water and shook, removing any none fat soluble impuritys. Then dumped the water out, leaving the pure lycopene. I then added some olive oil, and vitamine c to begin the break down of the lycopene. I then added a few drops of this to a jar filled with water and shook again. The smell was initially very musky but changed to this scent that is actually changing into another scent as I speak.


ahh, I love the scent of being on step ahead of everyone else.

Edited by anagram, 26 November 2012 - 01:08 AM.

[Adaptogen]

what does it smell like?

[anagram]

the liquid smells like tomatos at the moment. but its definitely changing into something else, more of a chocolatey scent I think. but that is only the smell from the bottle, when I put it on my skin, I begin to smell fragrant. the change is probably due to oxidation or cyclization of the Lycopene into smaller compounds.

I would not recommend doing this though. The tomato smell is awful. and as it changes, it smells like metallic-blood smell and goes to old people smell. its also super musky, no fun.

Edited by anagram, 26 November 2012 - 09:18 PM.

[Turnbuckle]

The more I look at my beautiful bottle of astaxanthin & C60, the more I think you had a terrific idea, anagram. One Longecity user found that C60 restimulated the stem cell injection in his knee, possibly by promoting stem cell differentiation. So would astaxanthin take that to the next level while simultanenously protecting the C60 from oxidation?--

Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells.

In the present study, the effect of astaxanthin on improvement of the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells (NSCs) was evaluated. Treatment of astaxanthin-induced actives cell growth in a dose-dependent and time-dependent manner. Results from a clonogenic assay clearly indicated that astaxanthin can actively stimulate proliferation of NSCs.

[trance]

Are y'all just adding a capsule of astaxanthin to your C60oo, or adding C60 to a bottle of astaxanthin? If the later, where did you get a bulk bottle of astaxanthin?

Carrying it further ... why not add C60 to krill oil -- or for that matter: fish oil, carotenoid, or tocotrienol complexes?

Edited by trance, 27 November 2012 - 04:46 PM.

[Turnbuckle]

Are y'all just adding a capsule of astaxanthin to your C60oo, or adding C60 to a bottle of astaxanthin? If the later, where did you get a bulk bottle of astaxanthin?

Carrying it further ... why not add C60 to krill oil -- or for that matter: fish oil, carotenoid, or tocotrienol complexes?

I added .6 mg/ml astaxanthin (from capsules) to .6 mg/ml C60 in EVOO. Why that amount? It was completely arbitrary. Then I diluted a single dose of 1/2 teaspoon in yet more EVOO.

As for your suggestions of other oils or carotenoids, do you have a logical reason for any of those?

[trance]

Just thinking out loud as it were -- astaxanthin is a natural component of krill oil, so there may be other beneficial substances in the unisolated components or cofactors within krill oil as well. (Of course, the very opposite could be true too, since all of this is relatively uncharted territory.)

And astaxanthin is a carotenoid, and if C60 possibly enhances its actions, then the same could be true for the other members of the carotenoid complexes.

Then, for that matter, why stop there ... what other known oil-based antioxidant type compounds might benefit from a synergistic relationship with C60 & C60 adjuncts?

Edited by trance, 27 November 2012 - 05:19 PM.

[Turnbuckle]

Just thinking out loud as it were -- astaxanthin is a natural component of krill oil, so there may be other beneficial substances in the unisolated components or cofactors within krill oil as well. (Of course, the very opposite could be true too, since all of this is relatively uncharted territory.)

And astaxanthin is a carotenoid, and if C60 possibly enhances its actions, then the same could be true for the other members of the carotenoid complexes.

Then, for that matter, why stop there ... what other known oil-based antioxidant type compounds might benefit from a synergistic relationship with C60 & C60 adjuncts?

First of all, anything can happen, I suppose, but if we want to stick more or less with what is documented, that limits us to C60 in EVOO. Any other oil and who knows? As for astaxanthin, that has documented effects I linked to above. Saying that other materials might have the same effects because they belong to the same general class is a mighty big leap. You might as well say that graphite could substitute for C60 since both are pure carbon. Or you might assume that C70 won't act that differently from C60, but I've found that they are very different.

Edited by Turnbuckle, 27 November 2012 - 05:39 PM.

[Kevnzworld]

Nothing we supplement is taken in isolation. I didn't change or reduce my regimen because I added C60. I don't see why C60OO would be synergistic with just astaxanthin. It could potentially reduce the peroxidation potential of omega 3's given it's affinity for lipids. If it's true that C60's benefit is it's ability to protect mitochondria , then PQQ would also seem to work well with it.
I don't see why the astaxanthin has to be added to the olive oil as long as you take it daily anyway. The half life of fat soluble substances is relatively long.

[anagram]

let me just start out by saying (take! vitamine c)
I know it sounds weird but listen to my story...

I had been taking astaxanthin/ w lycopene and c60 together for awhile when I decided to stop because I wasn't feeling the c60 in full force.
I then discovered that xanthrophylls (astaxanthin, lycopene,...) undergo epoxidation.( luckily these epoxides don't cause genetic damage ).
one way the body gets rid of this epoxide group is with ascorbic acid(vitamine c), turning it into dehydrogenascorbic acid.
thinking about it, having the lycopene epoxides build up was probably what made me feel wired, draining me of my vitamine c, so I 500mgs and feel much better(alpha lipoic acid also does the trick), lemon juice has ascorbic acid, and citric acid in it so its a good thing to drink.



what the attached thumbnails are:

I included a little diagram of astaxanthin in the mitochondrial membrane. Imagine a c60 laying in between the chromophore system of the astaxanthin, in the mitochondiral membrane.

the other picture shows the chromophore system in astaxanthin (highlighted in red)

in the other picture, it is of what happens to this system when light hits it, it gains a delocalized electron and straightens out.



 PIC-Astaxanthin-membrane-no-words2.jpg   459.05KB   35 downloads

Attached Files

•  800px-Beta-carotene-conjugation.png   27.92KB   26 downloads
•  380px-RetinalCisandTrans.svg.png   8.13KB   14 downloads

Edited by anagram, 28 November 2012 - 01:37 AM.

[hav]

well, I got a bottle of c60 and soon after taking a drop, I realized how useful this compound really is. One day, long after becoming an expert c60 taker, I truly realized the slowness of my grandparents. To help I decided to slip some drops of c60 on my grandpas toast and olive oil(he has dementia from his boxing days and sits in front of the TV all day, cant piss straight either). I felt bad though because I think that as he was eating his toast he was thinking he was about to die, he seems to be a quick responder to c60.

Am I the only one here that sees a problem with slipping someone c60 without their informed consent?

Howard

[Anthony_Loera]

I see a problem with it.

A

Edited by Anthony_Loera, 28 November 2012 - 09:33 PM.

[Adaptogen]

plenty of people give their sick parents/grandparents medicine. just because it's not prescribed by a doctor doesn't mean its not okay

Edited by Adaptogen, 28 November 2012 - 11:42 PM.

[anagram]

I have to pose Hav and anthony_loera a question,

If you saw someone you love not getting proper care for an illness, what exactly would you do?

I have sent my grandparents hundreds of dollars worth of supplements, and most of them got returned to me right after the expiration date happened, and only a few pills taken, I cannot reason with my grandparents.

I suggested citi-coline, and my grandma told me, "ill ask the doctor about it", and you can guess what happened next, they got medical marjuana. The only way to help my grandparents is secretly.

Anyway, If someone doesn't know whats right for themselves, i usually will not act except in this case. these people are sort of part of my family, I hate to see them suffer.
In regards to me putting a drop of c60-oo dissolved in more olive oil, to my grandfather once, how on earth is that even close to wrong?

its not like I am fluoridating his water or adding perfluorooctanoic acid to his food,
i am giving him a safe "supplement", that many may find controversial but so are just about all other supplements.
we don't want c60 becoming illegal and if anything, what I have done helps show its safety and effectiveness at helping with dementia.

[anagram]

oh and anthony_loera, I saw your interview and really enjoyed learning about c60, but I have one question, can you really use c60 unfiltered?
on your website, there is a link for c60 but has anyone mixed this themselves?

[maxwatt]

@anagram - there is a thread on making your own C60. Current thinking is buy ultrapure C60 from SES, grind it in a small ceramic mortar and pestle to reduce the particle size, then add 1/2 gram to a 750 ml bottle of quality extra virgin olive oil. Shake at least once every day. After a few days to a week or two, the oil will turn a purplish-red color easily visible when back-lighted; if the oil was very green colored to start, the solution might appear brown. Even if some C60 remains undissolved, it is not thought to be toxic and you have a couple years supply, depending on dose, at 0.8mg of C60 per ml. (Thanks to niner and others for the research and experimentation supporting this procedure.) Buy an infant medicine syringe at a drug store in the baby supply section, and you can measure out milliliter doses easily, though you might need a wide mouth bottle.

Despite every enthusiastic testament in these fora, there is no guarantee there will be any benefit, nor does Longecity as an institution recommend consuming this -- but you might want to try it on your dog, cat or pet mice. (Or if your code of ethics permits, on your pet grandparents, as one poster claimed to have done;)

[anagram]

thanks for the info maxwatt, I will be buying some c60 you know, for fun, and not taking it (wink wink).
I need one other thing though and that is the url for SES please?

[pleb]

just type in SES fullerine into your search engine, I've bought 5 grams of the lowest purity as have a few others,99.5% cat number 600-9950

after reading many posts on here i don't think the ultrapure at 4 times the price is worth it as the impurities are microscopic

even with import and delivery to the UK mixed and taken at the 1.5mg per day dose it still works out at less than a Dollar fifty for a weeks supply including the cost of the oil,

[Turnbuckle]

just type in SES fullerine into your search engine, I've bought 5 grams of the lowest purity as have a few others,99.5% cat number 600-9950

after reading many posts on here i don't think the ultrapure at 4 times the price is worth it as the impurities are microscopic

even with import and delivery to the UK mixed and taken at the 1.5mg per day dose it still works out at less than a Dollar fifty for a weeks supply including the cost of the oil,

I'm going the other way on this. I started with 99.5% in April and found no problem with intermittent use, and so tried the fullerene extract (30% C70 and higher) and found no problem with that used once a week, but when I tried a low daily dose (1/4 mg twice a day) I got some very strange pains in my legs and neck after a few days and which went away a day or two after I stopped. So, after so many months of trying different protocols, I've come to these conclusions: Continuous dosing is not good, and the C70 & higher is not good, especially when taken daily. Thus my next batch will be the 99.95% C60 purity and I will go back to my 2.5 mg once a week regimen.

[pleb]

just type in SES fullerine into your search engine, I've bought 5 grams of the lowest purity as have a few others,99.5% cat number 600-9950

after reading many posts on here i don't think the ultrapure at 4 times the price is worth it as the impurities are microscopic

even with import and delivery to the UK mixed and taken at the 1.5mg per day dose it still works out at less than a Dollar fifty for a weeks supply including the cost of the oil,

I'm going the other way on this. I started with 99.5% in April and found no problem with intermittent use, and so tried the fullerene extract (30% C70 and higher) and found no problem with that used once a week, but when I tried a low daily dose (1/4 mg twice a day) I got some very strange pains in my legs and neck after a few days and which went away a day or two after I stopped. So, after so many months of trying different protocols, I've come to these conclusions: Continuous dosing is not good, and the C70 & higher is not good, especially when taken daily. Thus my next batch will be the 99.95% C60 purity and I will go back to my 2.5 mg once a week regimen.

sorry i should also have said it was the cheapest C60 not the mixed,
i got over the tiredness by taking it an hour before going to bed,

[Turnbuckle]

just type in SES fullerine into your search engine, I've bought 5 grams of the lowest purity as have a few others,99.5% cat number 600-9950

after reading many posts on here i don't think the ultrapure at 4 times the price is worth it as the impurities are microscopic

even with import and delivery to the UK mixed and taken at the 1.5mg per day dose it still works out at less than a Dollar fifty for a weeks supply including the cost of the oil,

I'm going the other way on this. I started with 99.5% in April and found no problem with intermittent use, and so tried the fullerene extract (30% C70 and higher) and found no problem with that used once a week, but when I tried a low daily dose (1/4 mg twice a day) I got some very strange pains in my legs and neck after a few days and which went away a day or two after I stopped. So, after so many months of trying different protocols, I've come to these conclusions: Continuous dosing is not good, and the C70 & higher is not good, especially when taken daily. Thus my next batch will be the 99.95% C60 purity and I will go back to my 2.5 mg once a week regimen.

sorry i should also have said it was the cheapest C60 not the mixed,
i got over the tiredness by taking it an hour before going to bed,

Yeah, I knew what you meant, but there is still a substantial amount of higher fullerenes in the 99.5% variety. Consider I was taking 1/4 mg twice a day of the 70% stuff, which was only 150 micrograms/day of higher fullerenes. You'd get that much from a 30 mg dose of the 99.5% C60.

[pleb]

just type in SES fullerine into your search engine, I've bought 5 grams of the lowest purity as have a few others,99.5% cat number 600-9950

after reading many posts on here i don't think the ultrapure at 4 times the price is worth it as the impurities are microscopic

even with import and delivery to the UK mixed and taken at the 1.5mg per day dose it still works out at less than a Dollar fifty for a weeks supply including the cost of the oil,

I'm going the other way on this. I started with 99.5% in April and found no problem with intermittent use, and so tried the fullerene extract (30% C70 and higher) and found no problem with that used once a week, but when I tried a low daily dose (1/4 mg twice a day) I got some very strange pains in my legs and neck after a few days and which went away a day or two after I stopped. So, after so many months of trying different protocols, I've come to these conclusions: Continuous dosing is not good, and the C70 & higher is not good, especially when taken daily. Thus my next batch will be the 99.95% C60 purity and I will go back to my 2.5 mg once a week regimen.

sorry i should also have said it was the cheapest C60 not the mixed,
i got over the tiredness by taking it an hour before going to bed,

Yeah, I knew what you meant, but there is still a substantial amount of higher fullerenes in the 99.5% variety. Consider I was taking 1/4 mg twice a day of the 70% stuff, which was only 150 micrograms/day of higher fullerenes. You'd get that much from a 30 mg dose of the 99.5% C60.

Ah Thanks I'm taking 1-1/2 mg a day I'll also see about cycling it and take it split into two 5mg lots over a week for the other reasons, and take note of the different amounts mentioned

Edited by pleb, 29 November 2012 - 09:52 PM.

[Turnbuckle]

I'm not recommending daily dosing, quite the opposite. But I thought such a small dose would not be a problem. I was wrong.

[anagram]

thanks, I wasn't sure what SES was until I looked it up(lazy me). I will be buying some of the c60 99.9% pure and making my own.
In the mean time, I am beginning to love the c60 astaxanthin combo. When i take it, it feels stronger than normal c60, like it gets deeper into your cells or something. the only downside of it is that I feel c60 tiredness in the afternoon. I have hypothesized that after taking the asta+c60oo, the astaxanthin is oxidativly removed from the c60, leaveing c60 inside the oxidation rich regions of your body.

[anagram]

hey, I thought I would let you all know that my grand father is still alive and well. He seems to be getting better, and my grandmother as well, seem to have a bigger social life.

I also thought I would update the discussion on aged astaxanthin +c60. based on my experience, the astaxanthin seems to make the c60 10x stronger, and made me feel a bit ill. If I take it, It feels like I just downed 3 whole droppers of c60, but the feeling lifts and I feel extremely clear headed after about 10 minutes, clearer than before. To help explain how potent its antioxidant strength is, I took 1.5 mg melatonin 24+ hours ago and can still sort of feel it. I'm not tired, in fact the complete opposite, but to better clarify my experience, I basically feel as if I took a melatonin earlier in the day, and have come down from it, except I have felt like that all day.

I wouldn't do more than a few drops of astaxanthin c60 combo, its way to strong.

[Turnbuckle]

I also thought I would update the discussion on aged astaxanthin +c60. based on my experience, the astaxanthin seems to make the c60 10x stronger, and made me feel a bit ill. If I take it, It feels like I just downed 3 whole droppers of c60, but the feeling lifts and I feel extremely clear headed after about 10 minutes, clearer than before. To help explain how potent its antioxidant strength is, I took 1.5 mg melatonin 24+ hours ago and can still sort of feel it. I'm not tired, in fact the complete opposite, but to better clarify my experience, I basically feel as if I took a melatonin earlier in the day, and have come down from it, except I have felt like that all day.

I wouldn't do more than a few drops of astaxanthin c60 combo, its way to strong.

Do you think this might just be from adding the astaxanthin to EVOO and thereby making it more available?

[anagram]

definitely, when I take the astaxanthin + c60, I feel like I have more energy, though this comes some time after taking it. I suspect that the c60 has more time to move around body when it has the astaxanthin attached, and therefore becomes more viable to your cells. I feel like it is a slower metabolized version of plain c60 which in my opinion feels like its there and gone in a few, this however feels present for days. I would not recommend supplementing only with this because it actually feels like it builds up to uncomfortable levels. my verdict is to use it sparingly with normal c60.

sparingly as in take it not every day, it feels really really potent. another thing I should add is that I feel much much younger, like all the methyl groups on my DNA have been removed. I mean honestly, I really actually feel much younger.

At night I take astaxanthin + c60, a very small sublingual dose of PQQ(to increase DNA synthesis), a spoon of molasses(for purines), l-lysine, l-ornethine, alpha lipoic acid(for histone deacytelase inhibition), sometimes a lycopene capsule, and 1.5mg of melatonin( for mitochondria uncoupling). I woke up this morning with an ultra clear mind, absolutely nothing I couldn't do. my day went along with literally the cleanest, most solid feelings I've ever had. literally nothing compares as a nootropic. it wasn't like I was on drugs, I was fully aware, conscious, and normal.
the only downside is that melatonin may mess up your pineal gland, and my breath smells in the morning from all the purines, and I've grown half an inch and my nose has grown 1 cm in one week.


also, something I should add is that my mitochondria are now extremely powerful, I am a little hungery all the time, but never really really hungery, and I seem to be able to metabolize terpenes really easily now. oh and to make sure that I don't get cancer, I have used tea tree oil around the house to get rid of all alfatoxin producing molds, and fungi.

right now I feel like im a million years old and yet a child at the same time, its pretty far out actually.

Edited by anagram, 01 December 2012 - 04:21 AM.

[maxwatt]

Right, astaxanthin... whose your dealer?

[anagram]

ha, well... albert hoffmen

jk, natures bounty

Edited by anagram, 01 December 2012 - 04:35 AM.

[Kevnzworld]

Right, astaxanthin... whose your dealer?

Just an FYI here. Astaxanthin is produced by nutrex under the name " Bioastin ". They now sell it in 4 mg and 12 mg gel caps.
This is a carotenoid, good but not better than lycopene, lutein etc. All are lipid soluble.