101 replies to this topic

[medievil]

Anybody tried 5-MeO-MiPT for nootropic uses? Wikipedia mentions that 3mg-6mg might be beneficial for these purposes.

Ive got 5-meo-dipt here (foxy) but my scale is broken so couldnt try it yet unfortionally.

Kassem i do, its excellent stuff but i mainly used it for anhedonia, it also helped with the work i did sometimes and worked as a social stimulant.

5 meo mipt and dipt and amt will show nootropic benefits beyond just sero agonism, as the 5 meo's are monoamine reuptake inhibitors and AMT a monoamine releaser they will also show benefits simular to stimulants.

As for 5 meo dalt wich i tried a few times, i dont think it would be a great nootropic but im sure it can be a excellent therapeutic tool for depression, ocd, social anxiety, anhedonia and perhaps other disorders in low daily doses. Definatly a extremely potent antidepressant.

The interesting thing of this thread is that tolerance does not occur to the effects of therapeutic treshold doses, in contrast to the actual doses used for psychedelic experiences.

Edited by medievil, 28 November 2012 - 10:56 PM.

[medievil]

Many psychedelics are very empathy inducing, like 5 meo dalt i wonder wheter theyd have any use in disorders like psychopathy, who knows.

[medievil]

Anybody have experience with 2-CD. Those anecdotes were awesome, MeDieViL.

Too bad I react very bad to 5-HTergic psychedelics now. I seem to have some kind of bad sensitization to them. LSD and 4-AcO-DMT no longer agree with me.

Have you tried others? what about a low treshold dose?

[Connect]

Perhaps to best consolidate forum users threshold use, individuals should provide a brief outline of their experience with any substance.

Substance:
Dosage:
Method of Consumption:
Effect: (eg mood, empathy, etc.)
Nootropic potential:
Tolerance:


I am very interested in this topic, however organized information and anecdotal reports are difficult to find in one place. Since we have individuals on this forum that are both conscious of longevity and nootropicity (definitely a made up word) we could collaborate and find the best psychedelics. I preferably would like to utilize a psychedelic that has little to no tolerance, has nootropic potential and has a reputable safety profile. So far LSD, 2-CD, 5-Meo-Dalt, 5-meo-dipt, 5-meo-mipt, 4-aco-dmt, 2-CE, and others have been mentioned. However, it would be nice to see an organized report from those you have experience. Just a thought. I appreciate your input thus far and your efforts medievil to dig up some anecdotal reports. What do you think is the safest, lacks tolerance and has some nootropic benefit? Thanks:)

[medievil]

I beleive they all dont develop tolerance in treshold doses, nootropic potential has been reported many times but the mood and energy boost can give ppl the ilusion it acts as a nootropic, the anecdotes on 2CD are promosing tough.

People here should try dual and back or learning stuff while trying them in those doses to get a better idea, one thing is for sure, they are antidepressive, help ocd, anxiolytic, prosocial etc in those doses, its been reported over and over again.

Lets not forget many are 5HT2B agonists and can lead to cardiac fibrosis with long term use, many have safety data behind them but not chronically.

[medievil]

With regards to 5 meo dalt i think its benefits mostly apply to increased empathy and a good mood, its known to bind strongly to 5HT1A so it will be a strong anxiolytic too.

So far 2CD is what i was most impressed with.

I have tried 2CB in a treshold dose once and it seemed to finetune me, to elaborate everything seemed to have a bigger frequency and my mind seemed to be finetuned, def nootropic effects subjectively but i didnt to any cognitive tests so cant say for sure, it seemed at first glance the best one for this purpose tough.

[medievil]

Is anyone else familiar with the combination of low dose psilocin (or 4-aco-dmt, aka psilacetin) and piracetam? If you interpret it correctly, Entheogens have been used by shamen exclusively for nootropic purposes. They suddenly obtain knowledge from a 'drug spirit'. This is in my eyes a clear primitive description of a potent value changing and meme annihilating nootropic.

I have had quite remarkable results in terms of demolishing writer's block, inducing creativity and expanding my horizons. I feel like instead of just a depth-wise approach to intellect, this is the only true solution for a broader perspective.

I've used 5-10mg psilacetin with 1-5g piracetam maximum once per week. This combined with meditative practice and the method of loci easily facilitates the creation of mental palaces and mnemonic encoding. It does away with the linearity of learning and creates a childlike associative and receptive intelligence state. I've found that learning languages on this combination is equally easy as it was when I was a child. It dissolves any pre-existing hurdles or barriers that your personality or experience are creating and allows unrestrained cognition to be directed.


If anyone else has experience with this, or any questions, please go ahead.

Psilacetin (4-aco-dmt) can be obtained online, and this is fully legal. Psilacetin has no effects on its own, and immediately metabolises into psilocin upon ingestion. Therefore it is sensible just to refer to it as being identical when only referencing effects. It is less confusing and stressing than a mushroom experience. It seems that the psilocybin and some phenylethylamines contained in the mushroom further modulate the experience. Most users have found psilacetin to be greatly superior and more comfortable with less nausea. The strong stimulating and deeply emotional effects of mushrooms can be partially ascribed to these additional alkaloids.

Here is something from the wikipedia entry worth looking at:

Quote

Several available reports of O-Acetylpsilocin compare it favorably to psilocybin, describing it as more euphoric, gentle, warm, and colorful. It has also been described as less jarring, and less likely to produce nausea, and it has been noted by users that O-Acetylpsilocin is a somewhat sedating psychedelic. However, many of these comparisons are made with mushrooms, not pure psilocybin. In addition, it is unknown to what degree expectancy plays a role in shaping that experience.

There are claims of subjective differences in effect between the acetylated and not acetylated forms of psilocin. Some users report that O-Acetylpsilocin lasts slightly longer than psilocin; others report that it lasts for a considerably shorter time. Many users report less body load and nausea compared to psilocin. Some users find that the visual distortions produced by O-Acetylpsilocin more closely resemble those produced by DMT than those produced by psilocin. These differences could be possible if Psilacetin is active itself and not merely as a prodrug. Many users, however, can not tell the difference between these two compounds when ingested.


Thus a nootropically useful dose would cap at 10 - 13mg, while a perfect dose for expanding your mental horizons would be around 15 - 20mg. Personally I would argue that 5-7mg of psilacetin and 5g of piracetam are quite enough. The reason why most people just see the 'transcendental' effects are because such low dosing is difficult with other substances. The nootropic effects at doses between 4-10mg combined with piracetam are incredible. Do not take more than 30mg. If you only want nootropic effects, stay below 13mg. Paradise lost, and found!

As subjective as you might think these effects are, here is an anecdote that I personally enjoy:

I was playing guitar around several sober individuals. I had eaten some mushrooms and piracetam 20 minutes prior and was waiting for it to kick in. I'm a decent player but nothing impressive even by youtube video standards. Once the effects started off fully, I descended slowly into a fully hypnotic zone. And the only thing that snapped me out of it was the people around me cheering and telling me that my playing was amazing. I did not remember a single note I played, but people talked about this for weeks after. Now I understand Jimi.

One of my friends is particularly interested in TETRIS, and after trying my combination he scored 5 times his regular score. I think the only mistake people can make here is to underestimate.

If you're adept at something creative before taking this combination, expect to get a whole lot better.


(If you are really serious about getting the most out of this, noise cancelling earmuffs and a blindfold can do wonders for your imagination. Richard Feynman used deprivation tanks and ketamine to accomplish roughly the same thing, but my method is not only a bit more DIY and user accessible but also safer on a pharmacological basis. )

After significant amounts of research with several friends and longecity members, and also based on the John Hopkin's University studies the optimal doses of psilacetin (4-aco-dmt) would be something like this:

Nootropic Dose: 0.08 * kg to 0.15 * kg
Transcendent Dose: 0.25 * kg to 0.35 * kg
Ego Death: 0.4 to 0.7 * kg

The individual dosages depend on tolerance, metabolism and uptake. I recommend people start with the nootropic dose and then after becoming experienced with transcendent doses, they can try ego death. I think a single ego death experience is absolutely adequate and nootropic doses are far more useful in the long run.

You can check vendor legitimacy on "safeorscam.com".

As for supplementation during the trips:

• 1 tablespoon of cacao nibs (improves mood and focus)
• 1-2g of piracetam (instead of muddled visuals and thoughts, things become geometric and more readily understood)

http://www.longecity.org/forum/topic/54718-psilocin-and-piracetam-for-mnemonic-encoding-and-creativity/

[medievil]

Bluelight:

I mentioned this once before in a post called LSD and its lingering effects on me. I went through a long spell of taking small doses every day, for about almost a year (9 months or so?), specifically for this very purpose.


The trick is not to take enough so that you're actually "tripping." And don't worry about the over-hyped tolerance that everyone speaks of, because I assure you that acid always works, even when taking it every day... remember the trick is not to trip, anyway.

Keeping in mind I was starting off with properly calibrated 100mcg doses, I would take approximately 20 mcg a day for a week or so, and eventually kept it at about 40mcg. A couple times I would try going over the mark (initially concerned about tolerance), but it would end up actually making me feel like I was tripping, so I would back off the next day.

I suppose a lot of how I felt that year could be chalked up to placebo effect or whatever. I don't care though. All I know is that what it did for me during that year is similar to what people who take antidepressants tell me their meds do for THEM. Only difference is I'm not (nor have I been) depressed about anything. So maybe it's better to say it's a general mood enhancer? However you slice it, low-dose LSD is a whole different ballgame from recreational (or spiritual) LSD use.

Very interesting thread to check out:
http://www.bluelight...eciation-Thread

[leftside]

Well I tried 5-MeO-MiPT last night. Measured 60mg on my scale and then eyeballed 1/4 of that. I thought no chance in hell is such a tiny amount going to effect me. Wrong! Dabbed it onto my finger and then put it onto my tongue. Within 10 mins I was tripping hard. The next 4-5 hours were intense. I started listening to electronic music, but after a couple of hours I lost interest and started listening to some old Cramps music. Full blown psychedelic visuals - bright colors were way brighter, text on the computer monitor/TV was moving all over the place, strong visuals wherever I looked. Horny as hell.

After the "intense" 4-5 hours I chilled listening to more music (still very high, but psychedelic visuals had calmed down) and then for hours 7-9 I watched the last couple of episodes of season 2 of Spartacus. It was so dramatic, over-the-top, bloody and theatrical. It was aswesome.

Went to bed 9 hours after taking the substance. Slept ok.

Side effects were some agitation, tight muscles, some stomach cramps, increased heart rate. Nothing too bad.

Nootropic effect? LOL. Maybe at a lower dosage - say 3-5mg, but certainly not at 15mg.

[medievil]

Haha try a mini dose next time mate, in those doses they can act as nootropic, either way sounds like you had a nice experience:)

[leftside]

Yes - it was good. Just extremely unexpected that such a small amount could be so strong. This is a good little reminder that I have to be very careful when measuring the other research chemicals that I have, and will be experimenting with, over the coming weeks and months.

[medievil]

Yeah being carefull is important, im waiting to experiment mostly with my 5 meo dipt and cannabinoids till i have a working scale again, some things like 5 meo dalt are more forgiving and its possible to eyeball them.

[Adaptogen]

are any of these as safe as 4-aco-dmt?

any info on 25c-nbome? i heard 25i caused a few seizures and deaths

[leftside]

are any of these as safe as 4-aco-dmt?

any info on 25c-nbome? i heard 25i caused a few seizures and deaths

I took 600ug of 25c-nbome at the weekend. Strong! Full-on psychedelic experience. Nootropic value = 0

Took at 2pm. Came on fast (custom made nasal solution). Peaked after about 2 hours. Stayed peaking for about another 5-6 hours. Was almost completely down at 1am.

I also have some 25i-nbome. I'll try that another day.

[Adaptogen]

someone posted on longecity that 25c had huge nootropic potential but its possible that they were being influenced by the euphoric effects. how expensive were these chems for you?

[leftside]

someone posted on longecity that 25c had huge nootropic potential but its possible that they were being influenced by the euphoric effects. how expensive were these chems for you?

About $20 for 10mg of the 25c-nbome + nasal spray bottle For about 20 "hits".

[noopeptisgood]

I've somewhat recently partaken in some 4-AcO-DMT consumption. I've taken about 20mg each time, and I always feel very lucid and happy afterwards. Thoughts flow and everything is very pleasurable. At low doses I do feel that it could be a fun tool to get the gears turning.

I see that 5-MeO-DALT has been mentioned. In my experience it is not very recreational at all. Smoking it produces intense heart palpitations that result in a miserable three minute high. Ingesting it produces an awkward 50 minute high, but it did feel somewhat mentally stimulating. Nowhere near the therapeutic capacity of 4-AcO though.

I don't think daily threshold doses is the way to go, but rather more intermittent, stronger experiences.

Edited by noopeptisgood, 06 December 2012 - 10:15 PM.

[Adaptogen]

yeah 4-aco-dmt is really great, i feel like it has made me significantly more creative. when on it, i can suddenly play instruments by ear perhaps twice as good as i can when not dosing(also could be they sound better to me because im hopped up on tryptamines)

[Adaptogen]

does anyone have any knowledge of reagent tests? I am trying to make sure the substance i purchased is actually 4-aco-dmt...

see my post here: http://www.longecity..._30#entry562536

[leftside]

Anybody tried 5-MeO-MiPT for nootropic uses? Wikipedia mentions that 3mg-6mg might be beneficial for these purposes.

yes it is, friend of my friend used that for this purpose, he said if yout overgo first wave of body buzz then it has fairly mood stabilizing benefits which can provide purity of thoughts.. it has therapeutical properties in terms of antidepressant effect, but you may find it is similar way of action like maoi (as cited in wiki: "although additional mechanisms of action such as inhibition of monoaminereuptake may be involved also"). Sense of music is also heightened so if you play an instrument so you may more easily decect mistakes you were making and bring greater insight into whole piece..

I tried 5mg last night. It was awesome. Definitely has therapeutical properties, but way too strong for nootropic purposes. Maybe at 1mg? Sense of music was definitely heightened. I also had quite strong visuals for a couple of hours, but it felt more like MDMA than a regular tryptamine.

I've also tried 25mg of this stuff. You are into full blown "trip" territory at those dosages.

Just beware that even at 5mg I felt very uncomfortable for the first hour. Had to visit the bathroom and generally felt like crap, but then it "broke through" and it was very, very good. I guess watching a dark Batman movie whilst I was coming up didn't help, but once I turned it off and started listening to good electronic music everything was fine.

[medievil]

BREAKING NEWS

There's a psychedelic available as good as lsd in health shops or pharmacy's or whatever, its a essential oil with pretty much all glowing reports.
http://www.drugs-for...ad.php?t=131824

Haha best find yet in my search for interesting goodie's that are available.

[leftside]

Have you actually tried that mix? I did. Did bugger all. That guy 69ron or whatever his name is, is also on other forums. I think he would get high even if you pissed on him.

Stick to the RC's. Cheaper, much easier to digest (no exotic recipes - simply ingest 25mg = job done), and far more reliable.

[branks]

NBOME's are both cardio and neurotoxic. Many people report feeling fried/having issues with working memory/motivation for weeks following use. Not worth it.

[ericthered10]

Please excuse my ignorance, but RC's? NBOME's? What do they stand for?

[branks]

Legal high potency chemicals that people decide to use in a guinea pig fashion. Alot of them are toxic. Many of them contain halogens.

[moleface]

I'm interested in this too.

I'm aware that psychedelics can induce paranoia, but I find that I get into a lasting profoundly happy mindset if I'm able to confront every single negative thought that I'm bombarded with during a bad trip and then find a way to be ok with my flaws as a human being. It does take a lot of strength to deal with that sort of ordeal though, and I don't fault people who can't deal with that experience.

I've had single experiences with psychedelics where the positive effects were still there six months after the trip. I achieved this in my late teens/early 20s and the therapeutic effect lasted for several years, even though I remained completely sober and never touched any other drugs during that period.

Rather than go the weird toxic research chemical route, I'm currently looking into legal natural psychedelics like amanita etc. I haven't done any real psychedelics since those earlier revelatory experiences over a decade ago, and I think I could use that sort of experience right now to reset my operating system.

I lost a close friend to synthetic cannabinoids, and I'm not fucking with the RC scene ever again. As much as I love getting high, it's not worth polluting my body with experimental psychedelics from underground labs in China. That scene is baaaaad news, and it's a shame that drug prohibition is pushing people to take risks like that with their brains and bodies. I don't look down on it - I totally respect brave psychonauts who take informed calculated risks with novel psychoactive compounds, but I honestly don't think that most of these people would be driven to experiment with gray market RCs if the world had a more sane drug policy.

Edited by moleface, 11 March 2013 - 11:41 PM.

[medievil]

Have you actually tried that mix? I did. Did bugger all. That guy 69ron or whatever his name is, is also on other forums. I think he would get high even if you pissed on him.

Stick to the RC's. Cheaper, much easier to digest (no exotic recipes - simply ingest 25mg = job done), and far more reliable.

I agree entirely, i posted that when i was all hazy of that tea and wasnt thinking straight or something as i felt excitement for something stupid, still its interesting its so easy to get and all you have to do is ingest some of the oil.

No idea what branks is on about, missed all those reports of toxiticy, only saw things like that with mephedrone or dragonfly inducing severe vasoconstriction.

Their mao i imagine to have does not indicate cardio or neurotoxiticy or our member here saw some hidden documentation but i doubt it.

Edited by medievil, 11 March 2013 - 11:55 PM.

[branks]

You missed reports of toxicity with the NBOME series even though there have been many reported deaths due to either siezures or cardiac events? Even renal toxicity reports. Really strange indead. The majority of the nbome series is also halogenated.

With that out of the way, 25-I nbome is a potent full agonist of the receptors. 25-i nbome is a phenylethylamine which is halogenated. Phenyethylamines (not all, just some) are known to have neurotoxic as they generate reactive oxygen species, and also may induce stereoselective DNA attacks as with other phenylethylamines with a secondary amine.

Such a powerfully binding molecule uncovers internalization motifs on the cytoplasmic side of its cognate receptor. Since its a full agonist the internalization (or endocytosis) phenomenon will be significantly expressed. This causes plasma membrane invagination, essentially the cells suck in the 25I-Receptor complex so you end up with a halogenated phenethylamine inside your brian cells (i.e. makes it much easier for the drug to damage your DNA or generate ROS and fuck up neuronal function).

If you want brain cancer or want to fuck your heart, go ahead.

Edited by branks, 12 March 2013 - 12:06 AM.

[medievil]

Will post more later, but i had the impression overdoses caused those issues wich isnt relevant to the toxiticy of the actual compound as everything is toxic is toxic in overdose.

[branks]

The compound itself is toxic and the dose-response curve is dramaticly different between different people. Some people have taken as high as 12mg without negative effects where as people have died on doses less then 2mg. This is in no way a safe chemical, regardless of dose and the way it acts on receptors is in no way of nootropic value. There are many anecdotes of people coming out of the experience mentally worse for the wear, and many people reporting permanent side effects.

Edited by branks, 12 March 2013 - 12:14 AM.