This is all very interesting. I don't have any hypothesis to add here but as a continuous user of C60OO I think perhaps I should change the dosing my regimens overall.
Perhaps something like 5 days on with my stack and then one or two weeks off. So like ~14mg (20ml) C60OO, NR, Pterostilbene/Resveratrol and Honokiol from Mon-Fri one week and then pause for a week, then do it again. Then try every two weeks. This would certainly save money too, although I'd probably increase the dosage on NR to 1g per day. I'd probably also eat more anti-oxidant on those days as well.
My reasoning is that some people are seeing benefits from continuous use while there is also sufficient reason not to use it continuously. There's also the hypothesis about fission and fusion. So I'd be using it daily but in short bursts with frequent, longer breaks.
Anecdotally speaking, as of yesterday, 6 days into C60OO dosing with my high quality homemade stuff and after a 2 week break, I've begun experiencing allergies again. My seasonal allergies went away for at least a couple of years now and I assume this was related to some kind of decline in the immune system over reactiveness. Now I'm sneezing after hanging out in the park and am getting a stuffy nose. Definitely allergies. This is self-reporting and anecdotal, perhaps my allergies never fully went away and I'm misremembering. It is spring after all and they aren't severe. It could be that I just forgot experiencing them slightly last spring. It has been a long time though and they used to be super bad all the way up until just 3 or 4 years ago, then they started going away.
Also I have experienced no change in the degree of Essential Tremor I've had since I was 12. The tremor got worse after I turned 36 and has since become worse over the past 6 years since then. It's neurodegenerative and so I don't know if I should be expecting a change here or not. If it did decrease I would know because I could see it in a comparison of myself in video and in how well pictures turn out when I take them.
Are there any updates on this hypothesis?
It can be related to what you say