7 replies to this topic

[Brainfart]

Has anybody looked at Thymosin Beta 4 for neuro protectiveness? It seems like there is a rise of body builders using if for joint and muscle restoration.

http://www.ncbi.nlm....pubmed/23050817

Edited by Brainfart, 10 December 2012 - 09:00 PM.

[dear mrclock]

Thymosins are small proteins present in many animal tissues. They are named thymosins because they were originally isolated from the thymus, but most are now known to be present in many other tissues.

so basically when we eat meat products we consume them from various tissues. do you think they have some biological activity like that or its more complex procedure of processing and using them as drugs ?

[golden1]

it has to be administered IM or I think it gets broken apart like other peptide things..

[dear mrclock]

you mean IV, i dunno what IM is. but i was thinking if its present in all tissues in animals, we consume it but i guess it degrades during cooking or when consumed.

[jeancludd]

you mean IV, i dunno what IM is. but i was thinking if its present in all tissues in animals, we consume it but i guess it degrades during cooking or when consumed.

http://en.wikipedia....cular_injection

[daouda]

SQ also seems to work well for TB4

[Brainfart]

What is TB-500?
TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (TB-500). It is a first-in-class drug candidate that promotes the following*:

• Endothelial (blood vessels) cell differentiation
• Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
• Keratinocyte migration
• Collagen deposition; and
• Decreases inflammation.
One of TB500 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.

This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. Thymosin beta-4 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule.

Tß4 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.

An additional key factor of TB500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.

Research confirms that TB500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. TB-500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.

[Flex]

see

http://www.longecity...knownunderated/

Edited by Flex, 13 April 2014 - 03:56 AM.