Spindler's vast armies of lab mice prove there is hardly any supplement that extends lifespan....in mice.
This should not be too much of a surprise for people who have followed Spindler's research through the years, or for those who have enough temerity (calling Opales, where are you?) to acknowledge epidemiological evidence showing no (or negative) effects from several vitamin studies (with acknowledgement to the flaws).
And Spindler DOES know how to extend the lifespans of mice, being the inaugural winner of the Methuselah Mouse Prize.
Spindler tested over 60 supplements, even some of our (the Longecity community's) favorites. Blueberries? No lifespan extension...in mice. Ortho-core? Doesn't extend lifespan....in mice. LEF mix? Doesn't work (in mice). Krill oil? Doesn't work (in mice).
Metformin? Maybe a small effect (in mice).
And just to flip the coin. Spindler frequently mentions how CR works so well in mice. In fact CR is SPECTACULAR at extending the lifespan....of mice (and many other species). In primates? Not so great.
This is good research (in mice). Everyone should take notice. I still think that a low dose quality multivitamin (like Vimmortal, which is currently out of production, sorry), is probably, at least slightly beneficial, because we are talking about ESSENTIAL nutrients. Dr. Ames'; triage theory of aging does hold a little weight with me. However, expensive multi's with over-doses of many vitamins and minerals, increasingly look like a very poor investment.
I suspect that Longecity members are squaring their healthspan curve by careful supplementation and through various other lifestyle modifications (CR, exercise, diet), but if you are spending big bucks on supplements, maybe you should reconsider. Especially when acknowledging the tragic lack of funding for real rejuvenation research.