91 replies to this topic

[Area-1255]

So to answer some questions. When I was using Aniracetam I rarely used choline, maybe 1 or 2 times a week and it was 250mg of CDP choline. I found it wasn't helpful and made me depressed and tired. As for aniracetam, the effects were subtle and didn't do much combined with noopept it seemed, I may revisit that experiment at a later time. The last week however I have been taking 100mg of l-theanine first thing in the morning on an empty stomach, eating 30-40 mins later and then taking my noopept. Currently I add 10mgs of noopept powder a day (from peak nootropics) into a half ounce of water and take a teaspoon at a time every 4 hours. This seems to level out the effects so it is felt consistently through the day with no ups or downs. The l-theanine seems to even out my mood so I get no irritability or anxiousness like I occasionally get from noopept. However, splitting up my noopept doses the way I have has also helped a lot with the irritability and anxiety, the theanine just seems to smooth things out as a final touch. Pea protein was also mentioned as being high in glutamic acid, my morning breakfast shake has pea protein, orange juice, and hemp oil in it, then I take my first noopept dosage afterwards. Funny enough, that pea protein has never bothered me when taken by itself and it seems to make the noopept work a lot better. But to much taken with the noopept can send me down a road of unpleasant glutamate side effects, one of which being nasty headaches. The theanine seems to prevent that though. Without the pea protein the noopept works, just less and the negative effects (anxiety and irritability) seem more prevalent. It feels like a juggling act with noopept in terms of to much or to little glutamate and finding that sweet spot for optimal effects.

Well a lot of comes down to overall diet too, and remember that different amino acids have different excretion rates, and some are more bioavaliable then others...some amino acids compete with each other. At the end of the day, your overall homeostasis in coordination with what you want to achieve in life is of the ultimate importance. It doesn't matter how big or small - but that it matters to YOU.

People will inevitably have TONS of different reasons for a particular action, or even taking a particular supplement. But unless you examine yourself and know your bodies own responses (be in tune with your body's signals) - some of it could be placebo effect or exaggerated based on an UNKNOWN INTERACTION.

 

Here's an example, you go the store and buy some spicy chips...or maybe a ramen noodle soup, now you get back, it's 4PM and you take piracetam, and eat the chips and / or soup....without realizing, MSG is in both those things (the soup and chips), now conveniently the piracetam you take is a pure powder diluted in water, without the capsule. Both the chips/soup as well as the Piracetam will absorb at practically the same time - now how much of the stimulate effect is actually coming from the Piracetam...? Especially if you are an inexperienced user.....how much can you attribute to piracetam...but you assume it is because you don't realize there is MSG...so now you have a FALSE READING and EXAGGERATED  INTERPRETATION of the effects of Piracetam. So NOW, you THINK you are alright with that dose, you think it's optimal. But it's not...next day you are wondering why you are NOT feeling the effects of piracetam at that dosage..you start consider other things that may be irrelevant...you worry, stress yourself out - NOW.....stress hormones are kicking in...because you are SOOO focused on the supplement and not homeostasis and having a BROAD view of everything around you and you aren't taking into consideration everything necessary - thus this allows for a double-Edged-Sword attack on your psychology and a DISTORTED perception of the supplement.

 

Bottom line is, examine EVERYTHING...but do it diligently, whatever you aim to do, with or without supplements...be on high alert, and in tune to your diet, sleep amount, exercise etc.

 

Don't beat yourself up about getting only 5 hours ONE night, nor criticize yourself for having a bad diet on ONE day...because some LITTLE thing threw you off...no, aim for positivity, but be vigilant and alert in all you do!

 

This is the recipe of genius, this is the recipe of Achievers in life...to explore blindly is to ask for problems, but to examine everything...well this is the feature of the brilliant and the accomplished.

[Ames]

Does anyone else find that whilst supplementing with glutamic acid or MSG it feels like 99 percent of it is being converted to GABA. Perhaps i just have a peculiar brain chemistry, phenibut actually made me much MORE anxious and extremely tense with horrible clenching and bruxism, as does alcohol to a lesser degree. Glutamic acid however feels how i imagine benzos and suppose to feel. It always induces a sense of intense relaxation with me, completely annihilates any anxiety i have instantly and for the majority of the day.

 

Glutamate may be anxiolytic through its direct facilitation of long term potentiation in NMDA receptors, possibly in the amygdala. The increase in synaptic plasticity allows for less rigidity and greater ability to change. When LTP / increase in synaptic plasticity happens in the hippocampus and amygdala, it may facilitate the ability to better cope with and process emotional experience(s). See the correlate of the anxiety research on the glutaminergic pharmaceutical cycloserine.

 

There is also theory that links theta wave production to LTP and phase transitions (resets) in the aforementioned brain structures. Phase resets are linked to the moment when a new neural pattern takes the place of an old encoded pattern. Thus facilitating the same method of anxiety reduction / PTSD reduction  / LTP through a different means. I wouldn't be surprised if maximal success depended on an adequate yet not oversupplied glutamate pool. I'd take an even money wager that intracellular glutamate is reduced in the brains of persons with GAD or PTSD. Though, I haven't looked for any research.

 

The aforementioned theta wave production can be trained with neurofeedback with the alpha-theta (Peniston) protocol or TAGsync, depending on your willingness to experiment with a more established or newer protocol. Cycloserine would be guaranteed to be properly targeted from the first time and would be much less money; though, I've heard that it decreases in its effect over time, likely similar to all antibiotics. Glutamate is probably a great best cheap option assuming one is comfortable with the dose and the possible chance of less or none crossing the BBB and being transported to the needed structures. Though, I would take felt experience over theory in that regard.
 

Edited by golgi1, 28 July 2015 - 09:56 PM.