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Increase Elastin production and utilization


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#31 happy lemon

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Posted 12 February 2013 - 02:35 PM

Logic,

I was sold on the Tropoelastin promoters and Tropoelastin cross-linkers.

Do you know which topical product is?

The patent list in your post says that the applicant is Johnson & Johnson Consumer Companies, Inc.

#32 sapentia

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Posted 12 February 2013 - 06:19 PM

You guys could also consider using a product that contains tropoelastin directly patented as elastotropin in this product http://www.dermalast...view=elastropin
Not trying to plug that particular product, but I have used it for the past 5+ years and have been pleased.

Edited by sapentia, 12 February 2013 - 06:19 PM.


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#33 Logic

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Posted 12 February 2013 - 10:03 PM

Logic,

I was sold on the Tropoelastin promoters and Tropoelastin cross-linkers.

Do you know which topical product is?

The patent list in your post says that the applicant is Johnson & Johnson Consumer Companies, Inc.


Had a big post typed out; explorer bombed! :mad:

http://www.aveenopro...ng-System-Night
http://www.aveenopro...Day-with-SPF-30

I cant comment on the other ingredients or company.

I plan to make my own extracts.

Edited by Logic, 12 February 2013 - 10:14 PM.


#34 bernard

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Posted 12 February 2013 - 11:56 PM

Amazing topic this one. I'm enjoying the information a lot. Thanks for the contributions.

#35 happy lemon

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Posted 13 February 2013 - 02:37 AM

Thank you Logic!

#36 Logic

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Posted 13 February 2013 - 03:25 PM

Thank you Logic!


Pleasure. :)
Do keep us posted if you buy/use the product.

#37 Logic

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Posted 13 February 2013 - 03:34 PM

These are the people that invented Epitalon:
http://appliedyouth....ed94e97c16#p701
http://www.longecity...ragalus-thread/
Which, as you can see, is itself very good for your skin.

Their site:
http://eng.gerontolo...rch/compliment/

I would love to hear from someone who has tried these.

#38 rwac

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Posted 14 February 2013 - 09:09 AM

Here's a study that says gelatin (also fish oil/borage oil, which is not necessarily all that great) improves skin elasticity. Green tea increases conductance (water content) of skin and reduces perivascular inflammation, whatever that means.

http://www.nuskin.co...en_study_01.pdf

#39 happy lemon

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Posted 15 February 2013 - 01:25 PM

Thank you Logic!


Pleasure. :)
Do keep us posted if you buy/use the product.


Hi Logic,

After reviewing the ingredients, I find that it is a bit difficult for me to incorporate Aveeno into my current regime.

I don't like the Day Cream; while the Concentrate does not have either dill extract or blackberry extract; otherwise, I would apply it before Retin-A.

#40 niner

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Posted 16 February 2013 - 01:45 AM

After reviewing the ingredients, I find that it is a bit difficult for me to incorporate Aveeno into my current regime.

I don't like the Day Cream


What part of it do you not like, the sunscreen formulation?

#41 happy lemon

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Posted 16 February 2013 - 03:37 AM

After reviewing the ingredients, I find that it is a bit difficult for me to incorporate Aveeno into my current regime.

I don't like the Day Cream


What part of it do you not like, the sunscreen formulation?


Yes, I don't like using the formulations and prefer using zinc oxide ones.

#42 Logic

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Posted 16 February 2013 - 03:49 PM

After reviewing the ingredients, I find that it is a bit difficult for me to incorporate Aveeno into my current regime.

I don't like the Day Cream


What part of it do you not like, the sunscreen formulation?


Yes, I don't like using the formulations and prefer using zinc oxide ones.



What about the night formulation?
http://www.aveenopro...ng-System-Night
Or are there other ingredients in that, that arent good, or clash?

Have you considered making your own extract?
It would seem its as easy as:
  • Toss some dill and vodka in a blender.
  • Let the brew stand for a week or 2, with an odd shake.
  • Filter with a coffee filter.
  • Simmer off the alcohol and most of the water to end with a concentrate to add to your current cream.

Same for the blackberry leaf.

Edited by Logic, 16 February 2013 - 03:54 PM.


#43 happy lemon

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Posted 17 February 2013 - 04:35 AM

What about the night formulation?
http://www.aveenopro...ng-System-Night
Or are there other ingredients in that, that arent good, or clash?


I don't want to apply a cream before Retin-A as it may buffer the latter. Also, I am used to applying Retin-A just before hitting the bed because the presence of light can break down it

http://www.drbaileys...-retin-a-cream/

Have you considered making your own extract?
It would seem its as easy as:

  • Toss some dill and vodka in a blender.
  • Let the brew stand for a week or 2, with an odd shake.
  • Filter with a coffee filter.
  • Simmer off the alcohol and most of the water to end with a concentrate to add to your current cream.
Same for the blackberry leaf.


Hmmm...sound easy but I would like to see if there is any finished ones (extract) available in the market so that I can make one serum that I can use it in the daytime.

http://www.ebay.com/...=item5637ae071c

#44 Logic

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Posted 17 February 2013 - 12:56 PM

Hmmm...sound easy but I would like to see if there is any finished ones (extract) available in the market so that I can make one serum that I can use it in the daytime.

http://www.ebay.com/...=item5637ae071c


I speak under correction; but isnt it dill plant/leaf extract you'r after?

I would /am going to make the 2 extracts; 1 dill, 1 BBL, and add em both to a base cream.
I dont know if tossing both together into a blender will work??

#45 happy lemon

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Posted 17 February 2013 - 01:23 PM

I speak under correction; but isnt it dill plant/leaf extract you'r after?


Yes.

I find it a bit difficult if I follow the procedure, that you have listed previously, to prepare the extract.

http://www.google.co...ved=0CDUQ6AEwAA
  • [0034] For example, a blackberry extract may be prepared by an extraction with water, alcohols such as ethanol, or combination thereof. It is preferred to use an extractant including both ethanol and water.
  • [0035] The blackberry plant parts are preferably dried prior to extraction. It is preferable to use only the leaves of the blackberry plant and not other plant parts such as the fruit (berries) of the blackberry, its branches, or roots.
  • [0036] In one embodiment, blackberry leaf extract is prepared as follows: a) an extractant containing an alcohol selected from the group consisting of methanol, ethanol, n-propanol, and isopropanol is added to blackberry leaves, and b) the blackberry leaves are contacted with the extractant for up to 72 hours.
  • [0037] The ratio of the mass of extractant to leaf solids is preferably established such that at least a 10-fold mass of extractant relative to the leaf solids but preferably no more than a 50-fold mass of extractant relative to the leaf solids is obtained, preferably a 10-to 20-fold mass. A 14-to 18-fold mass of extractant relative to the leaf solids is particularly preferable. Good results were achieved with a 16-fold mass of an ethanol-containing solvent (relative to the leaf solids).
  • [0038] The time for performing extraction step b) is at most 72 hours but can also be shorter. With particularly short extraction times only a very dilute extract is obtained in step b). It is therefore preferable to extract the blackberry leaves in step b) for at least 1 hour, in particular for at least 2 hours. The necessary extraction time is chosen on the basis of the quality of the blackberry leaves to be extracted, particularly their age, and of the other extraction conditions, particularly the extraction temperature. At elevated extraction temperatures, in particular at an extraction temperature in the range from 60 to 100°C, preferably in the range from 80 to 100°C, the extraction time is preferably 1 hour to 6 hours, particularly 2 hours to 4 hours.
  • [0039] In addition, it is particularly preferable to perform the extraction in step b) by refluxing the extractant, particularly at temperatures up to about 100°C, preferably in the range from 80 to 100°C. In this case the extraction time is preferably no more than 24 hours.
  • [0040] The extraction temperature is established on the basis of the extractant that is used. If an ethanol-containing solvent is used, a temperature in the range of 60°C to 100°C, in particular in the range of 80°C to 100°C, is preferred, particularly if a mixture of ethanol and water is used as the extractant as described below.
  • [0041] It is preferable if the extractant contains an alcohol, particularly ethanol, in an amount of at least 20 wt.% relative to the total weight of extractant. It is likewise preferable if the extractant contains water in an amount of at least 15 wt.% relative to the total weight of extractant. It is particularly preferable if the extractant simultaneously contains at least 20 wt.% of an alcohol (preferably ethanol) and at least 15 wt.% of water relative to the total weight of extractant.
  • [0042] Particularly preferred blackberry leaf extracts are obtained with an extractant consisting of ethanol and water in a weight ratio of 2:8 (2 parts by weight of ethanol mixed with 8 parts by weight of water) to 8:2, preferably in a weight ratio of 3:7 to 7:3, particularly preferably in a weight ratio of 3:7 to 1:1.


#46 Logic

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Posted 17 February 2013 - 03:14 PM

Patents try to cover every possibility. That makes em confusing.

Vodka is basically a mixture of ethenol and water.
Ethenol/alcohol boils @ 80C and water @ 100.
So simmering your extract above 80C will get rid of all alcohol and some most of the water; leaving a nice concentrate...

#47 JohnD60

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Posted 17 February 2013 - 06:49 PM

My attempt to produce Dill extract by dissolving in Vodka for four days and then evaporating at room temperature has been a failure. More Mold than extract has been produced. The extract produced is effectively unusable because of the mold contamination, and I estimate (it is not completely dry yet), that only 1.5 grams of extract was produced from 1.5 oz (43g) of Fresh Dill. I am guessing that by heating the vodka, one could accelerate the evaporation to a point that mold would not grow. But I am limited by the fact that my lab is my kitchen. I think that evaporating the vodka in my kitchen oven would be dangerous. So, given my limitations, I think that my only choice I have is to heat it at a low simmer around 160F.

Edited by JohnD60, 17 February 2013 - 07:02 PM.


#48 Logic

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Posted 17 February 2013 - 07:17 PM

Bad luck JohnD60.

From re reading the patent info I'm temptet to simmer off the alcohol and most water before filtering.
Then adding the 2 concentrates to my base cream.

Blackberry Leaves are going to be a challenge to find here though.

#49 bernard

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Posted 17 February 2013 - 08:28 PM

What about eating like 100g of Dill/day ? Can it yield any of the effects of the Dill extract or is it too minuscule of an amount to matter ?

#50 niner

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Posted 18 February 2013 - 03:40 AM

Here's a formula based on the patent for blackberry leaf extract:

Obtain some 191 proof grain alcohol, such as Everclear. This is illegal to sell in some states. Take 100ml of the grain alcohol and add 24 ml of water. This will result in a 77 wt% ethanol solution, the ideal extractant for blackberry leaf. Get a quantity of blackberry leaves. It's important that you get the correct species. Remove stems, roots, and fruit. Weigh the leaves, and for every gram of leaf, measure out 16 grams of extractant. 16 grams of 77% ethanol should be 13.6ml. Place the leaves and extractant in a boiling flask to which you can affix a water-cooled condenser. Apply enough heat to boil the solution while passing cold water through the condenser. The condenser should stick straight up so that the condensate drips back into the boiling flask. This is known as reflux condensation. Allow the solution to boil under reflux for 2 to 4 hours. Filter the extractant, and evaporate to dryness, being careful not to overheat the extract. The last bit of drying, after nearly all the ethanol has been driven off, might be done in a relatively low temperature drying oven.

#51 happy lemon

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Posted 18 February 2013 - 02:13 PM

Blackberry Leaves are going to be a challenge to find here though.


You may order blackberry leaves from:

http://www.mountainr...Blackberry Leaf

Apart from leaves, they have root and root powder too.

#52 Logic

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Posted 18 February 2013 - 06:58 PM

What about eating like 100g of Dill/day ? Can it yield any of the effects of the Dill extract or is it too minuscule of an amount to matter ?


A good question. Also elastin is an intigral part of veins and???
More research reqd on both Dill and Blackberry Leaf in-vivo.

#53 Aurel

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Posted 18 June 2015 - 08:52 PM

You can now buy prepared 20:1 dill extract on alibaba. 5kg is the minimum amount. Price is 35$ per Kg. Shelf life 2 years.

 

http://www.alibaba.c..._730313015.html






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