70 replies to this topic

[kurdishfella]

vitamin c via collagen helps and with hard hair etc

[johnhemming]

About a month after starting 5-HTP, I added more vitamin B-6 to my stack, to ensure that the 5-HTP would always have enough B-6 available to complete the chemical conversion to serotonin.
 

 

Strikes me that the Serotonin is converted to Melatonin and that is having the effect on hair.

[sensei]

I saw a reversion from greying to color when I consumed LARGE amounts of C60- OLIVE OIL.

Large = 200+ml at one sitting and/or 50ml/day for a week or longer.

After I stopped taking C60 regularly the hair became grey again.

Recently, I have been fasting for 36, 48, and even 60 hours. I have noticed some grey whiskers in my beard and moustache have reverted to color.

I believe it is the MTOR inhibition and autophagy induction by olive oil (maybe c60 has some role) and fasting that causes stem cell regeneration and release.

[Mind]

Really need before and after pictures.

 

I have yet to see anyone reverse grey hair, only people who claim to have reversed grey hair.

[sensei]

Really need before and after pictures.

I have yet to see anyone reverse grey hair, only people who claim to have reversed grey hair.

Well, I don't want it to re-grey, but some places literally waffle back and forth. I'll do what I can.

[Young Paul]

there was a study on rats using a herb called polygonum multiflorum that did reverse grey hair

 

https://www.ncbi.nlm...les/PMC4657090/

[johnhemming]

My experience is that a vellus hair can turn terminal, new hairs can be pigmented, but it is rare to turn a white hair pigmented.

[flash10101]

Anyone has experience with the peptide TB500? 

 

I used it some time ago to accelerate healing of an injury and a lot of people noticed that my hair got darker (on the head and the beard). I don't really have grey hair so can't tell for sure it would reverse grey hair as well, but found that quite interesting, especially since that happened quite quickly (2-3 weeks) and was very noticeable.

 

 

[ta5]

Here's an interesting blog post:

Can you Reverse Grey Hair? New Updates.

 

Update: September 6, 2023

A new South Korean company named YJ Lab is raising funds to start a large-scale clinical trial for its unique melanin restoration technology. The company recently developed a regenerative material that restores the pigment of grey hair. It re-activates damaged melanocytes and removes active oxygen in order to restore hair color. It has already conducted successful internal trials.

Interestingly, YJ Lab is developing a specially made comb equipped with its refillable solution. Consumers can then conveniently apply this melanocyte regeneration material into the scalp.

Update: May 22, 2023

Per a new study from Takahiro Suzuki et al, topically applied Rapamycin could reverse grey hair via mTORC1 inhibition. Rapamycin elevates the production of melanin and pigmentation. I covered rapamycin in my post on autophagy.

 

Also, there's this new study:

Dedifferentiation maintains melanocyte stem cells in a dynamic niche

Kevin Mann talks about this study (He's annoying, but it's pretty good info.)

Here are some other articles on the same study.

 

[Neurocryo]

People should check their genetics first.  I think there’s a mut in IRF4 that does it.

People should check their genetics first.  I think there’s a mut in IRF4 that does it.

[ta5]

Antioxidants (Basel). 2024 Dec 17;13(12):1549. doi: 10.3390/antiox13121549.

Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice

Machiko Iida, Takumi Kagawa, Ichiro Yajima, Akihito Harusato, et al.

Little is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and diosmetin) on hair were investigated according to the sequential processes of hair graying that were previously clarified in model mice [Ednrb(+/-);RET-mice]. External treatment with luteolin, but not that with hesperetin or diosmetin, alleviated hair graying in Ednrb(+/-);RET-mice. Internal treatment with luteolin also mitigated hair graying in the mice. Although both luteolin treatments had very limited effects on hair cycles, the treatments suppressed the increase in p16ink4a-positive cells in bulges [senescent keratinocyte stem cells (KSCs)]. Both of the treatments also suppressed decreases in the expression levels of endothelins in KSCs and their receptor (Ednrb) in melanocyte stem cells (MSCs) and alleviated hair graying in the mice. Luteolin is a special antioxidant with an anti-graying potency through improvement of age-related dysfunction in signaling between endothelins in KSCs and their receptor in MSCs. Luteolin for topical and oral use is commercially available to people in the form of supplements. Similar processes of hair graying in Ednrb(+/-);RET-mice and humans have been reported. These results are encouraging for the practical application of luteolin as a medicine with an anti-graying effect on hair in humans.

PMID: 39765877