8 replies to this topic

[malbecman]

I found this recent human study interesting. Hopefully none of us interested in longevity are smokers but I bet there are some former smokers out there.
I can't yet access the full article on this one.



Curr Med Chem. 2012 Dec 28. [Epub ahead of print]
Anti-inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers.

Bo S, Ciccone G, Castiglione A, Gambino R, De Michieli F, Villois P, Durazzo M, Cavallo-Perin P, Cassader M.

Source

Department of Medical Science, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy. sbo@molinette.piemonte.it.

Abstract

Objective: Smokers are characterized by a low-grade systemic inflammatory state and an oxidant-antioxidant imbalance. Few human studies were conducted on the effects of resveratrol, a natural compound with anti-inflammatory and antioxidant properties, and no trial on smokers has been performed to date. We evaluated whether resveratrol has beneficial effects on markers of inflammation and oxidative stress in smokers. Methods and Results: A randomized, double-blind, cross-over trial was performed in 50 healthy adult smokers: 25 were randomly allocated to "resveratrol-first" (30-days: 500mg resveratrol/day, 30-days wash-out, 30-days placebo) and 25 to "placebo-first" (30-days placebo, 30-days wash-out, 30-days 500mg resveratrol/day). Resveratrol significantly reduced C-reactive protein (CRP) and triglyceride concentrations, and increased Total Antioxidant Status (TAS) values. After analyzing data with general linear models to assess period and carry-over effects, the ratios of the values after resveratrol to those after placebo were respectively: 0.47 (95%CI 0.38-0.59) -CRP- and 0.71 (95%CI 0.65-0.78) triglycerides-, while TAS increased by 74.2 µmol/L (95%CI 60.8-87.6). Uric acid, glucose, insulin, cholesterol, liver enzyme concentrations, and weight, waist circumference, and blood pressure values did not significantly change after resveratrol supplementation. Conclusions: Because resveratrol has anti-inflammatory, anti-oxidant, and hypotriglyceridemic effects, its supplementation may beneficially affect the increased cardiovascular risk of healthy smokers.

PMID: 23298135

[Dolph]

The antiinflammatory effects of resveratrol seem to be reproducable. As I use it essentially exclusively in the hope to improve my personal prevention of CVD, I find that highly encouraging. I think it would be very interesting to see some dose response work to be done in this direction.
The triglyceride lowering effect is somewaht a surprise, isn't it?

[malbecman]

Yes, the triglyceride lowering effect was a bit of a surprise. Most studies so far have seen no effect with that particular parameter but then this is the first study we've seen with known smokers. (?)

[catrinac]

Resveratrol is a scam. The rate of living theory is idiotic.

[Dolph]

Did you even read what we were talking about? We don't care if resveratrol prolongs life, we want to know if it acts as an anti inflammatory agent.

[Kevnzworld]

I have reduced my CRP from 1.4 to .3 by taking curcumin, quercetin , omega 3 's and resveratrol ( 200mg ). This has occurred over a four year period.
My triglycerides have remained stubbornly high at 125. I do drink wine, and I've read that fructose converts to triglycerides so that may be a contributing factor.
Resveratrol does seem to have a large body of evidence as an anti inflammatory agent.
Quote " This study confirms the anti-inflammatory activity of resveratrol and its derivatives and suggests a potential clinical relevance in the therapy of inflammatory diseases."
http://www.mendeley....-17-modulation/
In this study however, quercitan was shown to be more effective
Quote :
Conclusion: These data suggest that quercetin is equally or more effective than trans-RSV in attenuating TNF-α–mediated inflammation and insulin resistance in primary human adipocytes.
http://ajcn.nutritio...92/6/1511.short

[Dolph]

Normally there is hardly any fructose left in wine, BUT alcohol itsself is able to increase TG!

Interesting data about quercetin. My Belle de Boskoop suddenly tastes even better.

[Jean-François Savouret]

I consider that the most essential action of Resv is as a protective agent against smokers diseases, including cancer, oxidative stress, inflammation and bone resorption. I attach some references.

JFS

Attached Files

•  Casper_AhR_resver_1999.pdf   173.29KB   1 downloads
•  Revel_JAT_2003.pdf   350.91KB   1 downloads
•  Revel_RT_2001.pdf   993.39KB   0 downloads
•  Savouret_Review_Resv_cancer_2002.pdf   39.58KB   1 downloads
•  Singh_resv_bone_2000.pdf   373.07KB   0 downloads

[Jean-François Savouret]

Hi,

As a rebound on this, I'd like to point out a simple fact about resv and the related larger fields of environmental pollution and human medicine.

There is a srong tie between AhR function and its target genes (cytokines, chemokines ...) in the field of cell activation in inflammation. Diabetes is also a Resv target (Glp-1 and glucose transport). If you link diabetes and inflammation, you have metabolic syndrome (obesity, 60% of the US population) at hand and the correlation between smoking and metabolic syndrome is premature CV death. So I think it's a worthy field of research.

Talking about research, why couldn't this forum extend to a job/position platform for those wishing to do research in the longevity/morbidity unified concept? A lot of good dedicated candidates would certainly pop up.

JFS