I've read the various info on this drug out of Russia and it's mechanism of action, etc. I know there's been a few references to it in other posts, but I'm wondering if anyone has tried it and what your experiences have been?
Thx,
Posted 15 January 2013 - 04:08 AM
Posted 14 May 2013 - 03:56 AM
Posted 14 May 2013 - 08:56 AM
Posted 14 May 2013 - 05:46 PM
Posted 14 May 2013 - 05:56 PM
Did you take it sublingually?Good for you yada
yeah, I bought some as well after I had posted above...but, I didn't notice much of an effect and the research indicated it took, like, 10 of those pills a day to reach efficacy...If that's the case, too expensive.
How are you doing with Apo? Still positive effect?
Posted 14 May 2013 - 06:14 PM
Posted 14 May 2013 - 09:28 PM
Posted 14 May 2013 - 10:03 PM
Posted 15 May 2013 - 01:42 AM
Posted 15 May 2013 - 02:07 AM
Posted 15 May 2013 - 03:20 AM
Posted 16 May 2013 - 12:27 PM
Edited by formergenius, 16 May 2013 - 12:28 PM.
Posted 16 May 2013 - 06:28 PM
Posted 16 May 2013 - 06:33 PM
twice a day for a month to feel a noticeble effect ? you can get immediate effect from eating food or drinking water. if a drug takes that long to work, dump it
Edited by Rior, 16 May 2013 - 06:37 PM.
Posted 16 May 2013 - 06:37 PM
Edited by dislocation, 16 May 2013 - 06:37 PM.
Posted 16 May 2013 - 06:41 PM
patience ? more like time, money and discipline waste. if something is so beneficial and praised for its positive effect on your body, it must be as great as take one and feel it type of effect. like a cup of coffee. does it take 12 weeks to feel the effect ? lol
Posted 16 May 2013 - 08:37 PM
1 tablet - 3 mg = 3 * 10 ^ (-6) gram
The concentration of the active substance 10 ^ (-15) nanograms per gram = 10 ^ (-24)
Of active substance per tablet 3 * 10 ^ (-6) * 10 * 10 ^ (-25) = 3 * 10 ^ (-31) grams
From Wikipedia, we learn that the average weight of 150 KDa antibodies = 150 * 1.66 * 10 ^ (-22) = 2.49 * 10 ^ (- 24) grams
Learn how many tablets need to have appeared in one molecule of the active substance to divide the mass of the molecule by weight of active substance per tablet:
(2.49 * 10 ^ (-24)) / (3 * 10 ^ (-31)) = 0.83 * 10 ^ (7) = 8300000
So, out of 8.3 million tablets of "medicine" one contains one molecule of the active ingredient, and 8299000 999 do not contain anything.
Such cases ...
Edited by formergenius, 16 May 2013 - 08:40 PM.
Posted 17 May 2013 - 12:49 AM
patience ? more like time, money and discipline waste. if something is so beneficial and praised for its positive effect on your body, it must be as great as take one and feel it type of effect. like a cup of coffee. does it take 12 weeks to feel the effect ? lol
I don't even know how to respond to this.
All I can say is that it sounds like you're looking to get high on initial effects, rather than induce long-term benefits. Little thing worth realizing: Most drugs that induce an immediate effect that's positive, usually end up having a bad long-term effect. That said, many things that have a not-so-wonderful initial effect, or perhaps no initial effect at all, induce long-term changes that--if you have discipline enough to take it every day--is worth millions more to have long-term permanent changes than an initial high that goes away. It's how pharmacology usually tends to work.
A good example is Memantine. It acts as an antagonist at the NMDA receptor, which induces initial BAD effects. However, to overcompensate for the antagonism at the NMDA receptor, it causes your body to upregulate the production of said receptors--which induces a great long-term effect and results, for many people, in increased memory and increased concentration and focus.
Posted 17 May 2013 - 02:29 AM
patience ? more like time, money and discipline waste. if something is so beneficial and praised for its positive effect on your body, it must be as great as take one and feel it type of effect. like a cup of coffee. does it take 12 weeks to feel the effect ? lol
I don't even know how to respond to this.
All I can say is that it sounds like you're looking to get high on initial effects, rather than induce long-term benefits. Little thing worth realizing: Most drugs that induce an immediate effect that's positive, usually end up having a bad long-term effect. That said, many things that have a not-so-wonderful initial effect, or perhaps no initial effect at all, induce long-term changes that--if you have discipline enough to take it every day--is worth millions more to have long-term permanent changes than an initial high that goes away. It's how pharmacology usually tends to work.
A good example is Memantine. It acts as an antagonist at the NMDA receptor, which induces initial BAD effects. However, to overcompensate for the antagonism at the NMDA receptor, it causes your body to upregulate the production of said receptors--which induces a great long-term effect and results, for many people, in increased memory and increased concentration and focus.
you are refering to this drug ? http://www.ncbi.nlm....pubmed/21860092
not sure i will be trying it reading this.
and also relating your substance to take long term for benefit, its impossible to be sure if anything long term actually works considering placebo is huge effect when it comes to time. time changes a person naturally, time heals or makes things worst. hard to judge change in a person based on a single ingredient they have been taking long term with subtle effects.
Memantine treatment improved spatial and recognition memory performance in the Ts65Dn mice, though not to the level of normosomic littermate controls. Despite these memory improvements, histological analysis found no morphological signs of neuroprotection of basal forebrain cholinergic or locus coeruleus neurons in memantine-treated Ts65Dn mice. However, memantine treatment of Ts65Dn mice gave rise to elevated brain-derived neurotrophic factor expression in the hippocampus and frontal cortex, suggesting a mechanism of behavioral modification.
its impossible to be sure if anything long term actually works considering placebo is huge effect when it comes to time. time changes a person naturally, time heals or makes things worst. hard to judge change in a person based on a single ingredient they have been taking long term with subtle effects.
Posted 17 May 2013 - 06:11 AM
Posted 17 May 2013 - 07:40 AM
Posted 18 May 2013 - 12:20 PM
Rior thanks for the update. I agree, dislocation has some odd viewpoints. If you want immediate relief, go for benzo's I suppose. Running a mile won't make you lose a pound either.
I took some Tenoten today, just couldn't wait. Damn! I think it was the Tenoten.. I took two, and I just felt soooo tired. Strange. Anxiolytic yes, but sedative as well alas.
Dinner at a crowded restaurant seemed less distressing, but I had to put all my will into not lying down on the couch I was seated in.
Just took two more, with one hour apart. Still feeling tired, which is good I suppose because I need the sleep. I'll have to evaluate full effects on sleep in the morning.
I sucked at chess today though, but then again I haven't really been as good as I used to be for a long time.
There's not much clarity as of yet. Hoping this will gain over time?
Anyways not nearly long enough of a trial to support any concrete claims on effects. Could be placebo.
Posted 20 May 2013 - 04:23 PM
Edited by mwestbro, 20 May 2013 - 04:23 PM.
Posted 20 May 2013 - 04:53 PM
I did a little searching, and Tenoten is clearly a homeopathic product. That doesn't bother me any, as I've gotten good results from a variety of homeopathic remedies, but it may bother some of you. Interestingly, the company doesn't seem to want to emphasize the homeopathic nature of their products. In the US, many companies grab homeopathic status enthusiastically in order to avoid FDA oversight, but maybe the incentives are different in Russia. Anyway, Tenoten is a combination (sometimes called a "potency chord") of three homeopathic dilutions of antibodies to S100. The three dilutions are 12C, 30C, and 200C. Since Tenoten is a homeopathic remedy, I assume it will act like a homeopathic remedy. I'm not particularly interested in defending homeopathy here, but if you plan to use Tenoten, you should know what a homeopath would expect from it. Tenoten won't operate according to traditional pharmacological principles. Homeopathy is a regulatory therapy, and the effect you get depends on the prior condition of the recipient. In particular, it won't necessarily have the same effect every time you take it. A homeopath would tell you to take it until you get a good therapeutic response, and then stop. If you continue taking it, you may get what is called a "proving", in which you manifest the symptoms the remedy is intended to treat in exaggerated form. In other words, you start out feeling better, then it stops working, then you feel much much worse. As I said, I have no particular interest in defending homeopathy here, but there is a theoretical structure behind all of this. As an aside, I think there is a lesson here. We have several people taking a drug they don't know very much about. All of them report effects of some sort. Now, the lesson you draw depends on your pre-existing assumptions. Either we can conclude that we have a bit of anecdotal evidence for homeopathy, or that it is harder than we think to evaluate drugs purchased over the Internet. Take your pick.
Mike
Posted 20 May 2013 - 04:58 PM
Posted 20 May 2013 - 05:36 PM
Posted 20 May 2013 - 05:42 PM
Posted 20 May 2013 - 05:54 PM
Edited by Rior, 20 May 2013 - 05:55 PM.
Posted 20 May 2013 - 05:57 PM
Posted 20 May 2013 - 05:58 PM
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