5 replies to this topic

[umbillicaria]

Smart denizens of Longecity- have any females experimented with the Ciltep stack? Isn't there's effect on testosterone levels?

Also I wanted to report good, consistent results alternating days between Ciltep and piracetam (800mg) and centrophenoxine. I feel clear, focused, and (verbally) fluent every day --though to a lesser degree than my initial piracetam experience, which prompted deliciously creative insights and fluidity of thought.

1 month with steady results.
Hoping to keep it goin. Tired of the chasing the piracetam dragon...

Other supps: bupropion, NAC, citicholine, vitamin D

[abelard lindsay]

Smart denizens of Longecity- have any females experimented with the Ciltep stack? Isn't there's effect on testosterone levels?

Here's some interesting research regarding effects of the PDE4 inhibiting component of the CILTEP stack on females in particular. It appears it's an aphrodisiac, equivalent to the female version of viagra (PDE5 for men vs PDE4 in women) at least in mice. Can you tell us if it works?:

J Sex Med. 2013 Jan 24. doi: 10.1111/jsm.12058. [Epub ahead of print]
Inhibition of Phosphodiesterase 4 Enhances Clitoral and Vaginal Blood Flow Responses to Dorsal Clitoral Nerve Stimulation or PGE1 in Anesthetized Female Rats.
Castiglione F, Bergamini A, Russo A, La Croce G, Castagna G, Colciago G, Salonia A, Rigatti P, Montorsi F, Hedlund P.
Source
Urological Research Institute, Department of Urology, San Raffaele Hospital, Milan, Italy; Department of Clinical Pharmacology, Lund University, Lund, Sweden.
Abstract
INTRODUCTION.: Cyclic adenosine 3'5' monophosphate (cAMP) is produced by adenylate cyclase after activation by, e.g., vasoactive intestinal polypeptide or prostaglandin E1 (PGE1). The cAMP-degrading phosphodiesterase 4 (PDE4) is expressed in the vagina and clitoris, but no information is available on the functional role for PDE4-related signals in the female neurovascular genital response. AIM.: The aim of this study is to study the effect of inhibition of PDE4 with rolipram on nerve- and PGE1-induced vaginal and clitoral blood flow responses of rat. METHODS.: Measure of clitoral and vaginal blood flow and blood pressure in anesthetized rats during activation of the dorsal clitoral nerve (DCN) before and after intraperitoneal administration of rolipram or sildenafil (phosphodiesterase type 5 inhibitors [PDE5]) and nitro-L-arginine (L-NNA) (nitric oxide synthase inhibitor). Effect by topical administration of PGE1 on genital blood flow was also evaluated. MAIN OUTCOME MEASURE.: Blood flow was recorded as tissue perfusion units (TPU) by a Laser Doppler Flowmeter. Mean arterial blood pressure (MAP) was recorded (cmH(2) O) in the carotid artery. Blood flow responses are expressed as TPU/MAP. Unpaired t-test and an analysis of variance were used. RESULTS.: Compared with control stimulations, rolipram (0.3 mg/kg) caused a twofold increase in peak blood flow (P < 0.05) and fourfold increase of the rate of clitoral blood flow during activation of the DCN (P < 0.05). Simultaneously, a twofold increase in peak blood flow and threefold increase in rate of blood flow were noted in the vagina (P < 0.05). Similar effects were noted for sildenafil (0.2 mg/kg) (P < 0.05). Inhibitory effects by L-NNA (60 mg/kg) on blood flow responses to DCN activation were significantly lower for rats treated with rolipram than with sildenafil (P < 0.05). PGE1-induced (10 μg) blood flow responses were significantly higher (P < 0.05) in rats treated with rolipram than with sildenafil. CONCLUSIONS.: These findings suggest that the cAMP/PDE4 system may be of similar functional importance as the nitric oxide/cyclic guanosine monophosphate/PDE5 pathway for neurovascular genital responses of the female rat.
© 2013 International Society for Sexual Medicine.

Edited by abelard lindsay, 26 January 2013 - 07:58 PM.

[umbillicaria]

!!!!! I was wondering if my cycle was off. I have noticed increased libido. Fascinating

[abelard lindsay]

!!!!! I was wondering if my cycle was off. I have noticed increased libido. Fascinating

Wow! Isn't science great? Any difference in effects between artichoke extract and quercetin?

Edited by abelard lindsay, 27 January 2013 - 07:39 AM.

[umbillicaria]

I have not tried the quercetin yet. I'm using nature's way artichoke 600mg and 100 mg of 10% forskolin, so pretty low dose. I tried doubling the artichoke one day and my heart started racing and skipping beats about 3 hours later (about 11am). I was sweating a lot too. This settled down by mid evening. Very uncomfortable. wondered if this was because of the Bupropion? I'm nervous about quercetin as its more potent and lasts longer than artichoke, right?

[abelard lindsay]

I have not tried the quercetin yet. I'm using nature's way artichoke 600mg and 100 mg of 10% forskolin, so pretty low dose. I tried doubling the artichoke one day and my heart started racing and skipping beats about 3 hours later (about 11am). I was sweating a lot too. This settled down by mid evening. Very uncomfortable. wondered if this was because of the Bupropion? I'm nervous about quercetin as its more potent and lasts longer than artichoke, right?

Bupropion and CILTEP both work on the dopamine system so they would most likely potentiate each other. I would not take higher doses of the stack or take the stack with quercetin if I was on that, especially given the symptoms you experienced at higher doses.

Edited by abelard lindsay, 27 January 2013 - 09:34 PM.