91 replies to this topic

[Crevetterebelle]

Hi everybody

First : results ( Mine is Capelle, not Foucault)

Edited by Crevetterebelle, 21 August 2013 - 08:22 PM.

[Crevetterebelle]

And next, the new list of my ratties... 10 of my old rats died during the epidemic episode, and ... I still have 24 residents.
Females - Birthday - Ages

Males - Birthday - Ages

[AgeVivo]

Wonderful! Creverterbelle, I add the males, as the picture did no go through your last post:

If someone wants to type down such information, please go ahead.

Creveterbelle, this week-end I will tell the ages & gender of your ratties to the researcher who made the tubes that you have, he will indicate what tube number to use for what rat.

Cheers

[Crevetterebelle]

But I don't understand, yesterday pictures are okay.. Lol I add again Monday

Edited by Crevetterebelle, 24 August 2013 - 08:07 AM.

[AgeVivo]

oh, indeed, strange. Here are females

[AgeVivo]

Ok Crevetterbelle, let's start with the 10 older rats for each gender and the tubes you already have:

Very Aged Females
INC Stella 25/10/2010 - 34 month old: bottle 16 (wow what an old lady; very best regards)
TRA Iris 07/01/2011 - 31 month old: bottle 18
IND Schweppes 19/04/2011 - 28 month old: bottle 2
Aged Females
CAT Ozalée 27/07/2012 - 18 month old: bottle 19
CAT Eloane 02/02/2012 - 18 month old: bottle 3
RTD Aelis 22/03/2012 - 17 month old: bottle 5
Mid-age Females
TRA Feeling 23/08/2012 - 12 month old: bottle 14
RTD Hope 09/11/2012 - 9 month old: bottle 8
RTD No fear 26/12/2012 - 8 month old: 11
RB Requiew (FocADream) 24/02/13 - 6 month old: bottle 9

Very Aged Males
TRA Curly 07/01/2011 - 31 month old: bottle 1
IND Arc-en-ciel 19/04/2011 - 28 month old: bottle 20
Aged Males
RTD Ohanzee 20/01/2012 - 18 month old: bottle 17
IND Akadoc 19/02/2012 - 17 month old: bottle 4
DMH-TRA Klauss 28/03/2012 - 16 month old: bottle 7
Mid-age Males
RTD Undisclosed Desires 17/07/2012 - 13 month old: bottle 15
RTD Starlight 27/07/2012 - 13 month old: bottle 12
TRA Njut 23/08/12 - 12 month old: bottle 10
RTD Time (IsRunningOut) 26/11/2012 - 9 month old: bottle 6
LAD Leprochain 29/11/12 - 9 month old: bottle 13

(sorry if I have mistyped some names; there are some funny names I may not have understood ;-)

For the 6 younger ratties... adults first! I will soon send you some other tubes.
Let me know if you have any question.
Cheers

Edited by AgeVivo, 25 August 2013 - 10:36 PM.

[Crevetterebelle]

RB Requiem (ForADream) 24/02/13 - 6 month old: bottle 9

LAD Leprechaun 29/11/12 - 9 month old: bottle 13

All it's ok for me When I will beggin the protocol with the bottle here.
Thanks !

[AgeVivo]

When I will beggin the protocol with the bottle here.

I don't know if it is a question: start when you want. Don't hesitate to drop a line of when you start, when you give them, if something special happens, share links etc.
I'll be happy to follow, discuss, and I'm sure I'm not the only one.
Cheers!

[AgeVivo]

Hi Creverterbelle, hope all is well. I understand that you have started? As discussed we will send you the tubes for the youngest later, when they will be a bit older and when you are used to regularly treating your raties with c60

[AgeVivo]

@all, I have received a message from creveterbelle: the experiment has started last Monday, September 9th 2013!

[AgeVivo]

@all, it has been a long time; crevetterbelle told me that she had stopped feeding her rats with c60 or placebo after 2/3 months (so some time ago) and she is now ppreparing the list of things that happened to her rats until now, in order to post it here. It will take her some time, but we will then reveal what tube was what and it will be interesting to see!
In more details, once we will be clear with the data (analysis 1), I will ask to get the list of c60 and the list of placebo, but without knowing what is what, so that we will first decide, based on the data and the 2 lists , if one group seemed to do better than the other one (analysis 2). Last but not least we will be revealed what group is what (analysis 3) --- whether we get solid results or not, this should educate us a lot about open, placebo-based and potential bias while doing research --- a lot of scientific fun to come!

[YOLF]

Did the treatments stop due to concerns?

[Crevetterebelle]

Hi, I prepare the recap for this week.


I had to stop treatment of a moving I could not continue by preparing my boxes, work and take care of my rats, give the bread with the protocol take me 2 hours each time.
I took since 10 February, and tomorrow one again ! =)

[VP.]

Thank you for your hard work.

[AgeVivo]

I am impatient!

[Crevetterebelle]

Bonjour, j'écris en français pour que ce soit plus simple pour moi, si quelqu'un a besoin d'une traduction ... j'en confie la tache a Agevivo ! =)

Alors j'ai fait un petit récap des décès depuis Septembre 2013 - mois où j'ai repris le protocole.
Je met toutes les informations possibles, et ce dans un ordre chronologique.

9 Septembre 2013 - Protocole repris.
1/ Arc-en-Ciel - DOB : 19/04/2011 - DOD : 11/10/2013 - 30 mois
Cause - Détresse respiratoire.

2/ Iris - DOB : 07/01/2011 - DOD : 24/10/2013 - 34 mois
Cause - Vieillesse

3/ Schweppes - DOB : 19/04/2011 - DOD : 27/11/2013 - 31 mois
Cause - Vieillesse et defaillance neurologique.

Arret en Decembre de la prise du protocole.

4/ Stella - DOB : 25/10/10 - DOD : 04/01/2014 - 38 Mois
Cause - Vieillesse

5/ Curly - DOB : 07/01/2011 - DOD : 06/01/2014 - 36 mois
Cause - Eutha suitre vieillesse

6/ Eloane - DOB : 02/02/2012 - DOD : 19/01/2014 - 23 mois
Cause : Tumeur Utérine

7/ Akadoc - DOB : 19/02/2012 - DOD : 24/01/2014 - 23 mois
Cause : Inconnue soupçonnée neurologique.

Reprise du traitement/Protocole début MARS
8 / Aelis - DOB : 23/03/2012 - DOD : 04/04/2014 - 24 mois
Cause : Abcès faciale virulent.



Voilà pour le récapitulatif des decès de ces derniers mois. Il faut se dire que la plupart des décès de cause neurologique sont dues à l'andémie qui a frappé la troupe courant mai 2013, certaines des pathologies trouvées, ont un impact sur le neuro des touchés.
Actuellement la troupe se compose de 21 rats :
Femelles : 8 - 5 nées en 2012, 3 nées en 2013
Mâles : 13 - 8 nés en 2012 - 4 nés en 2013, et 1 né en 2014.

Je continue la prise du produit comme indiqué, et il me reste donc des fioles "actuellement" inutilisées puisque j'ai eu des décès... si vous voulez les redonner aux nouveaux rats pas de soucis, je vous fait la liste dans le post suivant.

[Crevetterebelle]

Bottle used :

Very Aged Females
CAT Ozalée 27/07/2012 - 26 month old: bottle 19
Aged Females
TRA Feeling 23/08/2012 - 19 month old: bottle 14
RTD Hope 09/11/2012 - 16 month old: bottle 8
Mid-age Females
RTD No fear 26/12/2012 - 15 month old: bottle11
LAD PetiteSouris - 12/2012 - 15/16 month old - Bottle ?
RB Requiem (ForADream) 24/02/13 - 13/14 month old: bottle 9
TRA Oneira - 18/05/2013 - 10 month old - Bottle ?
TRA Selenia - 21/06/2013 - 9 month old - Bottle ?


Very Aged Males
RTD Ohanzee 20/01/2012 - 26 month old: bottle 17
DMH-TRA Klauss 28/03/2012 - 24 month old: bottle 7
RTD Undisclosed Desires 17/07/2012 - 20 month old: bottle 15
RTD Starlight 27/07/2012 - 20 month old: bottle 12
TRA Njut 23/08/12 - 19 month old: bottle 10
Aged Males
RTD Time (IsRunningOut) 26/11/2012 - 16 month old: bottle 6
LAD Leprechaun 29/11/12 - 16 month old: bottle 13
Mid-age Males
RTD Uprising 26/12/2012 - 15 month old : Bottle ?
TRA Zoom 18/05/2013 - 11 month old : bottle ?
CAT Nox 21/06/2013 - 10 month old : Bottle ?
RDH NightCall 01/08/2013 - 8 month old : bottle ?
Young males
FLA-RDH PiouPiou 12/11/2013 - 5 month old - Bottle ?
RTD Bubble Gum 02/01/2014 - 3 month odl : Bottle ?

Bottle non used.
B1 - B2 - B3 - B4 - B5 - B16 - B18 - B20.
One mâle without bottle.

[YOLF]

English, please edit if you can finish it:

Hello, I write in French to make it easier for me , if someone needs a translation ... I entrusted the task has Agevivo ! = )

So I did a little recap of deaths since September 2013 - the month where I used the protocol .
I put all the information possible , and in chronological order .

September 9, 2013 - Protocol resumed.
1 / Arc -en- Ciel - DOB : 19/04/2011 - DOD: 10/11/2013 - 30 months
Cause - Respiratory distress .

2 / Iris - DOB : 07/01/2011 - DOD: 10/24/2013 - 34 months
Cause - Old age

3 / Schweppes - DOB : 19/04/2011 - DOD: 27/11/2013 - 31 months
Cause - Old age and neurological defaillance .

Stop in December of taking the protocol.

4 / Stella - DOB : 25/10/10 - DOD: 04/01/2014 - 38 Months
Cause - Old age

5 / Curly - DOB : 07/01/2011 - DOD: 01/06/2014 - 36 months
Cause - Eutha suitre old

6 / Eloane - DOB : 02/02/2012 - DOD: 19/01/2014 - 23 months
Cause: Uterine Tumor

7 / Akadoc - DOB : 19/02/2012 - DOD: 01/24/2014 - 23 months
Cause: Unknown suspected neurological .

Retreatment / Protocol beginning in March
8 / Aelis - DOB : 23/03/2012 - DOD: 04/04/2014 - 24 months
Cause: virulent facial abscess .



That's the summary of deaths in recent months. It must be said that most deaths are due to neurological cause the andémie that hit current troop May 2013, some of the pathologies found , have an impact on the neuro touchdowns.
Currently the band consists of 21 rats :
Females: 8-5 born in 2012, born in 2013 3
Male : 13.08 born in 2012-4 born in 2013 and one born in 2014.

I continue taking the product as directed and therefore it remains for me vials "currently" unused since I 've had death ... if you want to restore to new rats do not worry, I made ​​up the list in the post next.

[AgeVivo]

Very great! I am looking at it carefully. Cheers.

[AgeVivo]

Ok, so I have looked. Very nice! Thank you very much, all information is very coherent: very good quality, bravo!

In order for other persons to follow I have made a table. The last column allows to guess if it could have had a "life extending treatment":

 

 

I am wondering if we should disclose some results or none as only 8 of the rats have died so far, and disclosing would reveal you what tube is what. I am Ok for either (tradeoff between being scientifically strict or flexible, being interesting for other research, etc): I am going to discuss it. People can express their opinions of course.

Except for the youngest, I can send you bottles for the 8 ratties that have not received solutions yet ---- if you are interested (do not feel obliged of course; if interested, simply send me your adress by email).

 

Very great!

Edited by AgeVivo, 09 April 2014 - 06:30 AM.

[YOLF]

Given the disease outbreak, I think we should hold off on revealing any data yet.

 

Attn readers: the voting is for quality of posting rather than disagreeing with someone's opinion.

Edited by cryonicsculture, 12 April 2014 - 01:47 AM.

[thedarkbobo]

Hey, I am watching your good work too

 

Well, looks like we need to wait some more for results. Could say that if the three first lived longer than they should then it's very nice, given the fact that they started taking it late in their life.

C60 shouldn't prevent diseases so those death causes should probably be explained well, in case C60 acted in some bad way.

 

I wonder if the stress (you said you had to move - change apartaments?) shortened their life span.

[Crevetterebelle]

Les causes neurologiques, sont malheureusement de longue date, meme si elles interviennent de manière spontannées et fulgurante malheureusement nous ne pouvons pas prévoir qui est touché ou non dans la troupe.

Concernant les données, je peux continuer a l'aveugle cela ne me dérange pas.

Sachez que j'ai déménagé le 25/01/2014, et que donc seul un decès est survenu APRES le stress du déménagement et ce largement après : 2mois après, je pense pouvoir dire que cela n'a pas eu d'incidence sur le deces d'AELIS, 04/04/2014.

Ce qu'il faut savoir. J'ai parmis ces rats, des frères et soeurs, dont on a un suivi généalogique. 
Curly, Loki, Lo Yu, Iris, Pensée etaient frères et soeurs, ils ont tous eu de très longues vies à la maison, 2 frères chez une adoptante ayant vécu 2 ans et demi sans protocole,e t sans soucis de santé particulier. Leurs parents qui étaient a la maison, sont morts respectivement : 
- Maman Gaya, 18 mois, epanchement pleural 
- Papa Loupiot, 24 mois, Otite encephalite.

Aelis a perdu sa maman, d'un abcès facial / dentaire aussi ce qui entre dans sa génétique.
Ce sont des exemples, si vous avez besoin de plus d'info la dessus, je peux aussi essayer d'en apporter.

 

[AgeVivo]

Translation:

- we don't know which rats had caught the disease that cause spondatenous neurologic traumas and death, so that's sadly a noise for interpreting results.

- Ok to continue blindly! Data will be revealed later

- Moving house shouldn't have had any incidence of deaths. I move in late January, and the only death here (Aelis) is from earch April: very distant dates.

- Among the rats here, some are brothers and sisters and we have some lifespan data points in their family history

- Example 1:  Curly (in the current list, dead at age 36), Loki, Lo Yu, Iris (in the curent list, dead at age 33.5), Pensée: they were brothers and sisters, have all lived long in my (former) house, while 2 of their brothers were living elsewhere and lived up to 2.5 years (without specific protocols nor specific health issues) -- I had also their parents at home and they lived up to 18 and 24 (...difficult to translate the names of the causes of death...)

- Example 2: Aelis's mother had died like him from facial abscess: certainly some genetic link

- I can provide other examples if useful.

Edited by AgeVivo, 09 April 2014 - 08:18 PM.

[AgeVivo]

Given that you handle rats so well -- some very long lived ratties -- I think that with the 7 rats aged approx 9-11 months you should test the time-specific procedure of the reported article by Baati et al. This is the "gold standard" thing to do, I was going to look for a researcher in a lab but I thinkthat you are well positionned to do it; will write more later about it (busy week-end and I need to go back to the article to be very precise about the time-specific procedure).

[YOLF]

Any rats in that age group that you plan on breeding Belle?

[Crevetterebelle]

Crevetterebelle* it means : shrimp rebel

I haven't got plan for breeding now, because after the May's virus, i have to stop breeding, for a crawlspace.

Agevivo, why not but i haven't got lot of time to prepare a big experiment,but I can find on the principle and understanding that there has to.

 

Sorry for my english, google trad helps me haha.
 

[AgeVivo]

yes of course. what you did so far is already great.

The initial experiment has a very special frequency, and with time, preliminary results and discussions I wonder if it may have contributed to the so large life extension reported:

-- they started with male Wistar rats at age 10 months

-- they administered the solutions every day during one week (une fois par jour sept jours d'affilés; typiquement pendant des congés)

-- then weekly until the end of the second month (ensuite une fois par semaine sept semaines d'affilées)

-- and then every two week until the end of the 7th month of the experiment (ensuite une fois toute les deux semaines pendant 5 mois)

So, in total, only 7 months of treatment however the animals (reportedly) lived very long.

One explanation would be (no one knows so far how reproducible the result is and, if well reproducible, what explains it) that the fast and strong start with c60 could have adapted the liver (as it is demonstrated that c60 protects the liver very well against strong oxidative attacks, so it does something to the liver (even if non toxic)). Slowly disminishing the dose is standard in pharmacology to avoid counter reactions of the body.

 

So, depending on your time you would (or not):

-- stop administering the solutions that you are currently giving (we are in an unknown territory in terms of duration of treatment, so I would guess that it is equally interesting to continue and stop; but I would like to know what other LongeCIty members think?)

-- receive solutions to test the frequency of the original paper on your 7 rats aged 9-11 months.

 

Please do what you feel like, in terms of time and will to contribute. What you are doing so far is great; in general researchers do not work on other topics very different than their topic (obviously), so it is difficult to have researchers test c60 on lifespan: it is quite a mixture of different research-worlds (where Baati et al happen to be).

[Crevetterebelle]

Yesterday, RTD Ohanzee died... cause old age. 27 months.

I look at your proposition AgeVivo, I think it's possible in fact but i don't know if I my job program allows it... 

[AgeVivo]

Understood, no worry. Take care of you. In any case it is only *if* you happen to have one week of vacations some time and at home. You are doing a great job and I will be very happy to discover what rat was treated by what!

Edited by AgeVivo, 23 April 2014 - 02:21 AM.