[quote name='BioFreak' timestamp='1359812573' post='563436']
Maybe age had it's toll on his brain. Here is at least one of the studies he meant when referencing to collodial gold in RA:
Management of Rheumatoid Arthritis: Rationale for the Use of Colloidal Metallic Gold
Read More:
http://informahealth.../13590849762411The study he referenced was clearly not about colloidal gold, but about gold salts.
[/quote]
Even if that is one of the studies he "meant" to reference, it was a study by Abraham himself, with no peer review or even peer participation. This doesn't mean it didn't happen or was undertaken dishonestly, but the reason we have peer review and peer participation in medical and scientific studies is so that, if someone performs a study fraudulently or incorrectly, more than one person in a given field must risk their reputation and professional standing to corroborate such a study. It's not a perfect system, but it generally works quite well, and those that sidestep this system do not endear themselves to the scientific community or people at large who are interested in the results of serious research.
[quote name='BioFreak' timestamp='1359812573' post='563436']
[quote]So your point is, "He's only working with old, historical applications of elements, so of course nobody else in current times has done any research supporting his claims"? He's been making these claims for some time now, and colloidal gold has been used in many other applications. If his 'research' had any merit, others would follow up on it, and the scientific and medical communities would pick it up and run with it. Why haven't they? Hopefully your response will not be one related to conspiracies or the scientific and medical community "not wanting us to know about" such breakthroughs.[/quote]
This is all or nothing thinking. Its like saying So many people have been running the 100m, and none of them broke the world record. Until... someone did. Maybe not the best example. OK, lets have an example thats closely related: In the early days of medicine, iodine was something like a panacea. Nobody knew what it did, but it did it well. Then came the "chemical revolution" in medicine, where artificial created medicines could be patented, which was a exiting new field. And it is how it always is with new things: New good, old bad, esp. if its a revolution of some kind. So it happened that someone created artificial thyroid hormone. Two studies followed, not only to prove that t3 I believe it was works well, but to show that all history of iodine science was wrong. That its bad. That Its even toxic in dosages normally prescribed. That picture was one people at that time saw over and over again, because much of medicine was using other high dose elements, and indeed, those were toxic and better alternatives were a blessing. Well, this was not true for iodine, but if fit in the picture, and two studies, by the same physicians, that wanted to promote a competitor to iodine, never replicated, made iodine a bad medicine, in fact banished it from the world (unless it is in mcg amounts). Now I don't say that t3, t4 are useless, they have their place, thats not the point. The point is that not everything gets replicated, and even if it does, the mechanisms may be to complex to be understood at that time. So the community comes to a conclusion which later can prove to be wrong. Iodine is in fact a very good way to get cells to excrete lead, bromide, fluoride, and some other stuff I forgot. It also is an anti cancer agent, which is being used a lot in breast cysts. They simply slowly disappear over months or years instead of becoming cancer. And the main actor who got iodine back, mostly with his own studies, was abraham.
[/quote]
Certainly, there is give and take in science and medicine. Over time, certain methodologies are emphasized or de-emphasized, and occasionally this occurs counter to proper scientific method, or even truth. However, this is a self-correcting process, and given millions of researchers studying simultaneously without end for decades upon decades, sooner or later the communities involved make short work of incorrect beliefs via cold, hard, factual studies. Let us take a look at iodine, since this seems to be the focal point of your support for Abraham's legitimacy.
We can start simply, with a link to Iodine's Wikipedia page, sub-section Dietary Intake (
http://en.wikipedia....#Dietary_intake): "The daily Dietary Reference Intake recommended by the United States Institute of Medicine is between 110 and 130 µg for infants up to 12 months, 90 µg for children up to eight years, 130 µg for children up to 13 years, 150 µg for adults, 220 µg for pregnant women and 290 µg for lactating mothers. The Tolerable Upper Intake Level (UL) for adults is 1,100 μg/day (1.1 mg/day). The tolerable upper limit was assessed by analyzing the effect of supplementation on thyroid-stimulating hormone".
These measurements are in micrograms, or thousandths of a milligram. This is not a couple of greedy, patent-holding doctors making a statement - it is the collective determination of the United States Institute of Medicine. But don't take them at their word; let's get information from other sources as well.
You mention and emphasize that various forms of iodine are indeed harmful, but that elemental iodine is not. I believe you merely misspoke, but let's look at elemental iodine. A quick Google search for "iodine MSDS" (Material Safety Data Sheet, a standard document in scientific, medical, and engineering circles) turns up the following as the first two results:
http://www.sciencela...?msdsId=9927547http://www.nvcc.edu/...msds/iodine.pdfThe first is direct from ScienceLab.com, a well-known and reputable supplier of laboratory chemicals and equipment; the second is a reprint of a Fisher Scientific MSDS. Both are companies which sell elemental iodine, which as you mentioned has various uses across multiple fields of work.
Though both documents agree that the LD50 for iodine is quite high (the LDlo, all that's currently available for humans, is 28 mg per kg), neither minces words about the danger of consuming ANY measureable amount of elemental iodine. Let us keep in mind that, although a substance may not kill you, it may still be extremely harmful to you, especially if taken for long periods of time. Here is the ScienceDirect iodine MSDS section on Hazards Identification as well as the section on First Aid Measures:
[quote]
Section 3: Hazards Identification
Potential Acute Health Effects:
Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Hazardous in case of skin
contact (corrosive), of eye contact (corrosive). Slightly hazardous in case of skin contact (permeator). The amount of tissue
damage depends on length of contact. Eye contact can result in corneal damage or blindness. Skin contact can produce
inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by
burning, sneezing and coughing. Severe over-exposure can produce lung damage, choking, unconsciousness or death.
Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching,
scaling, reddening, or, occasionally, blistering.
Potential Chronic Health Effects:
Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS:
Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL
TOXICITY: Not available. The substance is toxic to thyroid. The substance may be toxic to blood, kidneys, liver, skin, eyes.
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure of the eyes
to a low level of dust can produce eye irritation. Repeated skin exposure can produce local skin destruction, or dermatitis.
Repeated inhalation of dust can produce varying degree of respiratory irritation or lung damage.
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Cold water may be used. WARM water MUST be used. Get medical attention immediately.
Skin Contact:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get
medical attention immediately.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
attention.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may
be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or
corrosive. Seek immediate medical attention.
Ingestion:
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Serious Ingestion: Not available.
[/quote]
...and here is the Fisher Scientific MSDS section on Hazards Identification:
[quote]
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Danger! May cause allergic skin reaction. Harmful if swallowed, inhaled, or absorbed through the skin. Causes burns by all
exposure routes. At ordinary temperatures, iodine sublimes to a violet gas with a characteristic, irritating odor. Target
Organs: Respiratory system, eyes, thyroid, skin.
Potential Health Effects
Eye: Causes severe eye irritation. May cause eye burns. Vapors cause eye irritation.
Skin:
Harmful if absorbed through the skin. May cause severe irritation and possible burns. Rare instances of allergic
reactions to topical iodine solutions characterized by fever and generalized skin eruptions have lead to death. At
least one death after topical application of a strong iodine tincture to one-third of the body has been recorded.
Ingestion: Harmful if swallowed. May cause burns to the digestive tract.
Inhalation: Harmful if inhaled. Causes severe respiratory tract irritation. Extreme exposures could result in a build-up of fluid
in the lungs (pulmonary edema) that might be fatal in severe cases.
Chronic:
Chronic exposure can lead to iodism characterized by headache, excess salivation, nasal discharge,
conjunctivitis, laryngitis, bronchitis, stomatitis, enlarged submaxillary glands, and skin rashes. Chronic ingestion of
iodides during pregnancy has resulted in fetal death, severe goiter, and cretinoid appearance of the newborn.
Chronic exposure can affect thyroid function. Some references (e.g. Dreisbach's Handbook) say that iodine and
iodine compounds are potent sensitizers and that repeated contact may cause sensitivity dermatitis, laryngeal
edema, serum sickness with lymph node enlargement, and joint pain and swelling.
Section 4 - First Aid Measures
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid
immediately.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: POISON material. If swallowed, get medical aid immediately. Only induce vomiting if directed to do so by
medical personnel. Never give anything by mouth to an unconscious person.
Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
[/quote]
Given the above, it would be a mistake to say that elemental iodine is safer than other forms. In fact, it is very dangerous to consume on its own. Do we require iodine for health? Yes. But we don't ingest it in the form of pure, elemental iodine...we ingest it in bound forms such as iodide, which are broken down in the body to yield iodine in very small amounts, as required by the thyroid gland, and so forth. Even Lugol's iodine (or Lugol's solution), as referenced by Abraham and your oft-cited iodine4health.com, a solution of between 1% and 5% elemental iodine, though used very sparingly in the past by doctors treating very specific illnesses, is "irritating and destructive to mucosa, such as the lining of the esophagus and stomach. Doses of 10 mL of 5% solution have been reported to cause gastric lesions when used in endoscopy. The lethal dose of free iodine for an adult human of 2 to 3 grams (2000-3000 mg) free iodine represents 40 to 60 mL (less than 2 fluid ounces) of 5% Lugol's solution." (
http://en.wikipedia....iodine#Toxicity).
[quote name='BioFreak' timestamp='1359812573' post='563436']
Despite the historical evidence, despite the actual evidence, do you see a change in mind in medicine? Nope. Do you see big studies using Iodine for detoxification, or for breast cysts? Nope.
[/quote]
Yes, I do see big studies related to iodine and breast cysts and tumors. These have been going on for decades, without the need for Abraham and his co-salesmen. For example (just in the first page of a quick PubMed search for ["iodine" "breast" -milk]):
http://www.ncbi.nlm..../pubmed/8221402 - "Iodine replacement in fibrocystic disease of the breast."
http://www.ncbi.nlm....pubmed/23171625 - "The potential of iodine for improving breast cancer diagnosis and treatment."
http://www.ncbi.nlm....pubmed/14757962 - "Role of iodine in antioxidant defence in thyroid and breast disease."
http://www.ncbi.nlm....pubmed/12927031 - "The thyroid, iodine and breast cancer."
http://www.ncbi.nlm....pubmed/10720070 - "Tissue iodine content and serum-mediated 125I uptake-blocking activity in breast cancer."
http://www.ncbi.nlm..../pubmed/8637209 - "Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat."
http://www.ncbi.nlm....pubmed/15239792 - "The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia."
http://www.ncbi.nlm....pubmed/21688833 - "Targeted delivery in breast cancer cells via iodine: nuclear localization sequence conjugate."
http://www.ncbi.nlm....pubmed/22027149 - "Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors."
http://www.ncbi.nlm....v/pubmed/343535 - "Iodine and mammary cancer."
Note that none of these involve or cite Abraham or any of the other doctors you've mentioned, all of whom are only notable for the fact that they all work together selling these obscure products on a few websites together. Isn't it just a little strange that the community at large does not have any interest in these doctors, and that they all happen to work together at the same places to sell products based on references to the supposed work of one another?
[quote name='BioFreak' timestamp='1359812573' post='563436']
Now iodine has some very important uses, and modern medicine is still more occupied with creating new molecules they can patent, or with researching gene technology.
[/quote]
"Modern medicine" is interested in all avenues of improvement, not just those that offer the most profit regardless of efficacy. Of course profits drive a huge amount of research, but there is also research driven by the desire to cure and treat illnesses, which is after all the very concept of the Hippocratic Oath (
http://en.wikipedia....ippocratic_Oath). It is always possible for a person or group of people to conspire to do the wrong thing for monetary gain, but it isn't reasonable to assume that EVERY legitimate doctor and researcher has conspired to do so. "Modern medicine" isn't some shadowy organization with fanatical members all sworn to secrecy and intent on making as much money as possible regardless of helping or harming people - it's a consortium of many different organizations and individuals. If there are indications that a certain treatment is more effective than other treatments, SOMEONE will look into this, and if its cost or efficacy is better than the current treatment options, this will lead to its adoption by the medical community in general. This happens regularly in medicine, and isn't at all shunned or suppressed; it is encouraged.
[quote name='BioFreak' timestamp='1359812573' post='563436']
Long story short: it may be unlikely, but that proves nothing. In fact I have shown you several reasons why it might not be so unlikely at all. If you look carefully you will see that NONE of his iodine studies can be found on pubmed too. Why? Maybe because his studies lack financing and are therefore badly setup (no double blind studies with lots of samples).
[/quote]
I don't believe you have shown any reasons why it "might not be so unlikely at all". According to all relevant studies, there is no evidence for colloidal gold improving you IQ. Abraham's study, which was performed by him and two other people working for Optimox (the company and site which you pointed to, that sells the colloidal gold you're referring to) were not corroborated by anyone (and hence, may not have even occurred), and despite the fact that the study states that the "encouraging results of this pilot study warrant further evaluation of colloidal metallic gold in a larger number of subjects of different age groups.", this 1998 study was never followed up by anyone, including Abraham himself. Certainly you don't expect anyone to accept that Abraham can't afford to perform more studies and at the same time, everyone else in the medical community is either conspiring against us in order to make more money, or too scared of those engaged in this conspiracy to speak up. This is not impossible in the literal sense, but being honest, you must admit it is extremely unlikely.
[quote name='BioFreak' timestamp='1359812573' post='563436']
Maybe it is because its killing your career as a researcher if you oppose "common knowledge", even if it is flawed, and won't even get published.
[/quote]
Actually, if you oppose common knowledge and provide evidence in a proper, double-blind, placebo-controlled, peer-reviewed study to the contrary of current practice and understanding, you don't "kill your career" - you become famous (at the very least, within your field). This is how science is propelled forward. If we never challenged the existing understanding of the universe, we would never invent or discover anything. To say that this does not occur in science is completely incorrect. If you're saying that Abraham will eventually become famous when science catches up to his discoveries and performs some real studies, then that's an opinion and you're entitled to it. However, you should keep in mind that there is no evidence for this and much evidence to the contrary, and Abraham gives all the indications of being intentionally deceptive.
[quote name='BioFreak' timestamp='1359812573' post='563436']
I've seen examples of this now in several sciences, at least in physics, or medicine. So because of this reasons, it can be that you do not get published, and if you do, who will take the risk on his career and follow your lead? And then, its not only your career you should be worried about, and future funding of studies, but who the hell will fund a study to replicate a study like that?
[/quote]
Out of curiosity, who are you referring to when you say you have "seen examples of this now in several sciences, at least in physics, or medicine"?
The kind of people and groups that will fund studies like the one you're describing are manifold and diverse. Needless to say, such entities exist, and if science dictates, they will carry out such studies, even for no profit. Academia is immersed in studies with no profit in sight, and that's just one place you'll find research being performed for the sake of science and not just profit. In any case, the fact that no one has performed studies linking colloidal gold ingestion with increased IQ except for Abraham and two co-workers at a place selling the stuff (assuming this study took place and bore the results they claim, which we have no choice but to accept at face value or discard in disbelief) points to only two options: "It doesn't work", or "We don't know if it works". If this is all you're proposing, great. Otherwise, you'll have to point to something providing evidence for Abraham's claims. In the absence of evidence, all we have is his reputation, and given what we've discussed, that doesn't shine too favorable a light on his prospects for believability.
[quote name='BioFreak' timestamp='1359812573' post='563436']
So the only thing that proves that abraham is wrong with his gold studies, is someone replicating his studies, with the same settings, but more samples, and doubleblind. Have you seen this? I haven't, but would be glad if you could point me to such a study. Unless we have such a study, all I can say is: It looks interesting. All you can say is: there is no proof. But you can not say that its a scam, bogus, or simply not true. We simply have not enough evidence to come to a conclusion.
[/quote]
Agreed; I cannot state for certain that Abraham is being intentionally deceptive and selling a bogus product. All I can say is that, based on the evidence already discussed, it certainly looks that way, and there is no evidence to support his claims. We have a guy (no pun intended) who does not appear to be legitimate, selling something with no evidence of its effect. Your statement above is correct.
[quote name='BioFreak' timestamp='1359812573' post='563436']
Now you might be arguing that a guy who has only published stuff on his website is a scam, and I totally agree. But this is not the case. Search on pubmed for Guy abraham, or for abraham ge. You'll see that the studies fit the summary about him I posted earlier. He's done a lot of research, he's done this time. To me it seems he does not prove anymore that he can do research, he simply stopped researching what he can get funds for and researches what hes passionate about. With less funding and thus, less quality. Maybe he's showing some mental decline too, as you stated by referencing that RA study, maybe he is not so careful about writing his studies because he knows they won't be published anyways. Who knows.
[/quote]
Yes; he has been involved in legitimate research with other doctors at real universities in the past. Whether today he is prone to make mistakes in studies as you stated above, or mis-cites intentionally to deceive prospective buyers, this does not improve his standing. There are plenty of doctors in the world, and not all of them are honest professionals who would do no wrong. Unfortunately, there are some people in the world who have no problem selling snake oil.
[quote name='BioFreak' timestamp='1359812573' post='563436']
All I know is that he did exactly the same for iodine, and he was right all along.
[/quote]
What was he right about "all along", and when did he state that this was the case, but was "ignored" by the community? I don't think this occurred. It appears that iodine has had its place for quite a while, and is still used and researched by many institutions, but that Guy Abraham's claims concerning iodine are incorrect and potentially harmful.
[quote name='BioFreak' timestamp='1359812573' post='563436']
And then there is the problem with assessing if it worked or not. Of those people who have tried it, may not have felt much different. I mean, it's likely that you really feel the effects when you are working on complicated stuff. And you have to be aware of it. And the last point is tricky. So one would have to get a good iq test, do it before, and after taking that stuff, and then report the results. Noone did. So even if it worked for the people who took it, it might not be enough to say "wow 20 points iq more is huge try it too!!!", maybe they just didnt feel enough for it to be worth reporting.
[/quote]
Yes; this is always the case, with anything intended to improve cognitive ability. We get past this hurdle by performing very specific tests. Search for the various nootropics on PubMed or elsewhere, and you will see the specific ways we determine what a substance will and will not do.
[quote name='BioFreak' timestamp='1359812573' post='563436']
And then there is the case with the "target group". I guess I am the first one to bring this to attention of a group who is a) willing to try new things b) being aware of sensing psychological changes because we have experience with trying out stuff that might only be subtile, and sensing it and c) where some people are willing to do a proper test setup with pre, mid and post test, in this case iq tests and nback would be interesting.
[/quote]
Yes, Longecity is a great place for this sort of discussion, and I'm glad you brought it here. And yes, pre, during, and post tests are always great for determining effects on cognition; I wish more tests of this sort were performed by regular nootropic users, and people partaking in other forms of attempted cognitive improvement.
[quote name='BioFreak' timestamp='1359812573' post='563436']
But here we have a problem: its not hip to take old school elements. Maybe. I mean, what can they do? thats so last century at best. lol. ok, maybe I am exaggerating a bit now. But what I want to say is that because of these circumstances, it is at least possible, that there is something that may work that hasn't been tested, or put to trial by the community yet.
[/quote]
Yes, it is possible. Many things are possible. The next step after making a hypothesis is to test that hypothesis, and determine whether or not it is correct.
[quote name='BioFreak' timestamp='1359812573' post='563436']
Listen, its a fine line between all this conspiracy and "they dont want us to know" shit and stating facts, how they happened. With iodine, it was no conspiracy of the medical community, it was the circumstances that let the system fail by not replicating 2 key studies, or by not understanding how iodine worked because it was simply too complex to comprehend at that time. There is a big difference between this and the usual "they dont want us to know bla bla" paranoid thinking. With gold its simply, that it's not hip to study it, and too hard to find funding, I guess.
[/quote]
Based on what I could dig up, it doesn't seem like this occurred at all. What was iodine's hidden usefulness, and how was this suppressed? I'd like to know specifics, if possible. From what I can tell, iodine never fell from use in its specific applications, except when other methods proved more effective, less costly, or less harmful or dangerous.
(post continued in a few minutes, as apparently making my entire post at once exceeded the maximum allowed quotes
Edited by LBGSHI, 04 February 2013 - 07:30 AM.