18 replies to this topic

[topsykretts]

SHORT VERSION:

I've lost some hearing in my left ear due to a single use of heroin. Are there any nootropics or supplements or any other ideas anyone might have that could restore some of my hearing?

LONG VERSION:

I have lost a portion of my hearing (mostly in the mid-high frequency range, but I can't be specific, I haven't had a hearing test since this happened) due to injecting heroin one night and passing out in a chair. When I was found by a friend I had to be carried to a nearby bed on the floor and could barely hear. My hearing came back mostly over the next day or so.. but perhaps a week or two after this I fell asleep one night with my left ear against the pillow and when I woke up I could barely hear from that ear. I'm not sure why it was delayed, and I first assumed it was due to wax, but after removing the wax from my ears as best as possible my hearing has not returned in that ear. It did actually restore somewhat a few months ago, but then went back to how it was. In place of the frequencies that I'm missing I have tinnitus across that range of frequencies.

Another interesting thing to note is that when I change position.. go from sitting to standing or from standing to bending down I will hear a rushing sound in my ear, like blood is filling up some area.

Is there anything that I can take that will restore my hearing? I've heard vinpocetine might help.

[MrHappy]

SHORT VERSION:

I've lost some hearing in my left ear due to a single use of heroin. Are there any nootropics or supplements or any other ideas anyone might have that could restore some of my hearing?

LONG VERSION:

I have lost a portion of my hearing (mostly in the mid-high frequency range, but I can't be specific, I haven't had a hearing test since this happened) due to injecting heroin one night and passing out in a chair. When I was found by a friend I had to be carried to a nearby bed on the floor and could barely hear. My hearing came back mostly over the next day or so.. but perhaps a week or two after this I fell asleep one night with my left ear against the pillow and when I woke up I could barely hear from that ear. I'm not sure why it was delayed, and I first assumed it was due to wax, but after removing the wax from my ears as best as possible my hearing has not returned in that ear. It did actually restore somewhat a few months ago, but then went back to how it was. In place of the frequencies that I'm missing I have tinnitus across that range of frequencies.

Another interesting thing to note is that when I change position.. go from sitting to standing or from standing to bending down I will hear a rushing sound in my ear, like blood is filling up some area.

Is there anything that I can take that will restore my hearing? I've heard vinpocetine might help.

I would go see a doctor. There are too many variables to troubleshoot this over a forum chat and the doctor can clean/inspect your ear canal with better tools than you have access to.

[hadora]

are you taking other substances right now (antidepressants, benzo, nicotine, alcohol, cannabis, caffeine ....) ?

[renfr]

Too late the damage is already done, maybe stem cell research will help with your problem but I don't think any nootropic will.
Neuroplasticity might help but there's no guarantee.
I too have slight hearing loss and permanent tinnitus on my right ear, no nootropic has helped so far, my best bet currently is anything that can boost dopamine and acetylcholine as these are most involved in neuroplasticity, for instance L Dopa used in post concussion syndrome (immediatly I think) had huge effects in recovery.

[Turnbuckle]

Heroin is often cut with quinine, which can cause temporary hearing loss.

http://www.ncbi.nlm....les/PMC1380185/


I have some age-related loss at high frequencies, and I noticed shortly after beginning C60 that I got some of that back. I can't say for sure, however, since I didn't get tested for it either before or after. There is, however, a patent application at WIPO that claims the restoration of hearing loss with fullerene derivatives--

http://patentscope.w...WO/2006/028635 )&maxRec=1

The mechanism is possibly the stimulation of stem cells, though they don't mention this.

Edited by Turnbuckle, 16 March 2013 - 10:27 PM.

[hadora]

Too late the damage is already done, maybe stem cell research will help with your problem but I don't think any nootropic will.
Neuroplasticity might help but there's no guarantee.
I too have slight hearing loss and permanent tinnitus on my right ear, no nootropic has helped so far, my best bet currently is anything that can boost dopamine and acetylcholine as these are most involved in neuroplasticity, for instance L Dopa used in post concussion syndrome (immediatly I think) had huge effects in recovery.

did you try high dose piracetam (8 grams +) ? i use it with vinpocetine and it work very good for my right ear tinnitus but you have to stop taking any ototoxic substances (there are a TONS of them)

even L dopa is ototoxic if i remember right

Edited by hadora, 17 March 2013 - 06:02 AM.

[renfr]

Too late the damage is already done, maybe stem cell research will help with your problem but I don't think any nootropic will.
Neuroplasticity might help but there's no guarantee.
I too have slight hearing loss and permanent tinnitus on my right ear, no nootropic has helped so far, my best bet currently is anything that can boost dopamine and acetylcholine as these are most involved in neuroplasticity, for instance L Dopa used in post concussion syndrome (immediatly I think) had huge effects in recovery.

did you try high dose piracetam (8 grams +) ? i use it with vinpocetine and it work very good for my right ear tinnitus but you have to stop taking any ototoxic substances (there are a TONS of them)

even L dopa is ototoxic if i remember right

Nope piracetam even in very high doses did nothing for me or it was very subjective.
I don't take any kind of ototoxic substance.
I think that my damage is due to an overreacting auditory cortex and despite trying any kind of protective supplement such as antioxidants and neurotransmitter modulation (NAC, lipo GSH, fish oil, choline, lipo C, dopamine, serotonin, GABA, etc...) it hasn't changed. It's sure less worse than the first month where it occured and has significantly decreased from its beginning but I don't think it's decreasing anymore.
I'm putting my bet on AM-101 and I guess time will help too.

[brainslugged]

OP should certainly try high doses of piracetam
http://www.ncbi.nlm..../pubmed/9131921

Also, look into Naftidrofuryl.

Best thing to do is to see a doctor, though.

even L dopa is ototoxic if i remember right

L-Dopa is neurotoxic too. You probably shouldn't be taking it unless a doctor has given it to you. It causes/accelerates dopamine toxicity and increases chances of parkinson's and general brain deterioration.

[renfr]

L Dopa is not neurotoxic, what is neurotoxic is one of its metabolite that is DOPAC.
There are several ways to protect your neurons from DOPAC neurotoxicity :

More interestingly, low vitamin D impairs conversion of DOPAC to homovanillic acid due to COMT decrease, this suggests that despite vitamin D being supportive of dopaminergic function is also able to protect the CNS from toxic metabolites such as DOPAC.(http://www.ncbi.nlm....pubmed/19500655)

NAC can protect the substantia nigra. (http://onlinelibrary....20107/abstract and http://www.ncbi.nlm....pubmed/21446024)

Vitamin B6 deficiency is linked with low levels of homovanillic acid (non-toxic metabolite of DOPAC). (http://www.ncbi.nlm..../pubmed/2761676)

Also bacopa can decrease DOPAC neurotoxicity and selegiline protects dopaminergic neurons by increasing SOD.
Selegiline is used in conjunction with L Dopa in parkinson patients and the addition of selegiline can extend L dopa effects by several years.
L-Dopa was just the molecule used in these cases but the point here is that increasing dopamine neurotransmission can increase neuroplasticity.

Edited by renfr, 17 March 2013 - 08:39 AM.

[hadora]

Too late the damage is already done, maybe stem cell research will help with your problem but I don't think any nootropic will.
Neuroplasticity might help but there's no guarantee.
I too have slight hearing loss and permanent tinnitus on my right ear, no nootropic has helped so far, my best bet currently is anything that can boost dopamine and acetylcholine as these are most involved in neuroplasticity, for instance L Dopa used in post concussion syndrome (immediatly I think) had huge effects in recovery.

did you try high dose piracetam (8 grams +) ? i use it with vinpocetine and it work very good for my right ear tinnitus but you have to stop taking any ototoxic substances (there are a TONS of them)

even L dopa is ototoxic if i remember right

Nope piracetam even in very high doses did nothing for me or it was very subjective.
I don't take any kind of ototoxic substance.
I think that my damage is due to an overreacting auditory cortex and despite trying any kind of protective supplement such as antioxidants and neurotransmitter modulation (NAC, lipo GSH, fish oil, choline, lipo C, dopamine, serotonin, GABA, etc...) it hasn't changed. It's sure less worse than the first month where it occured and has significantly decreased from its beginning but I don't think it's decreasing anymore.
I'm putting my bet on AM-101 and I guess time will help too.

if vinpocetine don't work for you i don't think AM 101 will work as they share the same mechanism of action (nmda antagonism)

[renfr]

Too late the damage is already done, maybe stem cell research will help with your problem but I don't think any nootropic will.
Neuroplasticity might help but there's no guarantee.
I too have slight hearing loss and permanent tinnitus on my right ear, no nootropic has helped so far, my best bet currently is anything that can boost dopamine and acetylcholine as these are most involved in neuroplasticity, for instance L Dopa used in post concussion syndrome (immediatly I think) had huge effects in recovery.

did you try high dose piracetam (8 grams +) ? i use it with vinpocetine and it work very good for my right ear tinnitus but you have to stop taking any ototoxic substances (there are a TONS of them)

even L dopa is ototoxic if i remember right

Nope piracetam even in very high doses did nothing for me or it was very subjective.
I don't take any kind of ototoxic substance.
I think that my damage is due to an overreacting auditory cortex and despite trying any kind of protective supplement such as antioxidants and neurotransmitter modulation (NAC, lipo GSH, fish oil, choline, lipo C, dopamine, serotonin, GABA, etc...) it hasn't changed. It's sure less worse than the first month where it occured and has significantly decreased from its beginning but I don't think it's decreasing anymore.
I'm putting my bet on AM-101 and I guess time will help too.

if vinpocetine don't work for you i don't think AM 101 will work as they share the same mechanism of action (nmda antagonism)

AM-101 is a selective molecule, it antagonizes NMDA receptors of the inner ear.
http://www.aurismedi...pies/am_101.php

[hadora]

Too late the damage is already done, maybe stem cell research will help with your problem but I don't think any nootropic will.
Neuroplasticity might help but there's no guarantee.
I too have slight hearing loss and permanent tinnitus on my right ear, no nootropic has helped so far, my best bet currently is anything that can boost dopamine and acetylcholine as these are most involved in neuroplasticity, for instance L Dopa used in post concussion syndrome (immediatly I think) had huge effects in recovery.

did you try high dose piracetam (8 grams +) ? i use it with vinpocetine and it work very good for my right ear tinnitus but you have to stop taking any ototoxic substances (there are a TONS of them)

even L dopa is ototoxic if i remember right

Nope piracetam even in very high doses did nothing for me or it was very subjective.
I don't take any kind of ototoxic substance.
I think that my damage is due to an overreacting auditory cortex and despite trying any kind of protective supplement such as antioxidants and neurotransmitter modulation (NAC, lipo GSH, fish oil, choline, lipo C, dopamine, serotonin, GABA, etc...) it hasn't changed. It's sure less worse than the first month where it occured and has significantly decreased from its beginning but I don't think it's decreasing anymore.
I'm putting my bet on AM-101 and I guess time will help too.

if vinpocetine don't work for you i don't think AM 101 will work as they share the same mechanism of action (nmda antagonism)

AM-101 is a selective molecule, it antagonizes NMDA receptors of the inner ear.
http://www.aurismedi...pies/am_101.php

it is not selective to the NMDA receptors of the inner ear this is why it is injected in the ear and not taken orally but even if it was selective to the inner ear the problem remain the same

what is the cause of your tinnitus ? mine came from the pain medication Ixprim ( Tramadol + paracetamol )

Edited by hadora, 22 March 2013 - 09:52 PM.

[renfr]

I think it was caused by too much racetams, I was taking really high doses of racetams, +1000mg aniracetam, 4000mg oxiracetam and then one day suddenly I noticed a loud tinnitus.
I don't think paracetamol is responsible for tinnitus, tramadol is likely the cause because it acts on serotonin, your tinnitus might be recoverable but the problem with the tinnitus is central habituation and this sets up as fast as 3 months. It's been almost one year (early june 2012) that I got my tinnitus so I guess nothing will do. The only thing we can do is protect our ears as to not make it worse.

[12 String]

Recent experiment regrew cochlear hair cells using a simple research chemical. I have hopes that human studies will quickly follow.
There is a video link on this page that explains the study and results pretty clearly.
http://www.sciencedi...896627312009531

I've tried most of the recommendations for hearing loss or tinnitus and not had results. When the haircells are gone, there's not much you can do except try and regrow them, which until now seemed impossible.

[hadora]

I think it was caused by too much racetams, I was taking really high doses of racetams, +1000mg aniracetam, 4000mg oxiracetam and then one day suddenly I noticed a loud tinnitus.
I don't think paracetamol is responsible for tinnitus, tramadol is likely the cause because it acts on serotonin, your tinnitus might be recoverable but the problem with the tinnitus is central habituation and this sets up as fast as 3 months. It's been almost one year (early june 2012) that I got my tinnitus so I guess nothing will do. The only thing we can do is protect our ears as to not make it worse.

i can confirm you first hand that aniracetam is ototoxic, when i took it after i got tinnitus it worsened
it has been 1 year and 3 months that i have tinnitus and fortunately piracetam and vinpocetine work well for me
The biggest problem when you develop tinnitus is that you can't take drugs anymore because 99% of them have some form of ototoxicity (all antidepressants, the majority of benzo, alot of racetams, nicotine, cannabis, alcohol etc....), better not to be sick lol

[hadora]

Recent experiment regrew cochlear hair cells using a simple research chemical. I have hopes that human studies will quickly follow.
There is a video link on this page that explains the study and results pretty clearly.
http://www.sciencedi...896627312009531

I've tried most of the recommendations for hearing loss or tinnitus and not had results. When the haircells are gone, there's not much you can do except try and regrow them, which until now seemed impossible.

SPI-5557 (sound pharmaceutical) is in preclinical trial for cochlear hair regeneration, i hope they move to phase I quickly

[topsykretts]

I am happy to report that I appear to have restored my hearing. I think the vinpocetine helped, but I've been taking a combination supplement called focus factor which contains a variety of things including vinpocetine. It may have something to do with benzos as well, I spent several days at a friends house and used a fair amount of benzos (xanax and klonopin) during that time, as well as a very small amount of heroin nasally. I can't be sure what it was that fixed it unfortunately.

[Luminosity]

Congratulations. How about entering a rehab to address the underlying problem?

[nickdino]

https://www.fightagi...r-ear/#comments