37 replies to this topic

[BieraK]

http://www.ncbi.nlm....pubmed/26150769
 

Looking downstream: the role of cyclic AMP-regulated genes in axonal regeneration.

Siddiq MM1, Hannila SS2.

Author information

 

Abstract

Elevation of intracellular cyclic AMP (cAMP) levels has proven to be one of the most effective means of overcoming inhibition of axonal regeneration by myelin-associated inhibitors such as myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein. Pharmacological manipulation of cAMP through the administration of dibutyryl cAMP or rolipram leads to enhanced axonal growth both in vivo and in vitro, and importantly, upregulation of cAMP within dorsal root ganglion neurons is responsible for the conditioning lesion effect, which indicates that cAMP plays a significant role in the endogenous mechanisms that promote axonal regeneration. The effects of cAMP are transcription-dependent and are mediated through the activation of protein kinase A (PKA) and the transcription factor cyclic AMP response element binding protein (CREB). This leads to the induction of a variety of genes, several of which have been shown to overcome myelin-mediated inhibition in their own right. In this review, we will highlight the pro-regenerative effects of arginase I (ArgI), interleukin (IL)-6, secretory leukocyte protease inhibitor (SLPI), and metallothionein (MT)-I/II, and discuss their potential for therapeutic use in spinal cord injury.

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Forskolin+PDE4 inhibitor+TDCS = Axon Growth?

 

[Mian Ali Ismail]

Has anyone tried any chemical that has actually helped for any neurodegenerative disease ? Thnks

[normalizing]

stem cell therapy, everything else is bullshit

[Reloading]

Bump! Any news about this matter?

[lourdaud]

Bump. Anything new?

[John250]

Anyone using sheng di huang? Have you noticed and improvement in adrenal fatigue?

[normalizing]

im skeptical some herbal extract will do anything noticeable. thought they always show promise in petri dishes

[StevesPetRat]

https://www.alzheime...(14)01300-4/pdf

Eighteen month-old male Wistar rats were fed either a Control diet or a diet enriched with Fortasyn Connect (FC), a specific nutrient combination containing uridine, the omega-3 PUFAs docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium. The Control diet was fed for 4 weeks while the FC diet was fed for either 4 or 6 weeks. After these intervention periods, the rats were sacrificed and hippocampi were obtained for analyses of NogoA levels.
 
Results: Levels of Nogo-A were decreased by 66% (p<0.05 vs. Control) in group that received the FC diet for 6 weeks. Dietary intervention with the FC diet for 4 weeks tended to reduce Nogo-A levels.

Caveat: obviously the 4 week intervention did not produce a positive result with adequate statistical significance, so you may take the other with a grain of salt.

Edited by StevesPetRat, 06 July 2018 - 05:54 AM.