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Sunifiram?

sunifiram

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#271 Isochroma

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Posted 07 April 2013 - 12:44 AM

As for the Shulgin protocol, it's not really formal but it's the approach Alexander found was most safe and useful when trying untested chemicals.

He started with very tiny doses - often 1mg - and doubled the dose after suitable washout periods.

He also avoided combining untested new chemicals with other drugs, especially ones that can be potentiated like stimulants - at least until he had some experience with the new chemical and then only gradually.

As for my own diet, it includes zero caffeine or alcohol - both drugs which can be hazardous when mixed with others. Caffeine due to its potentiation and alcohol because it disables the liver and significantly alters metabolism of most drugs. Preventing drug clearance can result in toxic levels being reached and sustained enough to cause injury, depending on the drug.

In normal cases a physician would advise before putting a patient on a drug to abstain from certain other drugs/herbs. Interactions would be tested first.

That isn't the case here - Sunifiram is untested and unapproved, yet still about 99.999% of such complications can easily be prevented by careful exploration of low doses to higher doses working from a 'clean' foundation of natural foods and vitamins/minerals.

Edited by Isochroma-Reborn, 07 April 2013 - 01:08 AM.


#272 Isochroma

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Posted 07 April 2013 - 12:55 AM

Now, I wonder what amazing places 55mg Sunifiram + some LSD would take one?


Caffeine is a weak stimulant! I wonder what would happen with a single Amphetamine pill of 10mg, or a pill of MDMA?


Even weak Piracetam has all the rollers at Bluelight in a tizzy because it turns their MDMA into high-energy psychedelic trips.


Somebody will have to try these things, or someone will make the mistake of unknowingly trying them... one or the other, soon we will know if this is what it is like knocking on Heaven's door.


Remember, a power amplifier amplifies both the good and the bad and makes kittens roar like lions.


Be sure to turn your volume down before jacking into the Sunny Matrix, please.


Enjoy your flights!


Edited by Isochroma-Reborn, 07 April 2013 - 01:21 AM.


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#273 MizTen

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Posted 07 April 2013 - 01:04 AM

DO NOT TAKE OVER 100MG DO NOT TAKE OVER 100mg
i learned this the hard way guys
i started at 10mg and felt very well, almost everything everyone here got like enhanced vision, feeling aware and less need for sleep.
i wanted to try high doses and see how this feels, i went from a bare 15mg to 150mg, BAD IDEA VERY BAD IDEA also i took my car with a bud, 30 mins after i felt funny almost like on a psychedelic or something my vision was warping everywhere i could barely see the traffic lights
i started sweating a lot like crazy yet it wasn't hot at all, having hot flashes and i felt in an intermediate state between dream and reality, i told my pal i'm not feeling alright at all he wa sseeing that i was truly sweating to death you could see it from my clothes really
i didn't want to call an ambulance yet i thoguht i could make it thought i was not really conscious of anything, i could think but not move properly my limbs were shaking ike you know you take 10 cups of coffee i wasn't able to read anything at all my vision was too distorted from that (no hallucinations though), i had some kind of dizziness and huge patches they were purple on my vision
then later my heart started having a chest pain it was really beating fast and pumping hard like a heart pounding you know, my friend immediatly called an ambulance and i went to the ER, i was hooked up to a heart rate monitor it was beating over 160 a,d blood pressure was very high they administered me a drug thru IV and it got better overtime they told me i did a hypertensive crisis they asked me what did i take, i told them i don't know what happpened i didn't want to give a bad rep to this compound.
now read me up be very careful with very high doses, this is very DANGEROUS
maybe there is an interaction with my stack, i bodybuild and this is what i take daily:
- 5 grams creatine
- hydroxycut + NO xplode
- ultra strenght multivitamin
- 5 grams piracetam
- 10 grams fish oil
- 3 grams taurine
- one teaspoon caffeine anhydrous
i don't want to discourage anyone top take high doeses but heres my story in case


Wow, sorry this happened. But you are OK, I hope. Thanks for posting. Yes, your stack and the suni dose were way too much. It is amplified by anything stimulant, and likely other things. Lucky you had a friend with you.

#274 Isochroma

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Posted 07 April 2013 - 01:17 AM

It appears Sunifiram not only completely destroys all Caffeine tolerance but it also potentiates Caffeine enormously.

What was a normal dose to a tolerant user became an overdose. And yes - though Sunifiram itself has no toxicity - he could easily have died from heart failure / excess blood pressure. It may have been the equivalent of taking 100x the normal Caffeine dose.

A regular Heroin user's doses would kill a person who never used it before - tolerance.

There is no drug yet that so completely reverses Heroin tolerance and likewise for most other commonly-used depressants - but there is now for at least one stimulant.

It's actually really good news because if such chemistry holds for others as consistently then Caffeine just got one Hell of a lot more affordable.

One bean instead of one cup of coffee. One bite of a chocolate bar. Rocket to Mars.

And I was planning on buying 10g Adrafinil and likely combining it with Sunifiram!

Luckily Adrafinil/Modafinil are much more selective and so there is good reason to believe such cardiac problems will not occur. Both are mild stimulants.

How much more sensitive to their effects can the human body be made?

What true powers lie behind the deceptive masks of things as we thought they were for our whole lives?

In the case of caffeine, its toxicity and the symptoms of overdose should not be confused - they are different beasts. Overdose symptoms occur well below the doses that produce toxicity and are the result of excessive stimulation rather than poisoning.

Increasing the body's sensitivity to Caffeine is good for more reasons than your wallet - the sensitivity is to the stimulant effects but some of the other negatory effects in the whole body, such as the elimination burden on liver, kidneys, etc. are purely dose-related.

That means that to get the same effect under Sunifiram potentiation - a much smaller dosage - say 1/5 - is needed. That means only 1/5 the money cost and also 1/5 the toxic burden on liver, kidneys, etc for the same amount of desired effects.

Changing that balance alters the Return on Investment or ROI of a molecule and may even elevate the ROI from negative to positive valuation in the purely biochemical sense.

Edited by Isochroma-Reborn, 07 April 2013 - 01:28 AM.


#275 wurm

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Posted 07 April 2013 - 01:23 AM

where did you actually read it potentiate stimulant, own experience or something real?
if this potentiate too much this could be dangerous, they should put a warning or something because if there was i wouldn't touch this even with a bargepole
maybe this drug is a new psychedelic, i hope not or the government will ban it
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#276 Isochroma

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Posted 07 April 2013 - 01:34 AM

Sunifiram makes other drugs more powerful by making your body more sensitive to them.

It doesn't do anything by itself other than facilitate things your body already does.

Sunifiram is not a psychedelic but you experienced severe brain issues due to caffeine overdosage.

Caffeine in very high doses results in such effects - doses you would never have experienced otherwise.

These are all good things but you were doing the equivalent of shouting into an amplifier that had lost its sensitivity due to tolerance, aging and damage - and lack of full evolutionary capacity too.

Sunifiram restored your amplifier to full operational capacity - maybe even better than full - and suddenly you found yourself shouting into an amplifier turned up to the maximum.

The amp put out a very very loud sound that almost stopped your heart dead.

That is the measure of how much more responsive a body can become once it's aging, damage and tolerance are removed.

That's what it is like to truly become young again - even better than young in fact - better than even Nature could evolve or God could design.

And that is the very core and essence of becoming transhuman - transcending the pitiful limitations of our old shell.

With new powers comes new dangers and responsibilities.

The first steps are always full of both danger and opportunity.

Know this all who read here and decide if you want to stay within safe boundaries or move into the uncharted realms where both your dreams and your nightmares can come true.

Edited by Isochroma-Reborn, 07 April 2013 - 01:35 AM.


#277 Izan

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Posted 07 April 2013 - 01:47 AM

i wonder what sunifiram will do for both sulbutiamine en phenylpiracetam, people experience rapid tolerance with those two substances.

#278 Introspecta

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Posted 07 April 2013 - 01:52 AM

I don't think he is the first person to mix caffiene with Sunifram. MisTez reported drinking a cup of coffee and didn't mention anything about potentiation but maybe didn't realize how it added the extra stimulation...

I normally don't feel the caffiene in Yerba Mate because of the Theobromine I think but It did seem like the effects were greatly improved after having a cup of Yerba mate with 2 tea bags. I hope this is the case as I'm trying to get off caffiene and it would make it much easier if Tea and yerba mate will actually work. When not taking Sunifiram I'll still have caffiene withdrawals if only drinking tea or Yerba Mate. This will make it much easier to taper off and use sparingly.

#279 peakplasma

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Posted 07 April 2013 - 01:59 AM

i don't want to discourage anyone top take high doeses but heres my story in case

Wurm, I'm so sorry what happened to you and I really hope you're feeling better.

I think it might be a good idea to take a break from Sunifiram and recuperate. Please keep us updated about any lingering symptoms you may experience.

Thank you for posting your experience; it is an important contribution to determining the known risks and the "unknown unknowns" of Sunifiram.

#280 emckai

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Posted 07 April 2013 - 02:06 AM

Sunifiram makes other drugs more powerful by making your body more sensitive to them.

It doesn't do anything by itself other than facilitate things your body already does.

Sunifiram is not a psychedelic but you experienced severe brain issues due to caffeine overdosage.

Caffeine in very high doses results in such effects - doses you would never have experienced otherwise.

These are all good things but you were doing the equivalent of shouting into an amplifier that had lost its sensitivity due to tolerance, aging and damage - and lack of full evolutionary capacity too.

Sunifiram restored your amplifier to full operational capacity - maybe even better than full - and suddenly you found yourself shouting into an amplifier turned up to the maximum.

The amp put out a very very loud sound that almost stopped your heart dead.

That is the measure of how much more responsive a body can become once it's aging, damage and tolerance are removed.

That's what it is like to truly become young again - even better than young in fact - better than even Nature could evolve or God could design.

And that is the very core and essence of becoming transhuman - transcending the pitiful limitations of our old shell.

With new powers comes new dangers and responsibilities.

The first steps are always full of both danger and opportunity.

Know this all who read here and decide if you want to stay within safe boundaries or move into the uncharted realms where both your dreams and your nightmares can come true.



So basically Sunifiram will make other racetams more powerful in the body?
Maybe that is why Sunifiram hasn't been doing anything for me, I've only been taking Sunifiram alone.

Tomorrow i'll take 15mg of Sunifiram with Piracetam.

#281 Introspecta

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Posted 07 April 2013 - 02:16 AM

I took nothing other than Sunifram and got effects. Well I added Yerba Mate but was feeling effects before it kicked in. Try taking 20mg or 30 mgs and you will most likely feel effects before adding piracetam.
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#282 Isochroma

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Posted 07 April 2013 - 02:23 AM

Sunifiram combines well with Piracetam - I started by ovelapping the two yesterday taking 10mg and also trying 139mg Sunifiram with 5g Piracetam.

However, the Sunifiram's effects were so powerful that I just didn't notice the Piracetam much.

That may change as Piracetam's residual effects fade in the coming days.

Expect the most powerful potentiations to be with Psychedelics and Stimulants.

Also, your reaction to combining Sunifiram and any stimulant will crucially depend on how tolerant you already are to the stimulant, especially caffeine.

If you're high-dosing caffeine due to a builtup tolerance, or even if you needed high doses from the beginning - be prepared for a potential suprise. Potentiation suprise that is - though results will vary so the best advice I can give is to stop all caffeine/stimulant intake before starting Sunifiram and only restart it gradually in small doses - say 1/10 of normal dose.

Caffeine is also hidden in many foods including most soft drinks and is present in many (a majority) of workout supplements, often with a different names.

Ingredients that Contain Hidden Caffeine lists them including the unrecognizable chemical name of trimethylxanthine or 1,3,7-trimethylxanthine.

Some workout supplements also contain other stimulant(s):

From "Is the Seller to Blame? Workout Supplement Challenged After Death of Soldier"

Pronounced “jacked,” as in “jacked up,” Jack3d contains a powerful stimulant called dimethylamylamine, or DMAA for short, which some medical experts and health regulators say has similar effects on the body as amphetamines.


Even the unregulated Phenethylamine sold on many sites and part of workout formulas is a stimulant or quickly metabolized into natural stimulants inside the brain. Any of these if overdosed or overpotentiated via Sunifiram can result in a 'hypertensive crisis': too-high blood pressure and/or heart fibrillation/failure.

Hypertensive crises can result in permanent brain damage and retina damage - loss of eyesight - even if the person does not appear to suffer immediate damage. This is because the too-high blood pressure bursts open the weak super-thin blood vessels inside the retina and brain. They are the weakest because they are so thin - there isn't room for thick blood vessels in the retina or brain due to the fine networks of cells they serve.

When the thin blood vessels burst then cells that need blood don't get it and worse, the blood spills into areas it shouldn't be causing much more damage.

Just taking PEA or certain other stimulants with a MAO inhibitor or reuptake inhibitor can also result in such problems.

Edited by Isochroma-Reborn, 07 April 2013 - 03:11 AM.


#283 renfr

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Posted 07 April 2013 - 02:33 AM

If he really took one teaspoon caffeine as he said then it's more than normal.
1 teaspoon caffeine is the equivalent of 5000mg of caffeine, some people have died from taking only 2000mg.
Your symptoms are that of caffeine overdose, consider yourself being lucky because you're not dead.
I don't think Sunifiram is the cause at all, either it is a troll trying to sully Sunifiram and refrain everyone to take it (there was a troll months ago who admitted to try to give a bad reputation to nootropics) or either it is a lucky idiot who took too much caffeine.
Whether it was tested on animals or humans at very high doses doesn't matter, 100 times the dose is enough to claim that it is likely safe at 100mg, best is to double up the dose each time and not jump from a small dose to a huge one.

By the way, anyone knows the half-life of this compound?

#284 MizTen

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Posted 07 April 2013 - 02:36 AM

I don't think he is the first person to mix caffiene with Sunifram. MisTez reported drinking a cup of coffee and didn't mention anything about potentiation but maybe didn't realize how it added the extra stimulation...

I normally don't feel the caffiene in Yerba Mate because of the Theobromine I think but It did seem like the effects were greatly improved after having a cup of Yerba mate with 2 tea bags. I hope this is the case as I'm trying to get off caffiene and it would make it much easier if Tea and yerba mate will actually work. When not taking Sunifiram I'll still have caffiene withdrawals if only drinking tea or Yerba Mate. This will make it much easier to taper off and use sparingly.


I realized fairly soon, (maybe on the 2nd day) that there was some interaction with caffeine. In fact, I started checking my other supplements to see how much total caffeine I was getting. But wurm was taking a lot of caffein, and I think Isochroma may be right that sunifiram removes tolerance. But I swear up and down that the effects of sunifiram did not feel like any stimulant I've ever taken.

Ironically, or maybe luckily, I had already decided that caffeine was not all that helpful for me on a daily basis and planned to use it only on an "as needed basis", such as driving at night or on a day when I've had too little sleep the night before and something important is coming up.

The Yerba Mate might be a really good accompanyment to the sunifiram, (in small doses!) it sounds like it worked for you. There are also a few other nootropic teas that may really potentiate the happy, sparkly, colorful effects of sunifram without increasing the stimulant like effect.

Edited by MizTen, 07 April 2013 - 02:41 AM.


#285 Isochroma

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Posted 07 April 2013 - 02:39 AM

Those with built-up tolerance to a stimulant are at the worst risk of overpotentiation if they combine said stimulant with any drug that reverses such tolerance - like Sunifiram does.

There are a number of variables however - including usage history, genetics and other factors so caution is warranted.

As for half-life, it was reported earlier in this thread that the acute effects last 3-4 hours, with some experiencing residual difficulty falling asleep for longer. I don't have any trouble falling asleep on 55mg immediately before bed, but it has taken me about 1/2 hour longer to fall asleep so far.

#286 MizTen

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Posted 07 April 2013 - 02:47 AM

i wonder what sunifiram will do for both sulbutiamine en phenylpiracetam, people experience rapid tolerance with those two substances.


On the 3rd day, I took it with part of my usual stack, which includes sulbutiamine, piracetam, picamilon, centrophenoxine, and hordenine. Whether or not that changed anything with the sunifiram, I don't know. I'd only been taking the noots for about a month before sunifiram. I washed out for 3 days before starting the sunifiram.

But I didn't really hit a let-down stage with the suni until the sixth day.

Edited by MizTen, 07 April 2013 - 02:51 AM.


#287 Isochroma

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Posted 07 April 2013 - 02:59 AM

Well, I have a nice wonderful report for everyone!

My second day of Sunny is done and I just took the 7:30p dose:

10:30a: 55mg
1:30p: 55mg
4:30p: 55mg
7:30p: 55mg
10:30p: 55mg
Bedtime: 55mg

Total = 330 mg/day

After a record-shattering 5.75 hours of sleep last night - the hours of which would normally leave me an afternoon zombie nodding off every minute and fighting to stay awake - it didn't happen this time.

Even in a normal 8.5-9 hours of sleep regime with saturation dosing of Piracetam + Oxiracetam or Piracetam + Pramiracetam - both of which were the best racetam stacks I tested - I was still nodding off and unable to keep focus and keep going.

The brilliant shine of Sunny has cleaned out my eternal mind - or it seems so far. I am confident in the continuation of these effects because I stack lots of high-dose supplemental vitamins and minerals along with high-dose fish oil to provide the 'building materials' that are demanded when the brain restructurizes to the extent that Sunifiram drives it to.

Eternal Sunshine of the Energized Mind

Edited by Isochroma-Reborn, 07 April 2013 - 03:02 AM.


#288 MizTen

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Posted 07 April 2013 - 03:02 AM

I want to add that today is the 12th day since I first took sunifiram. I didn't take it yesterday, nor any other nootropics. Today I took 30mg, which is very high compared to my previous doses of between 8-15mg in the course of 6 hours.

But it is having a downside so I will stop. My memory is fuzzy, i.e. "what did I come into this room for, where did I put something...etc.." This is a little below my normal baseline, not much, but even so, I think my brain is tired and needs a break.

I hate that the happy sunny effect is now absent. But there are also some mild positives still lingering, and I've got some ideas for how to use this and other noots more effectively. The thing is, sunifiram seems so responsive to so many things that it's hard to sort out all the variables.

#289 renfr

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Posted 07 April 2013 - 03:08 AM

But it is having a downside so I will stop. My memory is fuzzy, i.e. "what did I come into this room for, where did I put something...etc.." This is a little below my normal baseline, not much, but even so, I think my brain is tired and needs a break.

Could be excess dopamine release triggered by Sunifiram. High dopamine causes low serotonin and so on, serotonin is selectively involved in short-term memory, it should resolve with long-lasting use.

#290 Isochroma

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Posted 07 April 2013 - 03:24 AM

MizTen:

Potentially lack of choline. You can try synthetic choline but I recommend eating eggs (the yolks contain the choline) and fish/meat daily because the natural sources contain needed cholesterol and other co-factors that prevent the problems caused by intaking isolated choline. Problems that are extensively documented in post after post on this forum and others - including depression.

Supplement with 14g+ fish oil - that's only one 213g can of salmon - if you don't like or can't afford to swallow fishoil gelcaps.

Take B-Complex 100mg.

Those are my best recommendations.

I have reviewed many hundreds of cases similar to yours that occur with racetams. The cause of racetams working for a short while and then failing is because your brain is short on raw materials and change is being demanded faster than it can supply them. The racetam/raceram works temporarily because there's a 'pool' of available material that even a deficient brain maintains for basic operation.

However, the intake rate is too low (the water intake is only a thin pipe for example) so when that pool becomes depleted after a few days then the effect decreases or vanishes, or bad effects like headaches begin.

Omega-3 is the prime example since it's the main component of all brain membranes and a lot more. The B-Complex is also crucial and very deficient in a 'normal diet'.

I encourage you to invest in the time and funds to find out the cause - this molecule is very rewarding and it would be a crying shame to lose the initial effects. Since racetams and likely racerams have no tolerance effect then by logical conclusion the only alternative explanation I can think of is depletion of a limited pool of source materials.

Edited by Isochroma-Reborn, 07 April 2013 - 03:26 AM.


#291 MizTen

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Posted 07 April 2013 - 03:36 AM

MizTen:

Potentially lack of choline. You can try synthetic choline but I recommend eating eggs (the yolks contain the choline) and fish/meat daily because the natural sources contain needed cholesterol and other co-factors that prevent the problems caused by intaking isolated choline. Problems that are extensively documented in post after post on this forum and others - including depression.

Supplement with 14g+ fish oil - that's only one 213g can of salmon - if you don't like or can't afford to swallow fishoil gelcaps.

Take B-Complex 100mg.

Those are my best recommendations.

I have reviewed many hundreds of cases similar to yours that occur with racetams. The cause of racetams working for a short while and then failing is because your brain is short on raw materials and change is being demanded faster than it can supply them. The racetam/raceram works temporarily because there's a 'pool' of available material that even a deficient brain maintains for basic operation.

However, the intake rate is too low (the water intake is only a thin pipe for example) so when that pool becomes depleted after a few days then the effect decreases or vanishes, or bad effects like headaches begin.

Omega-3 is the prime example since it's the main component of all brain membranes and a lot more. The B-Complex is also crucial and very deficient in a 'normal diet'.

I encourage you to invest in the time and funds to find out the cause - this molecule is very rewarding and it would be a crying shame to lose the initial effects. Since racetams and likely racerams have no tolerance effect then by logical conclusion the only alternative explanation I can think of is depletion of a limited pool of source materials.


Thanks, Isochroma, I'm good with the dietary side due to being on a Paleo type diet (with some dairy) for about 18 months. Lots of pastured eggs, wild Alaskan salmon, grass fed beef and lots of veggies. The dietary change alone corrected or reduced a lot of problems, especially inflammation, fatigue, and anxiety. My supplements are really good. Additionally, I take centrophenoxine. There will be some tweaking to do though, to see if the effects will return. It appears that the effects of coluracetam did last. Maybe that will be the best noot in the end.

But I think that it is very likely, as you say, that the pool of available resources becomes depleted, even in someone like me who has a very nutrient dense diet with enough choline and B-vitamins. The drug itself causes such an increase in brain activity that you probably need to pay even closer attention to what you are eating, doing, etc.

The possible potentiators people have mentioned are really fascinating, as someone commented, sunifiram effects are rather "organic" and so it seems may be the best potentiators, tea, exercise, Yoga!, meditation, outdoors, etc.

Edited by MizTen, 07 April 2013 - 03:44 AM.


#292 Isochroma

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Posted 07 April 2013 - 04:04 AM

Centrophenoxine is a xenobiotic (unnatural) source of choline and could be your problem too since it affects cholinergic regulatory systems.

Might try a week off the Centro and retest the Sunifiram alone.

The rest of your diet sounds good.

#293 Darkat

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Posted 07 April 2013 - 07:20 AM

Some very interesting information on sunifiram on here. I got my supply on Thursday last week and started on it on Friday - 8mg. Definitely got the increased awareness of hot colours and have also found it to enhance music(like oxiracetam used to do with me, but it wore off). Would also agree about the sharp edges effect. Took 10mg sunifiram on Saturday and again this morning.

No sense of a stimulant effect and can't say that I have noticed it potentiating caffeine (in coffee). It does certainly give a "all is well" effect, very calming - probably better for weekends rather than workdays, so I am looking to take it just at weekends - hopefully this will stop any tolerance building up, that other people have mentioned. I will continue with my low dose of nefiracetam in the week - the only racetam that I have taken that has never lost it's effects - calming/anxiolitic, increased focus.

Would agree that sunifiram potentiates racetams though - took some oxiracetam on Saturday afternoon and it definitely had some of the nice effects it had when I first took it back in October. The two certainly seem to go well together.

Not noticed any negative effects - typing, etc seem fine - although I have to say that I have had this effect from noopept - spastic typing, forgetting where keys are, etc. In fact, I have found noopept to be really quite negative in regards to working memory and will be stopping using it. Is this anything to do with the proline? I know it is a dipeptide of glycine and proline, and have a not read something somewhere about proline being an amnesiac substance?

:)

#294 Dissolvedissolve

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Posted 07 April 2013 - 07:45 AM

Not noticed any negative effects - typing, etc seem fine - although I have to say that I have had this effect from noopept - spastic typing, forgetting where keys are, etc. In fact, I have found noopept to be really quite negative in regards to working memory and will be stopping using it. Is this anything to do with the proline? I know it is a dipeptide of glycine and proline, and have a not read something somewhere about proline being an amnesiac substance?


There is an interesting study I read a while back suggesting that noopept's short and long-term effects are quite different. The short-term effects seem to be largely mediated by noopept, and I find them to be thoroughly non-nootropic, though pleasant. The longer term effects seem to be largely mediated by a metabolite, cyclopropylglycine, that seems to increase BDNF and NGF. (I don't have the link right now, but you can search Pubmed.)
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#295 Darkat

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Posted 07 April 2013 - 07:57 AM

Thanks for the information Dissolvedissolve, I had read about the cyclopropylglycine metabolite from noopept - this is a natural nootropic I believe, that exists in the brain anyway. However, I would still like to know what happens to the proline off the noopept since I have definitely read about that having amnesia causing effects.

At the moment, I think I am happy with the nefiracetam and sunifiram, with a bit of oxiracetam every now and again. I will leave noopept alone - I take nootropics to enhance brain function, not to make my memory worse.

;)

Edited by Darkat, 07 April 2013 - 07:57 AM.


#296 emckai

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Posted 07 April 2013 - 03:50 PM

I'll probably skip Sunifiram today, going hiking in a few hours and I don't want any discomfort. I'm not sure how i'll react with Sunifiram+Piracetam.

I will wait until tomorrow!

#297 Introspecta

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Posted 07 April 2013 - 04:08 PM

Music sounds amazing on Sunifiram closely resembling Amphetamines. I've always loved electronic music especially Drum and Bass and listening to it right now the enhancement is so close to amphetamine. I'm not saying the effects of sunifiram are amphetamine like although there could be a smidgen of comparison due to the stimulant semi euphoric effects.

Isochroma do you get any teeth clenching from the stimulant effects when super dosing this stuff?

#298 renfr

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Posted 07 April 2013 - 04:47 PM

I am almost convinced that this compound interacts a lot with dopamine due to the following reports :
- much more motivation
- short term memory impairment
- difficulty typing on the keyboard
- food is more tasty
- less need for sleep
I guess I will taper off sulbutiamine before trying this, I don't want to end like that other guy though it's probable that it was only because of the caffeine that this happened to him.
I'll receive my stash this week so I will report very soon.

#299 Isochroma

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Posted 07 April 2013 - 06:08 PM

Food is more tasty... yes!
Jaw Clenching... no!
LESS NEED FOR SLEEP... YES!!!!!!

Last night: 5:45a bedtime / 10:35a WIDE AWAKE: Total = 4 hours 50 minutes.

Normal requirement = 8.5 - 9 hours.

When I woke up this morning I immediately noticed the visuals are super-sharp even before the first dose.

Edited by Isochroma-Reborn, 07 April 2013 - 06:09 PM.


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#300 Introspecta

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Posted 07 April 2013 - 06:09 PM

Yeah I was thinking the same. In all honesty so far i'm receiving more Drug like effects than Nootropic Effects..Maybe the better Nootropic effects are from the low dosing after a period of time.





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