1565 replies to this topic

[Dissolvedissolve]

Think there is tolerance, but little to early to tell, I have been increasing the dose each time as I have got a bit braver, at first was veryncatiousnwith a 20mg but have taken 200mg and also inhaled smaller doses, hmakes you cough. I want to thoroughly test this , and find out tolerance issues and also withdrawal problems, I am prepared for both and accept the unknown side effects, I have been dip sticking my urine and monitoring blood pressure, but still there is a risk as no real human trials, they have tested up to 1mg/kg in mice but no way of knowing the relevant human dose but I'm guessing its higher, no evidence to back this up but we have bigger brains, more synapses and receptors for it to work on. I'm also on memantine so some of my NMDA receptors are blocked, hopefully protecting me from risks of glutamate hyperactivity.

You realize that human doses in terms of mg/kg are much lower than rat doses, right? I did the calculations a page or two back, and the largest dose tested in a single rat study is equivalent to roughly 200 mg in humans.

[paul]

I read that also, they quoted 0.09 mg or something low for the corresponding human dose, do you know how they work this out?

Thanks for NMR quibi, I am planing to buy 50 grams but am waiting to see if either sun nootropics or newstar nootropics launches unifiram or irda-21. Do you have any plans on these as I could then combine the cost of ems postage. There would be a huge demand especially if you launched Nsi-189 or plR-8-147, I'd be happy to pay higher prices as these last two compounds are in a different league, hopefully this group buy will work, think this shows the demand for these compounds.

Edited by paul, 07 May 2013 - 07:43 PM.

[Dissolvedissolve]

You get corresponding dosages via allometric scaling. Just enter in the weights for the test animal and a human, and it'll work out the dosage. If the animal dosage is given in mg/kg, you need to multiply by the weight of the animal to get the animal dosage, and plug that in. http://home.fuse.net.../allometry.html

[health_nutty]

I'm thinking 10mg 3x a day is too much for me. The effects seem to build up over time. 10mg 3x used to do nothing for color saturation. Now red lights are waaaaaay enhanced and I'm getting some signs of overdoing it (mild headaches, more difficult to concentrate, overstimuation). I'm cutting back, stat!

[Isochroma]

Sunifiram has continued to work better for me each day - though it was already good enough on day two.

Rather than tolerance, Sunifiram exhibits a positive therapeutic effect which means each dose results in a net improvement of brain function. Therefore - as others have pointed out in this thread - the effects get stronger each day.

It's one month today since I started and I've got only about one dose left from the 5g I bought last month.

And I'm still sleeping only four hours each night and waking up to new brilliant days!

For my whole life I have always required 8.5-9 hours sleep each night.

Not anymore

Edited by Isochroma-Reborn, 07 May 2013 - 10:51 PM.

[Isochroma]

Today I received my second Sunifiram order - this one ten grams - from New Star Nootropics.

A two-month supply in that same tiny jar that the five grams arrived in.

I paid for Express Mail shipping so it arrived to Canada in only eleven days.

EC201724916US

There is a very strong effect of higher intelligence which I am receiving from Sunifiram. The effect is consistent and becomes more valuable each day. Not only am I more positive in my daily activities but I am thinking levels deeper.

It's been only thirty days since I started Sunifiram but over the course of that time drastic and evolutionary changes to my internal self-image and the way I do things have occurred. I am less rushed - rather slower now but not the slowness of Aniracetam - just the lazy slowness of knowing everything - but more effective. There isn't so much work when I'm not running back and forth due to inefficient task allocation and/or forgetfulness. Sunifiram eliminated such inefficient behaviours by about ninety percent.

The part I like the most though is being able to work all afternoon without a trace of sleepiness/brain fatigue. Even though my condition is very bad - muchly decayed since starting Piracetam in the summer of 2008 - Sunifiram has not let me down one single day.

Even saturation doses of Piracetam + Pramiracetam or Piracetam + Oxiracetam could only knock back the fatigue by 90% and still left me - as of last month - in a half-awake state. I'm still taking the Piracetam for its extra unique benefits - including mental speed, anti-dizziness effect, and a few others which are hard to describe.

Edited by Isochroma-Reborn, 08 May 2013 - 02:25 AM.

[brendan1]

Based on you guys experiences, what dosing regimen would you suggest for starting out? I started this thread but am just now expecting my first order any day now from New Star. Thanks!

Edited by brendan1, 08 May 2013 - 06:46 PM.

[health_nutty]

5mg in the morning for a few days. Then up to 10mg. Suni is strong stuff.

[Passion]

Isochroma, I remember your first experiences with Piracetam were pretty intense. You saw the world in a new light, you had the vernacular and written proficiency of a world-renowned 18th century novelist, and you had your life completely changed. These effects have seemingly diminished for you as far as Piracetam goes. You've mentioned in this forum that Sunifiram tops Piracetam but would you say it's as good (or close to as good) as Piracetam was the first month that you took it?

In particular, I'm referring to this post (and the ones following it):
http://www.longecity...ep/#entry336426

[paul]

Nearly everyday somebody tells me that I am speaking to fast, never had this problem before I started on sunifiram. My dose is on the high side, still taking around 200mg plus a day. Anyone else noticed this, The lay public will think this is mania, it's not, it's just enhanced cognition, faster thinking, Mania, you do irrational things. I have an app which plays lecture videos up to 3x speed, this is starting to sound slow and have been looking if there are any apps which can go faster, think this says a lot about this compound, will the effects last, who knows, but only way to find out is to continue taking it.

[Dissolvedissolve]

Nearly everyday somebody tells me that I am speaking to fast, never had this problem before I started on sunifiram. My dose is on the high side, still taking around 200mg plus a day. Anyone else noticed this, The lay public will think this is mania, it's not, it's just enhanced cognition, faster thinking, Mania, you do irrational things. I have an app which plays lecture videos up to 3x speed, this is starting to sound slow and have been looking if there are any apps which can go faster, think this says a lot about this compound, will the effects last, who knows, but only way to find out is to continue taking it.

It's actually a symptom of mania to deny that one is manic. It's common for manic individuals to state that not only are they not sleeping, but they don't need to sleep. They've moved beyond the need for sleep.

I'm not sure if I'd call manic actions irrational per se. For that manner, people can often accomplish many things when they're hypomanic.

My point is not to suggest that you're manic, but just to encourage you to be careful. Your perception of your cognition and your cognition as it is measured are two very different things.

[paul]

Found it, apps called rate-tweak, but you need cydia (jailbreak). Voiceovers fastest speed is now twice as fast!

I realise this is of no relevance to anyone, I'm posting it just to show that these results are real, Dissolveddissolve, I will let you know if I get sectioned lol, but you are right, it's a huge risk taking any chemical that hasn't been fully tested and even more so at a higher dose. I would not recommend taking it to anyone. You have to decide for yourself in life what risks your willing to take so if anyone does decide to take this or any other chemical that's untested, think long and hard, the saying what goes up must come down is very true, I'm taking memantine and cerebrolysin in the hope that this will not happen, but who knows.

[paul]

Ignore my last posts, I raised my dose of cerebrolysin as I thought it would help protect against side effects so I can't be sure if the improvements i have noticed are due this.

[baronjpetor]

Just had a pretty bad reaction to Sunifiram. I probably went above the recommended dose (15mg morning and 15mg afternoon) and I felt pretty depressed all day (with also a heavy brain fog and lowest motivation ever). I exercise 6 days a week, and today I felt so bad that I had to kick my butt to go.
It's almost as if I had been a stranger to myself all day long :-/ I'm just starting to come back to baseline.
I guess I depleted something in my brain but don't have a clue about what it could be. Any ideas ?
Overall, I'm gonna stop using Sunifiram on a daily basis. I'll only use it once or twice per week and I'll stick to the 5-10mg range.

[Passion]

I had a very similar experience. I just tried Sunifiram for the first time today at 7mg in the AM and 7mg in the afternoon. I felt really disconnected from myself like I was an observer giving an autonomous body generalized commands. I got mild brain fog and reacted very poorly to stress. At one time, my heart even started palpitating in reaction to a simple confrontation. Everyone's chemistry is different. This one isn't for me. Let's hope Coluracetam does the trick when it becomes available.

I'm still feeling the negative effects but they are slowly fading away.

[Dissolvedissolve]

I felt really disconnected from myself like I was an observer giving an autonomous body generalized commands. I got mild brain fog and reacted very poorly to stress.

I've gotten similar reactions from pramiracetam - reliably, in fact, to the extent that I never use it. It seems to be a sort of dissociation, typically triggered by NMDA antagonism. An NMDA-based mechanism seems logical given that nearly all racetams modulate NMDA. Sunifiram is known to modulate NMDA as well, but the bizarre thing is that I believed it was positive modulation, which would seemingly reduce dissociative feelings.

[health_nutty]

I'm down to 5mg 3x and the side effects are all but gone. Positive effects are still there, but mute subtle. Larger doses are ok every once and a while but over time I feels seriously depleted!

Sent from my SCH-I510 using Tapatalk 2

[NFP]

I had a very similar experience. I just tried Sunifiram for the first time today at 7mg in the AM and 7mg in the afternoon. I felt really disconnected from myself like I was an observer giving an autonomous body generalized commands. I got mild brain fog and reacted very poorly to stress. At one time, my heart even started palpitating in reaction to a simple confrontation. Everyone's chemistry is different. This one isn't for me. Let's hope Coluracetam does the trick when it becomes available.

I'm still feeling the negative effects but they are slowly fading away.

that sounds very much like depersonalization. i had it for months and it was the WORST experience of my life. throw it in the trash and dont look back.

[Southern_Lights]

During finals week I revisited this substance, tried between 1-5mg multiple times daily (Used the noopept 15mg scooper and divided into about 10 piles and dosed according to how I was feeling.).

Definitely started to feel the "warmth" it is hard to quantify but it is there. Usually I feel very cold, but not on days with suni. It is turning to summer here as well and the temps have been in the 80s for the first time in awhile, but this warmth is internal and very comforting.

On at least two separate occasions I felt.... really good, a familiar, uncanny, and very pleasant state of being.... I don't really know how to describe it. But it was like I was a kid again almost in terms of muscle/joint pain and general discomfort. Those symptoms that I experience on a general day to day basis were eliminated.

^ These periods only lasted about 2 hours, which was disappointing. It was also not suni alone, it was combo (amps+cannabis+supplements).

Also tree leaves seemed to appear fractal-ed. It was quite interesting. The details of even far away objects were very pronounced, and again everything seemed to relate to a fractal.

[paul]

You might be right about the NMDA antagonism, I have been taking memantine (an NMDA antagonist with a 70 hour half life) at 40mg since October 12 to protect from damage and tolerance as I have been taking ethylphenidate as I have had a pretty hefty workload. Ethylphenidate is a legal amphetamine (it's one of those legal highs but helps you concentrate rather then any euphoria). Maybe this is why I have been able to tolerate a high dose, when you first start of on memantine you get incredible brain fog, fatigue, forgetfulness even at 10mg, it took me 3 months to build up to a dose of 40mg. This is very interesting as I'm sure the sunifiram is adding something to the cerebrolysin. I got a full nights sleep last night, feel so much better, I had got buy on 4 hours in 3 nights without even noticing any tiredness, still just a workable level of hypomania. Will be switching to a lower dose soon, still lots of work on at the moment and need the extra push.

[deeptrance]

I have just taken my first dose of sunifiram, within minutes of the mail arriving. I used the tiny scoop that New Star Nootropics includes with orders, and would guess I took between 10 and 20mg. Not concerned about precision yet since I've never tried it and the doses people are taking are all over the map.

I'm bipolar and I recognize some of the hypomania that's being talked about in recent posts. Comments about not having to sleep very much are definite warning signs to me, and the extreme praise that some people heap on sunifiram also comes across as being a bit on the manic side.

Regarding sleep, I think there's a lot of irresponsible chat going on now partly because of modafinil, about how there's no known reason why we should have to sleep if we can get the same benefits in some other manner such as through a pill. This, to me, is very naive. It assumes that we know everything about how sleep benefits us, but we don't. Sure, we can produce more wakefulness and a subjective feeling that we don't need as much sleep by taking certain substances, but what is the long term cost? How does it affect all of our complex interactive biological processes, our dreams, our emotions? We don't know.

A further risk associated with this talk of needing less sleep has already been mentioned here, which is that sleep deprivation can trigger mania. All of these processes work together to produce our subjective experience and what I see going on is that people are getting amped up on a manic high through various means, and inevitably there are later posts talking about the crash.

We're at our best when all of our biochemical processes are balanced, not when they're maxed out.

All that said, it's fun to play with these substances to see what they do, and to ride the rollercoaster with eyes wide open. Happy trails!

[Stormy]

Random update after further use:

I'm one of the people who was experiencing depression and anxiety during the "come-down", and I'm not experiencing this at all anymore. Unfortunately, the "fun" effects seem to also not be happening much or at all - the extreme happiness, the perspective shifts where I feel like a kid again - I haven't experienced these in a while, which admittedly, is a bit of a bummer. However, Suni still puts me in a pretty good mood, and it definitely seems to have the long-term\cumulative effect of making my thoughts flow more quickly, clearly, and effortlessly. None of my friends or coworkers have been commenting on any sort of peculiar or uncharacteristic behavior out of me (and I tend to keep company with people who wouldn't hesitate to tell me if I seemed to be acting strangely), so I don't think it's making me manic or anything like that.

As for how this stuff affects my sleep - this one's a doozy. If I take a dose (approx 10 mg = my standard dose) in the morning or early afternoon, I don't have any trouble getting to sleep that night. However, if I take it in the late afternoon or any point in the evening, one of two things happens: I either can't get to sleep at all, OR I can sleep, but when I wake up, I feel like I haven't slept at all. It's like the sleep is worthless, and it's so weird, especially considering the reports from people who are requiring less sleep but feeling awesome afterwards as opposed to thoroughly pooped. I've also seen reports of people having nightmares, though, and I (thankfully!) haven't had any of those. The only thing I've ever taken that (to my knowledge) affected my dreams at all is Pramiracetam, and that gave me vivid dreams, but not bad or scary ones. So bizarre.

[ThePhoeron]

Still waiting for my 1g sunifiram and 30g piracetam to be shipped from NSN, day 3. When I do get it---based on all the discussion here---I think I'm going to start with suni on its own, 5mg, twice daily for seven days, and then stack suni at the same dose with 2g of piracetam for another 7 days, and then wash-out. I have no previous experience with noots, so this should be very interesting.

Any other programmers on here that have already tried suni, with or without a stack? How is it for coding benders compared to, say, artistic pursuits?

[MangekyōPeter]

Just a quick note that Psilocybin does appear to go well with Sunifiram (tried the combination 3 times now, albeit at relatively low 1.2 - 2g dosages, dry)

But yeah, the whole experience was similar to one where high doses of Piracetam were mixed with shroomz.

[andrea23]

Could be possible to prepare a "Liquid sunifiram", does it decompose for long times in water?


100mg (solute): 100000mg (100 gr water) = 5mg (solute) : x mg (water)

5 gr of water on the scale will be 5 gr of sunifiram, adding 100gr of water, 10gr of water will be 10 gr of sunifiram, is this exact?

Edited by andrea23, 11 May 2013 - 10:43 AM.

[gnappi]

Hello friends, today I started using sunifiram. I took a dose of 5 mg in the morning and went out to ride my bike and wow, WOW!!! What a clarity of thought!! What a energy!! I felt like a teenager again!!! The effect is absolutely natural, without being stimulated as if I had taken caffeine or ephedrine. I'm in love with suni!!! : ^)) p.s.: I took only the sunifiram, without any other substance that could interfere with my assessment. I'm 44 years old.

[brendan1]

That's awesome... Thanks for the report. Did you take orally or sublingual ?

[Bismarck]

I felt like a teenager again!!! ... I'm 44 years old.

,

Anyone whos sleep was impacted by sunifiram should be carefull and change dosage or timing so their sleep isnt impacted.

[gnappi]

That's awesome... Thanks for the report. Did you take orally or sublingual ?

Orally, with some water. I intend to keep a low dose of 5mg twice a day to prevent tolerance and use, whenever possible, before any physical activity, because I believe it helps to intensify the effect.

[brendan1]

Thanks. Got my first shipment in this morning and took about 5 mg about an hour ago. Dont feel anything yet though.