13 replies to this topic

[spermidine]

if anyone is taking this supplement, can you provide account for any positive or side effects both long term or short term. i started taking it for a while and im not sure if it directly the PQQ to cause this but, i feel much much more tired somehow. i assume it might be related to alcohol consumption too, but since i started PQQ in the morning, during the day i have mild fatigue and shortness of breath. perhaps im exagerating but could PQQ play a role in this ?

[spermidine]

gonna stop that shit. causes strange side effects like heart pain (once a while), strange feeling of dissociation, malaise over time and zero of the proposed benefits that are attributed to it. was hoping others share their painful experiences with it, but thats ok, ill just share mine and hope no noobie uses this in the future.

[xsiv1]

Only critique I've found on it was http://www.chris-ant...rch.html#pqqvit

[bobz1lla]

gonna stop that shit. causes strange side effects like heart pain (once a while), strange feeling of dissociation, malaise over time and zero of the proposed benefits that are attributed to it. was hoping others share their painful experiences with it, but thats ok, ill just share mine and hope no noobie uses this in the future.

What brand were you using? dose? I've read numerous reviews, claiming energy boost with prolonged use, without side effects you describe.

Edited by bobz1lla, 07 April 2013 - 11:14 PM.

[spermidine]

was LEF brand. i never had good results from any LEF supplement. dunno whats with their hype. and maybe cuz i combo it with many other things especially alcohol so im not sure it singely caused problems but i stopped it anyway

[Kevnzworld]

PQQ, theoretically stimulates mitochondrial biogenesis. Unless you have some severe condition, it's supplementation ( 20mg or less ) isn't something you will " feel " .
If you don't fully understand a supplement, and the science behind it..DON'T take it.

[bobz1lla]

I take a few different LEF brand supps. Haven't had the issues you describe. I am fond of their multi and hawthorn/arjuna.

[filo74]

I purchased the Jarrow brand PQQ and began to take it. I only took it for 2 days. It gave me a very bad headache both days and on the last day, I felt horrible....a heavy pressure from my upper torso all the way up to my head. I felt horrible...like I was going to die. As soon as I discontinued it, the symptoms stopped. This is very strange, as people are strong proponents of this substance. I tried it because I have ADD and have been taking prescribed Dexedrine for the past 3 years and have a high tolerance to it. I sometimes need to take 40mg a day. Because of this consistent use and the fact that this drug can and will cause nuerotoxicity over time, I decided to take PQQ. Why it had this effect on me, I have no clue. I would love to know why. And yes...the days I took the PQQ, I also took Dexedrine as prescribed. My job is one in which I have to work 24 hours with very challenging and stressful moments that can happen anytime during that period. Add to that that I may only get 1 hour of sleep within those 24 hours.....usually average 2-3 hours of sleep. I get two days of rest after those 24 hours, but having a highly gifted toddler running around and a pregnant wife, it is not easy to just go to sleep. I have been doing this type of work for 13 years and can definitely say that sleep deprivation has caught up to me as it does with most in my profession. Anyhow, I digress....I am currently taking Coq10, fish oil, magnesium, a multi-vitamin and probiotics and occasionaly a broad spectrum B complex vitamin. I also take 1-3 mg's of melatonin at night. I am also prescribed clonazepam, which I take on an as-needed basis for acute anxiety due to the horrible crap and suffering I have had the privilege to see in the past 13 years.

[xsiv1]

So, we're you taking PQQ to combat potential neurotoxicity? Also, have you been through the gamut of ADD drugs and found that one to be the only one that's effective? There are numerous compounds out now that could help prevent neurotoxicity aside from PQQ and perhaps an alternative to adderall will work for you.

Edited by xsiv1, 06 September 2013 - 05:26 PM.

[jerrybusey]

PQQ, theoretically stimulates mitochondrial biogenesis. Unless you have some severe condition, it's supplementation ( 20mg or less ) isn't something you will " feel " .
If you don't fully understand a supplement, and the science behind it..DON'T take it.

I got mine for that purpose and I didn't expect to feel anything but I do consistently feel a slight stimulatory effect when I take it. I wouldn't say it's anything particularly bad or good but it is noticeable to me.

I don't know why we would expect a biologically active compound to impact one but only one system in cells or the body as a whole.

[JohnnyP]

OP you mentioned alcohol consumption? I am not trying to be ciritical but can you elaborate on that?

[filo74]

So, we're you taking PQQ to combat potential neurotoxicity? Also, have you been through the gamut of ADD drugs and found that one to be the only one that's effective? There are numerous compounds out now that could help prevent neurotoxicity aside from PQQ and perhaps an alternative to adderall will work for you.

Yes, have tried ALL of them. Adderall had way too much L-amp symptoms like the rapid HR and hypertension and diaphoresis. Adderall is only 75% Dextroamphetamine. When I switched to Dextroamphetamine (Dexedrine) it erased the negative symptoms......it's 100 % D-amp which works in controlling my ADD.

So do you know of any other potent supplements that are very good for protecting against nuerotoxicity other than the ones I already take ?

Thanks

[lourdaud]

So, we're you taking PQQ to combat potential neurotoxicity? Also, have you been through the gamut of ADD drugs and found that one to be the only one that's effective? There are numerous compounds out now that could help prevent neurotoxicity aside from PQQ and perhaps an alternative to adderall will work for you.

Yes, have tried ALL of them. Adderall had way too much L-amp symptoms like the rapid HR and hypertension and diaphoresis. Adderall is only 75% Dextroamphetamine. When I switched to Dextroamphetamine (Dexedrine) it erased the negative symptoms......it's 100 % D-amp which works in controlling my ADD.

So do you know of any other potent supplements that are very good for protecting against nuerotoxicity other than the ones I already take ?

Thanks

PQQ, magnesium, methyl B12, minocycline

[cat-nips]

gonna stop that shit. causes strange side effects like heart pain (once a while), strange feeling of dissociation, malaise over time and zero of the proposed benefits that are attributed to it. was hoping others share their painful experiences with it, but thats ok, ill just share mine and hope no noobie uses this in the future.

Day 1: PQQ afternoon dosing in an attempt to alleviate the Dexedrine crash. It worked somewhat. I don’t remember what else I took with it. Maybe a multivit, but I do remember being able to have a good exercise session afterwards with no post fatigue.

Day 2: AM dosing with Dexedrine and Fish Oil. Tired all day. Couldn’t get anything done as I’d try to start something and my energy or motivation would fizzle and I’d end up just sitting there too fatigued to think or move. Don’t remember much either except that my head finally cleared after 9pm and stayed awake until 4, finishing a couple of the things in just a few mins what I couldn’t do all day.

Day 3: AM dosing 2 hours post Dexedrine with coffee. Was positive and planning my day before I took PQQ. Right after, I nodded off and have been dazed all day, too fatigued to move and once again unable to get anything done or even think clearly. Pissed about wasting 2 days on this.

Took the Jarrow brand of PQQ combined with 100 CoQ10. Reason for taking was reducing amp neurotoxicity and for possible blood pressure and blood sugar support. Both tend to get too high for comfort sometimes. I take 10mg Lisinopril for this but would prefer not to go higher. In July, my Omega supplement was a combined product containing 100mg of CoQ10. By the end of the month I noticed a solid and consistent trend towards stable energy, better sleep, more power during workouts and drastically reduced irritability. The only slight downside was a slight feeling of being out of breath. My blood pressure even stabilized to the point where I didn’t feel the Lisinopril for it was necessary so I stopped it. I finally identified it as the influence of Ubiquinone in the Fish Oil. I then ran out and things have deteriorated a lot since I ran out. Blood pressure went up again and the irritability came back as well as the palpitations and anxiety and fatigue. The Omega supplement I used this month has no coQ10 but it is also from the same company - Nordic. This is what led me to try the Jarrow combined brand of PQQ/CoQ10.

Not sure why this is happening. I may try taking it at night tomorrow, but based on my recent experience, I won’t be using PQQ again, at least not in the mornings.

Edited by cat-nips, 26 August 2019 - 09:58 PM.