Okay. I was just a bit concerned because AMPHs are vasoconstrictors and thought adding a NOS inhibitor would overdue it.
Yeah, I am still a bit worried about it. Just be careful, not that I think you won't.
Oh wow. I didn't think it would've aggrevated ADHD symptoms. My goal with Inositol was to synergize with an SSRI in reducing depression/anxiety through independent pathways. So I'd be fighting it on two fronts essentially. So to exagerate it, the comparison would be a benzo in which reducing anxiety will also mean inducing cognitive "dysfunction". How bad can Inositol make ADHD? If it really does have the comparable efficiency rate as SSRIs as claimed, I'd still go for it. But I'll take your advice. I'll slowly titrate my dose up starting at 3-4g.
The side effects were
pretty bad in me, worst side effects that I have ever had, but I haven't taken many meds with well-known side-effects.
I read somewhere that ADHD-PI, when it is close to combined type but not quite there, could be due to a problem covering the hyperactivity/impulsivity side. Kinda a double dysfunction where there is ADHD-C underneath, but then there is something else causing fatigue and suppression of impulse, so the H and I parts aren't really absent, just counteracted, hence PI subjects do not react as well to medicine because you are only solving one of the diseases. I can't even remember where I read it, though. It wasn't in a scientific journal.
Inositol solved a lot of problems but also caused otherwise absent (or highly subdued) H/I symptoms. I can't help but think that there COULD be some truth to the dual-disease speculation.
That second link you provided is tempting me to try MB even more even if anxiety isn't really my primary problem. Keep in mind, I also wanted to take Memantine for it's Alpha7 antagonism. The guy that suggested Blue Lotus to me experimented with Memantine and generally had good results all around (stim tolerance, cognitive boost). The antagonism is followed by an upregulation which is the desired goal. Though I haven't looked at the studies referenced on Wiki yet.
Interesting. Let us know how it goes. I am wanting to look into antagonism for upregulation, but right now I don't have much faith in the whole concept of it. I guess by decreasing tonic activity (constant, background activation) through antagonism, you could sensitize the receptors and they would be more responsive to purposeful activation. I am not sure if that is how it works though, it could very well be the oposite or it could just be complete nonsense. Otherwise, upregulation via antagonism doesn't seem like a very good goal. The receptors will, at maximum, return to homeostasis activation levels, right? More receptors, but they are also being antagonized, so what does it matter? I need to look up more about it, but I have been busy recently.
I wonder if nicotine upregulates alpha-7
as well.
Side note about fear extinction. I heard the Kappa receptor is involved with fear but I haven't bothered researching it.
Interesting. From a quick search, I didn't see much solid evidence about kappa receptors helping with fear extinction, but mu receptors look pretty promising. Interestingly, MB
reduces mu opioid receptor tolerance... (even though that study indicates that MB does not have direct activity on NOS,
it probably does)
If I was to ever consider a reuptake inhibitor. It would be Focalin XR as the half-life of Ritalin/Concerta being too short and also effecting the PNS (unnecessary).
I'm not one to abuse drugs. Disregarding money, I have a fairly good understanding of drugs enough to understand how destructive it can get. Even more common ones like weed and tobacco. It's usually subtle with a poor excuse to continue. I've kept my usage to a minimum and a year later with some self-control. My tolerance and abuse hasn't built at all.
My stack doesn't consist of stimulants. I was just gonna say it when you said it with stims impairing judgement. Yes, I agree, in certain situations, stims are fantastic but it's still flawed even in it's prime. For example, during my earlier months with my recreational stack, when I was "high" (was using below therapeutic doses), I would make plans ahead of time so if I was busy in the zone, I would make plans that required my current high 12 hours later. Even though I knew my current awesome feelings would be nonexistent later, I thought I would push through. When the 12 hours came, I just wasn't in the mood to commit as strongly as before. This is an example of impaired judgement. You think the hypomanias gonna last when it just isn't. I still kinda have this problem to this day but it's better now.
Not only that but figuratively it forces the brain to operate at a level I'm not particularly comfortable with at times. Basically, I'm not me. My crazier side takes over and does whatever it feels. With my stack, I wanna sustain a natural feeling to it but also have enough strong benefits.
I understand. Well, if this stack is successful, I will be happy to take it.
I didn't experience much of the planning problems you described while on ritalin. The only problem I had of that sort was making my schedule over-ambitious for the summer/fall, but I thought that I would surely be able to get stimulants perscribed (that was my main distortion, feeling like everything would work out), it wasn't of the same nature. If the stack fails, I would suggest focalin over dextroamphetamine, but lets hope it doesn't fail. Ritalin provides a very calm and complacent feel IME, contrary to amphetamine which I hear is more speedy.
I have pondered over and avoided Accutane for way too long and for good reasons but I really think it's time to make a pact with the devil. Minocycline is identical to Doxycycline and my other two relatives who've tried Minocycline failed and resorted to Accutane. The success rate is so high and eliminating my acne would be a +1000 to my ego. If Doxy doesn't work and I go on Accutane, I plan on continuing my gallon of water daily method and Green Vibrance shake (73 different ingredients with 25 billion probiotics per serving!!). Green Vibrance didn't do shit for me for anything when on it for 13+ months but I hope it'll reduce some of the GI side effects of Accutane.
Well, I am not going to argue. Good luck. It IS cyst-like acne, right? Otherwise you really need to think it over. If it isn't cystic, be sure you have tried retin-a, exfoliates, and benzoyl peroxide.
I had moderate, non-cystic acne, and I used benzoyl peroxide in the morning, salicylic acid wash at night after a shower, rewashed face, retin-a, and it helped control it for most of my Highschool years. I don't need it anymore, but it was a big help when I would use it. I assume you have tried these, but it couldn't hurt to mention them before you take accutane.
A lot of people have taken both Selegiline and COMT inhibitor like EGCG or Olive Leaf and report success. Yadayada tried it and liked the combo. COMT's function is similar to MAO in which is degrades certain neurotransmitters like dopamine. Certain COMT inhibitors are used as treatment for Parkinsons.
interesting. I will have to check that out. I was unaware that they could be combined together with good results.
Once I begin my stack, my recreational stack will have to be put on hold for a while. I'm not that unthrilled to do so. Would have liked to at least try MDMA once for the hell of it (seperate topic with seperate list of supplements to prevent neurotoxicity). But again, it's not a big deal. I'd also have to abstain from recreational weed for good. I'll stick to light beer whenever possible hehe. But overall, I think my days of not only illegal drug usage is over but also studying neuroscience like a madman is slowly coming to a close and will if this stack is successful. It's been fun learning the brain but I think I still need to explore other avenues as well aka living life before returning to this field with maybe a career involved.
Man, I feel you on that last point. My major is computer science, and that is where I plan to hold a job, but psychology and pharmacology have all but taken over my free time, especially in the last year. I know more about medicine than I know about programming, lol. There is just so much to learn. You read a study, and then you look up "oh I wonder what that is", "hmm... what other medicines do this" and before you know it, you have spent the entire day. Pubmed abstracts and wikipedia pages are just perfectly formed into bite-sized pieces, ha ha.
Too many interests, not enough time, money, or concentration.
