4029 replies to this topic

[Godof Smallthings]

Excellent! Thank you for taking the time to post. Order placed.

Edited by Godof Smallthings, 21 August 2013 - 04:47 AM.

[Plasticperson]

Efficacy of super-pulsed 905 nm Low Level Laser Therapy (LLLT) in the management of Traumatic Brain Injury (TBI): A case study

"We selected 905 nm wavelength based on a previ- ous scientific study that demonstrated that the 905 nm superpulsed wavelength employed by the system was able to increase inducible Nitric Oxide Synthase (iNOS) expression by 700%, as compared to numerous other wave-lengths that showed little or no effect [5]. iNOS has been well documented in numerous clinical studies to cause temporary vasodilation by signaling endothelial cells located in capillary walls to become flaccid and relax. Additional studies have shown that 810 nm and 665 nm wavelengths may also be effective, but those specific wavelengths are not able to produce as much iNOS expression, when compared to 905 nm superpulsed technology [6]. An average power for the superpulsed 905 nm laser diodes was initially chosen to be 50 mW based on personal experience, but further clinical inves- tigations may uncover more clinically effective average power settings. "

very interesting

*sorry if someones already posted this study

[Psionic]

I bought these ($3.5 each), http://www.ebay.com/...=item2a014931d9

looks like they are selling like hot cakes, but I am not sure how many of the end customers will use it on their brains

[Rumpelstiltskin]

Efficacy of super-pulsed 905 nm Low Level Laser Therapy (LLLT) in the management of Traumatic Brain Injury (TBI): A case study

"We selected 905 nm wavelength based on a previ- ous scientific study that demonstrated that the 905 nm superpulsed wavelength employed by the system was able to increase inducible Nitric Oxide Synthase (iNOS) expression by 700%, as compared to numerous other wave-lengths that showed little or no effect [5]. iNOS has been well documented in numerous clinical studies to cause temporary vasodilation by signaling endothelial cells located in capillary walls to become flaccid and relax. Additional studies have shown that 810 nm and 665 nm wavelengths may also be effective, but those specific wavelengths are not able to produce as much iNOS expression, when compared to 905 nm superpulsed technology [6]. An average power for the superpulsed 905 nm laser diodes was initially chosen to be 50 mW based on personal experience, but further clinical inves- tigations may uncover more clinically effective average power settings. "

very interesting

*sorry if someones already posted this study

Interesting. Thx.

[Nattzor]

Has anyone tested laser/LED without any CoQ10 and PQQ?

[lostfalco]

Has anyone tested laser/LED without any CoQ10 and PQQ?

Yeah, I did for months with the Vetrolaser. I noticed increases in focus and mental endurance from the laser alone. My major confounding factors are Modafinil, Pregnenolone, and BP Coffee. I was on BP Coffee and Moda for quite a while before adding the laser. The preg addition overlaps a little more with the laser addition.

[Nattzor]

Has anyone tested laser/LED without any CoQ10 and PQQ?

Yeah, I did for months with the Vetrolaser. I noticed increases in focus and mental endurance from the laser alone. My major confounding factors are Modafinil, Pregnenolone, and BP Coffee. I was on BP Coffee and Moda for quite a while before adding the laser. The preg addition overlaps a little more with the laser addition.

Oh nice, so TULIP is quite new then?

[lostfalco]

Has anyone tested laser/LED without any CoQ10 and PQQ?

Yeah, I did for months with the Vetrolaser. I noticed increases in focus and mental endurance from the laser alone. My major confounding factors are Modafinil, Pregnenolone, and BP Coffee. I was on BP Coffee and Moda for quite a while before adding the laser. The preg addition overlaps a little more with the laser addition.

Oh nice, so TULIP is quite new then?

It is, yeah. I've been using the laser for at least 6+ months (I'll have to double check my records to give you a more exact date) and TULIP for 2 months. These should be considered public anecdotal self-experiments...suggestions for people to pursue, not established scientific fact (not even close, in fact). I've asked a few people who are much better at quantification and blinding than I am to try it out and give us some better self-experimental data. Hopefully, they will. You know who you are. =)

In the meantime, the Naeser pilot study has some interesting data of this sort for two TBI sufferers. Check it out if you get a chance. The improvements in multiple functional categories by standard deviations is quite remarkable. http://dspace.mit.ed...58#files-area

Edited by lostfalco, 21 August 2013 - 02:48 PM.

[lostfalco]

If you guys want to learn more about the extremely fundamental role that energy (released from chemical/electrostatic bonds) plays in driving the mechanisms of biology I would suggest checking out this book. http://www.amazon.co...k/dp/B00918JR5Q

[middpanther88]

Start very low...2 minutes per region. Try that for a while and see if it works for you. Make subsequent adjustments if necessary. Think of 10 minutes per region as a tentative upper limit (even though that's still very low compared to the studies). 2 days on, 1 day off per region OR every other day...I don't currently recommend every day even at these low doses. But who the hell am I? ha Please use your reasoning/critical thought and read the studies. I'm just a dude. =) Pay attention to your body's response and be safe. Expect to make a few adjustments along the way and for it to take a little time (though, not long). Less is more with lllt.

Is there a map that describes the location the laser should be put for X effects?

[NFP]

Hey lostfalco, one question, I just got my vetrolaser in the mail (!!!) but which laser should I use? the single beam or the 3 beam?

[lostfalco]

Hey lostfalco, one question, I just got my vetrolaser in the mail (!!!) but which laser should I use? the single beam or the 3 beam?

3 beam =)

[Mr Matsubayashi]

I was curious about how much of the applicable spectrum is provided by sunlight.

Applicable Range:
620 – 1150 nm (Julio C. Rojas F. Gonzalez-Lima)
Mean (approx.) intensity / nm = 0.9W/m^2 /nm (Sea Level)
Delta (nm) = 530nm
530*0.9 = 477W/m^2
477/10^4 = 0.0477W/cm^2
0.0477*1000= 47.7mW/cm^2

(Please identify mistakes)

Sunlight = Noot? :P This isn’t perfect as cytochrome oxidase has absorption peaks within the band identified above, the sunlight spectrum is gappy at sea level and a study identified the following:

“Substitution of an LED for a laser of the same
wavelength may deliver the same amount energy by varying the power or exposure time.
However, this reciprocity rule has been disproven in photobiology and photomedicine [19].”

I have ordered 2 torches from ebay,
5W 940nm and 5W 850nm

Attached Files

•  spectrum illustration.jpg   103.31KB   34 downloads

Edited by Mr Matsubayashi, 22 August 2013 - 12:19 PM.

[swen]

Very interesting thread. Thanks Lostfalco, it's too advanced for me to understand what's exactly going on. But ordered a small led light to start and test

Also, is anyone familiar with the recipe of coconut oil with dissolved Q10? Supposedly the bio availability of the Q10 will be much better.

Maybe a nice recipe to take besides the bulletproof coffee

RECIPE (from purebulk dot com)

Recipe

Coconut Q10 (Coenzyme Q10 & Coconut Oil Recipe for Increased Bioavailability)

• Heat 16 fluid ounces coconut oil to between 150°F (65°C) and 158°F (70°C) in a sauce pan on the stove.
• Add 25 grams Coenzyme Q10 powder. The powder will melt instantly and dissolve into the hot oil.
• Stir for one minute.
• Remove from heat and allow to cool to between 80°F (27°C) and 90°F (32°C).
• Pour mixture into a rigid plastic or glass resealable food storage container and allow to cool to room temperature.
• At below 76°F (24.4°C) coconut oil will turn solid, but that's alright.
• The blended oil should be kept sealed but refrigeration is optional.
• A level half teaspoon of this oil, liquid or solid, will net approximately 130 milligrams Co-enzyme Q10, which is in the usual range of a commonly recommended serving size for this most bio-available form of CoQ10.
• Do not exceed a serving size of 1 level teaspoon (260 milligrams) of the blended Coenzyme Q10 coconut oil per day, except under the care and supervision of a physician.
• Take your CoQ10 preferably with a fatty food at meal time. You may spread it on toast, or add it to any food like you would as if it were butter.

This 16 fluid ounce recipe will net 96 level teaspoons, or 192 level 1/2-teaspoons, enough highly bio-available coconut oil dissolved Coenzyme-Q10 for more than a 6 month supply.


Cheers

[Nattzor]

I will try to do it a bit more objective but I'm wondering a few things. How long time does it usually take before you notice anything? 1-2 weeks?

The measurements that will be taken will be on Quantified-Mind and maybe on a depression scale. I currently don't have depression, but I don't feel like I'm on top of the world. Can you link some studies on depression and LLLT?

[NFP]

So i did 1 minute on each side (f3 & f4) last night. Definitely felt a change in perception after the 2 minute session.. more focused but was still able to fall asleep easily.

I woke up 2 hours earlier than normal today and wasn't groggy at all. I woke up ready to take on the world, I felt great. Thats as far as the obvious effects went.. Ive noticed a couple other things but its too early to distinguish them from placebo. This looks very promising so far.

[Plasticperson]

“Substitution of an LED for a laser of the same
wavelength may deliver the same amount energy by varying the power or exposure time.
However, this reciprocity rule has been disproven in photobiology and photomedicine [19].”

does this mean that the laser is more effective than the led or vice versa?

[Mr Matsubayashi]

“Substitution of an LED for a laser of the same
wavelength may deliver the same amount energy by varying the power or exposure time.
However, this reciprocity rule has been disproven in photobiology and photomedicine [19].”

does this mean that the laser is more effective than the led or vice versa?

My interpretation is that the same energy (J/cm^2) dose at a different rate (mW/cm^2) of application may not create the same therapeutic benefit. This idea validates the need for testing brain lasers instead of just going outside. It also validates the need for testing different intensities of application for different durations of time.

For a good starting point refer to the studies.

[lostfalco]

“Substitution of an LED for a laser of the same
wavelength may deliver the same amount energy by varying the power or exposure time.
However, this reciprocity rule has been disproven in photobiology and photomedicine [19].”

does this mean that the laser is more effective than the led or vice versa?

My interpretation is that the same energy (J/cm^2) dose at a different rate (mW/cm^2) of application may not create the same therapeutic benefit. This idea validates the need for testing brain lasers instead of just going outside. It also validates the need for testing different intensities of application for different durations of time.

For a good starting point refer to the studies.

Exactly. Non-identical effects. The main point isn't that A is beneficial while B is non-beneficial/harmful.

Your comment about validating the need for testing different parameters seems completely valid to me. =)

[alpal]

hey Lostfalco,

what was the longest number of consecutive days that you've used LLLT and what were effects? How is your experience different when using PQQ Coq10 and not using?

I'm trying to optimize dosages by better understanding the effects of the variables.

Thanks!

[lostfalco]

hey Lostfalco,

what was the longest number of consecutive days that you've used LLLT and what were effects? How is your experience different when using PQQ Coq10 and not using?

I'm trying to optimize dosages by better understanding the effects of the variables.

Thanks!

In this study the beneficial effects ceased on day 5. http://www.ncbi.nlm....les/PMC3538543/ I've set this in my mind as a tentative limit (even though there are many factors involved). NSS stands for neurological severity score and is a 10 task test used to assess animal models of brain trauma.

I'm not extremely dogmatic about dosing. A lot more research needs to be done. The general trend of the research seems to indicate that less is more...which is why my dosing recommendations are so low. As with just about everything, there are also indications that dosing too high and/or dosing too frequently are bad things. Minimum effective dosing is our friend.

I've never exceeded 3 consecutive days.

I had excellent results with just the laser for months. My personal recommendation is that everyone start there. Use a very low dose and only stimulate a couple of spots. As you become more comfortable with it begin stimulating more spots. I'm currently lasering my whole brain...mostly with the LEDs atm.

PQQ and CoQ10 took it to the next level. It's important to keep in mind here that there are also many other things that can be added to enhance the effects. TULIP is centered around ATP production. This is an extremely fundamental power source for the human body. If you take care of this one thing it can have MANY positive downstream effects. It's not a panacea but it's foundational enough to be a starting point for just about anyone wanting to improve their health, longevity, and vitality.

If any of you guys have the time....please read this incredible book. http://www.amazon.co...=life's ratchet Your jaw will hit the floor as the pieces of the puzzle begin to fall into place right before your eyes...mine did.


Effects of repeated dosing.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/
Group 3 that received 14-daily laser Tx; Fig. 1C) showed improvement in NSS until day 5 at which point the mice had received 5 daily laser Tx. However, the improvement then ceased, as more laser Tx were given, and at day 14, the advantage over group 9 (real-TBI 14 sham Tx) had disappeared.

[Mr Matsubayashi]

lostfalco and OpaqueMind, If you do not mind answering,

How many hours do you sleep per night?
Has any part of your stack affected your ability to sleep?
Do you exercise regularly, if so, is it predominantly cardio or weight?

Thanks

[lostfalco]

I'm sure many of you already know this...but if you want a quick introduction to what is going on inside your body I highly recommend checking out this TED video. As I mentioned previously, ATP is the main energy source that powers the molecular machines in your body.

Chemical energy is ultimately converted to mechanical energy causing our nanomachines to move. Their coordinated, aggregate movement allows us to do pretty much everything we do.

As Hoffman says, "The breakdown of ATP liberates a large amount of energy, which contributes most of the energy that drives a molecular motor."

Later on he says, "At low ATP concentrations, Block found that the bead was pulled by the motor with a speed of 50nm per second...As they raised the ATP concentration, the motor became faster, finally reaching a maximum speed of 500nm per second. At this speed, the little molecule would transverse an entire cell in about a minute."

This is what I think TULIP is doing. It is raising ATP concentrations in our bodies thereby accelerating pretty much ALL of our nanomachines simultaneously (with an emphasis on brain acceleration, of course...this is the information age). That is why almost everything is enhanced. Now this is the best part...since everything is going faster, balance is maintained. By all indications, it seems extremely healthy to me. Remember, your nanomachinery devoted to clean up of plaques and killing of malfunctioning cells will also be enhanced. Additionally, your machinery that copies and checks for errors in your DNA will also be enhanced thereby (possibly) reducing your risk of mutation. I have so much more to say here, but I think this is enough for now. As far as I can tell, 'information energetically expressed' is about as fundamental as we can get. There is an element of randomness here that I don't currently see a way to eliminate and there are also inherent properties of the nanomachines, the tracks they walk on (not all walk), the storm they live, etc. That's why accelerated ATP production is not a cure-all (among other reasons). It should help with A LOT of things though.

For those of you thinking this is NZT....I realized something...it's not. It's actually Aaron Cross.

Here's an actual video of myosin V walking.

Edited by lostfalco, 24 August 2013 - 05:23 PM.

[Nattzor]

This linear relationship was observed with a power density of 7.5 mW/cm2 CW (0.9 J/cm2), where an increase of 41% in cortical ATP was observed; and with a power density of 37.5 mW/cm2 PW (100 Hz, 4.5 J/cm2), where an increase of 157% in cortical ATP was observed. An increase in cortical ATP of 221% was observed with fluence of 31.5 J/cm2, delivered with a power density of 262.5 mW/cm2 PW, 1000 Hz.

- http://www.ncbi.nlm....les/PMC3065857/

[lostfalco]

This linear relationship was observed with a power density of 7.5 mW/cm2 CW (0.9 J/cm2), where an increase of 41% in cortical ATP was observed; and with a power density of 37.5 mW/cm2 PW (100 Hz, 4.5 J/cm2), where an increase of 157% in cortical ATP was observed. An increase in cortical ATP of 221% was observed with fluence of 31.5 J/cm2, delivered with a power density of 262.5 mW/cm2 PW, 1000 Hz.

- http://www.ncbi.nlm....les/PMC3065857/

Great find Nattzor. That's a very good summary of current thinking on lllt/photobiomodulation. As you can see, I'm being extremely cautious in my recommendations and it seems very possible that we can do better. I'd rather err on the side of safety for now. =)

[tdmonster99]

Forgive me if this was covered earlier, but would you feel comfortable buying this CoQ10 and PQQ combo supplement? http://www.ebay.com/...=item1c35f06b29

I can't believe how low the price is.

[Godof Smallthings]

As a backbone reaction, I am very skeptical of this. In Thailand, quality always costs - usually it is even more expensive than in the West. Generally, supplements are very expensive here, which is why most people order theirs online from international sources.

Is there a simple way of verifying whether these pills contain what is claimed?

Edited by Godof Smallthings, 24 August 2013 - 10:11 PM.

[Joe Cohen]

Hey LF,
You've previously expressed interest in M blue. I happened to make a post about it that explains clearly and simply how to use it. It has at least 1 MOA in common with LLLT, so I think it could be apropos for people trying to enhance their mitochondria. The effects are similar to LLLT.
http://selfhacked.co...itive-enhancer/

[mait]

Hi. I have been using Rhodiola Rosea with TULIP (inc LLLT 2x a week 2min per spot on total of 3 brain areas bilaterally) stack recently and it seems to have very good synergy. I did a little bit research and found this: http://www.ncbi.nlm....pubmed/15500079

Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles.


We studied the effects of oral treatment with extracts from Rhodiola rosea (50 mg/kg) and Rhodiola crenulata (50 mg/kg) roots on the duration of exhaustive swimming and ATP content in mitochondria of skeletal muscles in rats. Treatment with R. rosea extract significantly (by 24.6%) prolonged the duration of exhaustive swimming in comparison with control rats and rats treated with R. crenullata. R. rosea extract activated the synthesis or resynthesis of ATP in mitochondria and stimulated reparative energy processes after intense exercise. Experiments proved different pharmacological characteristics of R. rosea and R. crenulata: R. rosea is most effective for improving physical working capacity.

Atm my TULIP (and related substances) stack consist of:

300mg of ALCAR
5g of Creatine (taken with 1g of baking soda for better absorption)
20mg of PQQ and 100mg of CoQ10
Shilajit 600mg
LLLT 2x a week 2min per spot on total of 3 brain areas bilaterally with 300mw laser (either 660nm or 830nm wavelength)
Pregnenolone 100mg
C60 in EVOO 6mg (planing to increase the dose to 24mg) a week in one dose
Rhodiola rosea extract (1%/3%) 250mg

Whats most important is the perceived effectiveness of this stack. Concentration seems better, talk more coherent and even calculus/math a bit easier to tackle.

Edited by mait, 26 August 2013 - 09:29 AM.

[OpaqueMind]

Having recently shifted to a fat-centric diet I find all cognition greatly enhanced, and it seems especially synergistic with the TULIP stack. Oh and MCT oil fackin rules. Props to LostFalco for pointing me in the direction of bulletproof-ness.

lostfalco and OpaqueMind, If you do not mind answering,

How many hours do you sleep per night?
Has any part of your stack affected your ability to sleep?
Do you exercise regularly, if so, is it predominantly cardio or weight?

Thanks

I sleep exactly 8 hours a night, and I haven't found any part of this stack to interfere with my sleep. In the past I have had very fragmented sleep, but I've been rigorously following a CBT-Insomnia program for the last month or so, and the stack has not interfered with that one iota. In fact, my sleep may even be better on days when I use the laser. And yes I exercise regularly, mostly every day, and generally its intense cardio stuff like HIIT and squash. I also like to walk a lot. Not so much weight training these days though.