4029 replies to this topic

[Shorty]

The lost son has returned! Good to see you mate.

[mettmett]

I think lost falco was just living up to his name by being absent

[lostfalco]

@_@'

He's back...

Thanks, Chris! Somebody's gotta shoot ultrasound through their head while standing on a vibration plate with an oxygen cannula in their nose and a laser up their ass. (not recommended...ok, sort of recommended)

 

Seriously though, I am really interested to see what molecular hydrogen is like in combination with everything else (you should have seen the girl's face at the scuba shop when I asked her if they sold Hydreliox. ha http://en.wikipedia.org/wiki/Hydreliox )

 

Here's a good free full text summary article on H2. http://www.sciencedi...163725814000941

Edited by lostfalco, 19 September 2014 - 12:35 PM.

[lostfalco]

I'm now three weeks into the first treatment block of a quantified, non-blinded ABAB experiment with LLLT. So far the data looks like its trenting towards a pretty decent boost of reaction time, and perhaps smaller increases in other scores that may not be significant. I'd consider it a big succes thus far, but I've also developped a persistent late insomnia over the same time period, and I've ruled out every pther possible cause I have data on except stress over the start of the new school year... has anybody had insomnia from TULIP?

 

Googling LLLT and insomnia turns up chinese studies aiming (infra)red lasers at the hypothalamus through the nostrils for treating insomnia, which is a pretty interesting idea. That thing regulates homeostasis for everything, including sleep management, as well as your entire endocrine system - I'd venture to say that tiny little knob of neurons is about as important to your wellbeing as your entire cortex, and it should be very hittable through the nose. I'm thinking of buying a laser and trying it, but I'm not sure what the dose should be with the increased distance but decreased bone mass inbetween. The chinese devices use a very low power device that takes 60 minutes to complete a treatment, and I don't think I'm up for waiting that long.

 

ETA: Glad to see lostfalco is alive and well.

Thanks, Raza. I'm glad to be alive as well. =)

 

Really cool that you are quantifying your results! I'll be very interested to see what your data looks like on LLLT. 

 

Sorry about the insomnia. I still laser before bed most of the time and I don't seem to have any problems. 

 

I know BigPapa and a few other people were looking into intranasal LLLT. I haven't tried it yet but I'll bet you could find some pretty cheap individual LEDs on ebay or Alibaba to give it a go with. 

 

Keep us updated on your results. 

[lostfalco]

The lost son has returned! Good to see you mate.

Thanks, Shorty...I appreciate it. How've you been doing? Is your dad still doing alright?

[lostfalco]

I think lost falco was just living up to his name by being absent

Now if only I could live up to that Falco part!

[Area-1255]

Damn LF you just came back with a vengeance! 5 notifications and I swear I just refreshed the page after a slight 4 min break from the Comp. lol!

How ya doin buddy?

 

 

Edited by lostfalco, 17 September 2014 - 11:54 PM.

[swen]

I've had a nice boost in wakefulness and performance since changing from 100mg to 200mg ubiquinol in the last 6 days. Overall now taking:

 

LLLT every 2 to 3 days, 48 LED, 40 seconds per spot. Evening.

Ubiquinol 200mg morning

PQQ 20mg morning every other day

2g D-ribose + NAC

Curcumin+bioperine twice/day, but not within 2 hours of completing LLLT. I should probably wait even longer.

EPA+DHA

 

Today I increased to 300mb ubuiqionol and it was like modafinil without the anxiety. Lostfalco is taking 300mg.

 

I want to add uridine + choline later.

 

"...dRib-induced reactive oxygen species (ROS) were partially suppressed by gliclazide and completely inhibited by NAC. " - http://www.ncbi.nlm....pubmed/22315655

 

 

 

 

When do you take NAC? You mention a study that ROS is inhibited by NAC. Joe Cohen on http://selfhacked.co...review-of-lllt/ also mentions that NAC suppresses ROS and therefore suppresses an mechanism of LLLT. You use NAC in the morning?

[lostfalco]

Damn LF you just came back with a vengeance! 5 notifications and I swear I just refreshed the page after a slight 4 min break from the Comp. lol!

How ya doin buddy?

Doing well, man. I can't complain. 

[Area-1255]

 

Damn LF you just came back with a vengeance! 5 notifications and I swear I just refreshed the page after a slight 4 min break from the Comp. lol!

How ya doin buddy?

Doing well, man. I can't complain. 

 

Good to hear

[Shorty]

 

The lost son has returned! Good to see you mate.

Thanks, Shorty...I appreciate it. How've you been doing? Is your dad still doing alright?

 

My dad lives with me currently. He had a fever a couple of months ago and that somehow reverted the progress he had made. Not sure if fevers setting back stroke recovery is a documented thing but yeah... could be worse though, thanks for asking

[elitesagan]

 

I've had a nice boost in wakefulness and performance since changing from 100mg to 200mg ubiquinol in the last 6 days. Overall now taking:

 

LLLT every 2 to 3 days, 48 LED, 40 seconds per spot. Evening.

Ubiquinol 200mg morning

PQQ 20mg morning every other day

2g D-ribose + NAC

Curcumin+bioperine twice/day, but not within 2 hours of completing LLLT. I should probably wait even longer.

EPA+DHA

 

Today I increased to 300mb ubuiqionol and it was like modafinil without the anxiety. Lostfalco is taking 300mg.

 

I want to add uridine + choline later.

 

"...dRib-induced reactive oxygen species (ROS) were partially suppressed by gliclazide and completely inhibited by NAC. " - http://www.ncbi.nlm....pubmed/22315655

 

 

 

 

When do you take NAC? You mention a study that ROS is inhibited by NAC. Joe Cohen on http://selfhacked.co...review-of-lllt/ also mentions that NAC suppresses ROS and therefore suppresses an mechanism of LLLT. You use NAC in the morning?

 

 

Yeah, I actually don't take NAC or curcumin until the morning, so the ROS and inflammation from LLLT have several hours to work their magic.

[lostfalco]

 

 

The lost son has returned! Good to see you mate.

Thanks, Shorty...I appreciate it. How've you been doing? Is your dad still doing alright?

 

My dad lives with me currently. He had a fever a couple of months ago and that somehow reverted the progress he had made. Not sure if fevers setting back stroke recovery is a documented thing but yeah... could be worse though, thanks for asking

 

No problem, Shorty. I hope he starts feeling better soon. =)

[xks201]

Still taking the starch falco? What is proving to be most effective in cognitive enhancement?

[lostfalco]

Still taking the starch falco? What is proving to be most effective in cognitive enhancement?

What's up, xks?

 

Yeah, still taking BRM Unmodified Potato Starch and eating green bananas for resistant starch (Thanks, Joe!). I tried Hi-Maize Resistant Starch http://www.amazon.co...g/dp/B00993APG8  and liked it...just seemed to get better results with BRM. I'll probably try the Hi-Maize again at some point. 

 

I've also tried dozens of combos with things like inulin, FOS, GOS, arabinogalactan, psyllium husk, etc. I haven't noticed much of a difference compared to just BRM alone...as always, just my VERY subjective experience and there are a lot more things worth trying in the future. This is especially true as I add new commensals to my microbiome (or attempt to, at least).

 

For cognitive enhancement I'm getting excellent results with: LLLT, PQQ, Creatine, and Epicatechin/Cacao. Currently taking a break from CoQ10/Shilajit and using that money on epicatechin/cacao (which also seems to affect the microbiome, btw http://www.ncbi.nlm....pubmed/19810704 ).

 

Did I mention that I'm also currently obsessed with H2? ;) I should start trying it out in the next week or so. 

Edited by lostfalco, 23 September 2014 - 12:12 AM.

[mettmett]

So Falco, how many minutes are you lasering each spot now-a-days? Are you getting supplemental epicatechin or deriving it from cocoa consumption. And where are you getting a source for h2? Thanks :D

[mettmett]

Ok I watched the video so I know the source for h2. Very interesting stuff

[lostfalco]

So Falco, how many minutes are you lasering each spot now-a-days? Are you getting supplemental epicatechin or deriving it from cocoa consumption. And where are you getting a source for h2? Thanks :D

Hey, Mettmett. 

 

I'm still using the same LLLT protocol....whole brain, before bed (mostly), approx. 2min per spot, every other day. 

 

I'm using this for pure epicatechin even though it's a little overpriced/overhyped. http://www.blacklion...com/follidrone/

 

I actually found out about epicatechin surfing around on pubmed and was surprised to discover that it's recently become a fad bodybuilding supplement. I care a lot more about mitochondrial biogenesis in my brain than I do about inhibiting myostatin and looking like a Belgian Blue.  http://www.ilyke.net...720-mYHqxzt.jpg

 

I think you can probably get good results with just cacao and I'd recommend starting with that first...if you're not already taking it. Of course, ymmv and all that. ;)

 

For Hydrogen water I decided to go with this:  http://www.ebay.com/...r-/191342692281

 

For that amount of money it better freaking work! ha

 

The science looks pretty damn interesting on H2 but the hydrogen sticks all looked pretty 'scammy' to me so I decided to go with the H2 generator. Here it is in action.  

 

 

Here's a sales video that explains a little more about how H2 works.

 

Edited by lostfalco, 23 September 2014 - 05:31 AM.

[lostfalco]

Ok I watched the video so I know the source for h2. Very interesting stuff

I know man...it's really interesting! There are multiple ways to get H2 but most of the studies seem to indicate that water is better than inhaling H2 or getting your microbiome to make it for you. The literature is actually pretty extensive for something I had never even heard of until I stumbled across some studies on pubmed. It's pretty huge in Japan right now from what I hear. 

[mettmett]

Or the supplement he promotes in the video
http://coachkeegan.c...t/recovery-7-2/
Didn't they also talk about magnesium metal or elemental magnesium reacting with water to make h2?
After Google searching I find this amazon review where the user made his own h2 water relatively cheap
http://www.amazon.co...ursor=1&sort=rd
I ran across that black lion brand when I was trying to find epicatechin. I'll have to try it
Or the supplement he promotes in the video
http://coachkeegan.c...t/recovery-7-2/
Didn't they also talk about magnesium metal or elemental magnesium reacting with water to make h2?
After Google searching I find this amazon review where the user made his own h2 water relatively cheap
http://www.amazon.co...ursor=1&sort=rd
I ran across that black lion brand when I was trying to find epicatechin. I'll have to try it

[mettmett]

And apparently this is where black lion gets there epicat source
http://www.sigmaaldr...ng=en&region=US

Article:
http://www.prohormon...-lion-research/

[lostfalco]

Check this out! Remember when we talked about 'Mechanically Induced Synesthesia'? http://www.longecity...e-8#entry594400  Well, it's happening...and one of my favorite popular neuroscience writers, David Eagleman, is spearheading the project!  Holy crap, this is awesome. 

 

https://www.kickstar...science-project

 

 

Edited by lostfalco, 25 September 2014 - 05:10 AM.

[elitesagan]

The molecular hydrogen stuff is seriously interesting. Could it be the most effective and thorough anti-oxidant (also having anti-inflammatory effects)? Tempted to trial it with a Hayashi hydrogen stick. I admit the Lourde's generator looks tempting.

[DamnedOwl]

Check this out! Remember when we talked about 'Mechanically Induced Synesthesia'? http://www.longecity...e-8#entry594400  Well, it's happening...and one of my favorite popular neuroscience writers, David Eagleman, is spearheading the project!  Holy crap, this is awesome. 

 

https://www.kickstar...science-project

 

Wow!!! Well, that has got me rather excited anyway!

 

I'm going to chip into that.

[lostfalco]

The molecular hydrogen stuff is seriously interesting. Could it be the most effective and thorough anti-oxidant (also having anti-inflammatory effects)? Tempted to trial it with a Hayashi hydrogen stick. I admit the Lourde's generator looks tempting.

What's up, Elite?

 

Yeah, it looks pretty amazing on paper. It's a selective antioxidant (for the the hydroxyl radical), reduces inflammation (easily crosses the BBB), increases energy output, and increases glutathione and superoxide dismutase. Here's a recent article on the important relationship between cytokines and memory. 

 

Popular Article: http://www.scienceda...40912112518.htm

 

Pubmed: http://www.ncbi.nlm....pubmed/25209285

 

J Neurosci. 2014 Sep 10;34(37):12470-80. doi: 10.1523/JNEUROSCI.0542-14.2014.

Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus.

Czerniawski J1, Guzowski JF2.

Author information

 

Abstract

Although it is known that immune system activation can impair cognition, no study to date has linked cognitive deficits during acute neuroinflammation to dysregulation of task-relevant neuronal ensemble activity. Here, we assessed both neural circuit activity and contextdiscrimination memory retrieval, in a within-subjects design, of male rats given systemic administration of saline or lipopolysaccharide (LPS). Rats were exposed over several days to two similar contexts: one of which was paired with weak foot shock and the other was not. After reaching criteria for discriminative freezing, rats were given systemic LPS or saline injection and tested for retrieval of context discrimination 6 h later. Importantly, LPS administration produced an acute neuroinflammatory response in dorsal hippocampus at this time (as assessed by elevation of proinflammatory cytokine mRNA levels) and abolished retrieval of the previously acquired discrimination. The impact of neuroinflammation on hippocampal CA3 and CA1 neural circuit activity was assessed using the Arc/Homer1a cellular analysis of temporal activity by fluorescence in situ hybridization imaging method. Whereas the saline-treated subjects discriminated and had low overlap of hippocampal ensembles activated in the two contexts, LPS-treated subjects did not discriminate and had greater ensemble overlap (i.e., reduced orthogonalization). Additionally, retrieval of standard contextual fear conditioning, which does not require context discrimination, was not affected by pretesting LPS administration. Together, the behavioral and circuit analyses data provide compelling evidence that LPS administration impairs context discrimination memory by disrupting cellular pattern separationprocesses within the hippocampus, thus linking acute neuroinflammation to disruption of specific neural circuit functions and cognitive impairment.

 

I'd also strongly recommend checking out Joe's current series on inflammation: http://selfhacked.co.../interleukin-1/

Edited by lostfalco, 25 September 2014 - 01:28 PM.

[lostfalco]

Or the supplement he promotes in the video
http://coachkeegan.c...t/recovery-7-2/
Didn't they also talk about magnesium metal or elemental magnesium reacting with water to make h2?
After Google searching I find this amazon review where the user made his own h2 water relatively cheap
http://www.amazon.co...ursor=1&sort=rd
I ran across that black lion brand when I was trying to find epicatechin. I'll have to try it
Or the supplement he promotes in the video
http://coachkeegan.c...t/recovery-7-2/
Didn't they also talk about magnesium metal or elemental magnesium reacting with water to make h2?
After Google searching I find this amazon review where the user made his own h2 water relatively cheap
http://www.amazon.co...ursor=1&sort=rd
I ran across that black lion brand when I was trying to find epicatechin. I'll have to try it

Yeah Mettmett, you're totally right. Metallic/elemental magnesium creates hydrogen when dissolved in water. Some other options mentioned in the literature are turmeric, acarbose, and lactulose. These cause your microbiome to make it for you. 

 

Sorry about the long quote!

 

http://www.hindawi.c...cl/2012/353152/

 

"The second enigma is intestinal production of hydrogen gas in rodents and humans. Although no mammalian cells can produce hydrogen endogenously, hydrogen is produced by intestinal bacteria carrying hydrogenase in both rodents and humans. We humans are able to make a maximum of 12 liters of hydrogen in our intestines [68, 69]. Specific-pathogen-free (SPF) animals are different from aseptic animals and carry intestinal bacteria that produce hydrogen. The amount of hydrogen taken by water or gas is much less than that produced by intestinal bacteria, but the exogenously administered hydrogen demonstrates a prominent effect. In a mouse model of Concanavalin A-induced hepatitis, Kajiya and colleagues killed intestinal bacteria by prescribing a cocktail of antibiotics [43]. Elimination of intestinal hydrogen worsened hepatitis. Restitution of a hydrogenase-negative strain of E. coli had no effects, whereas that of a hydrogenase-positive strain of E. coliameliorated hepatitis. This is the only report that addressed a beneficial effect of intestinal bacteria, and no human study has been reported to date. Kajiya and colleagues also demonstrated that drinking hydrogen-rich water was more effective than the restitution of hydrogenase-positive bacteria. If intestinal hydrogen is as effective as the other hydrogen administration methods, we can easily increase hydrogen concentrations in our bodies by an  -glucosidase inhibitor, acarbose [70], an ingredient of curry, turmeric [71], or a nonabsorbable synthetic disaccharide, lactulose [68, 72, 73]. The enigma of intestinal bacteria thus needs to be solved in the future."

Edited by lostfalco, 25 September 2014 - 01:45 PM.

[lostfalco]

 

Check this out! Remember when we talked about 'Mechanically Induced Synesthesia'? http://www.longecity...e-8#entry594400  Well, it's happening...and one of my favorite popular neuroscience writers, David Eagleman, is spearheading the project!  Holy crap, this is awesome. 

 

https://www.kickstar...science-project

 

Wow!!! Well, that has got me rather excited anyway!

 

I'm going to chip into that.

 

Very cool, Damned! I think sensory substitution/augmentation has massive potential. It's really exciting to see a neuroscientist like Eagleman go after it. I'm not gonna lie...I would probably wear that vest around under my clothes. ha

 

 

[mettmett]

That's awesome. I think I'm going to be a guinea pig and test out the cheap metal rod alternative to producing h2. I already consume turmeric and those other two are prescription drugs so i won't be having those. Man I'm all about some hydrogen now too! I like how you can take it and not worry about it interfering with the gains from ROS created from exercise or lasering

[Joe Cohen]

Hey LF, 

long time....

 

Thought I'd chime in.

 

Hi-maize is 60% RS.  Green bananas have other fibers that seem to also have a cognitive effect.

 

If you're looking for another fiber that will give you a cognitive effect, try modified citrus pectin.  I think it's acting as GLP-1 agonist, which mimics orexin.

 

Cheers,

Joe

[Metagene]

Hello again Lostfalco!

The molecular hydrogen stuff is seriously interesting. Could it be the most effective and thorough anti-oxidant (also having anti-inflammatory effects)? Tempted to trial it with a Hayashi hydrogen stick. I admit the Lourde's generator looks tempting.

I believe this is the one used in the study below

http://www.amazon.co...i=SY115&simLd=1

http://openi.nlm.nih...09-100f01&req=4