4029 replies to this topic

[lostfalco]

 

It is somewhat of an open question whether single wavelengths or multiple wavelengths might be better. I think each experiment is worth a try. The MIT study from page one of this thread discussed two TBI patients who mixed 870nm and 633nm wavelengths with good effects. 850nm and 660nm are both worth a try individually and together imo.

 

Have you ever seen a study were LLLT effects were actually successful solely using light <800nm?

 

I remember hearing that the range for effective LLLT is 800nm to 2 microns, meaning 660 would be useless.

Hey, what's up Bateau? There are only a handful of transcranial human studies and none of them have used 660. The MIT study on two TBI patients included very low dose 633nm light in addition to 870nm light. This was a descriptive study on two patients with no controls so it should be viewed as very weak evidence. 

 

As for 660 being useless, check out zawy's discussion of the LLLT research on his website. He says it just as well as I can: "The ideal wavelengths are between 600 and and 900 nm, with the best results at specific ranges: 610-625, 660-690, 750-770, and 815-860 nm." http://heelspurs.com/led.html

 

Here are the absorption peaks for CCO. 

 

 

http://heelspurs.com/led.html#opti

 

 

 

 

Here's a response I gave to a poster on reddit a few weeks ago who claimed that ONLY 660nm works...pretty much the opposite of your question. =) Since that time another human study has come out which I'm still going through:

 

"Here are the six human transcranial LLLT studies. None of them use 660nm. 

810nm -- http://www.ncbi.nlm....les/PMC2796659/

808nm -- http://stroke.ahajou.../38/6/1843.long

808nm -- http://stroke.ahajou.../40/4/1359.long

870nm and 633nm -- http://dspace.mit.ed...le/1721.1/58558

1064nm -- http://www.ncbi.nlm....pubmed/23200785

1064nm -- http://www.ncbi.nlm....pubmed/26017772

The first study that you linked indicates the proper absorption spectra and, contrary to your claims, near infrared light is listed: http://www.ncbi.nlm....les/PMC2996814/

"Furthermore, low-intensity laser researchers Karu and Kolyakov have reported similarities between the absorption spectrum of cytochrome C oxidase and the action spectra for various biological responses of HeLa cells irradiated with monochromatic light of 580–860 nm. These action spectra demonstrate peak positions in the red range (between 613.5 and 623.5 nm), the far-red range (between 667.5 and 683.7 nm), and two peak positions in the infrared range (750.7–772.3 nm and 812.5–846.0 nm)."

 

"As mentioned above, low-intensity laser/LED research shows that like the PETC, the mitochondrial electron transport chain produces ROS when illuminated with certain wavelengths (e.g., 632.8, 812, and 820 nm) of monochromatic light. The generation of such ROS, in addition to increased ATP production, may be involved in stimulating restorative mechanisms."

Edited by lostfalco, 28 September 2015 - 09:05 PM.

[lostfalco]

Yes, he did say that in the interview with Joe. Look at 08:40 for about 20 sec. 

 

My device will arrive this week. I am a bit afraid to use it on my head, because I am bipolar II with very rapid cycling. I have many diseases (Alopecia Areata, Vitiligo, chronic eosinophilic proctitis, IGA-Nephritis, very severe food intolerances and bipolar II ultra rapid cycling).

 

My bipolar disorder is very difficult to control. If I keep my circadian rhythms and avoid food triggers it evens out on a slightly depressive level. Any antidepressive agent (even yoga and meditation if I do it daily or too often) kicks me into hypomanic symptoms. First I get euphoric, then this switches into anxiety/irritability/agitation and the I have very fast cycling between depression and this hypomanic state for 1-5 days until it evens out again.

 

So if LLLT has an strong antidepressive effect, it may kick me into this cycling.

 

On the other hand, I know that it increases BDNF, so the antidepressive action might be different from any other methods I tried so far. I know that bipolar people are lacking BDNF as well as major depressive people. But long term bipolar patient have increased BDNF compared to normal and in the study I read they said this was not due to medication.

 

It would be important to see the ratio BDNF/proBDNF they concluded.

 

 

So in your eyes, the upper limit is much higher? How do you know that? It would be great to get some more insight into that before I try anything. If I try it, I definitively start with 30 sec. max.

 

By the way, the hair won´t be a problem because I have no hair anymore ;-)

 

I am just checking out to use ICES everyday for 3-4 weeks and can report back to you if you like!

Thanks for the time link, Santino. You're right, he does seem to say that. I remembered him talking about 100mW^cm2 but I didn't remember him calling it an 'upper limit'. Weird.

 

I've historically taken Schiffer's position on the upper limit which uses the ANSI standard: "The level of light exposure at the skin was well below the irradiance allowed by the ANSI standard of 320 mW/cm2." http://www.ncbi.nlm....les/PMC2796659/

 

If you're really worried about the upper limit...check out this recent study. ha It uses light at doses absurdly higher than anything we've been using. The ten patients mentioned seemed to be fine using Watts per cm2!

 

http://www.ncbi.nlm....les/PMC4550182/

 

"In ten patients with chronic TBI (average time since injury 9.3 years) given ten treatments over the course of 2 months using a high-power NIR laser (13.2 W/0.89 cm(2) at 810 nm or 9 W/0.89 cm(2) at 810 nm and 980 nm), symptoms of headache, sleep disturbance, cognition, mood dysregulation, anxiety, and irritability improved. Symptoms were monitored by depression scales and a novel patient diary system specifically designed for this study. NIR light in the power range of 10-15 W at 810 nm and 980 nm can safely and effectively treat chronic symptoms of TBI. The clinical benefit and effects of infrared phototherapy on mitochondrial function and secondary molecular events are discussed in the context of adequate radiant energy penetration."

 

For a counterpoint to this study's concern about brain penetration, check out Zawy's discussion of the research. 

http://heelspurs.com/led.html

http://heelspurs.com/led.html#deep

[Bateau]

Is anybody familiar with the math necessary to understand what duration someone should use their LLLT device, which changes depending on the intensity of the device?

 

I just bought this 15W 850nm device and need to know how long to use it.

Edited by Bateau, 30 September 2015 - 02:09 AM.

[lostfalco]

Is anybody familiar with the math necessary to understand what duration someone should use their LLLT device, which changes depending on the intensity of the device?

 

I just bought this 15W 850nm device and need to know how long to use it.

http://www.longecity...-48#entry621375

[Bateau]

Thanks lostfalco.

 

It seems like this is to figure out the duration for specifically the brain assuming that only 2% penetrates the skin & skull.

 

Does anyone know what the duration would be for tissue exposure that doesn't have to penetrate through bone?

 

I'm looking to also try this on muscles as well as maybe other organs, maybe even use it intentionally only for the skin in certain areas.

 

Sorry for all the questions without contributing much.

[lostfalco]

Mouse study. Enjoy! =)

 

"E and Q activate Akt- and Ca2+-mediated signaling pathways that converge on NOS and CREB resulting in synergistic improvements in neuronal mitochondrial performance which confer profound protection against ischemic injury."

 

"These improvements were accompanied by corresponding increases in cyclic AMP response element binding protein (CREB) phosphorylation and the expression of CREB-target genes that promote neuronal survival (Bcl-2) and mitochondrial biogenesis (PGC-1α)."

 

"Oral administration of E+Q (75mg/kg; once daily for 5days) reduced hypoxic-ischemic brain injury."

 

http://www.ncbi.nlm....pubmed/26363153

 

Neuroscience. 2015 Sep 10;308:75-94. doi: 10.1016/j.neuroscience.2015.09.012. [Epub ahead of print]

Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways.

Nichols M1, Zhang J2, Polster BM3, Elustondo PA4, Thirumaran A5, Pavlov EV6, Robertson GS7.

Author information

Abstract

In view of evidence that increased consumption of epicatechin (E) and quercetin (Q) may reduce the risk of stroke, we have measured the effects of combining E and Q on mitochondrial function and neuronal survival following oxygen-glucose deprivation (OGD). Relative to mouse cortical neuron cultures pretreated (24h) with either E or Q (0.1-10μM), E+Q synergistically attenuated OGD-induced neuronal cell death. E, Q and E+Q (0.3μM) increased spare respiratory capacity but only E+Q (0.3μM) preserved this crucial parameter of neuronal mitochondrial function after OGD. These improvements were accompanied by corresponding increases in cyclic AMP response element binding protein (CREB) phosphorylation and the expression of CREB-target genes that promote neuronal survival (Bcl-2) and mitochondrial biogenesis (PGC-1α). Consistent with these findings, E+Q (0.1 and 1.0μM) elevated mitochondrial gene expression (MT-ND2 and MT-ATP6) to a greater extent than E or Q after OGD. Q (0.3-3.0μM), but not E (3.0μM), elevated cytosolic calcium (Ca2+) spikes and the mitochondrial membrane potential. Conversely, E and E+Q (0.1 and 0.3μM), but not Q (0.1 and 0.3μM), activated protein kinase B (Akt). Nitric oxide synthase (NOS) inhibition with L-NG-nitroarginine methyl ester (1.0μM) blocked neuroprotection by E (0.3μM) or Q (1.0μM). Oral administration of E+Q (75mg/kg; once daily for 5days) reduced hypoxic-ischemic brain injury. These findings suggest E and Q activate Akt- and Ca2+-mediated signaling pathways that converge on NOS and CREB resulting in synergistic improvements in neuronal mitochondrial performance which confer profound protection against ischemic injury.

 

[BigPapaChakra]

 

Mouse study. Enjoy! =)

 

"E and Q activate Akt- and Ca2+-mediated signaling pathways that converge on NOS and CREB resulting in synergistic improvements in neuronal mitochondrial performance which confer profound protection against ischemic injury."

 

"These improvements were accompanied by corresponding increases in cyclic AMP response element binding protein (CREB) phosphorylation and the expression of CREB-target genes that promote neuronal survival (Bcl-2) and mitochondrial biogenesis (PGC-1α)."

 

"Oral administration of E+Q (75mg/kg; once daily for 5days) reduced hypoxic-ischemic brain injury."

 

http://www.ncbi.nlm....pubmed/26363153

 

Neuroscience. 2015 Sep 10;308:75-94. doi: 10.1016/j.neuroscience.2015.09.012. [Epub ahead of print]

Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways.

Nichols M1, Zhang J2, Polster BM3, Elustondo PA4, Thirumaran A5, Pavlov EV6, Robertson GS7.

Author information

Abstract

In view of evidence that increased consumption of epicatechin (E) and quercetin (Q) may reduce the risk of stroke, we have measured the effects of combining E and Q on mitochondrial function and neuronal survival following oxygen-glucose deprivation (OGD). Relative to mouse cortical neuron cultures pretreated (24h) with either E or Q (0.1-10μM), E+Q synergistically attenuated OGD-induced neuronal cell death. E, Q and E+Q (0.3μM) increased spare respiratory capacity but only E+Q (0.3μM) preserved this crucial parameter of neuronal mitochondrial function after OGD. These improvements were accompanied by corresponding increases in cyclic AMP response element binding protein (CREB) phosphorylation and the expression of CREB-target genes that promote neuronal survival (Bcl-2) and mitochondrial biogenesis (PGC-1α). Consistent with these findings, E+Q (0.1 and 1.0μM) elevated mitochondrial gene expression (MT-ND2 and MT-ATP6) to a greater extent than E or Q after OGD. Q (0.3-3.0μM), but not E (3.0μM), elevated cytosolic calcium (Ca2+) spikes and the mitochondrial membrane potential. Conversely, E and E+Q (0.1 and 0.3μM), but not Q (0.1 and 0.3μM), activated protein kinase B (Akt). Nitric oxide synthase (NOS) inhibition with L-NG-nitroarginine methyl ester (1.0μM) blocked neuroprotection by E (0.3μM) or Q (1.0μM). Oral administration of E+Q (75mg/kg; once daily for 5days) reduced hypoxic-ischemic brain injury. These findings suggest E and Q activate Akt- and Ca2+-mediated signaling pathways that converge on NOS and CREB resulting in synergistic improvements in neuronal mitochondrial performance which confer profound protection against ischemic injury.

 

 

I remember you mentioning epicatechin before. How did it work out for you? I'd be interested in personally using this combo myself as I've seen some interesting information on querectin for neuroprotection and rehabilitation, and I know epicatechin has some nice information behind it and is present in moderately high quantities in chocolate which has no shortage of evidence as an amazing functional food/neutraceutical. 

[lostfalco]

I remember you mentioning epicatechin before. How did it work out for you? I'd be interested in personally using this combo myself as I've seen some interesting information on querectin for neuroprotection and rehabilitation, and I know epicatechin has some nice information behind it and is present in moderately high quantities in chocolate which has no shortage of evidence as an amazing functional food/neutraceutical. 

 

Hey, what's up Papa? It's been a while man. I hope you're doing well!

 

I loved epicatechin...I just wish it wasn't so overpriced. It was a fad bodybuilding supplement about a year ago and that drove the prices up to about $50 a bottle. It's still about that price. If you find a quality, affordable source then definitely let me know. 

[Area-1255]

http://www.longecity...5-nearlyfamous/

http://www.longecity...rcrine-systems/

http://www.longecity...view=getnewpost

[lostfalco]

So, as many of you know I think one of the most fundamental components of optimal functioning (probably 'the' most) is thermodynamic disequilibrium...aka gradient creation. My first goal in seeking health and intelligence is to create the best possible hydrogen/proton gradient in my mitochondria. This is EXTREMELY foundational. Electrons are used to power pumps which pump protons across a membrane which creates...a gradient. This gradient can then be used to do work as protons flow back through ATP synthase creating ATP (think of how flowing water is used to power a water wheel; see videos below). ATP is then used to help create further gradients (calcium, sodium, etc.) which affect learning and memory (ATP powers sodium and calcium pumps which create these gradients across cell membranes). Ultimately, we have gradients that depend on gradients.  

 

This is an organizing principle of the entire universe, not just biological systems. See Harvard professor Eric Chaisson's work: http://www.amazon.co...e/dp/0674009878    

 

Side note: I think 'a gene for intelligence' will never be found. Reason: 1) intelligence depends on gradients, 2) gradients depend on multiple genes (mitochondrial genes AND nuclear genes). 

 

Side note 2: I think life on earth most likely arose at hydrothermal vents at the bottom of the ocean. Reason: thermodynamic disequilibrium. See Nick Lane's fascinating discussion: http://www.amazon.co...f=rdr_ext_tmb  

 

Side note 3: Gradient creation is the reason that nootropic 'stacks' are so important. The membrane is made of fats (phospholipids), the pumps are made of protein (folded strings of amino acids), these structures are built by genes, it's a liquid water environment, the gradients are made of ions, etc, etc, etc. You need MANY different elements to optimize the function of your brain. The pursuit of ONE ultimate nootropic is most likely in vain imo. This is why substance X may work for a while but then stop working for you. It ultimately doesn't optimize your gradients (think of how receptor down regulation would affect cell membrane gradients and subsequent intracellular signaling caused by ions flowing into the cell). Embrace a multi-faceted approach over a period of time long enough to create gradient changes. Focus on your hydrogen/proton gradient first and once you've optimized that you can worry about calcium, sodium, potassium etc. gradients.   

 

Side note 4: This is why LLLT works so well. Photons add energy to electrons which enhance the proton gradient in your mitochondria. It's hard to get any more fundamental than this!

 

Side note 5: Think of things that might interfere with your gradients and how those things can be avoided. 

 

Side note 6: Remember that a gradient must be created, then used, THEN recreated again. This is often forgotten in discussions that I've observed...though not always. =)

 

A huge number of diseases are caused by malfunctioning gradients. Check out this study for the role of complex I in the electron transport chain. =)

 

http://www.ncbi.nlm....pubmed/21924235

 

http://www.sciencedi...005272811002003

 

Biochim Biophys Acta. 2012 Jun;1817(6):851-62. doi: 10.1016/j.bbabio.2011.08.010. Epub 2011 Sep 2.

Understanding mitochondrial complex I assembly in health and disease.

Mimaki M1, Wang X, McKenzie M, Thorburn DR, Ryan MT.

Author information

Abstract

Complex I (NADH:ubiquinone oxidoreductase) is the largest multimeric enzyme complex of the mitochondrial respiratory chain, which is responsible for electron transport and the generation of a proton gradient across the mitochondrial inner membrane to drive ATP production. Eukaryotic complex I consists of 14 conserved subunits, which are homologous to the bacterial subunits, and more than 26 accessory subunits. In mammals, complex I consists of 45 subunits, which must be assembled correctly to form the properly functioning mature complex. Complex I dysfunction is the most common oxidative phosphorylation (OXPHOS) disorder in humans and defects in the complex I assembly process are often observed. This assembly process has been difficult to characterize because of its large size, the lack of a high resolution structure for complex I, and its dual control by nuclear and mitochondrial DNA. However, in recent years, some of the atomic structure of the complex has been resolved and new insights into complex I assembly have been generated. Furthermore, a number of proteins have been identified as assembly factors for complex I biogenesis and many patients carrying mutations in genes associated with complex I deficiency and mitochondrial diseases have been discovered. Here, we review the current knowledge of the eukaryotic complex I assembly process and new insights from the identification of novel assembly factors. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes.

Copyright © 2011 Elsevier B.V. All rights reserved.

 

 

 

Edited by lostfalco, 03 October 2015 - 08:08 PM.

[BigPapaChakra]

Awesome post, Falco!

 

I'd recommend you look into the work of A.I. Oparin, Syndney Fox, and Vladimir Vernadsky (on biospherology), though. They are, IMHO, some of the greatest minds in geophysics and geobiology, surface chemistry, evolution, etc. but their work may actually indicate that life didn't originate in a reducing, potentially alkaline environment (one example would be the cold, deep ocean depths), and likely originated in a oxidizing, potentially acidic environment; one example is perhaps volcanic basins. Their work is extremely well complemented by Gerald Pollack's work on early cells and protoplasms and the lack of a phospholipid membrane being needed in early environments, and some of the newer work put forth by the Electric Universe people and Saturn being the Earth's first true sun, which would've included a warmer earth for a time, illuminated by increasingly large amounts of photonic energy. 

[lostfalco]

Awesome post, Falco!

 

I'd recommend you look into the work of A.I. Oparin, Syndney Fox, and Vladimir Vernadsky (on biospherology), though. They are, IMHO, some of the greatest minds in geophysics and geobiology, surface chemistry, evolution, etc. but their work may actually indicate that life didn't originate in a reducing, potentially alkaline environment (one example would be the cold, deep ocean depths), and likely originated in a oxidizing, potentially acidic environment; one example is perhaps volcanic basins. Their work is extremely well complemented by Gerald Pollack's work on early cells and protoplasms and the lack of a phospholipid membrane being needed in early environments, and some of the newer work put forth by the Electric Universe people and Saturn being the Earth's first true sun, which would've included a warmer earth for a time, illuminated by increasingly large amounts of photonic energy. 

Thanks, Papa. I appreciate it. 

 

Have you read Nick Lane's book yet?

[BigPapaChakra]

I have not yet read them. I planned on reading one of them during Winter break between semesters, and another during summer. Any recommendation on what I should begin with? 

[Groundhog Day]

You say to start out at 30 seconds or so per spot and increase from there? How quickly can we move up the timing?

 

I just got this one:

 

http://www.amazon.co...ailpage_o02_s00

 

 

and I did 2 minutes on the upper sides of my forehead and 10-15 minutes on my left flank. I have significant health problems so I'm looking to do it longer as soon as I can.  I also do mild HBOT quite a bit, which generates ROS, so I will stop doing that while I do LLLT.

Edited by Groundhog Day, 05 October 2015 - 12:22 AM.

[lostfalco]

You say to start out at 30 seconds or so per spot and increase from there? How quickly can we move up the timing?

 

I just got this one:

 

http://www.amazon.co...ailpage_o02_s00

 

 

and I did 2 minutes on the upper sides of my forehead and 10-15 minutes on my left flank. I have significant health problems so I'm looking to do it longer as soon as I can.  I also do mild HBOT quite a bit, which generates ROS, so I will stop doing that while I do LLLT.

You can start upping the dose very quickly. My recommendations are there to encourage minimum effective dosing. I'd rather people err on the side of caution first. 

[BigPapaChakra]

You say to start out at 30 seconds or so per spot and increase from there? How quickly can we move up the timing?

 

I just got this one:

 

http://www.amazon.co...ailpage_o02_s00

 

 

and I did 2 minutes on the upper sides of my forehead and 10-15 minutes on my left flank. I have significant health problems so I'm looking to do it longer as soon as I can.  I also do mild HBOT quite a bit, which generates ROS, so I will stop doing that while I do LLLT.

Do you have a home unit for mHBOT? I've been interested in mHBOT over HBOT for quite some time, since some experts argue that mHBOT is more suitable for psychiatric and/or neurological issues (and potentially brain enhancement) than HBOT which may be more suitable for systemic issues, stem cell proliferation, anti-cancer therapies etc. 

 

Also, Falco (and anyone else interested) - when looking at some stuff by Nick Lane and some others, I found this guy: http://www.amazon.co...t=relevancerank he is apparently one of the only (or the only?) guys at his university to not only simultaneously earn a double doctorate, but complete them both in 6 years; and also obtain dual board licensure for both general and plastic surgery. He also invented the triple lumen venous catheter and has had greats such as szent-gyorgi as inspirations and mentors. So, definitely an intelligent individual to say the least. This book seems appealing: http://www.amazon.com/U-T-O-P-I-Unified-Theory-Participation-Aerobiosis/dp/1484883225/ref=sr_1_9?s=books&ie=UTF8&qid=1444013308&sr=1-9&keywords=randolph+m+howes+md 

U.T.O.P.I.A.: Unified Theory of Oxygen Participation in Aerobiosis as does: http://www.amazon.co...160_SR107,160_ Hydrogen Peroxide: A Health, Homeostatic and Protective Essentiality

[magta39]

Hey Lostfalco, what dosage schedule do you find works best for low dose tadalafil regarding brain function?  Do you take days off or washout periods?  Thanks.

[Groundhog Day]

 

You say to start out at 30 seconds or so per spot and increase from there? How quickly can we move up the timing?

 

I just got this one:

 

http://www.amazon.co...ailpage_o02_s00

 

 

and I did 2 minutes on the upper sides of my forehead and 10-15 minutes on my left flank. I have significant health problems so I'm looking to do it longer as soon as I can.  I also do mild HBOT quite a bit, which generates ROS, so I will stop doing that while I do LLLT.

Do you have a home unit for mHBOT? I've been interested in mHBOT over HBOT for quite some time, since some experts argue that mHBOT is more suitable for psychiatric and/or neurological issues (and potentially brain enhancement) than HBOT which may be more suitable for systemic issues, stem cell proliferation, anti-cancer therapies etc. 

 

Also, Falco (and anyone else interested) - when looking at some stuff by Nick Lane and some others, I found this guy: http://www.amazon.co...t=relevancerank he is apparently one of the only (or the only?) guys at his university to not only simultaneously earn a double doctorate, but complete them both in 6 years; and also obtain dual board licensure for both general and plastic surgery. He also invented the triple lumen venous catheter and has had greats such as szent-gyorgi as inspirations and mentors. So, definitely an intelligent individual to say the least. This book seems appealing: http://www.amazon.com/U-T-O-P-I-Unified-Theory-Participation-Aerobiosis/dp/1484883225/ref=sr_1_9?s=books&ie=UTF8&qid=1444013308&sr=1-9&keywords=randolph+m+howes+md 

U.T.O.P.I.A.: Unified Theory of Oxygen Participation in Aerobiosis as does: http://www.amazon.co...160_SR107,160_ Hydrogen Peroxide: A Health, Homeostatic and Protective Essentiality

 

 

Yeah, I have a home unit, a Solace 210. I have done about 40-50 sessions total since July.  Some 1 hour, but most 90 or 120 minute sessions.

[Santino]

What for did you use it Groundhog day and did the HBOT help?

 

You need to try and error with LLLT and beware that more is not more. There is a energy dependent windows. If you put too less photons through your skin, there will be no effect and if you apply too much then there also is no benefit.

 

 

[Groundhog Day]

What for did you use it Groundhog day and did the HBOT help?

 

You need to try and error with LLLT and beware that more is not more. There is a energy dependent windows. If you put too less photons through your skin, there will be no effect and if you apply too much then there also is no benefit.

 

I'm using it to prevent neurodegeneration. I've had severe chronic insomnia for 15 years and then a concussion nearly 4 years ago where neurological symptoms came about and then 4 months ago I was taking 450mg theanine a day and I now have constant muscle twitching.

 

I'm not sure whether or not it's helped. My neurotransmitters are so out of whack that I'm not a person that can ever relax so it kind of forces you to relax in a sense being trapped in there with nothing to do. I was actually falling asleep in it a bit in the beginning but not lately.

 

When I was researching (anecdotal) it seemed like the people with the best success did 70-100 or more treatments.

[BieraK]

 

What for did you use it Groundhog day and did the HBOT help?

 

You need to try and error with LLLT and beware that more is not more. There is a energy dependent windows. If you put too less photons through your skin, there will be no effect and if you apply too much then there also is no benefit.

 

I'm using it to prevent neurodegeneration. I've had severe chronic insomnia for 15 years and then a concussion nearly 4 years ago where neurological symptoms came about and then 4 months ago I was taking 450mg theanine a day and I now have constant muscle twitching.

 

I'm not sure whether or not it's helped. My neurotransmitters are so out of whack that I'm not a person that can ever relax so it kind of forces you to relax in a sense being trapped in there with nothing to do. I was actually falling asleep in it a bit in the beginning but not lately.

 

When I was researching (anecdotal) it seemed like the people with the best success did 70-100 or more treatments.

 

What results have you noticed?
I'm very interested in HBOT, however the price is high for me now.
For now I'm waiting for buy an oxygen concentrator, I want to combine it with low doses Methylene blue and Niacin (B3) for doing a oxygen therapy, however I need to study a bit more about the risks of combining Methylene blue with oxygen, methylene blue alone enhances oxygen consumption by the cells, combining it with methylene blue can be too much oxygen saturation for the cells..

Edited by BieraK, 06 October 2015 - 05:45 AM.

[lostfalco]

I have not yet read them. I planned on reading one of them during Winter break between semesters, and another during summer. Any recommendation on what I should begin with? 

I would start with Power, Sex, Suicide: Mitochondria and the Meaning of Life  http://www.amazon.co...duct/0199205647

 

Then read The Vital Question   http://www.amazon.co.../dp/0393088812/

 

Just my humble opinion though. =)

Edited by lostfalco, 06 October 2015 - 07:17 PM.

[lostfalco]

Hey Lostfalco, what dosage schedule do you find works best for low dose tadalafil regarding brain function?  Do you take days off or washout periods?  Thanks.

Hey magta, there is def some level of self experimentation that must be done depending on all of the other stuff you are taking. I seem to do well on 2.5 to 5mg/day and I definitely recommend taking a day or two off per week and washing out for a week or two occasionally. I pretty much follow the dosing recommendations for BPH which are in the range of 2.5 to 5mg/day for 26 weeks...except, as I mentioned, I take some days off. It's pretty much trial and error guesswork at this point since PDE5i's are in the early stages of being tested for enhancing brain function. 

[magta39]

 

Hey Lostfalco, what dosage schedule do you find works best for low dose tadalafil regarding brain function?  Do you take days off or washout periods?  Thanks.

Hey magta, there is def some level of self experimentation that must be done depending on all of the other stuff you are taking. I seem to do well on 2.5 to 5mg/day and I definitely recommend taking a day or two off per week and washing out for a week or two occasionally. I pretty much follow the dosing recommendations for BPH which are in the range of 2.5 to 5mg/day for 26 weeks...except, as I mentioned, I take some days off. It's pretty much trial and error guesswork at this point since PDE5i's are in the early stages of being tested for enhancing brain function. 

 

 

Thanks Losfalco for the clarifications!
 

[lostfalco]

 

Thanks Losfalco for the clarifications!
 

No problem. =)

[Amorphous]

Any good source to get tadalafil?

[lostfalco]

Any good source to get tadalafil?

I get mine from here: http://www.superiorpeptide.com

 

Of course, if you find a better source then please let us know. I've never run any tests on their products nor have I seen any COAs from them so I've been taking a small risk here. It might be stretching it to say I 'recommend' them.

 

Def seems like tadalafil though...I don't need to explain why. ha

 

On the plus side, they frequently have 50% off sales (usually on Fridays or holidays) so I would check Friday and this weekend and see if you can get it then. $17 is pretty reasonable. As always, no affiliation.  

[Amorphous]

 

 

Thanks. so many interesting compounds. Doesn't look like taking paypal.....

Edited by Amorphous, 09 October 2015 - 05:20 AM.

[Amorphous]

I've checked severals of them and basically no paypal.... Anyway superiorpeptide only offers 25mg/mlx30ml and no special for this week or columbus day. It looks like blueskypeptide.com offers 30mg/mlx30ml with buy 2+1 free and 40% off for columbus day. When checking online, it also has a better reputation from what I can search. 

[lostfalco]

I've checked severals of them and basically no paypal.... Anyway superiorpeptide only offers 25mg/mlx30ml and no special for this week or columbus day. It looks like blueskypeptide.com offers 30mg/mlx30ml with buy 2+1 free and 40% off for columbus day. When checking online, it also has a better reputation from what I can search. 

Thanks, Amorphous! If you order from them let us know how it goes. I'm always looking to upgrade my sources.