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Lostfalco's Extensive Nootropic Experiments [Curated]

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#3001 Jochen

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Posted 01 April 2016 - 07:57 AM

 

I have taken an interest in galantamine (Rhonda Patrick and others seems to have taken a very active interest in similar substances as well).

 

Still doing my research, and not even sure what brand I should be taking at this stage. If anyone has a recommendation,, I am all ears.

 

I would probably start with 4mg and might do some tests with up to 8 mg. Good call on combining it with Tadalafil.

 

Hey Jochen, I've been using Powdercity's galantamine. http://www.powdercit...antamine-powder

 

I would def recommend starting low as it can cause nausea at higher doses. 4mg is a good starting point imo. 

 

 

as always, thanks a bunch. Ordered some and will try it out for sure.

 

Since all the adverse effects are on the GI tract, would it be possible to consume this sublingually?

 

I know people are using it intranasal as well, I am investigating that at the moment.

If you look at the literature, most of the positive studies are actually conducted with intranasal galantamine.

 

 



#3002 streamlover

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Posted 03 April 2016 - 03:06 AM

Hi Guys,

New here...found this forum on a google search and noticed you discussed hydrogen water back in 2014 for a while. Didn't follow it all the way to see how it ended or why it died out but I did notice one of the issues was how to obtain it easily without breaking the bank. I just discovered the protocol a few months back, went to the molecularhydrogenfoundation.org website and got pretty excited reading all the studies showing efficacy treating so many conditions. I started using Mg rods + malic acid in a tightly sealed container to generate pretty decent concentrations of H2 and have been drinking it for about 3 months now. (Actually tried many different acids, containers, water temps, etc. but ended up with malic acid, boiling water...I use distilled, a beer-brewing bottle, and putting it initially in the freezer to lower the temperature rapidly.) Lots of nice benefits from this...reduced inflammation throughout my body, increased stamina in sports and exercise, completely disappeared a sometime afib condition I had had for several years, improved mood and a brain that just seems to work better. All of these benefits seem aligned with one or more of the studies they've done. I'm still not sure why this hasn't caught on more, at least with the alt-health folks but I think it might have something to do with the fact that the products on the market now claiming H2 Water benefits (mainly water machines and pills you drop in water and drink) don't really obtain the concentrations necessary to notice the great benefits.  I've tweaked this method to where I now get 2.5-3.5 ppms H2 which is higher than what they used in many of the studies. If you're interested in checking it out, here's the video I just posted on youtube a few days ago. DIY Hydrogen Water

 

Please feel free to comment here and please bring up any issues that could be considered problematic for discussion as you guys all seem to be pretty rigorous in your research. I mention the Mg overload issue in the video and have satisfied myself that this won't be an issue for me but I'm still a little concerned about others possibly having a problem with it. Also, I'm sure some will question the Mg rods 99.99% purity but I'm OK with that issue too. I would certainly stake my Mg rods against the purity of the Mg in the pills they sell. Anyway, you get the idea...take me to task regarding anything about this method. -Glen


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#3003 Bluecheer

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Posted 03 April 2016 - 10:57 AM

Hey falcon, sorry I know you must be getting sick of my questions but promise this will be the last one, as I will now start to experiment on the relation of improvement relative to my lifestyle/diet/LLLT etc.


Now I would just like to say thank you lostfalco, I don't think I have really expressed my gratitude... But I am very appreciative, I have always had aspirations but when I sat down to do the work had a mental block where I would turn almost ADHD like.. After using LLLT - (only after increasing the dose of the LLLT and PPQ & Coq10 ) I have gained something that I have lost a long time ago. Which was belief in my abilities. The reason is because I now have endless energy & focus.. No longer am I crippled by short term focus.
I can now seriously focus and study for 6+ hours... Where as I use to not be able to go 10 minutes at most.

Now with that being said I have not seen any increased effect sense increasing my dose to 1.5 minutes per area ( I now am at 2.0 mins per spot ) I feel like somethings blocking me from achieving more of a "perfect" mindset. In a perfect world I would have the money to attempt all of the things on your God stack, but unfortunately I do not have the funds at the current time.
So my question is,

If you were a 22 year old male who has just found out the power of LLLT, given the knowledge you know now what would you add next?

I would really like to increase my memory, and I am going to buy some more pregenlone powder as it has been effective before... But with this I would like to try some other things To improve my mind - I'm moving in July and need to save most my money so I'm probably only going to try one more batch of products.

I appreciate your help so far, and if you get the time your future help with this question.


Regards,
B

Edited by Bluecheer, 03 April 2016 - 11:09 AM.


#3004 Nick Kyz

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Posted 03 April 2016 - 12:12 PM

 

Abelard my friend, are you out there? This one's for you!

 

Rodent Study:

non-emetic (projectile vomit) doses of roflumilast = enhanced memory

non-efficacious doses of roflumilast + donepezil = corrected memory deficits  

 

https://www.ncbi.nlm...pubmed/26794595

 

Behav Brain Res. 2016 Apr 15;303:26-33. doi: 10.1016/j.bbr.2016.01.031. Epub 2016 Jan 18.

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.

Abstract

Enhancement of central availability of the second messenger cAMP is a promising approach to improve cognitive function. Pharmacological inhibition of phosphodiesterase type 4 (PDE4), a group of cAMP hydrolyzing enzymes in the brain, has been shown to improve cognitive performances in rodents and monkeys. However, inhibition of PDE4 is generally associated with severe emetic side-effects. Roflumilast, an FDA-approved PDE4 inhibitor for treatment of chronic obstructive pulmonary disease (COPD), is yielding only mild emetic side effects. In the present study we investigate the potential of roflumilast as a cognition enhancer and to determine the potential coinciding emetic response in comparison to rolipram, a classic PDE4 inhibitor with pronounced emetic effects. Cognition enhancement was evaluated in mice and it was found that both roflumilast and rolipram enhanced memory in an object location task (0.03mg/kg), whereas only roflumilast was effective in a spatial Y-maze (0.1mg/kg). Emetic potential was measured using competition of PDE4 inhibition for α2-adrenergic receptor antagonism in which recovery from xylazine/ketamine-mediated anesthesia is used as a surrogate marker. While rolipram displayed emetic properties at a dose 10 times the memory-enhancing dose, roflumilast only showed increased emetic-like properties at a dose 100 times the memory-enhancing dose. Moreover, combining sub-efficacious doses of the approved cognition-enhancer donepezil and roflumilast, which did not improve memory when given alone, fully restored object recognition memory deficit in rats induced by the muscarinic receptor antagonist scopolamine. These findings suggest that roflumilast offers a more favorable window for treatment of cognitive deficits compared to rolipram.

 

 

Interesting, I'm trying out Ibudilast (a related compound which is also a potent PDE4 inhibitor) for exactly this purpose.

http://www.metabolic...ion-in-the-ass/



#3005 mettmett

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Posted 03 April 2016 - 11:41 PM

What's the human equivalent dose for the leucine?

#3006 mettmett

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Posted 04 April 2016 - 03:47 PM

Ok it wouldn't let me edit my post, but I did the math:

 

For a 170lb person the HED is about 15 grams of leucine.

 

 

Formulas: 

1.  (a x b) / (c x 100) where (a) is the dose needed in g per 100 kg live weight, (b) is average weight of the animals to be treated and © is the average daily feed consumption at time of treatment.

(24 x 30) / (3 x 100) = 2.4g/kg leucine

2.   http://www.longecity...nimal-to-human/

2.4 x (3/37) = ~.195

.195 x 77 = ~15g leucine

 

Please correct me if I am wrong!

 

 

 



#3007 lostfalco

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Posted 04 April 2016 - 08:47 PM

Ok it wouldn't let me edit my post, but I did the math:

 

For a 170lb person the HED is about 15 grams of leucine.

 

 

Formulas: 

1.  (a x b) / (c x 100) where (a) is the dose needed in g per 100 kg live weight, (b) is average weight of the animals to be treated and © is the average daily feed consumption at time of treatment.

(24 x 30) / (3 x 100) = 2.4g/kg leucine

2.   http://www.longecity...nimal-to-human/

2.4 x (3/37) = ~.195

.195 x 77 = ~15g leucine

 

Please correct me if I am wrong!

Hey mettmett, I use this study to convert from mouse to human equivalent dosing. http://www.fasebj.or...2/3/659.full#T1

 

This is from the leucine + PDE5i study: https://www.ncbi.nlm...les/PMC4427070/

"HFD + leucine (24 g/kg diet; Sigma-Aldrich Co, St Louis, MO, USA)"

"For a 30 g mouse consuming ~3 g chow/day"

 

Ready for some math!?! Here goes (Sorry about the obnoxious underlining!):

 

The "24 g/kg" is 24 grams of leucine per kilogram of diet.​ Kind of tricky if you ask me.

 

A mouse eats 3g of chow per day which equals .003kg of chow per day (1g = .001kg). 

 

Therefore, the amount of leucine a study mouse eats per day is .072 grams per day (out of the .003 kg of food it eats per day). When converted to mg this comes out to 72mg of leucine eaten per day (1 gram = 1000mg). 

 

Each mouse weighs 30 grams which converts to .03kg (1 gram = .001kg). 

 

Thus, each mouse eats 72mg/.03kg which comes out to 2,400mg/kg (2,400mg of leucine per 1 kg of body weight per day). 

 

To convert this to human equivalent dosing use the first study cited above and get 2400 * (3/37) which equals 194.59mg of leucine per kilogram of bodyweight per day.

 

For a 60kg human this comes out to (60 * 194.59mg) 11,675.68mg of leucine per day which converts to 11.68grams of leucine per day. 

 

Assuming three meals per day this would come out to 3.89grams of leucine per meal (11.68grams / 3 meals) which is pretty close to a typical dose of whey protein! =)

 

Check my math and assumptions and let me know if I missed anything!


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#3008 mettmett

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Posted 04 April 2016 - 08:55 PM

Ok cool, I see where I went wrong.  Thanks for clearing that up!



#3009 lostfalco

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Posted 04 April 2016 - 08:57 PM

Ok cool, I see where I went wrong.  Thanks for clearing that up!

No problem =)



#3010 lostfalco

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Posted 05 April 2016 - 12:22 AM

Hi Guys,

New here...found this forum on a google search and noticed you discussed hydrogen water back in 2014 for a while. Didn't follow it all the way to see how it ended or why it died out but I did notice one of the issues was how to obtain it easily without breaking the bank. I just discovered the protocol a few months back, went to the molecularhydrogenfoundation.org website and got pretty excited reading all the studies showing efficacy treating so many conditions. I started using Mg rods + malic acid in a tightly sealed container to generate pretty decent concentrations of H2 and have been drinking it for about 3 months now. (Actually tried many different acids, containers, water temps, etc. but ended up with malic acid, boiling water...I use distilled, a beer-brewing bottle, and putting it initially in the freezer to lower the temperature rapidly.) Lots of nice benefits from this...reduced inflammation throughout my body, increased stamina in sports and exercise, completely disappeared a sometime afib condition I had had for several years, improved mood and a brain that just seems to work better. All of these benefits seem aligned with one or more of the studies they've done. I'm still not sure why this hasn't caught on more, at least with the alt-health folks but I think it might have something to do with the fact that the products on the market now claiming H2 Water benefits (mainly water machines and pills you drop in water and drink) don't really obtain the concentrations necessary to notice the great benefits.  I've tweaked this method to where I now get 2.5-3.5 ppms H2 which is higher than what they used in many of the studies. If you're interested in checking it out, here's the video I just posted on youtube a few days ago. DIY Hydrogen Water

 

Please feel free to comment here and please bring up any issues that could be considered problematic for discussion as you guys all seem to be pretty rigorous in your research. I mention the Mg overload issue in the video and have satisfied myself that this won't be an issue for me but I'm still a little concerned about others possibly having a problem with it. Also, I'm sure some will question the Mg rods 99.99% purity but I'm OK with that issue too. I would certainly stake my Mg rods against the purity of the Mg in the pills they sell. Anyway, you get the idea...take me to task regarding anything about this method. -Glen

Hey Glen, thanks for the video. Love it. 

 

The main reason I stopped pushing hydrogen water is that I didn't feel like the cost was worth the benefits and I didn't want people to spend $1000 without getting their money's worth. Your idea is much more affordable. I just ordered some of the drops you mentioned and I'll test my hydrogen water to see how it compares. Here's the machine I have. http://www.amazon.co.../dp/B00FBSST8G/

 

 



#3011 lostfalco

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Posted 05 April 2016 - 12:30 AM

 

 

Interesting, I'm trying out Ibudilast (a related compound which is also a potent PDE4 inhibitor) for exactly this purpose.

http://www.metabolic...ion-in-the-ass/

 

Very cool, Nick! Let me know how it goes for you. I've just started testing it out consistently (I've tried it a few times in the past) as well so it'll be cool to compare. 

 

Galantamine is somewhat similar to donepezil (though not exactly) so a galantamine + ibudilast combo might be interesting to test. 

 

Caffeine also causes acetylcholine release in the rodent prefrontal cortex so maybe: galantamine + ibudilast + caffeine. Just a thought. 

 

Where to order ibudilast (since people are probably curious =)): https://www.mimaki-f...roduct_id=35376

 


Edited by lostfalco, 05 April 2016 - 12:30 AM.


#3012 lostfalco

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Posted 05 April 2016 - 12:35 AM

 

Since all the adverse effects are on the GI tract, would it be possible to consume this sublingually?

 

I know people are using it intranasal as well, I am investigating that at the moment.

If you look at the literature, most of the positive studies are actually conducted with intranasal galantamine.

 

Hey Jochen, it works sublingually ime. Tastes nasty though. Tolerable, but nasty. 

 

I asked misteryouaresodumb to make intranasal galantamine available through Ceretropic a month or two ago. Not sure if he's gonna do it or not. Haven't tried powedercity's powder intranasally. Seems like it might burn a little. ha



#3013 lostfalco

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Posted 05 April 2016 - 12:38 AM

Hey guys I would like to experiment with intranasal insulin but wanted to ask lostflaco or the others if the Novolin 70/30 NPH type insulin was safe and recommended to use? I have some around the house so it would be easy

http://diabetesindog...n/Novolin_70/30

Ty

Hey baptistegia, it is very likely safe but the studies generally recommend the shorter acting insulins for better effects. Let me look back through the studies though and get back to you. It might work. 



#3014 lostfalco

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Posted 05 April 2016 - 12:48 AM

Hey falcon, sorry I know you must be getting sick of my questions but promise this will be the last one, as I will now start to experiment on the relation of improvement relative to my lifestyle/diet/LLLT etc.

Now I would just like to say thank you lostfalco, I don't think I have really expressed my gratitude... But I am very appreciative, I have always had aspirations but when I sat down to do the work had a mental block where I would turn almost ADHD like.. After using LLLT - (only after increasing the dose of the LLLT and PPQ & Coq10 ) I have gained something that I have lost a long time ago. Which was belief in my abilities. The reason is because I now have endless energy & focus.. No longer am I crippled by short term focus.
I can now seriously focus and study for 6+ hours... Where as I use to not be able to go 10 minutes at most.

If you were a 22 year old male who has just found out the power of LLLT, given the knowledge you know now what would you add next?

I would really like to increase my memory, and I am going to buy some more pregenlone powder as it has been effective before... But with this I would like to try some other things To improve my mind - I'm moving in July and need to save most my money so I'm probably only going to try one more batch of products.

I appreciate your help so far, and if you get the time your future help with this question.


Regards,
B

No problem, Bluecheer. Glad it's working for you!

 

Since you are 22 I would generally recommend that you avoid pharmaceuticals until you are 25. The male brain takes a while to develop and you don't want to interfere with it unless something is seriously wrong. 

 

So, of course I would recommend the big 6: diet, exercise, sleep, meditation, fasting, and standing. 

 

Whey protein should also combine nicely with TULIP. 

 

For memory, the best things are the 20/10 method and spaced repetition learning (I use Anki). Links to these should be listed at the bottom of the god stack list on my wildly incomplete, in progress, and scatter-brained website here: http://lostfalco.com/2016/04/02/tgs/


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#3015 Reformed-Redan

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Posted 05 April 2016 - 02:47 AM

What are your thoughts about pregnenolone, lostfalco?

 

It has quite a few benefits. Can you link the studies you found most promising?

 

Thanks.



#3016 lostfalco

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Posted 05 April 2016 - 03:19 AM

What are your thoughts about pregnenolone, lostfalco?

 

It has quite a few benefits. Can you link the studies you found most promising?

 

Thanks.

Sure, yada. Here's a post on preg from a few months back that sums things up pretty well. 

http://www.longecity...-83#entry741089


Edited by lostfalco, 05 April 2016 - 03:21 AM.


#3017 Reformed-Redan

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Posted 05 April 2016 - 03:44 AM

 

What are your thoughts about pregnenolone, lostfalco?

 

It has quite a few benefits. Can you link the studies you found most promising?

 

Thanks.

Sure, yada. Here's a post on preg from a few months back that sums things up pretty well. 

http://www.longecity...-83#entry741089

 

Awesome, thanks.

 

Have you been able to find a supplier for pregnenolone sulfate? I can't find any and that's the one I want...



#3018 Amorphous

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Posted 05 April 2016 - 04:06 AM

So clonidine is effective, just not as effective as guanfacine? Why is that? Clonidine effects more adrenic receptors more strongly. Maybe the selecitve action of guanfacine is the key.

https://en.wikipedia...anism_of_action
https://en.wikipedia...ne#Pharmacology

Yeah bigyellow, you've got it. It's most likely selectivity.

http://www.ncbi.nlm....pubmed/10192826

Neuropsychopharmacology. 1999 May;20(5):460-70. Guanfacine, but not clonidine, improves planning and working memory performance in humans.
Jäkälä P1, Riekkinen M, Sirviö J, Koivisto E, Kejonen K, Vanhanen M, Riekkinen P Jr.

Author information

Abstract

The present study compares, using a double-blind, placebo controlled design the effects of two alpha 2-agonists, clonidine (0.5, 2, and 5 micrograms/kg) and guanfacine (7 and 29 micrograms/kg) on spatial working memory, planning and attentional set-shifting, functions thought to be dependent on the "central executive" of the prefrontal cortex. Blood pressure and the subjective feeling of sedation were affected equally by clonidine and guanfacine. The 0.5 microgram/kg and 5 micrograms/kg doses of clonidine disrupted spatial working memory, but the medium dose had no effect. The 0.5 and 2 micrograms/kg doses of clonidine increased impulsive responding in the planning test. The 5 micrograms/kg dose of clonidine slowed responding at effortful levels of planning and attentional set-shifting tests. The 29 micrograms/kg dose of guanfacine improved spatial working memory and planning. Guanfacine had no effect on attentional set-shifting. These data indicate that guanfacine improved planning and spatial working memory, but clonidine dose-dependently disrupted performance. It is possible that the greater selectivity of guanfacine for alpha 2A-adrenoceptor subtype may underlie its differences from clonidine.

I've been using guanfacine for a while. Definitely, it increases spatial working memory, but not to a very extraordinary amount. Drowsiness and dry mouth is a killer. Idra-21, sunifiram, and coffee helped a little with somnolence. Dry mouth has no antidote. If there is a way to counteract dry mouth, increase in working memory and focus definitely worth to try to expand cognitive ability.

#3019 Nick Kyz

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Posted 05 April 2016 - 04:34 AM

Very cool, Nick! Let me know how it goes for you. I've just started testing it out consistently (I've tried it a few times in the past) as well so it'll be cool to compare. 

 

 

 

Galantamine is somewhat similar to donepezil (though not exactly) so a galantamine + ibudilast combo might be interesting to test. 

 

Caffeine also causes acetylcholine release in the rodent prefrontal cortex so maybe: galantamine + ibudilast + caffeine. Just a thought. 

 

Where to order ibudilast (since people are probably curious =)): https://www.mimaki-f...roduct_id=35376

 

I was thinking that exactly, galantamine + ibudilast. Somewhat aside but I was wondering if you posted your experiments anywhere else like Gwern or Joe. It would be cool to check in occasionally and see what you've been up to instead of wading through several pages of Q&A.



#3020 streamlover

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Posted 05 April 2016 - 05:23 AM

streamlover, on 02 Apr 2016 - 8:06 PM, said:snapback.png

Hi Guys,

New here...found this forum on a google search and noticed you discussed hydrogen water back in 2014 for a while. Didn't follow it all the way to see how it ended or why it died out but I did notice one of the issues was how to obtain it easily without breaking the bank. I just discovered the protocol a few months back, went to the molecularhydrogenfoundation.org website and got pretty excited reading all the studies showing efficacy treating so many conditions. I started using Mg rods + malic acid in a tightly sealed container to generate pretty decent concentrations of H2 and have been drinking it for about 3 months now. (Actually tried many different acids, containers, water temps, etc. but ended up with malic acid, boiling water...I use distilled, a beer-brewing bottle, and putting it initially in the freezer to lower the temperature rapidly.) Lots of nice benefits from this...reduced inflammation throughout my body, increased stamina in sports and exercise, completely disappeared a sometime afib condition I had had for several years, improved mood and a brain that just seems to work better. All of these benefits seem aligned with one or more of the studies they've done. I'm still not sure why this hasn't caught on more, at least with the alt-health folks but I think it might have something to do with the fact that the products on the market now claiming H2 Water benefits (mainly water machines and pills you drop in water and drink) don't really obtain the concentrations necessary to notice the great benefits.  I've tweaked this method to where I now get 2.5-3.5 ppms H2 which is higher than what they used in many of the studies. If you're interested in checking it out, here's the video I just posted on youtube a few days ago. DIY Hydrogen Water

 

Please feel free to comment here and please bring up any issues that could be considered problematic for discussion as you guys all seem to be pretty rigorous in your research. I mention the Mg overload issue in the video and have satisfied myself that this won't be an issue for me but I'm still a little concerned about others possibly having a problem with it. Also, I'm sure some will question the Mg rods 99.99% purity but I'm OK with that issue too. I would certainly stake my Mg rods against the purity of the Mg in the pills they sell. Anyway, you get the idea...take me to task regarding anything about this method. -Glen

Hey Glen, thanks for the video. Love it. 

 

The main reason I stopped pushing hydrogen water is that I didn't feel like the cost was worth the benefits and I didn't want people to spend $1000 without getting their money's worth. Your idea is much more affordable. I just ordered some of the drops you mentioned and I'll test my hydrogen water to see how it compares. Here's the machine I have. http://www.amazon.co.../dp/B00FBSST8G/

 

Hi Falco,

Thanks for the supportive post...I've posted links on several other alt-health boards with pretty much collective yawns from all so far. As everyone here must know, it's good to have company when trying out new protocols. I'll be interested to hear your results of testing the Lourdes machine. There's a facebook group, Hydrogen Water, which has discussions mainly between machine and pill salespeople (mostly MLM types, I think) and current or potential customers. They have a guideline against mentioning brand names there but I've seen posts that seem to imply the best machines get around 1.0 ppms or a little more. The Lourdes is one of the few that actually advertises a level for H2 produced...I think it's 1.2 ppms. I wish they all would cut to the chase and just document their H2 concentrations obtained with their machines under normal operation, since that seems to be the ONLY factor which, according to Tyler LeBaron, makes a difference in their therapeutic value. Then they could also publish a video showing someone testing the water since that's pretty hard evidence also. It might start to bring H2 Water supplementation out of the realm of wild claims of snake-oil hucksters to science based medicine with decent anecdotal reporting of perceived benefits. Peer-reviewed studies are great but I also like to hear user reviews. Big Pharma has steered clear of this technology so far, it seems, probably because they couldn't see how to make money selling the most abundant molecule in the universe.

 

If you decide to try the DIY method, it takes about 3 weeks to get the 5" rods delivered from the Ebay seller. This is definitely a drag and will keep some from trying it out. If anyone locates a better (faster) source, please share.  -Glen



#3021 Lucas N

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Posted 05 April 2016 - 07:26 PM

Hey lostfalco, what's up??

 

I want to know if you still doing EC + IDRA 21 stack for focus and cognitiion, and some working memory.

 

I want to try ephedrine + idra 21 (I already do caff).

 

Thanks man!


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#3022 lostfalco

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Posted 07 April 2016 - 02:43 AM

Umm...this, this, a million times this! Sorry, I get a little excited sometimes. =)

 

/u/shrillthrill posted this over on reddit but it's a great example of a multifaceted intervention with excellent results in young healthy people. Here's why I recommend "The Big 6" before everything else. Enjoy!

 

http://journal.front...2016.00117/full

 

"These findings cumulatively indicate that a multifaceted intervention can simultaneously produce substantial and enduring improvements across a wide variety of psychological and physiological systems in healthy young adults. The magnitude of the effect sizes indicate considerably greater changes than observed from more narrowly-focused interventions, including improvements in mood and stress that were more than 2.5 times greater than typically observed from mindfulness training alone (Grossman et al., 2004Eberth and Sedlmeier, 2012). These findings provide an important exception to the prevailing view that highly multifaceted interventions are less effective (Wilson et al., 2015). The present results indicate that multifaceted interventions that are effectively designed and sufficiently motivating can elicit large and diverse improvements that reveal the substantial adult capacity for cognitive, affective, and neural plasticity."

 

Here's the intervention (I don't think it's necessary/practical to go quite this long for each element):

 

"The intervention convened for 5 h each weekday over a period of 6 weeks. Each day included 2.5 h of physical exercise, 1 h of formal mindfulness practice, and 1.5 h of lecture or discussion on topics related to sleep, nutrition, exercise, mindfulness, compassion, relationships, or well-being.

 

Each day began with 1 h of exercise in which participants completed a sequenced collection of exercises that targeted flexibility, balance, coordination, strength, and body awareness. Rate of respiration during these exercises was reduced to five breaths per minute by syncing the breath to subtle variations in music designed for this purpose.

 

Participants then completed 1 h of mindfulness practice. The majority of this time was spent engaging in focused attention meditation in which attention is directed to a single aspect of sensory experience (e.g., the physical sensations of breathing or walking). Participants also completed guided compassion meditation in which they deliberately generated feelings of compassion (wishing freedom from suffering) and kindness (wishing happiness) first toward themselves and then toward loved ones, acquaintances, and eventually strangers.

 

Each afternoon began with 1.5 h of lecture, discussion, or activity. Participants were introduced to key concepts and best practices in sleep, exercise, nutrition, alcohol consumption, mindfulness, gratitude, empathy, compassion, active listening, stress management, goal pursuit, and happiness.

 

Participants then completed 1.5 h of exercise under the direction of a fitness instructor with certifications in Pilates, yoga, and personal training. Workouts focused on Pilates twice a week, yoga once a week, and body weight circuit training once a week. A detailed workshop on anatomy and movement was offered once a week.

 

Throughout the program, participants were advised to limit alcohol intake to no more than one drink a day, to eat a diet of primarily whole foods, to restrict consumption of non-produce carbohydrates to after exercise, and to sleep 8–10 h each night while keeping a regular sleep schedule. One alcoholic drink was defined as 1.5 ounces of distilled spirits, 12 ounces of beer, or 5 ounces of wine.

 

Twice during the intervention, each participant met privately with an instructor for 20 min to discuss personal challenges and opportunities. Outside of the program, participants were advised to complete two high intensity interval training workouts each week and to engage in random acts of kindness each day. Participants kept a daily log of hours slept, alcoholic drinks consumed, workouts completed, and random acts of kindness. Each weekend, participants also kept a food log. These logs were reviewed by instructors and returned to participants each week with comments and suggestions for improvement. Following the 6-week intervention, participants received no additional instruction or support."


Edited by lostfalco, 07 April 2016 - 04:11 AM.


#3023 lostfalco

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Posted 07 April 2016 - 11:55 PM

 

Have you been able to find a supplier for pregnenolone sulfate? I can't find any and that's the one I want...

 

 

http://www.longecity...-83#entry741089

 

Oral pregnenolone is converted into pregnenolone sulfate. http://www.ncbi.nlm....icles/PMC23857/

 

"Orally ingested P probably largely is converted to PS in the intestine, which is rich in steroid-conjugating enzyme activity, the PS being absorbed rapidly into the blood."


Edited by lostfalco, 07 April 2016 - 11:56 PM.


#3024 magta39

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Posted 08 April 2016 - 08:21 AM

 

 

Have you been able to find a supplier for pregnenolone sulfate? I can't find any and that's the one I want...

 

 

http://www.longecity...-83#entry741089

 

Oral pregnenolone is converted into pregnenolone sulfate. http://www.ncbi.nlm....icles/PMC23857/

 

"Orally ingested P probably largely is converted to PS in the intestine, which is rich in steroid-conjugating enzyme activity, the PS being absorbed rapidly into the blood."

Lostfalco, so do you think taking sublingual Pregnenolone would have different effects than if you just swallowed it to get the conversion to PS?  Another question is do you think tadalafil is safe for women to take in the small doses for nootropic effects?

 

 

 

 


 



#3025 bigyellowlemon

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Posted 08 April 2016 - 09:00 AM

I'm sure everyone has at least a little bit of glial scarring, from getting bumped on the head to having a micro transient ischemic attack/ micro aneurysm.

 

I know I have. A lot actually.

 

Chondroitinase ABC seems like it would help.

 

http://www.nature.co...ll/416636a.html

http://www.ncbi.nlm....pubmed/20620201

 

This combined with a NOGO inhibitor would prob be good.

 

I remember reading someone saying inhibiting NOGO would be bad, and that our brains uses it for a very important reason. I've forgotten what they were talking about however (I seem to have too much glial scarring). Do you guys think NOGO inhibition/breaking down glial scarring would be bad? What purpose does it serve? Controlling inflammation after brain damage?



#3026 bigyellowlemon

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Posted 08 April 2016 - 09:02 AM

Also, does anyone have any theories on what purpose PDE4 could have? It seems like PDE4i's are a mental panacea.

 

I've been wary lately of using nootropics. Biology is so damn complex, and here we are so arrogantly thinking we know how to control it. Maybe it's best to try to merely live a healthy life and let our own biology honed over millions of years do it's job. idk

 

 



#3027 bigyellowlemon

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Posted 08 April 2016 - 09:10 AM

Why don't all humans have a ton more Nicotine receptors? Maybe we're messing with something we shouldn't.

 

I think Gwern brought this up as an example of why we can't reliably improve intelligence.

 

 



#3028 lostfalco

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Posted 08 April 2016 - 01:47 PM

1. Lostfalco, so do you think taking sublingual Pregnenolone would have different effects than if you just swallowed it to get the conversion to PS?  

 

 

2. Another question is do you think tadalafil is safe for women to take in the small doses for nootropic effects?

 

 

1. Yessir, I think so. 

 

2. In low doses (5mg) it seems relatively safe for women to test out. 

 

https://www.ncbi.nlm...pubmed/22612985

"Daily tadalafil 5 mg treatment seems to improve subjective sexual aspects and could be used to treat genital arousal disorder of premenopausal women with type 1 diabetes."

 

https://www.ncbi.nlm...pubmed/26797204

"PDE5is could be an effective treatment modality for female sexual dysfunction. Although there were significant increases in adverse events in comparison with placebo, PDE5is were still relatively safe."



#3029 lostfalco

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Posted 08 April 2016 - 01:50 PM

Why don't all humans have a ton more Nicotine receptors? Maybe we're messing with something we shouldn't.

 

I think Gwern brought this up as an example of why we can't reliably improve intelligence.

Hey bigyellow, explain the logic here. The 'number of nicotine receptors' somehow indicates what we should or shouldn't mess with? Morally? What will be most likely be effective? Something else? Not sure what the argument is here. =)



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#3030 lostfalco

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Posted 08 April 2016 - 02:00 PM

1. I've been wary lately of using nootropics.

 

2. Biology is so damn complex, and here we are so arrogantly thinking we know how to control it.

 

3. Maybe it's best to try to merely live a healthy life and let our own biology honed over millions of years do it's job. idk

1. I think you mentioned that you are 18, correct? I would humbly suggest that you don't take nootropics, actually (wait till 25, if ever). Of course, feel free to make your own choices. Just my two cents. =)

 

2. It is extremely complex. I would never assume that I know how to 'control it'. I've made it very clear over the years that I read massive amounts of scientific literature and use that to inform my 'guesses' about what may or may not work. There are always risks/unknowns and this is why I've always called myself 'a foolish self-experimenter who lives on pubmed'. If that makes me 'arrogant'...so be it. =)

 

3. I'm totally cool with this.  


Edited by lostfalco, 08 April 2016 - 02:55 PM.






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