4029 replies to this topic

[lostfalco]

I want this.

 

Maybe one could build his own? Wondering if applying that every day could improve health/life span and to what degree.

 

Did you try LLLT on other parts of your body? Do you think this can significantly improve health? I plan to start with head but...who knows

 

It's like again with most meds. Your knee hurts? Get LLLT.

I would rather do LLLT to have healthier knee in the first place. And if you can do it with your knee and head, maybe (with adjusted light range?) you can apply to other parts...heart..

Me too!

 

In proper doses the mitochondrial effects could certainly have a positive influence on healthspan. 

 

I have used LLLT on other body parts (I don't currently) and yeah I think it could be used to improve health. People have reported positive effects on eyes, skin, joints, tendons, thyroid, testes, etc. My main focus is brain health so that's the only place I use it right now. 

[lostfalco]

The six bottles I bought under prime shipment have no label on them.   Intranasal insulin produces greater clarity than n-semax for me; in fact, It produces clarity with good mood. One thing bad about using insulin that way is that it smells very bad. It is a kind of smell that can be noticed miles away. I am not sure if it is just Novolin R. Maybe I should try humulin R some day. 

Intranasal insulin is on the list of microglia inhibitors, does that mean it can be used to replace Ibudilast? Actually, I am a bit confused about the list of cholinergic anti-inflammatory pathway inhibitors and microglia inhibitors; galantamine is on both list, huperzine A + memantine, and memantine by itself (?)

Nice! No label. I wonder why there's a difference. Hmm...

 

I-insulin is pretty cool stuff. Clarity plus mood is a nice combo. Glad it's working well for you. 

 

Sorry about the smell (and the mild burning sensation...just to warn everyone). Unfortunately humulin smelled pretty much the same. I don't really notice it after a minute or two. Does the smell stick with you all day?

 

I wouldn't call it a one to one replacement (ibudilast is pretty unique) but it can be used to lower microglial activity (theoretically). 

 

Galantamine helps with both. I listed memantine + huperzine because that combo was actually tested in the literature (the link next to the substances). 

 

Just a FYI. Guanfacine is available for purchase here: http://irc.bio/product/guanfacine/

 

A COA is also available on that website and I've spoken with the owner.

 

Cheers.

Thanks for the heads up, yada!

[lostfalco]

 

Regarding the amber bottles for insulin......yes, I ordered the same bottles for $7.95 and they have the ugly labels on them.

 

My Ibudilast took 2 weeks just to ship, and it will probably be another week or so until I get it.

 

I started I-Insulin last Monday. Here is my anecdote ( I take in early morning, 7-8am, no food)

 

I've had insulin resistance in my liver for a while, and I have good reason to believe in my brain now so I want to restore insulin signaling.

 

Day 1: half spray. Noted better mood about an hour after taking it. Had more energy than usual in afternoon and evening, didn't sleep great. Fasted 20 hours from previous day, only had 1 meal.... very unusual for me, but good.

Day 2: full spray. Noted better mood, improved verbal articulation in morning.

Day 3: full spray. Got very tired after protein-centric first meal, but no matter how tired I get after lunch, I find it impossible to nap, this day was unusual in that I took a nap for the first time in probably 5 years. It was 90 minutes or so too. At night I had a wet dream, first in 6-7 years. My libido has been dead for a while.

Day 4: full spray: Nothing of note

Day 5: decided to exercise first, then take insulin, then eat first meal to see if I could get longer gap between meals, less desire to eat, which is always accompanied by brain fog. Seemed to work somewhat, didn't get as much fatigue, brain fog in afternoon shortly after lunch.

Day 6:full spray this morning.

 

So far so good, I also started the Longvida curcumin on Day 2 so that might play a part in some of this. I've taken curcumin for years but not the Longvida version.

 

Thanks for the report Groundhog Day!

 

Damn, sorry about the labels. ha

 

Mimaki is a bit slow. Has it arrived yet?

 

Intranasal insulin experience sounds a little mixed but overall pretty good. Keep us updated if you have the time. There is a possibility it could help with peripheral insulin resistance through a central mechanism. Hope it does. =)

 

https://www.ncbi.nlm...pubmed/25028522

 

Diabetes. 2014 Dec;63(12):4083-8. doi: 10.2337/db14-0477. Epub 2014 Jul 15.

Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men.

Heni M1, Wagner R2, Kullmann S3, Veit R4, Mat Husin H5, Linder K1, Benkendorff C6, Peter A1, Stefan N1, Häring HU1, Preissl H3, Fritsche A1.

Author information

Abstract

Animal studies suggest that insulin action in the brain is involved in the regulation of peripheral insulin sensitivity. Whether this holds true in humans is unknown. Using intranasal application of insulin to the human brain, we studied the impacts of brain insulin action on whole-body insulinsensitivity and the mechanisms involved in this process. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic glucose clamp before and after intranasal application of insulin and placebo in randomized order in lean and obese men. After insulin spray application in lean subjects, a higher glucose infusion rate was necessary to maintain euglycemia compared with placebo. Accordingly, clamp-derived insulin sensitivity index improved after insulin spray. In obese subjects, this insulin-sensitizing effect could not be detected. Change in the high-frequency band of heart rate variability, an estimate of parasympathetic output, correlated positively with change in whole-body insulin sensitivity after intranasal insulin. Improvement in whole-body insulin sensitivity correlated with the change in hypothalamic activity as assessed by functional magnetic resonance imaging. Intranasal insulin improves peripheral insulin sensitivity in lean but not in obese men. Furthermore, brain-derived peripheral insulinsensitization is associated with hypothalamic activity and parasympathetic outputs. Thus, the findings provide novel insights into the regulation of insulin sensitivity and the pathogenesis of insulin resistance in humans.

 

Edited by lostfalco, 13 May 2016 - 12:44 AM.

[lostfalco]

LF, Finally got my Ibudilast after 2 weeks, and the company did send an email with tracking info about a week after I ordered.

 

Are you still taking Galantamine 7mg BID (14 mg daily) or did you change your dose on that?

Also, are you taking the ibudilast+galantamine with any sort of Choline?

Very cool. Thanks for the info. I looked back through my emails and never found tracking info. It's possible I deleted it. 

 

Yeah, 7mg twice a day for the capsules. If you're using the powder I would actually take less. 

 

I've taken galantamine with choline (CDP mostly) before but it usually seems to be a bit much for me. Currently not taking choline with the combo. 

Edited by lostfalco, 13 May 2016 - 02:19 AM.

[lostfalco]

In subthreshold/very small doses ketamine is wonderful in a cognitive enhancement sense, it can bring about interesting & insightful changes in perception. I used small doses as an aid for meditation type activity a few times. It's also good as a withdrawl aid and to reset drug tolerances. (memantine and iboga are much better).

 

I've never tried ketamine but I don't doubt that it could have cognition enhancing properties in very low doses. It is one of the most potent enhancers of synaptogenesis that I'm aware of (sorry Dihexa!). Intranasal ketamine looks interesting for depression (as do other routes of administration). https://www.ncbi.nlm...pubmed/26035196

 

Of course, the metabolite hydroxynorketamine appears to have some sort of effect on AMPA receptors and depression without the side effects. Something to certainly keep an eye on.  

 

https://www.ncbi.nlm...pubmed/27144355

 

Nature. 2016 May 4. doi: 10.1038/nature17998. [Epub ahead of print]

NMDAR inhibition-independent antidepressant actions of ketamine metabolites.

Zanos P1, Moaddel R2, Morris PJ3, Georgiou P1, Fischell J4, Elmer GI1,5,6, Alkondon M7, Yuan P8, Pribut HJ1, Singh NS2, Dossou KS2, Fang Y3, Huang XP9, Mayo CL6, Wainer IW2, Albuquerque EX5,7,10, Thompson SM1,4, Thomas CJ3, Zarate CA Jr8, Gould TD1,5,11.

Author information

Abstract

Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require several weeks, if not months, to respond to these treatments, and many patients never attain sustained remission of their symptoms. The non-competitive, glutamatergic NMDAR (N-methyl-d-aspartate receptor) antagonist (R,S)-ketamine exerts rapid and sustained antidepressant effects after a single dose in patients with depression, but its use is associated with undesirable side effects. Here we show that the metabolism of (R,S)-ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and that the (2R,6R)-HNK enantiomer exerts behavioural, electroencephalographic, electrophysiological and cellular antidepressant-related actions in mice. These antidepressant actions are independent of NMDAR inhibition but involve early and sustained activation of AMPARs (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors). We also establish that (2R,6R)-HNK lacks ketamine-related side effects. Our data implicate a novel mechanism underlying the antidepressant properties of (R,S)-ketamine and have relevance for the development of next-generation, rapid-acting antidepressants.

[Junk Master]

Thanks Lostfalco!  I'll give the liposomal form of Luteolin and give you a report.

[lostfalco]

Thanks Lostfalco!  I'll give the liposomal form of Luteolin and give you a report.

Sounds good Junk Master!

[Groundhog Day]

 

 

Regarding the amber bottles for insulin......yes, I ordered the same bottles for $7.95 and they have the ugly labels on them.

 

My Ibudilast took 2 weeks just to ship, and it will probably be another week or so until I get it.

 

I started I-Insulin last Monday. Here is my anecdote ( I take in early morning, 7-8am, no food)

 

I've had insulin resistance in my liver for a while, and I have good reason to believe in my brain now so I want to restore insulin signaling.

 

Day 1: half spray. Noted better mood about an hour after taking it. Had more energy than usual in afternoon and evening, didn't sleep great. Fasted 20 hours from previous day, only had 1 meal.... very unusual for me, but good.

Day 2: full spray. Noted better mood, improved verbal articulation in morning.

Day 3: full spray. Got very tired after protein-centric first meal, but no matter how tired I get after lunch, I find it impossible to nap, this day was unusual in that I took a nap for the first time in probably 5 years. It was 90 minutes or so too. At night I had a wet dream, first in 6-7 years. My libido has been dead for a while.

Day 4: full spray: Nothing of note

Day 5: decided to exercise first, then take insulin, then eat first meal to see if I could get longer gap between meals, less desire to eat, which is always accompanied by brain fog. Seemed to work somewhat, didn't get as much fatigue, brain fog in afternoon shortly after lunch.

Day 6:full spray this morning.

 

So far so good, I also started the Longvida curcumin on Day 2 so that might play a part in some of this. I've taken curcumin for years but not the Longvida version.

 

Thanks for the report Groundhog Day!

 

Damn, sorry about the labels. ha

 

Mimaki is a bit slow. Has it arrived yet?

 

Intranasal insulin experience sounds a little mixed but overall pretty good. Keep us updated if you have the time. There is a possibility it could help with peripheral insulin resistance through a central mechanism. Hope it does. =)

 

https://www.ncbi.nlm...pubmed/25028522

 

Diabetes. 2014 Dec;63(12):4083-8. doi: 10.2337/db14-0477. Epub 2014 Jul 15.

Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men.

Heni M1, Wagner R2, Kullmann S3, Veit R4, Mat Husin H5, Linder K1, Benkendorff C6, Peter A1, Stefan N1, Häring HU1, Preissl H3, Fritsche A1.

Author information

Abstract

Animal studies suggest that insulin action in the brain is involved in the regulation of peripheral insulin sensitivity. Whether this holds true in humans is unknown. Using intranasal application of insulin to the human brain, we studied the impacts of brain insulin action on whole-body insulinsensitivity and the mechanisms involved in this process. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic glucose clamp before and after intranasal application of insulin and placebo in randomized order in lean and obese men. After insulin spray application in lean subjects, a higher glucose infusion rate was necessary to maintain euglycemia compared with placebo. Accordingly, clamp-derived insulin sensitivity index improved after insulin spray. In obese subjects, this insulin-sensitizing effect could not be detected. Change in the high-frequency band of heart rate variability, an estimate of parasympathetic output, correlated positively with change in whole-body insulin sensitivity after intranasal insulin. Improvement in whole-body insulin sensitivity correlated with the change in hypothalamic activity as assessed by functional magnetic resonance imaging. Intranasal insulin improves peripheral insulin sensitivity in lean but not in obese men. Furthermore, brain-derived peripheral insulinsensitization is associated with hypothalamic activity and parasympathetic outputs. Thus, the findings provide novel insights into the regulation of insulin sensitivity and the pathogenesis of insulin resistance in humans.

 

 

Yeah, I just got it yesterday. Going to try it on Monday, I think. It got here super quick (2 days) via priority mail, it just took them nearly a month to ship it.

 

I'm liking the i-insulin so far, take it every morning. The chemical or petro smell is kind of offputting but it's okay.

 

I generally fast in the morning and like to exercise but I'm wondering, based on that study on the previous page, if I should be taking it after I eat. Will probably start doing that.

 

The study you posted here is very interesting and I am definitely lean so I am hoping for the best.

 

Edited by Groundhog Day, 13 May 2016 - 03:11 AM.

[normalizing]

Zinc, another component of Detemir and Humalog but not Apidra, has less potential for harm. Zinc is added to insulin preparations to prolong their action by causing the insulin monomers to form hexamers.

Zicam, a homeopathic nasal gel for the common cold containing 33 mM zinc, was ineffective [8] and was associated with anosmia [9]

[chris106]

Just ordered galantamine and Ibudilast,too.
 

I decided to be cautious and use parcel-forwarding via the UK (skypax) to germany - that's why I ordered right away, just in case the imminent psychoactive-substance ban in the UK might complicate the matter.

Galantamine has arrived allready, but Ibudilast might take a little longer still. Anyways, once I get to try them both, I will add another anecdotal report.

[Amorphous]

 

 

Nice! No label. I wonder why there's a difference. Hmm...

 

I-insulin is pretty cool stuff. Clarity plus mood is a nice combo. Glad it's working well for you. 

 

Sorry about the smell (and the mild burning sensation...just to warn everyone). Unfortunately humulin smelled pretty much the same. I don't really notice it after a minute or two. Does the smell stick with you all day?

 

I wouldn't call it a one to one replacement (ibudilast is pretty unique) but it can be used to lower microglial activity (theoretically). 

 

Galantamine helps with both. I listed memantine + huperzine because that combo was actually tested in the literature (the link next to the substances). 

 

 

I didn't notice the smell too much myself. It was the people in the building noticed the weird smells after I sprayed my nose and came out of the room. I can also sense the smell whenever I wash my face or take a shower even after several hours of the spray. 

I couldn't resist but order Ibudilast at last. The website seems weird especially the way it messes up my address when first registering and then from the confirmation of my orders. Hopefully, I will receive my orders. Does anyone have the same problem when ordering from the mimaki family pharmacy?

[normalizing]

so anyone got their stuff from mimaki family pharmacy or what? since its all the way in japan and the site looks cheap suspiciously made, im worried they will just swallow your money and not send products OR customs with seize them, any truth to that?

im kind of thinking of using them but perhaps start low not to lose the purchase? i found out they carry a lot of interesting things that are sold with prescriptions overseas, thats kind of a red flag tho, would they dare ship such things and do they even ask for prescription??

[lostfalco]

so anyone got their stuff from mimaki family pharmacy or what? since its all the way in japan and the site looks cheap suspiciously made, im worried they will just swallow your money and not send products OR customs with seize them, any truth to that?

im kind of thinking of using them but perhaps start low not to lose the purchase? i found out they carry a lot of interesting things that are sold with prescriptions overseas, thats kind of a red flag tho, would they dare ship such things and do they even ask for prescription??

Another order of ibudilast just arrived at my house today. So, they didn't take my money and send nothing and it made it through customs. =)   Of course, your own risk/reward decision is up to you. Totally understand if people don't want to order from overseas. 

[lostfalco]

 

 

 

Nice! No label. I wonder why there's a difference. Hmm...

 

I-insulin is pretty cool stuff. Clarity plus mood is a nice combo. Glad it's working well for you. 

 

Sorry about the smell (and the mild burning sensation...just to warn everyone). Unfortunately humulin smelled pretty much the same. I don't really notice it after a minute or two. Does the smell stick with you all day?

 

I wouldn't call it a one to one replacement (ibudilast is pretty unique) but it can be used to lower microglial activity (theoretically). 

 

Galantamine helps with both. I listed memantine + huperzine because that combo was actually tested in the literature (the link next to the substances). 

 

 

I didn't notice the smell too much myself. It was the people in the building noticed the weird smells after I sprayed my nose and came out of the room. I can also sense the smell whenever I wash my face or take a shower even after several hours of the spray. 

I couldn't resist but order Ibudilast at last. The website seems weird especially the way it messes up my address when first registering and then from the confirmation of my orders. Hopefully, I will receive my orders. Does anyone have the same problem when ordering from the mimaki family pharmacy?

 

Hmm. My girlfriend hasn't said anything about the smell and she's pretty likely to notice. I'll ask her and see what she says. 

 

Just got another delivery of ibudilast today. Yeah, their ordering site messed with my address when I entered it and I had to toy with it a bit to get the right one entered. Kind of a pain but it's the only source I know of. I'm all ears if anyone finds a new one!

 

 

Just ordered galantamine and Ibudilast,too.
 

I decided to be cautious and use parcel-forwarding via the UK (skypax) to germany - that's why I ordered right away, just in case the imminent psychoactive-substance ban in the UK might complicate the matter.

Galantamine has arrived allready, but Ibudilast might take a little longer still. Anyways, once I get to try them both, I will add another anecdotal report.

Very cool, Chris! Looking forward to hearing your results.

[airplanepeanuts]

 

Very cool. Thanks for the info. I looked back through my emails and never found tracking info. It's possible I deleted it. 

 

 

 

Could you check your account if they have tracking info there?  I ordered over a week ago and got no shipment notification by email or in my account, sadly.

[lostfalco]

 

 

Very cool. Thanks for the info. I looked back through my emails and never found tracking info. It's possible I deleted it. 

 

 

 

Could you check your account if they have tracking info there?  I ordered over a week ago and got no shipment notification by email or in my account, sadly.

 

Yep, I did get tracking this time but it was a week or two after I ordered. 

[MindExplorer]

My successful ibudilast order was the second time I've ordered from them. I think both times involved me sending an email about five days later to check in on the order status, to which I was sent a tracking number within a day or two if memory serves.

[normalizing]

that sounds all nice, but they do sell quite few things that require prescription if only some of the druggies sniff on that...

[lostfalco]

that sounds all nice, but they do sell quite few things that require prescription if only some of the druggies sniff on that...

No worries. Don't order if you're worried about it. I totally understand. 

[Kalliste]

I got my second catering-lamp after waiting a month for it to arrive from the UK. Now I have two 500w ruby-tinted red/infrared bulbs, they are fitted inside standard Halogens that can be bought at any department-store*.

 

Since summer is here and the sun is out I'm not using them very much. Come next winter my supposed nootropic, and definetly anti-SAD setup, will be these two lamps in the above picture and two normal white halogens with 150w each.

 

These red lamps produce a very nice pain-relief for my shoulders, which tend to tense up due to work, gym and family-life.

 

They can be applied to the head for a minute or two, longer if I use a fan to prevent brain-boiling.

 

My theory is that they should deliver most of the wavelengths of the red spectrum covered in this thread, in a very short time.

 

*Until environmental laws make it illegal here in the EU in 2017!? according to the salesperson :(

 

Attached Files

•  13092163_10153632471313034_2672726919820297561_n.jpg   82.19KB   4 downloads

[lostfalco]

you totally understand if i dont use a website you advertise. i, beyond totally, understand

 

Not sure what your point is here normalizing. I have no affiliation with them and I'm not 'advertising' for them. It's genuinely the only place I know of to buy ibudilast. If you have a better option then please share. I'll happily buy from them. 

 

I understand if anyone doesn't want to buy a prescription pharmaceutical from an overseas (for those of us in the US) pharmacy. That's a risk/reward calculation that's up to each individual to decide on and if someone decides it's not worth it then I get it. 

 

For me, I'm excited to finally have a pretty legitimate PDE4 inhibitor to experiment with. Been waiting for this for a long time. 

Edited by lostfalco, 18 May 2016 - 10:38 PM.

[umop 3pisdn]

I got my order from Mimaki without any problems. I am not sure how I feel about the stack so far, though. It does seem helpful with brain fog, but I'm realizing that maybe 'brain fog' wasn't my problem after all since otherwise not much has changed. I was thinking it might help address my depression since neuroinflammation is usually found there (though whether it's causative or not I don't know), but for my actual depression I've found that doing stuff like using a TENS machine on my tragus (or vagus nerve) has actually been more helpful over all. It has only been a week or so on galantamine and ibudilast, though, and I don't know if the effects are supposed to be somewhat cumulative or not.

Edited by umop 3pisdn, 18 May 2016 - 08:55 PM.

[Bluecheer]

 

I got my order from Mimaki without any problems. I am not sure how I feel about the stack so far, though. It does seem helpful with brain fog, but I'm realizing that maybe 'brain fog' wasn't my problem after all since otherwise not much has changed. I was thinking it might help address my depression since neuroinflammation is usually found there (though whether it's causative or not I don't know), but for my actual depression I've found that doing stuff like using a TENS machine on my tragus (or vagus nerve) has actually been more helpful over all. It has only been a week or so on galantamine and ibudilast, though, and I don't know if the effects are supposed to be somewhat cumulative or not.

 

I agree! I haven't seen much of an effect expect for maybe a slight sense of clarity in though (less brain fog), however slight is the key word there.


Hey falco, few questions - sorry mate.
LLLT is far more complicated and surpasses my knowledge, What is your thinking towards say Using LLT regularly without supplementing with PQQ or Coq10- just curious as it is extremely expensive stuff when your taking a double dose twice a day.


Id also like to explore more areas of increased mitochondrial function, or atleast things that have a side effect of helping my mitochondria .....  now I understand how dense this forum is with your findings on this area, but time is precious... Any suggestions you would recommend? - I quite enjoyed MK-677, PQQ & have found pregenolone extremely effective with memory.

thinking lithium, any guidance would be appreciated.


p.s I am over sensitive with almost any choline (headache's ) but galanatmine hasn't been that negative with me- just fyi if any one is thinking of using it but worried with this factor.

[lostfalco]

I got my order from Mimaki without any problems. I am not sure how I feel about the stack so far, though. It does seem helpful with brain fog, but I'm realizing that maybe 'brain fog' wasn't my problem after all since otherwise not much has changed. I was thinking it might help address my depression since neuroinflammation is usually found there (though whether it's causative or not I don't know), but for my actual depression I've found that doing stuff like using a TENS machine on my tragus (or vagus nerve) has actually been more helpful over all. It has only been a week or so on galantamine and ibudilast, though, and I don't know if the effects are supposed to be somewhat cumulative or not.

Thanks for the feedback, umop! Glad it seems to be helping with brain fog. Sorry to hear about the depression...it can be extremely multifactoral. Have you combined the stack with vagus nerve stimulation? They could possibly work together pretty well.

 

https://www.ncbi.nlm...les/PMC4535331/

 

"Direct electrical stimulation of the cholinergic anti-inflammatory pathway with electrodes that generate action potentials in the vagus nerve significantly inhibits cytokine production by innate immune cells in the spleen, liver, gastrointestinal tract, heart and other tissues that are innervated by the vagus nerve2,36–38. Stimulation of the vagus nerve significantly downregulates the production of TNF, IL-1, IL-6 and IL-8, but does not alter the production of the anti-inflammatory cytokines IL-10 and transforming growth factor-β (TGFβ). By restraining the output of potentially toxic mediators that are produced by innate immune cells, the cholinergic anti-inflammatory pathway protects the organism from organ damage and death during endotoxaemia, sepsis, haemorrhagic shock, colitis, arthritis, ileus, pancreatitis and other syndromes of excessive cytokine release."

 

 

https://www.ncbi.nlm...pubmed/27059884

 

J Physiol. 2016 Apr 5. doi: 10.1113/JP271539. [Epub ahead of print]

Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation.

Bonaz B1,2, Sinniger V1,2, Pellissier S1,3.

Author information

Abstract

Brain and viscera interplay within the autonomic nervous system where the vagus nerve (VN), containing approximately 80% afferent and 20% efferent fibres, plays multiple key roles in the homeostatic regulations of visceral functions. Recent data has suggested the anti-inflammatory role of the VN. This vagal function is mediated through several pathways, some of them still debated. The first one is the anti-inflammatory hypothalamic-pituitary adrenal axis which is stimulated by vagal afferent fibres and leads to the release of cortisol by the adrenal glands. The second one, called the cholinergic anti-inflammatory pathway, is mediated through vagal efferent fibres that synapse onto enteric neurons which release acetylcholine (ACh) at the synaptic junction with macrophages. ACh binds to α-7-nicotinic ACh receptors of those macrophages to inhibit the release of tumour necrosis (TNF)α, a pro-inflammatory cytokine. The last pathway is the splenic sympathetic anti-inflammatory pathway, where the VN stimulates the splenic sympathetic nerve. Norepinephrine released at the distal end of the splenic nerve links to the β2 adrenergic receptor of splenic lymphocytes that release ACh. Finally Ach inhibits the release of TNFα by spleen macrophages through α-7-nicotinic ACh receptors. Understanding of these pathways is interesting from a therapeutic point of view, since they could be targeted in various ways to stimulate anti-inflammatory regulation in TNFα related diseases such as inflammatory bowel disease and rheumatoid arthritis. Among others, VN stimulation, either as an invasive or non-invasive procedure, is becoming increasingly frequent and several clinical trials are ongoing to evaluate the potential effectiveness of this therapy to alleviate chronic inflammation. This article is protected by copyright. All rights reserved.

[lostfalco]

I got my second catering-lamp after waiting a month for it to arrive from the UK. Now I have two 500w ruby-tinted red/infrared bulbs, they are fitted inside standard Halogens that can be bought at any department-store*.

 

Since summer is here and the sun is out I'm not using them very much. Come next winter my supposed nootropic, and definetly anti-SAD setup, will be these two lamps in the above picture and two normal white halogens with 150w each.

 

These red lamps produce a very nice pain-relief for my shoulders, which tend to tense up due to work, gym and family-life.

 

They can be applied to the head for a minute or two, longer if I use a fan to prevent brain-boiling.

 

My theory is that they should deliver most of the wavelengths of the red spectrum covered in this thread, in a very short time.

 

*Until environmental laws make it illegal here in the EU in 2017!? according to the salesperson :(

Very nice, Cosmicalstorm. Love the setup. That's going to be illegal in Europe in 2017? Weird. Do you know what the rationale is?

[lostfalco]

I agree! I haven't seen much of an effect expect for maybe a slight sense of clarity in though (less brain fog), however slight is the key word there.

Hey falco, few questions - sorry mate.
LLLT is far more complicated and surpasses my knowledge, What is your thinking towards say Using LLT regularly without supplementing with PQQ or Coq10- just curious as it is extremely expensive stuff when your taking a double dose twice a day.


Id also like to explore more areas of increased mitochondrial function, or atleast things that have a side effect of helping my mitochondria .....  now I understand how dense this forum is with your findings on this area, but time is precious... Any suggestions you would recommend? - I quite enjoyed MK-677, PQQ & have found pregenolone extremely effective with memory.

thinking lithium, any guidance would be appreciated.


p.s I am over sensitive with almost any choline (headache's ) but galanatmine hasn't been that negative with me- just fyi if any one is thinking of using it but worried with this factor.

Thanks, Bluecheer! Good to hear it might be helping a little. My recommendations are definitely on the low end of dosing...especially for ibudilast. 30mg is a common dose and 60mg/day seems to be pretty well tolerated in the studies. If you are only noticing a bit more clarity then that is one route you could try and see if you notice anything different. 

 

LLLT is perfectly fine to use on its own and is actually the heavy hitter in that stack. If you only keep one then it's the one to keep. 

 

If you are cool with using pharmaceuticals then low dose PDE5 inhibition with sildenafil, tadalafil, or vardenafil are good options for mitochondrial function. This combines very well with LLLT and extremely well with ibudilast (PDE4i). I use 2.5 to 5mg max of tadalafil dosed first thing in the morning. 2.5mg per day lasts me 300 days with one purchase (no affiliation). https://www.superior...e.com/tadalafil

 

There are so many other things for mito function so let me know if you're not interested in PDE5 inhibitors and I'll give you some other suggestions. Tbh, MK-677 (10mg per day) + ibudilast (20mg per day) + tadalafil (2.5 to 5mg per day) + LLLT + pregnenolone is a pretty damn good stack. Ibudilast also mildly inhibits PDE3 so you could even go a little lower with tadalafil. You know the drill. Start low and slowly work your way up. 

 

https://www.ncbi.nlm...pubmed/24042162

 

J Pharmacol Exp Ther. 2013 Dec;347(3):626-34. doi: 10.1124/jpet.113.208017. Epub 2013 Sep 16.

cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury.

Whitaker RM1, Wills LP, Stallons LJ, Schnellmann RG.

Author information

Abstract

Recent studies demonstrate that mitochondrial dysfunction is a mediator of acute kidney injury (AKI). Consequently, restoration of mitochondrialfunction after AKI may be key to the recovery of renal function. Mitochondrial function can be restored through the generation of new, functional mitochondria in a process called mitochondrial biogenesis (MB). Despite its potential therapeutic significance, very few pharmacological agents have been identified to induce MB. To examine the efficacy of phosphodiesterase (PDE) inhibitors (PDE3: cAMP and cGMP activity; and PDE4: cAMP activity) in stimulating MB, primary cultures of renal proximal tubular cells (RPTCs) were treated with a panel of inhibitors for 24 hours. PDE3, but not PDE4, inhibitors increased the FCCP-uncoupled oxygen consumption rate (OCR), a marker of MB. Exposure of RPTCs to the PDE3 inhibitors, cilostamide and trequinsin, for 24 hours increased peroxisome proliferator-activated receptor γ coactivator-1α, and multiple mitochondrialelectron transport chain genes. Cilostamide and trequinsin also increased mRNA expression of mitochondrial genes and mitochondrial DNA copy number in mice renal cortex. Consistent with these experiments, 8-Br-cGMP increased FCCP-uncoupled OCR and mitochondrial gene expression, whereas 8-Br-cAMP had no effect. The cGMP-specific PDE5 inhibitor sildenafil also induced MB in RPTCs and in vivo in mouse renal cortex. Treatment of mice with sildenafil after folic acid-induced AKI promoted restoration of MB and renal recovery. These data provide strong evidence that specific PDE inhibitors that increase cGMP are inducers of MB in vitro and in vivo, and suggest their potential efficacy in AKI and other diseases characterized by mitochondrial dysfunction and suppressed MB.

 

 

https://www.ncbi.nlm.../pubmed/9329386

Study in growth hormone deficient males: "After treatment with 10 mg MK-677, IGF-I concentrations increased 52 +/- 20% (65 +/- 6 to 99 +/- 9 micrograms/L, geometric mean +/- intrasubject SE, P < or = 0.05 vs. baseline), and 24 h mean GH concentrations increased 79 +/- 19% (0.14 +/- 0.01 to 0.26 +/- 0.02 microgram/L, P < or = 0.05 vs. baseline)."

Edited by lostfalco, 18 May 2016 - 11:55 PM.

[Groundhog Day]

Lostfalco,

 

If I wanted to try vagus nerve stimulation with a TENS unit, where do I hook up the electrode pad? Just 1 of the 4 on the left side of my throat/neck?

Edited by Groundhog Day, 19 May 2016 - 07:52 PM.

[88LS]

anus

Seriously? You are being such an asshole - If you don't enjoy the discussion please leave.


Sent from my iPhone using Tapatalk

[umop 3pisdn]

I got my order from Mimaki without any problems. I am not sure how I feel about the stack so far, though. It does seem helpful with brain fog, but I'm realizing that maybe 'brain fog' wasn't my problem after all since otherwise not much has changed. I was thinking it might help address my depression since neuroinflammation is usually found there (though whether it's causative or not I don't know), but for my actual depression I've found that doing stuff like using a TENS machine on my tragus (or vagus nerve) has actually been more helpful over all. It has only been a week or so on galantamine and ibudilast, though, and I don't know if the effects are supposed to be somewhat cumulative or not.

Thanks for the feedback, umop! Glad it seems to be helping with brain fog. Sorry to hear about the depression...it can be extremely multifactoral. Have you combined the stack with vagus nerve stimulation? They could possibly work together pretty well.

 

https://www.ncbi.nlm...les/PMC4535331/

 

"Direct electrical stimulation of the cholinergic anti-inflammatory pathway with electrodes that generate action potentials in the vagus nerve significantly inhibits cytokine production by innate immune cells in the spleen, liver, gastrointestinal tract, heart and other tissues that are innervated by the vagus nerve2,36–38. Stimulation of the vagus nerve significantly downregulates the production of TNF, IL-1, IL-6 and IL-8, but does not alter the production of the anti-inflammatory cytokines IL-10 and transforming growth factor-β (TGFβ). By restraining the output of potentially toxic mediators that are produced by innate immune cells, the cholinergic anti-inflammatory pathway protects the organism from organ damage and death during endotoxaemia, sepsis, haemorrhagic shock, colitis, arthritis, ileus, pancreatitis and other syndromes of excessive cytokine release."

 

 

https://www.ncbi.nlm...pubmed/27059884

 

J Physiol. 2016 Apr 5. doi: 10.1113/JP271539. [Epub ahead of print]

Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation.

Bonaz B1,2, Sinniger V1,2, Pellissier S1,3.

Author information

Abstract

Brain and viscera interplay within the autonomic nervous system where the vagus nerve (VN), containing approximately 80% afferent and 20% efferent fibres, plays multiple key roles in the homeostatic regulations of visceral functions. Recent data has suggested the anti-inflammatory role of the VN. This vagal function is mediated through several pathways, some of them still debated. The first one is the anti-inflammatory hypothalamic-pituitary adrenal axis which is stimulated by vagal afferent fibres and leads to the release of cortisol by the adrenal glands. The second one, called the cholinergic anti-inflammatory pathway, is mediated through vagal efferent fibres that synapse onto enteric neurons which release acetylcholine (ACh) at the synaptic junction with macrophages. ACh binds to α-7-nicotinic ACh receptors of those macrophages to inhibit the release of tumour necrosis (TNF)α, a pro-inflammatory cytokine. The last pathway is the splenic sympathetic anti-inflammatory pathway, where the VN stimulates the splenic sympathetic nerve. Norepinephrine released at the distal end of the splenic nerve links to the β2 adrenergic receptor of splenic lymphocytes that release ACh. Finally Ach inhibits the release of TNFα by spleen macrophages through α-7-nicotinic ACh receptors. Understanding of these pathways is interesting from a therapeutic point of view, since they could be targeted in various ways to stimulate anti-inflammatory regulation in TNFα related diseases such as inflammatory bowel disease and rheumatoid arthritis. Among others, VN stimulation, either as an invasive or non-invasive procedure, is becoming increasingly frequent and several clinical trials are ongoing to evaluate the potential effectiveness of this therapy to alleviate chronic inflammation. This article is protected by copyright. All rights reserved.

 

 

Thank you. I discovered electrical vagus nerve stimulation a month or so ago and I really like it so far. For me the benefits aren't as numerous as meditation, but it does have some of the same benefits as meditation in my experience.

 

Lostfalco,

 

If I wanted to try vagus nerve stimulation with a TENS unit, where do I hook up the electrode pad? Just 1 of the 4 on the left side of my throat/neck?

 

TENSpros sells earclip electrodes, hook the positive pole onto your tragus, that's what I do at least and it seems to be the most common approach in studies.

 

Like this basically:

 

https://images.scien...1_1_900x600.jpg

 

They modified the electrode so the negative pole is on the other side of the clip, personally I just clip the negative pole onto my earlobe on the same ear.

Edited by umop 3pisdn, 19 May 2016 - 11:08 PM.

[Groundhog Day]

 

I got my order from Mimaki without any problems. I am not sure how I feel about the stack so far, though. It does seem helpful with brain fog, but I'm realizing that maybe 'brain fog' wasn't my problem after all since otherwise not much has changed. I was thinking it might help address my depression since neuroinflammation is usually found there (though whether it's causative or not I don't know), but for my actual depression I've found that doing stuff like using a TENS machine on my tragus (or vagus nerve) has actually been more helpful over all. It has only been a week or so on galantamine and ibudilast, though, and I don't know if the effects are supposed to be somewhat cumulative or not.

Thanks for the feedback, umop! Glad it seems to be helping with brain fog. Sorry to hear about the depression...it can be extremely multifactoral. Have you combined the stack with vagus nerve stimulation? They could possibly work together pretty well.

 

https://www.ncbi.nlm...les/PMC4535331/

 

"Direct electrical stimulation of the cholinergic anti-inflammatory pathway with electrodes that generate action potentials in the vagus nerve significantly inhibits cytokine production by innate immune cells in the spleen, liver, gastrointestinal tract, heart and other tissues that are innervated by the vagus nerve2,36–38. Stimulation of the vagus nerve significantly downregulates the production of TNF, IL-1, IL-6 and IL-8, but does not alter the production of the anti-inflammatory cytokines IL-10 and transforming growth factor-β (TGFβ). By restraining the output of potentially toxic mediators that are produced by innate immune cells, the cholinergic anti-inflammatory pathway protects the organism from organ damage and death during endotoxaemia, sepsis, haemorrhagic shock, colitis, arthritis, ileus, pancreatitis and other syndromes of excessive cytokine release."

 

 

https://www.ncbi.nlm...pubmed/27059884

 

J Physiol. 2016 Apr 5. doi: 10.1113/JP271539. [Epub ahead of print]

Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation.

Bonaz B1,2, Sinniger V1,2, Pellissier S1,3.

Author information

Abstract

Brain and viscera interplay within the autonomic nervous system where the vagus nerve (VN), containing approximately 80% afferent and 20% efferent fibres, plays multiple key roles in the homeostatic regulations of visceral functions. Recent data has suggested the anti-inflammatory role of the VN. This vagal function is mediated through several pathways, some of them still debated. The first one is the anti-inflammatory hypothalamic-pituitary adrenal axis which is stimulated by vagal afferent fibres and leads to the release of cortisol by the adrenal glands. The second one, called the cholinergic anti-inflammatory pathway, is mediated through vagal efferent fibres that synapse onto enteric neurons which release acetylcholine (ACh) at the synaptic junction with macrophages. ACh binds to α-7-nicotinic ACh receptors of those macrophages to inhibit the release of tumour necrosis (TNF)α, a pro-inflammatory cytokine. The last pathway is the splenic sympathetic anti-inflammatory pathway, where the VN stimulates the splenic sympathetic nerve. Norepinephrine released at the distal end of the splenic nerve links to the β2 adrenergic receptor of splenic lymphocytes that release ACh. Finally Ach inhibits the release of TNFα by spleen macrophages through α-7-nicotinic ACh receptors. Understanding of these pathways is interesting from a therapeutic point of view, since they could be targeted in various ways to stimulate anti-inflammatory regulation in TNFα related diseases such as inflammatory bowel disease and rheumatoid arthritis. Among others, VN stimulation, either as an invasive or non-invasive procedure, is becoming increasingly frequent and several clinical trials are ongoing to evaluate the potential effectiveness of this therapy to alleviate chronic inflammation. This article is protected by copyright. All rights reserved.

 

 

Thank you. I discovered electrical vagus nerve stimulation a month or so ago and I really like it so far. For me the benefits aren't as numerous as meditation, but it does have some of the same benefits as meditation in my experience.

 

Lostfalco,

 

If I wanted to try vagus nerve stimulation with a TENS unit, where do I hook up the electrode pad? Just 1 of the 4 on the left side of my throat/neck?

 

TENSpros sells earclip electrodes, hook the positive pole onto your tragus, that's what I do at least and it seems to be the most common approach in studies.

 

Like this basically:

 

https://images.scien...1_1_900x600.jpg

 

They modified the electrode so the negative pole is on the other side of the clip, personally I just clip the negative pole onto my earlobe on the same ear.

 

 

I searched through all their electrodes section and didn't see them, but found these in the supplies category:

 

http://www.tenspros....More_p_196.html

 

This looks like what you are talking about. Thanks a lot.