4029 replies to this topic

[lostfalco]

Lostfalco, have you combined PDE inhibitors with modafinil? I had found modafinil too emotionally dulling, but I've given it another try and it seems much better when I have PQQ (plus ubiquinol) and/or some caffeine in me. In fact, it lets me raise my PQQ dose to 20mg without feeling overstimulated and paradoxically brainfoggy (it widens PQQ's upside-down U into a monospaced font for me :D ). Do you happen to know if PDE inhibitors (in particular ibudilast or PDE5is) are said to be contraindicated with dopaminergics?

Hey MindExplorer, I've had no problems mixing 150mg Armodafinil with 20mg ibudilast and/or 5mg tadalafil. In my opinion they should actually be synergistic (for many people, not all). 

[lostfalco]

Hey LF,

 

I've been reading up on your success with Ibudilast and found it really interesting. I assume you're familiar with the vagus nerve infection theory? That theory seems to tie in very well with your own findings from what I've read of your research. Interestingly, I tried galantamine for the first time recently and had somewhat of a vagal episode (severe nausea, sweating, dizzy, pale, general malaise), which is the same thing I get very easily from exerting myself too much while exercising.

 

The vagus nerve keeps appearing wherever I look, and following on from the vagus nerve infection theory I'm tempted to perhaps try antivirals to see what nootropic effects (if any) they might have. It appears to me that glial cell inhibition with drugs such as Ibudilast may be very effective at treating the symptoms, but perhaps antivirals might treat the root cause. After all, what is the cause of the excessive microglial activation that you're treating? Would love to hear your thoughts on that.

Hey cheekz, I'm familiar with the vagus nerve infection theory. Yeah, if you've tried numerous things and none of them have worked then I would certainly look into antivirals. My one note of caution would be related to the "root cause" of microglial activation. Viral infection is certainly 'a' possibility...but it's only one possibility. There are many other possible causes of excessive microglial activation. For person A it might be a viral infection but for person B it might be a genetic mutation, for person C a food allergy, etc. I definitely agree with you though...the vagus plays a huge role.

[lostfalco]

Speaking of irisin. Glu-Asp-Arg is Pinealon and  Ala-Glu-Asp-Gly is Epitalon

 

 

 

Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.

 

http://link.springer...0517-016-3167-y

Use sci-hub to grab the full text.

Very interesting, Nuke! Nice find. I hadn't put that together.

 

I've got some reading to do. 

[lostfalco]

Speaking of irisin. Glu-Asp-Arg is Pinealon and  Ala-Glu-Asp-Gly is Epitalon

 

 

http://link.springer...0517-016-3167-y

Use sci-hub to grab the full text.

Here's the full text of the paper if anyone wants to check it out. 

Attached Files

•  Short Peptides and Telomere Length Regulator Hormone Irisin.pdf   314.39KB   21 downloads

Edited by lostfalco, 05 July 2016 - 04:42 AM.

[lostfalco]

As many of you know, I'm a pretty big fan of bright light therapy. I've been using it for years and it helps significantly with attention, mood, and wakefulness for me. 

 

Here's another recent study testing it for Nonseasonal Major Depressive Disorder.  https://www.ncbi.nlm...pubmed/27267951

 

I use this guy at home: http://amzn.to/1YtRsOk

 

I use this one at work: http://amzn.to/1YtSvxz  

 

 

 

https://www.ncbi.nlm...pubmed/27267951

 

J Affect Disord. 2016 May 26;203:1-8. doi: 10.1016/j.jad.2016.05.062. [Epub ahead of print]

A sham-controlled randomized trial of adjunctive light therapy for non-seasonal depression.

Chojnacka M1, Antosik-Wójcińska AZ2, Dominiak M3, Bzinkowska D2, Borzym A3, Sokół-Szawłowska M3, Bodzak-Opolska G3, Antoniak D3, Święcicki Ł2.

Author information

 

Abstract

 

BACKGROUND:

The aim of the study was to examine the efficacy and safety of morning bright light therapy (BLT) in the treatment of patients with a current major depressive episode (MDE) in bipolar and unipolar disorder without a seasonal pattern. It was a randomized, sham-controlled trial.

 

METHODS:

Adults, ages 18-70 years were randomized to treatment either with BLT or a sham negative ion generator (as a placebo control). The subjects were required to be on a stable and therapeutic dose of psychotropic medication for at least 4 weeks prior to enrollment and their treatment had to be insufficiently effective. Their clinical state was monitored at the baseline and at the end of treatment. The Hamilton Depression Rating Scale-21 items (HDRS-21), Montgomery-Asberg Depression Rating Scale (MADRS), Beck Depression Inventory (BDI-II), Clinical Global Impression-Severity (CGI-S) and Patient Global Impression (PGI) were used. The results were analyzed with an intention-to-treat (ITT) analysis.

 

RESULTS:

Ninety-five patients were enrolled (50 diagnosed with bipolar disorder and 45 with unipolar depression). Fifty-two patients were randomized to treatment with BLT and forty-three were in the placebo group (ITT population). Eighty-three subjects completed the study. There were 12 dropouts (5 in the light group and 7 in the placebo group). After 14 days of treatment, a significant improvement was found in all groups (p<0.001). The subjects treated with BLT did not significantly differ in terms of improvement in HDRS-21 scores at the endpoint when compared to patients treated with placebo (p=0.2). However, further analysis demonstrated significantly higher response (50% v. 27.9%, p=0.02) and remission rates (28.8% v. 11.6%, p=0.04) among patients treated with morning BLT when compared to placebo group. It should be noted that in the population of drug-resistant patients, BLT was more efficacious than placebo. There were no statistically significant differences between unipolar and bipolar disorders (p=0.4).

 

CONCLUSION:

Although overall improvement in HDRS-21 scores were not superior in the BLT group, both response and remission rates were significantly higher among patients treated with BLT relative to those receiving the sham intervention. BLT was also more efficacious than placebo in the population of patients with drug-resistant depression. Further studies to define the subpopulation of patients with non-seasonal depression who may benefit the most from BLT are needed.

Edited by lostfalco, 06 July 2016 - 03:48 AM.

[lostfalco]

New rodent study on LLLT for depression.

 

"As a whole, these findings shed light on a novel strategy of transcranial LLLT on depression improvement by ameliorating neurotransmitter abnormalities and promoting mitochondrial function in PFC (prefrontal cortex)."

 

https://www.ncbi.nlm...pubmed/27379735

 

Mol Neurobiol. 2016 Jul 5. [Epub ahead of print]

Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.

Xu Z^1,2, Guo X², Yang Y³, Tucker D⁴, Lu Y⁴, Xin N¹, Zhang G^1,2, Yang L¹, Li J⁵, Du X³, Zhang Q⁶, Xu X^7,8.

Author information

 

Abstract

Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobility, neurotransmitter deficiency, and energy metabolic decline. Low-level laser therapy (LLLT) has been investigated in a variety of neurodegenerative disorders associated with mitochondrial dysfunction and functional impairments. The goal of this study was to examine the effect of LLLT on depression-like behaviors and to explore the potential mechanism by detecting mitochondrial function following LLLT. Depression models in space restriction mice and Abelson helper integration site-1 (Ahi1) knockout (KO) mice were employed in this work. Our results revealed that LLLT effectively improved depression-like behaviors, in the two depression mice models, by decreasing immobility duration in behavioral despair tests. In addition, ATP biosynthesis and the level of mitochondrial complex IV expression and activity were significantly elevated in prefrontal cortex (PFC) following LLLT. Intriguingly, LLLT has no effects on ATP content and mitochondrial complex I-IV levels in other tested brain regions, hippocampus and hypothalamus. As a whole, these findings shed light on a novel strategy of transcranial LLLT on depression improvement by ameliorating neurotransmitter abnormalities and promoting mitochondrial function in PFC. The present work provides concrete groundwork for further investigation of LLLT for depression treatment.

 

Edited by lostfalco, 07 July 2016 - 11:36 PM.

[lostfalco]

New popular article: "Novel Drug Shows Promise for Improving Memory Loss after Traumatic Brain Injuries" http://www.dddmag.co...-brain-injuries

 

"Treating rats with an experimental drug at three months following a traumatic brain injury (TBI) improves their learning memory ability, as reported in a new study published online today in the July edition of The Journal of Neuroscience. The drug, a selective phosphodiesterase 4 subtype inhibitor (PDE4B), is currently under development by Tetra Discovery Partners, a privately held biotechnology company and is being tested as a potential therapy for TBI by University of Miami / Miami Project researchers."

 

Have any of you guys heard of a good PDE4B inhibitor that reduces tumor necrosis factor-α levels and increases phosphorylated CREB? Oh yeah, now I remember. =)  

 

"Ibudilast inhibits PDE4A, 4B, 4C and 4D with IC50 values 54, 65, 239 and 166 nM." http://www.lostfalco...n-fog-two-step/

 

Don't worry, I just punched myself in the face for being a smartass.

 

Seriously though, if you're struggling with recovery from a TBI then I think ibudilast is definitely worth a try. The link to my page above will show you where to buy it. 

 

Here's the actual study!

 

http://www.jneurosci...6/27/7095.short

Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

 

Abstract

Learning and memory impairments are common in traumatic brain injury (TBI) survivors. However, there are no effective treatments to improve TBI-induced learning and memory impairments. TBI results in decreased cAMP signaling and reduced cAMP-response-element binding protein (CREB) activation, a critical pathway involved in learning and memory. TBI also acutely upregulates phosphodiesterase 4B2 (PDE4B2), which terminates cAMP signaling by hydrolyzing cAMP. We hypothesized that a subtype-selective PDE4B inhibitor could reverse the learning deficits induced by TBI. To test this hypothesis, adult male Sprague-Dawley rats received sham surgery or moderate parasagittal fluid-percussion brain injury. At 3 months postsurgery, animals were administered a selective PDE4B inhibitor or vehicle before cue and contextual fear conditioning, water maze training and a spatial working memory task. Treatment with the PDE4B inhibitor significantly reversed the TBI-induced deficits in cue and contextual fear conditioning and water maze retention. To further understand the underlying mechanisms of these memory impairments, we examined hippocampal long-term potentiation (LTP). TBI resulted in a significant reduction in basal synaptic transmission and impaired expression of LTP. Treatment with the PDE4B inhibitor significantly reduced the deficits in basal synaptic transmission and rescued LTP expression. The PDE4B inhibitor reduced tumor necrosis factor-α levels and increased phosphorylated CREB levels after TBI, suggesting that this drug inhibited molecular pathways in the brain known to be regulated by PDE4B. These results suggest that a subtype-selective PDE4B inhibitor is a potential therapeutic to reverse chronic learning and memory dysfunction and deficits in hippocampal synaptic plasticity following TBI.                      

Edited by lostfalco, 07 July 2016 - 11:41 PM.

[Groundhog Day]

This agolmelatine looks very interesting. I'm confident I can get a hold of some here soon and test it. Thanks for bringing it to my attention.

[Amorphous]

 

I've been taking Ibudilast and galantamine for about 2 weeks. Results has been excellent. This week, somehow, I was not able to take the second dose in the mid-day. I didn't see any diminishing effect. The effect seems to last the whole day (over 8+ hrs). I am going to start my next cycle of pinealon in the coming week. Let see how they are going to work together.
Lostfalco- Thanks for you suggestion of Nasal spay bottle; otherwise I'll still be using a nasal drop bottle.

 

Amorphous, what kind of effect have you notice from this combination?

 

 

Oop, sorry for the late reply. It is hard to describe. It is like the feeling of clarity after a good meditation session, but it lasts the whole day without actually meditating. If I am busy at work, not only can I focus but I can also observe my inner thought... I am not sure if that make sense to you or not. I think you have to try it to get the sense of feeling. Remember, I also use intranasal insulin and that even intensify the sense of clarity and put me in a better mood. 

Try it if you can......I think that could be different from person to person.

[De La Torre]

I like the direction you're taking Amorphous. I feel that watching mindstream and emotions, without allowing the automatic, egoic response system to kick in, is key to the releasing of mental, emotional, and physical restrictions, on a much deeper level. Walking meditation is the ultimate goal, once you've attained a certain level of focus, and intention, in the sitting practice. If you're wanting to take your practice further, I can recommend an authentic teacher, who lives there in Cali, bro... 

[Bluecheer]

I would be interested in this recommendation De La Torre.. If that's alright (:

[De La Torre]

Yes, of course, Bluecheer!

 

His pseudonym is Raziyahu.

 

This is his podcast...

 

http://thelucidskyra...T21_25_45-07_00

 

This is the Lucid Sky site...

 

http://www.thelucidsky.org/

[lostfalco]

Just to give everyone a heads up...it looks like we might have some trouble getting ibudliast from Mimaki going forward.

 

Any vendors out there willing to help us out?

 

Anyone else find a reliable source?

Edited by lostfalco, 11 July 2016 - 05:17 PM.

[MindExplorer]

:( Is it the ibudilast specifically or purchases in general from Mimaki?

[lostfalco]

:( Is it the ibudilast specifically or purchases in general from Mimaki?

I've only checked ibudilast.

 

Someone reported yesterday that the link from my website was down.

 

I changed the link to the new one and it worked for a while but is no longer working.

 

Now, I can't even find pinatos on their site anymore. Looks like Ketas is still there but it's $88!

 

I'm guessing we made it too popular. ha

 

Anyway, I'm not sure if it's a temporary thing or not but it would be nice if a trusted vendor made it available so that we didn't have to worry about it going forward.

 

Any takers?

 

 

 

Edited by lostfalco, 11 July 2016 - 06:32 PM.

[nyckrazy]

damn....that blows. theres gotta be another source.

[MindExplorer]

LF, the sacrifices you make for sharing your discoveries with others

[lostfalco]

damn....that blows. theres gotta be another source.

I know!

 

It's the only source I know of atm so I'm up for suggestions.

 

Ibudilast is way up on my list of top nootropics with LLLT, intranasal insulin, etc. 

 

I'd be bummed to lose it for a while. 

[lostfalco]

LF, the sacrifices you make for sharing your discoveries with others

haha I'm SUCH a martyr. =)

 

Seriously though, as long as it helped some people then it's all good. We'll get a new source if we have to and hopefully Mimaki will start supplying it again soon.  

 

The one I'm really worried about is intranasal insulin. 

 

When people find out how amazing it is the gov't may start cracking down on OTC purchases. 

 

That's gonna be a tough one for vendors to supply. 

[lostfalco]

Rodent study on insulin + memantine using canules implanted into lateral ventricles.

 

http://www.ncbi.nlm....pubmed/27233828

 

Behav Brain Res. 2016 Sep 15;311:247-54. doi: 10.1016/j.bbr.2016.05.046. Epub 2016 May 24.

Insulin potentiates the therapeutic effect of memantine against central STZ-induced spatial learning and memory deficit.

Bahramian A1, Rastegar K1, Namavar MR2, Moosavi M3.

Author information

Abstract

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Memantine has been approved for moderate to severe AD, but evidence indicates that it does not modify disease progression. Recently insulin has been found to exert some beneficial effects on cognition. This study aimed to compare the protective effects of memantine and insulin in an animal model of memory deficit. It also evaluated the effects of combination therapy of these drugs. Adult male Sprague-Dawely rats approximately 8-10 weeks old were used. The canules were implanted bilaterally into lateral ventricles. STZ was administered on days 1 and 3 (3mg/kg in divided doses) and Memantine (5 or 10mg/kg/ip) or/and Insulin (3 or 6mU/icv) were started from day 4 and continued till day 13. The animal's learning and memory capability was assessed on days 14-16 using Morris water maze. On day 17 a visible platform test was done to assess the animals' visuomotor ability. After completion of behavioral studies the brain sections were stained with hematoxylin and eosin for routine histological evaluation. The results show that memantine in doses 5 and 10mg/kg improved memory at day 3 of training and memantine 5mg/kg was more potent than memantine 10mg/kg. Insulin in dose 3mU, but not 6 mU, reversed STZ-induced memory deficit from day 2 of training. When insulin was added to memantine, it increased the potency of memantine 5mg/kg in preventing a memory deficit, but surprisingly was not successful in impeding STZ-induced amnesia, in combination with memantine 10mg/kg. This research work revealed that insulin act more efficiently than memantine in reversing STZ-induced memory impairment. Additionally combination of insulin and memantine seems to act better than memantine alone, providing that a dose adjustment has been done. This study suggests considering the combination therapy of memantine and insulin in dementia and AD.

 

[MindExplorer]

Hopefully, the same reason that human insulin is currently OTC (presumably so that diabetics who run into an acute need and don't have a prescription on them don't drop dead) will still apply. When the existence of drug criminalization hinges on the ability for lawmakers to claim and/or convince themselves that it's for people's protection, it seems unlikely to me that they'd target a drug that's known more for saving lives than for being that thing that those Internet weirdos put up their noses. And also it would be weird to criminalize an endogenous compound that, unlike DMT, is known to and used by millions of people medically. But I've never been one to understand the war on drugs...

[lostfalco]

Hopefully, the same reason that human insulin is currently OTC (presumably so that diabetics who run into an acute need and don't have a prescription on them don't drop dead) will still apply. When the existence of drug criminalization hinges on the ability for lawmakers to claim and/or convince themselves that it's for people's protection, it seems unlikely to me that they'd target a drug that's known more for saving lives than for being that thing that those Internet weirdos put up their noses. And also it would be weird to criminalize an endogenous compound that, unlike DMT, is known to and used by millions of people medically. But I've never been one to understand the war on drugs...

Yeah, I'm with you MindExplorer. Hopefully the needs of diabetics will outweigh overzealous lawmakers...but you never know. I think OTC insulin is currently banned in Indiana due to a health officer on a "crusade".

 

"One state does require prescriptions for all insulin. Dr. Kevin Burke, a health officer for Clark County, Ind., led the effort to require prescriptions in his state."  http://www.npr.org/s...-but-should-you

Edited by lostfalco, 12 July 2016 - 03:26 AM.

[MindExplorer]

Oh wow. Well so much for my above logic lol

[macropsia]

Typical.... I find the first (legally available and negligibly psychoactive) drug that touches my idiopathic inflammatory disorder and it's immediately unavailable after one purchase. Galantamine is a good anti-inflammatory but the cholinergic enhancement of spasticity is prohibitive for me.

 

There are plenty of ibudi-suppliers on 'baba &c. as it's a pretty well established drug; the issue will be the laborious one of obtaining samples and having them tested. 

 

Also, I've found BPC-157 pleasantly active at doses as low as 50 μg, especially administered concurrently with 10 iu insulin per nare.

Edited by macropsia, 12 July 2016 - 07:27 AM.

[lostfalco]

Hey, what's up my friends! I hope you're all doing well. 

 

I'm currently writing a big intranasal insulin post (this is why the Genesis Protocol post is temporarily on hold) for Joe Cohen's selfhacked site, so sorry I've been out of the loop a bit. 

 

I will talk about how to use it to not only enhance cognition but to lose weight and fight cravings. 

 

Almost all of the human studies are here so you can read ahead if you want to! http://www.lostfalco...ain-injury-etc/

 

I'll let you all know when it's going to be published. 

 

Joe is a long-time friend of mine from Longecity and you can check out his site here. https://selfhacked.com

 

It's a treasure trove of experimental ideas. 

 

In the meantime, I've received a few questions about the safety of zinc in intranasal insulin. 

 

I recently posted a short discussion about it here if you want to check it out. http://www.lostfalco...l-insulin-safe/

 

How's everyone doing with i-insulin, btw?

 

Still working well for some? Not working for others?

 

I'm always curious to hear what people's experiences are since I'm only one person. =)

Edited by lostfalco, 18 July 2016 - 05:48 PM.

[lostfalco]

I haven't talked much about concentrated oxygen in a while but I recently broke out my concentrator again and I really do love this stuff. 

 

It's perfect for all day study sessions at my standing desk. 

 

It enhances mood, memory, reaction time, visuospatial memory, verbal performance, dual n-back scores, working memory, and brain energy levels.

 

Pretty cool. 

 

I've collected almost all of the human studies here if anyone wants to check them out. http://www.lostfalco...as-a-nootropic/

 

[Groundhog Day]

I haven't talked much about concentrated oxygen in a while but I recently broke out my concentrator again and I really do love this stuff. 

 

It's perfect for all day study sessions at my standing desk. 

 

It enhances mood, memory, reaction time, visuospatial memory, verbal performance, dual n-back scores, working memory, and brain energy levels.

 

Pretty cool. 

 

I've collected almost all of the human studies here if anyone wants to check them out. http://www.lostfalco...as-a-nootropic/

 

Lostfalco,

 

What model do you have or recommend? I was going to get one of these when I got my hyperbaric chamber last year (to use before I jumped in) but I held off on it because I was light on cash after the chamber and didn't know which one to buy.

 

I'm going to take another look. Is it possible to get a decent one for under $300?

[Groundhog Day]

Hey, what's up my friends! I hope you're all doing well. 

 

I'm currently writing a big intranasal insulin post (this is why the Genesis Protocol post is temporarily on hold) for Joe Cohen's selfhacked site, so sorry I've been out of the loop a bit. 

 

I'm always curious to hear what people's experiences are since I'm only one person. =)

 

my experience with it went like this, I started a couple of months ago:

 

4 days straight of 1 spray in the morning, fasting, no food after for several hours. Noted mood boost and not much else.

Stopped shortly after because I did 2 sprays and did not sleep at all that night (I have chronic insomnia, very sensitive to a lot of sups)

 

Month or so later I began taking it with food in the morning. About a week into it, I noticed it curbing my relentless hunger (from being insulin resistant 15 years) and getting full signals again while eating (ho-lee-shit).  I stuck with it 3 weeks or so until I was just ending up way too wired at night, not sleeping. Stopped for a few weeks, tried it again, didn't sleep again.

 

So my insulin sensitivity right now is not as good as it was when I was taking it, but it is still greatly improved. I might try taking it after dinner one of these nights, instead of in the morning, and see if that changes anything.

[lostfalco]

Lostfalco,

 

What model do you have or recommend? I was going to get one of these when I got my hyperbaric chamber last year (to use before I jumped in) but I held off on it because I was light on cash after the chamber and didn't know which one to buy.

 

I'm going to take another look. Is it possible to get a decent one for under $300?

Hey Groundhog Day, I bought mine off of ebay 3 years ago but I can't seem to find it there anymore. 

 

Here's one on alibaba that's almost exactly like the one I have. https://www.alibaba....4838.0.0.lAqlgL

 

I'll look on ebay and see if I can find one with similar specs to mine and get back to you. 

Edited by lostfalco, 20 July 2016 - 02:36 PM.

[lostfalco]

my experience with it went like this, I started a couple of months ago:

 

4 days straight of 1 spray in the morning, fasting, no food after for several hours. Noted mood boost and not much else.

Stopped shortly after because I did 2 sprays and did not sleep at all that night (I have chronic insomnia, very sensitive to a lot of sups)

 

Month or so later I began taking it with food in the morning. About a week into it, I noticed it curbing my relentless hunger (from being insulin resistant 15 years) and getting full signals again while eating (ho-lee-shit).  I stuck with it 3 weeks or so until I was just ending up way too wired at night, not sleeping. Stopped for a few weeks, tried it again, didn't sleep again.

 

So my insulin sensitivity right now is not as good as it was when I was taking it, but it is still greatly improved. I might try taking it after dinner one of these nights, instead of in the morning, and see if that changes anything.

Thanks for the feedback man!

 

It's powerful stuff so it makes sense that it might take a little adjusting. 

 

There's a big study going on right now with long term intranasal insulin as a potential vaccine for type 1 diabetes. It's called the INIT II trial. https://clinicaltria...how/NCT00336674

 

Here's a fascinating discussion about it on wikipedia. It's pretty cool. https://en.wikipedia.org/wiki/INIT_II

 

Anyway, the reason I bring it up is that they took insulin for 7 days straight and then changed to one dose per week from that point on. 

 

"Treatment will be administered daily for 7 consecutive days then on one day each week for 12 months." https://clinicaltria...how/NCT00336674

 

Of course, it's fairly different than what we're doing but it might be a dosing pattern worth trying out to see if it works better for you and doesn't interfere with sleep. 

 

Just a wild guess.

Edited by lostfalco, 19 July 2016 - 10:13 PM.