4029 replies to this topic

[ceridwen]

I haven't started the insulin yet and feel I'm fading very fast again. Having the 1St panic attack in 2 years. The front my face feels numb too.

[Junk Master]

Not to turn this into a Dihexa thread, but it is germane to any insulin/Dihexa combo so...

 

This is from "The science behind Dihexa" thread.

 

"The cursory pharmacokinetic characterization of dihexa included in this study indicated that it was stable in serum, had a long circulating half-life, and penetrated the BBB. Data from behavioral studies using scopolamine amnesia and aged rat models, where dihexa was able to reverse cognitive deficits, indicated that the metabolic stability and BBB permeability of dihexa were apparently high enough to attain therapeutic brain levels after oral administration."

 

When and why did people start using it in combo with DMSO, and if it was to improve bioavailability why didn't they just start injecting it IM?  I know many people have an aversion to needles, but there are also plenty of people here who IM Cerebrolysin, not to mention testosterone for TRT (and many other compounds).

 

I'm really interested in combining Dihexa with intranasal insulin but if necessary I'd rather use it IM v. with DMSO.  

 

Plus, if it's more effective IM, then I have an excuse to try Cerebrolysin..lol...

 

[Junk Master]

Hoping the best for you the best Ceridwen.  Haven't had a panic attack in 20 some years and it's hard to describe to those who have never had one just how awful they can be!  Got no advice except if you can't find a friend with Clonazepam, get help.

 

 

[lostfalco]

I haven't started the insulin yet and feel I'm fading very fast again. Having the 1St panic attack in 2 years. The front my face feels numb too.

I'm so sorry ceridwen. I hope you feel better soon. =)

[lostfalco]

Not to turn this into a Dihexa thread, but it is germane to any insulin/Dihexa combo so...

 

This is from "The science behind Dihexa" thread.

 

"The cursory pharmacokinetic characterization of dihexa included in this study indicated that it was stable in serum, had a long circulating half-life, and penetrated the BBB. Data from behavioral studies using scopolamine amnesia and aged rat models, where dihexa was able to reverse cognitive deficits, indicated that the metabolic stability and BBB permeability of dihexa were apparently high enough to attain therapeutic brain levels after oral administration."

 

When and why did people start using it in combo with DMSO, and if it was to improve bioavailability why didn't they just start injecting it IM?  I know many people have an aversion to needles, but there are also plenty of people here who IM Cerebrolysin, not to mention testosterone for TRT (and many other compounds).

 

I'm really interested in combining Dihexa with intranasal insulin but if necessary I'd rather use it IM v. with DMSO.  

 

Plus, if it's more effective IM, then I have an excuse to try Cerebrolysin..lol...

Yep...dihexa is orally active. That was actually one of the criterion used when the scientists selected it for testing. 

 

"Subsequent chemical modifications, which were designed to increase hydrophobicity and decrease hydrogen bonding, yielded an orally active, blood-barrier permeant, metabolically stabilized analog, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa), that exhibits excellent antidementia activity in the scopolamine and aged rat models and marked synaptogenic activity." http://www.ncbi.nlm....pubmed/23055539

 

"The pharmacokinetic barrier has recently been overcome with the synthesis of the orally active, blood-brain barrier-permeable analog N-hexanoic-tyrosine-isoleucine-(6) aminohexanoic amide (dihexa)." http://www.ncbi.nlm....pubmed/25187433

 

"Dihexa is a first-in-class compound that is orally active, penetrates the blood-brain barrier, and facilitates memory consolidation and retrieval." http://www.ncbi.nlm....pubmed/25649658

[lostfalco]

Very interesting stuff. Gonna give this a go once my bacteriostatic water arrives. Has anyone tried this intranasally yet?

 

http://www.ncbi.nlm....pubmed/23055539

 

Curr Neuropharmacol. 2016 May 2. [Epub ahead of print]

Brain-gut axis and pentadecapeptide BPC 157. Theoretical and practical implications.

Sikiric P1, Seiwerth S, Rucman R, Kolenc D, Batelja Vuletic L, Drmic D, Grgic T, Strbe S, Zukanovic G, Crvenkovic D, Madzarac G, Rukavina I, Sucic M, Baric M, Starcevic N, Krstonijevic Z, Lovric Bencic M, Filipcic I, Stancic Rokotov D, Vlainic J.

Author information

Abstract

BACKGROUND: 

Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice.

METHODS: 

Review of our research on BPC 157 in terms of brain-gut axis.

RESULTS: 

BPC 157 may serve as a novel mediator of Robert's cytoprotection, involved in maintaining of GI mucosa integrity, with no toxic effect. BPC 157 was successful in the therapy of GI tract, periodontitis, liver and pancreas lesions, and in the healing of various tissues and wounds. Stimulated Egr-1 gene, NAB2, FAK-paxillin and JAK-2 pathways are hitherto implicated. Initially corresponding beneficial central influence was seen when BPC 157 was given peripherally and a serotonin release in particular brain areas, mostly nigrostriatal, was changed. BPC 157modulates serotonergic and dopaminergic systems, beneficially affects various behavioral disturbances that otherwise appeared due to specifically (over)stimulated/damaged neurotransmitters systems. Besides, BPC 157 has neuroprotective effects: protects somatosensory neurons; peripheral nerve regeneration appearent after transection; after traumatic brain injury counteracts the otherwise progressing course, in rat spinal cord compression with tail paralysis, axonal and neuronal necrosis, demyelination, cyst formation and rescues tail function in both short-terms and long-terms; after NSAIDs or insulin overdose or cuprizone encephalopathies were attenuated along with GI, liver and vascular injuries.

CONCLUSION: 

BPC 157,a gastric peptide, may serve as remedy in various nervous system disorders.

 

[Junk Master]

Nope, but it's fascinating stuff!

 

The more research I do, the more I wonder about Brain-Gut Axis treatment with gastric peptides as an early intervention for children on the Autistic Spectrum.

 

I've got a 15 year old son, high-functioning, who had all kinds of constipation, stomach issues before we were lucky and receptive enough to search out a diagnosis.

 

Now he worries about me and my hydrogen water...lol..."Dad, you know hydrogen is flammable!"  "I promise I won't try any fire breathing."

[Groundhog Day]

Would it be better to inject BPC 157 into the stomach or up the nose?

[Q did it!]

Got my Novolin R. today just waiting for my spray bottle to arrive in the mail in two days time. Will report back with results and still using LLLT with good results! Should be making a review on IntransNasal Insulin on YouTube in the future. Would love to see popularity of things discussed and brought to the light by this thread to be explored by more people.

 

Love your new blog by the way LostFalco. And Doing a lot better with my bipolar disorder now that a year has passed and can delve back into biohacking relatively safely. Just got to avoid certain mechanisms of action. Antipsychotics are no fun :/

 

Glad to be back on Longecity!

[Razor444]

Here's a blog post on BPC 157, which I've got on my to-read list:

 

https://bengreenfiel...to-use-bpc-157/

 

I only heard about it a couple of days ago—and didn't know about its neuroprotective effects.

 

 

Edited by Razor444, 21 September 2016 - 11:34 AM.

[lostfalco]

Here's a blog post on BPC 157, which I've got on my to-read list:

 

https://bengreenfiel...to-use-bpc-157/

 

I only heard about it a couple of days ago—and didn't know about its neuroprotective effects.

Nice find, Razor! That is actually a great blog post. Wow. Props to Greenfield for actually linking where he bought the peptide, where to buy insulin syringes, how to get bacteriostatic water, how to properly inject (intramuscular/subcutaneous), etc. Really surprised a mainstream blogger went balls out like that. Thanks for the link!

 

And yeah, it seems to be neuroprotetive in rodent models.

 

http://www.ncbi.nlm....pubmed/19931318

 

Regul Pept. 2010 Feb 25;160(1-3):26-32. doi: 10.1016/j.regpep.2009.11.012. Epub 2009 Nov 18.

Traumatic brain injury in mice and pentadecapeptide BPC 157 effect.

Tudor M1, Jandric I, Marovic A, Gjurasin M, Perovic D, Radic B, Blagaic AB, Kolenc D, Brcic L, Zarkovic K, Seiwerth S, Sikiric P.

Author information

Abstract

Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported, improved muscle crush injury. After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24h post-injury period. Ultimately, the traumatic lesions (subarachnoidal and intraventricular haemorrhage, brain laceration, haemorrhagic laceration) were less intense and consecutive brain edema had considerably improved. Given prophylactically (30 min before TBI) the improved conscious/unconscious/death ratio in TBI-mice was after force impulses of 0.068 Ns, 0.093 Ns, 0.113 Ns, 0.130 Ns, 0.145 Ns, and 0.159 Ns. Counteraction (with a reduction of unconsciousness, lower mortality) with both microg- and ng-regimens included the force impulses of 0.068-0.145 Ns. A higher regimen presented effectiveness also against the maximal force impulse (0.159 Ns). Furthermore, BPC 157 application immediately prior to injury was beneficial in mice subjected to force impulses of 0.093 Ns-TBI. For a more severe force impulse (0.130 Ns, 0.145 Ns, or 0159 Ns), the time-relation to improve the conscious/unconscious/death ratio was: 5 min (0.130 Ns-TBI), 20 min (0.145 Ns-TBI) or 30 min (0.159 Ns-TBI).

 

Edited by lostfalco, 21 September 2016 - 07:02 PM.

[lostfalco]

Got my Novolin R. today just waiting for my spray bottle to arrive in the mail in two days time. Will report back with results and still using LLLT with good results! Should be making a review on IntransNasal Insulin on YouTube in the future. Would love to see popularity of things discussed and brought to the light by this thread to be explored by more people.

 

Love your new blog by the way LostFalco. And Doing a lot better with my bipolar disorder now that a year has passed and can delve back into biohacking relatively safely. Just got to avoid certain mechanisms of action. Antipsychotics are no fun :/

 

Glad to be back on Longecity!

What's up, Q! Great to hear that you're doing better. Looking forward to hearing your experience with i-insulin. 

 

Thanks for your kind words about the blog and spreading the word. I appreciate it!

 

Here's one of Q's videos on TULIP for those of you interested. 

 

[lostfalco]

Would it be better to inject BPC 157 into the stomach or up the nose?

Hey Groundhog Day, depends on your goal. I'm trying to target the brain so I'm probably gonna test it intranasally (depending on a bit more research). It's most frequently injected in the literature but it's also effective orally as well. I still haven't found any studies on intranasal administration so I'm shooting in the dark a bit here but it looks pretty safe so I'm not too worried about a little test run. 

[lostfalco]

Not sure if this would apply to the brain or not...but its still pretty cool.

 

BPC upregulates growth hormone receptors. 

 

https://www.ncbi.nlm...pubmed/25415472

 

Molecules. 2014 Nov 19;19(11):19066-77. doi: 10.3390/molecules191119066.

Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.

Chang CH1, Tsai WC2, Hsu YH3, Pang JH4.

Author information

Abstract

BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.

 

[lostfalco]

Ibudilast is a PDE4D inhibitor (albeit a bit weak). 

 

http://www.ncbi.nlm....les/PMC4498385/

 

Sci Rep. 2015 Jul 10;5:11332. doi: 10.1038/srep11332.

Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.

Wang ZZ1, Yang WX2, Zhang Y3, Zhao N4, Zhang YZ4, Liu YQ4, Xu Y5, Wilson SP6, O'Donnell JM5, Zhang HT7, Li YF4.

Author information

Abstract

Phosphodiesterase 4 (PDE4) has four isoforms (PDE4A-D) with at least 25 splice variants. PDE4 subtype nonselective inhibitors produce potent antidepressant-like and cognition-enhancing effects via increased intracellular cyclic AMP (cAMP) signaling in the brain. Our previous data have demonstrated that long-form PDE4Ds appear to be involved in these pharmacological properties of PDE4 inhibitors in the normal animals. However, it is not clear whether long-form PDE4Ds are critical for the behaviors and related cellular signaling/neuronal plasticity/neuroendocrine alterations in the depressed animals. In the present study, animals exposed to the chronic unpredictable stress (CUS), a rodent model of depression, exhibited elevated corticosterone, depressive-like behavior, memory deficits, accompanied with decreased cAMP-PKA-CREB and cAMP-ERK1/2-CREB signaling and neuroplasticity. These alterations induced by CUS were reversed by RNA interference (RNAi)-mediated prefrontal cortex long-form PDE4Ds (especially PDE4D4 and PDE4D5) knock-down, similar to the effects of the PDE4 subtype nonselective inhibitor rolipram. Furthermore, these effects of RNAi were not enhanced by rolipram. These data indicate a predominant role of long-form PDE4Ds in the pharmacotherapies of PDE4 inhibitors for depression and concomitant memory deficits. Long-form PDE4Ds, especially PDE4D4 and PDE4D5, appear to be the promising targets for the development of antidepressants with high therapeutic indices.

 

"Long-term exposure to unpredictable life stressors is a major precipitating factor in the development of depression in humans1. In addition, depression is generally accompanied by memory deficits which are critical determinants of functional outcome in this population2."

 

"Phosphodiesterase-4 (PDE4) inhibitors such as rolipram produce antidepressant-like5,6 and cognition-enhancing effects7,8,9,10 via cAMP signaling6,11. The cAMP signaling cascade is important in the mediation of neuroplasticity12, which is the neurochemical substrate of antidepressant efficacy13 and cognitive functions14. Although rolipram produces preclinical and clinical antidepressant efficacy, its therapeutic utility is limited by problematic side effects such as severe nausea and emesis15."

 

Edited by lostfalco, 21 September 2016 - 09:49 PM.

[Heisok]

Q, congratulations on your progress. Sorry my unsolicited advice is to tread lightly with supplements, and other bio type hacks, so-to-speak. You seem like the research type, but It could take awhile for you to figure out which combinations flip you one way or another on the mood scale. May I suggest tracking your sleep very closely.  Please follow through to update us on your progress with i-insulin. Would you also consider either within the video or elsewhere updating us as to your current stack?  Thanks.

Edited by Heisok, 22 September 2016 - 12:47 AM.

[Q did it!]

Heisok,

Right now its posted on my avatars page here on longecity. Just click the green cube. I need to uodate the text though but image is up to date.

And yeah already outlining my video for i-insulin. Really wanna do these review more organized.

[Heisok]

Thanks,

 

Be very careful.

[lourdaud]

 

LostFalco: I may be mistaken but I haven't seen you cover adrenal support. I'd be very interested in hearing any ideas you or anyone else might have for this (excluding serotonergics). In my opinion this is a fundamental part of any stack and especially if you're using stimulants.

 

Edit: One supplement I've tried is this http://www.iherb.com...20-Tablets/1605 but I can't say for sure how much it helped. Will try it again and report back.

Hey lourdaud, tbh I haven't focused in that area all that much. I attempt to keep my stimulant intake to a minimum most of the time. Right now, I'm a VERY occasional modafinil user and that's about it. I've even been off of caffeine for the past 3 or 4 months.

 

What stimulant are you combining with schisandra?

 

 

I see. Well that's probably a good idea.

Caffeine, adrafinil occassionally. Might go on low dose ritalin again soon, need it to cope with my ADHD.

Sucks really cause it puts your body in a lower energetic state or how to put it.. feel your body moving more sluggishly etc. :/

Have ordered schizandra again and will report back once I've trialed it for a while!

 

 

On another topic:
Has anyone found a reliable source for IN insulin that offers shipping to Europe?

 

 

EDIT: And Ibudilast, where do you buy this? Curious to try it with galantamine.

Edited by lourdaud, 22 September 2016 - 09:19 AM.

[lourdaud]

What's the verdict on hydrogen water?

[Junk Master]

IMO it works for muscle soreness in men over 45, but even with running it though a Brita filter I believe I'm still having some intestinal issues from the magnesium rod/malic acid method.  Either that, or I'm getting a stomach flu.  It's that time of year.

[ceridwen]

I thought I'd try intermittent fasting. It really worsened my condition. Massively increased burning pains.

[ceridwen]

and hissing. In a lot of pain it seems to have maxed out. This is the opposite of what I hoped it would do. Can anyone explan. I have type 2 diabets now as well
I have still not tried diabetes. My face is burning

[Bluecheer]

What's up my friends? There's a redditor named bicepts who's logging his experience with i-insulin if anyone wants to check it out. https://www.reddit.c...nasal_insulin/?

 

As most of you know, you can read about how to make it at home legally for $25 here. http://www.lostfalco...anasal-insulin/

 

Here's his most recent update. 

 

 

"*** Sept 13 update ***

Wow, so I'm just in the middle of tuning up my vehicles and hopped on the computer. I needed to update to say that I'm beginning to feel blown away by intranasasal insulin. I've always had a fascination with endocrinology and glucose metabolism, but I never paid very much attention to glucose metabolism and energy production in the brain. I am now.

 

I postulate that a lot of what we experience as "brain fog" is caused in part by glucose metabolism in the brain. It definitely affects downstream hormone metabolism in the way of ATP and phosphocreatine production as well. When I take intranasal insulin I do not experience any degree of brain fog whatsoever. I wake up feeling well rested, I stay up at night feeling sharp as a tack, and I do not experience any mental fatigue or cognitive slumps during the day. All that I've changed is added intranasal insulin to my daily regimen. I am starting to think that I don't need any other noots at all, but I will keep taking some choline supplements here and there along with noopept and some racetamic isomers for BDNF and NGF production.

 

This is definitely one to pay attention to, fellas. I now have my baby's momma on it at 20iu twice per day. She definitely has a lot of brain fog and doesn't take any noots. She has her final licensing exam for nursing coming up and I'm going to see how well this helps her study. We both have very complicated life situations (err... she's actually my "ex-wife" technically, but we're getting along great) so it should be very beneficial to her. I think she will really benefit from this as she has way more going on in her life than I do. I'll be sure to update you guys on how she's doing too. I am absolutely sold on this stuff and extremely excited to see where it heads in terms of scientific literature. I'm sure we're going to uncover a lot of great things about this route of administration."

 

Questions questions... Hmm

Firstly I was not aware you had a baby, So congratulations! Also, nd while I'm sure you have taken this into account (but still even the most meticulous minds miss things from time to time) Is it possible that you could attribute some degree of "When I take intranasal insulin I do not experience any degree of brain fog whatsoever. I wake up feeling well rested, I stay up at night feeling sharp as a tack, and I do not experience any mental fatigue or cognitive slumps during the day." to the fact that you have been on caffeine for 3-4 months?... having less of a dependency of stimulants can do wonders.. Especially when you are focusing on other healthy avenues in combination with fixing your circadian rhythm.. anyway just a thought..

You have without a doubt got me a little tingly at the idea of I-Insulin..The body of positive evidence is attractive.. But I am still some what reserved.. You said on your blog post that some of the side effects are "Minor stuffiness, a nose bleed here and there" Well (And I know how far away from your area of knowledge this is).. But do you think it could inflame the nasal air ways at all (I mean it probably does to some degree which is why those two side effects occur)?

 

I have Rhintis (asthma of the nose) .. at least I did during one doctor visit.. IT could have been caused because newly acquired seasonal allergy or something else, But either way... I feel like something as off hand as side effects being Minor Stuffiness or a Nose Bleed could be a bit more worrisome for me. ... ahh hell I'll probably experiment at least once or twice.. But I do worry about the possible inflammation then constriction of airways that it could potentially cause.

Do you think you could have any form of diabetes, and possibly that would be the a contributing factor for your cognitive benefits?  

 

What are Racetamic isomers? 

 

In this interview, https://selfhacked.c...herapy-expert/ 
Dr Michael Hamblin talks about how he will use LLLT on a singular spot on his forehead for about 15 minutes twice a week.. Could I ask your thoughts on this? 
____


Sorry for the compounded amount of questions, As always feel free to reply to what you would like, at your leisure or of course not at all.

Takecare Falcs

Edit : Have you seen any anecdotal or otherwise cases of younger people using Intranasal Insulin?? - I wonder If it would still be as effective with people with lesser amounts of brain inflammation. I found I was pretty much completely unaffected by the effects of Ibudilast. 

Edited by Bluecheer, 23 September 2016 - 12:29 PM.

[Bluecheer]

and hissing. In a lot of pain it seems to have maxed out. This is the opposite of what I hoped it would do. Can anyone explan. I have type 2 diabets now as well
I have still not tried diabetes. My face is burning

Ceridwen, These symptoms. Are more severe than that of something that should be fixed by the help of strangers on the internet.. Can I please request that you go see a doctor? 

I would also suggest that you immediately Slow/Or completely quit any of your recent experiments. If you are experiencing very negative effects from anything, do the sensible thing and see a doctor regarding your issue, be honest about your experiments to him/her aswell.

 

The human body can be fragile and you don't want to risk putting excessive strain on it. This is your 'one' and only body, and it can fail. Take care of it.


Also P S @ Q 
I have seen your blog before, I really enjoyed it. Sorry to hear about your bipolar disorder... I hope you overcome this unfortunate disorder. I currently work with people with disabilities both mental and physical. I understand how bad the upper spectrum's of it can be. Luckily you seem to be a sharp kid so hopefully that will have some positive effect on the long term outcome of your mental endurance.

Take care,

Edited by Bluecheer, 23 September 2016 - 12:38 PM.

[lostfalco]

 

What's up my friends? There's a redditor named bicepts who's logging his experience with i-insulin if anyone wants to check it out. https://www.reddit.c...nasal_insulin/?

 

As most of you know, you can read about how to make it at home legally for $25 here. http://www.lostfalco...anasal-insulin/

 

Here's his most recent update. 

 

 

"*** Sept 13 update ***

Wow, so I'm just in the middle of tuning up my vehicles and hopped on the computer. I needed to update to say that I'm beginning to feel blown away by intranasasal insulin. I've always had a fascination with endocrinology and glucose metabolism, but I never paid very much attention to glucose metabolism and energy production in the brain. I am now.

 

I postulate that a lot of what we experience as "brain fog" is caused in part by glucose metabolism in the brain. It definitely affects downstream hormone metabolism in the way of ATP and phosphocreatine production as well. When I take intranasal insulin I do not experience any degree of brain fog whatsoever. I wake up feeling well rested, I stay up at night feeling sharp as a tack, and I do not experience any mental fatigue or cognitive slumps during the day. All that I've changed is added intranasal insulin to my daily regimen. I am starting to think that I don't need any other noots at all, but I will keep taking some choline supplements here and there along with noopept and some racetamic isomers for BDNF and NGF production.

 

This is definitely one to pay attention to, fellas. I now have my baby's momma on it at 20iu twice per day. She definitely has a lot of brain fog and doesn't take any noots. She has her final licensing exam for nursing coming up and I'm going to see how well this helps her study. We both have very complicated life situations (err... she's actually my "ex-wife" technically, but we're getting along great) so it should be very beneficial to her. I think she will really benefit from this as she has way more going on in her life than I do. I'll be sure to update you guys on how she's doing too. I am absolutely sold on this stuff and extremely excited to see where it heads in terms of scientific literature. I'm sure we're going to uncover a lot of great things about this route of administration."

 

Questions questions... Hmm

Firstly I was not aware you had a baby, So congratulations! Also, nd while I'm sure you have taken this into account (but still even the most meticulous minds miss things from time to time) Is it possible that you could attribute some degree of "When I take intranasal insulin I do not experience any degree of brain fog whatsoever. I wake up feeling well rested, I stay up at night feeling sharp as a tack, and I do not experience any mental fatigue or cognitive slumps during the day." to the fact that you have been on caffeine for 3-4 months?... having less of a dependency of stimulants can do wonders.. Especially when you are focusing on other healthy avenues in combination with fixing your circadian rhythm.. anyway just a thought..

You have without a doubt got me a little tingly at the idea of I-Insulin..The body of positive evidence is attractive.. But I am still some what reserved.. You said on your blog post that some of the side effects are "Minor stuffiness, a nose bleed here and there" Well (And I know how far away from your area of knowledge this is).. But do you think it could inflame the nasal air ways at all (I mean it probably does to some degree which is why those two side effects occur)?

 

I have Rhintis (asthma of the nose) .. at least I did during one doctor visit.. IT could have been caused because newly acquired seasonal allergy or something else, But either way... I feel like something as off hand as side effects being Minor Stuffiness or a Nose Bleed could be a bit more worrisome for me. ... ahh hell I'll probably experiment at least once or twice.. But I do worry about the possible inflammation then constriction of airways that it could potentially cause.

Do you think you could have any form of diabetes, and possibly that would be the a contributing factor for your cognitive benefits?  

 

What are Racetamic isomers? 

 

In this interview, https://selfhacked.c...herapy-expert/ 
Dr Michael Hamblin talks about how he will use LLLT on a singular spot on his forehead for about 15 minutes twice a week.. Could I ask your thoughts on this? 
____


Sorry for the compounded amount of questions, As always feel free to reply to what you would like, at your leisure or of course not at all.

Takecare Falcs

Edit : Have you seen any anecdotal or otherwise cases of younger people using Intranasal Insulin?? - I wonder If it would still be as effective with people with lesser amounts of brain inflammation. I found I was pretty much completely unaffected by the effects of Ibudilast. 

 

Hey Bluecheer, that post was quoting a redditor named bicepts. "What's up my friends? There's a redditor named bicepts who's logging his experience with i-insulin if anyone wants to check it out. https://www.reddit.c...nasal_insulin/?  "

 

I've never been married, don't have kids, no baby mama, etc...  =)

 

I-insulin works on young, healthy humans without diabetes. http://www.lostfalco...anasal-insulin/

Edited by lostfalco, 23 September 2016 - 12:50 PM.

[lostfalco]

 

 

EDIT: And Ibudilast, where do you buy this? Curious to try it with galantamine.

 

This post has a link for purchasing ibudilast. http://www.lostfalco...n-fog-two-step/

[lostfalco]

and hissing. In a lot of pain it seems to have maxed out. This is the opposite of what I hoped it would do. Can anyone explan. I have type 2 diabets now as well
I have still not tried diabetes. My face is burning

Hey ceridwen, I'm really sorry to hear that you're not doing well. I'm not sure what would cause that. Definitely sounds like seeing a doctor is a good idea. 

[Bluecheer]

Hey Bluecheer, that post was quoting a redditor named bicepts. "What's up my friends? There's a redditor named bicepts who's logging his experience with i-insulin if anyone wants to check it out. https://www.reddit.c...nasal_insulin/?  "

 

 

 

 

 

I've never been married, don't have kids, no baby mama, etc...  =)

 

I-insulin works on young, healthy humans without diabetes. http://www.lostfalco...anasal-insulin/

 

Ohh my, I'm quite embarrassed. Sorry for that large waste in time. 

- 

 

I have recently had a large interest in Evolution as of late, And I have finished reading the book Sapiens By Yuval Noah Harrai which I highly recommend. The way my brain works, If I start focusing on one or more things.. the things start to merge, Anyway I started asking myself if human hairlessness could have contributed to Photobiomodulation from the sun.
And of course I found others have hypothesized this theory already:

 

http://www.ncbi.nlm....ubmed/25703782 

I feel like trying to pin point what caused human cognitive evolution, and them mimicking it today... Could be more beneficial then most methods for trying to Advance the stages of human consciousness (ie Cognition) - thought interesting thoughts to ponder ^

How is your Agomelatine use going?

 

Edited by Bluecheer, 24 September 2016 - 06:31 AM.

[Soalian]

Would BPC-157 be best administered locally at the site of the injury or does it work systemically in the body?