4029 replies to this topic

[pantastic]

There is a recent paper on impact of molecular hydrogen on athletic performance.

Also on this link you may find simplified animation how molecular hydrogen works

 

http://www.h2drinks....es/how-it-works

 

Also I saw how with molecular hydrogen gel one can treat psoriasis.

Attached Files

•  Pantovic_et_al_Molecular Hydrogen Supplementation and Multiple.pdf   280.64KB   4 downloads

[bossmanglb]

Tuning the mitochondrial rotary motor with light

 

http://www.ncbi.nlm....les/PMC4701522/

[lostfalco]

Tuning the mitochondrial rotary motor with light

 

http://www.ncbi.nlm....les/PMC4701522/

 

Thanks for the study!

[lostfalco]

There is a recent paper on impact of molecular hydrogen on athletic performance.

Also on this link you may find simplified animation how molecular hydrogen works

 

http://www.h2drinks....es/how-it-works

 

Also I saw how with molecular hydrogen gel one can treat psoriasis.

Thanks for the abstract and the link to the product. 

 

Do you know what ingredients they are using? I glanced through their pages but had trouble finding info. 

 

I'm guessing magnesium. 

[pantastic]

 

There is a recent paper on impact of molecular hydrogen on athletic performance.

Also on this link you may find simplified animation how molecular hydrogen works

 

http://www.h2drinks....es/how-it-works

 

Also I saw how with molecular hydrogen gel one can treat psoriasis.

Thanks for the abstract and the link to the product. 

 

Do you know what ingredients they are using? I glanced through their pages but had trouble finding info. 

 

I'm guessing magnesium. 

 

Yes you are making a good point, it is magnesium carbonate.

Check this link:

http://www.h2drinks....es/good-to-know

[lostfalco]

Yes you are making a good point, it is magnesium carbonate.

 

 

Check this link:

http://www.h2drinks....es/good-to-know

 

Got it. Thanks!

[lostfalco]

What's up my friends?

 

Hope you're all doing well. 

 

As most of you know I really like to use The 20/10 Method when I study to enhance my ability to record memories. 

 

I'm always amazed at how many new things I notice during the second 20 minute study period and even more amazed at all the things I see during the third 20 minute study period. 

 

I just wrote up a little ditty discussing it here if you want to check it out. http://www.lostfalco...he-2010-method/

 

Here's the study where I got the idea. 

 

Enjoy!

 

http://www.ncbi.nlm....les/PMC3782739/

 

Front Hum Neurosci. 2013; 7: 589. 

Published online 2013 Sep 25. doi:

 

Making long-term memories in minutes: a spaced learning pattern from memory research in education

Paul Kelley1,* and  Terry Whatson2

 

Abstract

Memory systems select from environmental stimuli those to encode permanently. Repeated stimuli separated by timed spaces without stimuli can initiate Long-Term Potentiation (LTP) and long-term memory (LTM) encoding. These processes occur in time scales of minutes, and have been demonstrated in many species. This study reports on using a specific timed pattern of three repeated stimuli separated by 10 min spaces drawn from both behavioral and laboratory studies of LTP and LTM encoding. A technique was developed based on this pattern to test whether encoding complex information into LTM in students was possible using the pattern within a very short time scale. In an educational context, stimuli were periods of highly compressed instruction, and spaces were created through 10 min distractor activities. Spaced Learning in this form was used as the only means of instruction for a national curriculum Biology course, and led to very rapid LTM encoding as measured by the high-stakes test for the course. Remarkably, learning at a greatly increased speed and in a pattern that included deliberate distraction produced significantly higher scores than random answers (p < 0.00001) and scores were not significantly different for experimental groups (one hour spaced learning) and control groups (four months teaching). Thus learning per hour of instruction, as measured by the test, was significantly higher for the spaced learning groups (p < 0.00001). In a third condition, spaced learning was used to replace the end of course review for one of two examinations. Results showed significantly higher outcomes for the course using spaced learning (p < 0.0005). The implications of these findings and further areas for research are briefly considered.

 

Edited by lostfalco, 03 August 2016 - 11:39 PM.

[streamlover]

I would be very suspect of the "Nano H2 Vita" product in terms of effectiveness. It does contain Magnesium and a weak acid which will produce H2 when combined in water but in experimenting with Mg compounds combined with acids, I could never produce any measurable H2. Elemental Mg is what's required and various pills (Active H2, etc.), which are Mg + Malic acid + filler, will produce low levels of H2 concentrations. (~.3ppm) This is not really a high enough concentration either to effectively notice any benefits imo, but I'd wager it's much more than the Nano H2 Vita product produces. They're counting on the strong placebo effect to produce results and there is definitely that working here since the evidence for H2 benefits is very compelling. The Nano H2 Vita ads use a clever pitch which touts the H2 benefits which are very real but neglect any mention of exactly how much H2 their product contains or how it might be measured. I bought one bottle of pills (Active H2) just to measure and haven't used them past that initial experimenting.

 

Check out the video on youtube (search "DIY hydrogen water") for a cheap method to make H2 water with therapeutic concentrations or consider a machine similar to the one Lostfalco bought if you have the $ and don't want to bother with the DIY process.

[airplanepeanuts]

.. or consider a machine similar to the one Lostfalco bought if you have the $ and don't want to bother with the DIY process.

 

So you think that is an effective machine? Thanks.

[lostfalco]

Check out the video on youtube (search "DIY hydrogen water") for a cheap method to make H2 water with therapeutic concentrations or consider a machine similar to the one Lostfalco bought if you have the $ and don't want to bother with the DIY process.

I don't mind if you link to your video Glen!

 

I'm all about saving people money. 

 

If a $12 experiment works better than a $1200 machine then go with $12!

 

There's a link to the machine I have on this page but it's hard for me to recommend for the price. http://www.lostfalco.com/devices/

 

Btw, I remember you mentioning stomach issues before.

 

Have you found a way to resolve them?

 

Here's his video for those of you wondering about Glen's diy method of making hydrogen water. 

 

Edited by lostfalco, 03 August 2016 - 11:37 PM.

[streamlover]

lostfalco, The only way I've "resolved" the stomach issues is to cut back on how much I drink from 5-6 half-liters/day to 3-4. I spent some time trying to work out a method whereby the H2-producing reaction was separate from the actual drinking water (similar to what's described here: super-saturated hydrogen generating apparatus) and I even tried to order the container they describe from the Japanese company but was unsuccessful. (By doing this, the Mg salts wouldn't get into the drinking water and there would be no limit on how much H2 water one could drink.) I've since become a little lazy and am waiting for someone to develop a better/cheaper technology while I drink the Mg-rich brew. If I get real lazy and don't drink much for several days, I notice the old inflammation creeping back into those areas it used to reside, so that's the incentive I have for keeping the routine going. Btw, the initial investment for this method is something like $50 for 6 rods, malic acid, and a few bottles...still not bad for giving the H2 water a tryout.

[zoobdo]

Hey lostfalco thanks for all the fantastic information! Ive read (skimmed) through the entire thread which took several days but was a great read. Ive been implemented the TULIP protocol for a couple weeks and started insulin this last week and ive got noticeable, albeit subtle effects.

 

I was wondering if youve done any research into nicotine for cognitive enhancement? 

 

On top of that, your next two top recommendations seem to be tadalafil and ibudilast, which one would you recommend experimenting with first?

 

Thanks in advance and keep up the great work! Lost the website btw

[lostfalco]

Hey lostfalco thanks for all the fantastic information! Ive read (skimmed) through the entire thread which took several days but was a great read. Ive been implemented the TULIP protocol for a couple weeks and started insulin this last week and ive got noticeable, albeit subtle effects.

 

I was wondering if youve done any research into nicotine for cognitive enhancement? 

 

On top of that, your next two top recommendations seem to be tadalafil and ibudilast, which one would you recommend experimenting with first?

 

Thanks in advance and keep up the great work! Lost the website btw

No problem, zoobdo! I'm glad you've found all 100+ pages of this monstrosity useful. =)

 

And thanks for your kind words about the website! I'm happy with its fledgling beginning so far and I'm super excited about what's to come. 

 

It's here if anyone hasn't taken a look yet. http://www.lostfalco...anasal-insulin/

 

Very cool you're combining i-insulin with TULIP. I've been calling it iLLLT or iTULIP (in my own mind, at least. ha). 

 

If you think about i-insulin enhancing glucose uptake into neurons it makes A LOT of sense that it would combine well with mitochondrial enhancers (then think about adding concentrated oxygen at the end of the electron transport chain! Beautiful). Of course, i-insulin is a growth factor in the brain as well so that undoubtedly adds to the effects. 

 

I have experimented with nicotine pretty extensively. You may recall when I attempted to combine it with galantamine (pretty early in this thread). Didn't go so well. ha

 

Unfortunately, nicotine doesn't seem to agree with me...with or without galantamine. I may come back to it at some point but for now it's in my box of failed experiments (I should write about all those sometime.). 

 

It's a really tough call between ibudilast and tadalafil...but I would try ibudilast first if I had to pick one. 

 

After you've tested them individually I'd def recommend a combo experiment. 

 

Check out this study! (it's an element of the Genesis Protocol...which I've decided to gradually release over time)

 

As most of you know tadalafil increases cGMP and ibudilast increases cAMP. 

 

Therefore, tadalafil/sildenafil + ibudilast = synergistic increase in neurite outgrowth/axon regeneration (in theory, of course). 

 

http://www.ncbi.nlm....pubmed/19646425

 

Brain Res. 2009 Oct 19;1294:12-21. doi: 10.1016/j.brainres.2009.07.071. Epub 2009 Jul 29.

cGMP promotes neurite outgrowth and growth cone turning and improves axon regeneration on spinal cord tissue in combination with cAMP.

Murray AJ1, Peace AG, Shewan DA.

Author information

Abstract

Cyclic adenosine monophosphate (cAMP) has been intensively studied in recent years in order to elucidate its contribution in intracellular signalling mechanisms that regulate axon growth and guidance, and also to test if its activation can promote axon regeneration after injury. Cyclic guanosine monophosphate (cGMP), however, has been given considerably less attention even though it too mediates intracellular signalling cascades activated by extracellular guidance cues. cGMP can promote neurite outgrowth in neuronal cell lines but its role in promoting growth and regeneration of primary neurons is not well established. Here, we have examined the effects of elevating cGMP activity on axon growth, guidance and regeneration in vitro. We have found that, like cAMP elevation, activation of cGMP increases rat dorsal root ganglion (DRG) neurite outgrowth on a polylysine substrate and that asymmetric cGMP elevation promotes attractive growth cone turning. When grown in an in vitro model of axon regeneration activation of cGMP alone was not sufficient to promote adult neurite outgrowth. However, when combined with cAMP elevation substantial regeneration of adult neurites is achieved, superior to that achieved with either cAMP or cGMP alone. Regeneration is enhanced still further with simultaneous application of a Nogo receptor blocking peptide, suggesting this combinatorial strategy could achieve far greater axon regeneration in vivo than targeting individual cell signalling mechanisms.

 

Edited by lostfalco, 05 August 2016 - 09:48 PM.

[Groundhog Day]

There is a recent paper on impact of molecular hydrogen on athletic performance.

Also on this link you may find simplified animation how molecular hydrogen works

 

http://www.h2drinks....es/how-it-works

 

Also I saw how with molecular hydrogen gel one can treat psoriasis.

 

I've been experimenting with H water the last month.... drinking about 32oz a day. The one big thing I have noticed is muscle soreness is greatly reduced. I have muscle soreness to the extreme, normally. So I would do maybe 10 pushups and the next couple of days my ribs and pecs would be extremely sore to the touch, like I was recovering from a physical assault. I did 100 pushups 2 days ago and I can barely feel it right now. (I'm fit and athletic build, not out of shape or overweight)

 

I've also noticed some surges in energy while exercising but I'm not 100% sure it's from the H water.

 

I'm planning to go up to 64oz just as soon as the rest of my Magnesium rods get here from China.

[lostfalco]

I've been experimenting with H water the last month.... drinking about 32oz a day. The one big thing I have noticed is muscle soreness is greatly reduced. I have muscle soreness to the extreme, normally. So I would do maybe 10 pushups and the next couple of days my ribs and pecs would be extremely sore to the touch, like I was recovering from a physical assault. I did 100 pushups 2 days ago and I can barely feel it right now. (I'm fit and athletic build, not out of shape or overweight)

 

I've also noticed some surges in energy while exercising but I'm not 100% sure it's from the H water.

 

I'm planning to go up to 64oz just as soon as the rest of my Magnesium rods get here from China.

 

That's awesome, Groundhog Day. Did you end up going with Glen's method for making hydrogen water?

[Groundhog Day]

Lostfalco,

 

Yes, thanks to you and then Glen for making a great video.

[lostfalco]

Lostfalco,

 

Yes, thanks to you and then Glen for making a great video.

No problem. I'm glad you got to try it out.

 

And yeah, huge props to Glen!

 

Here's his video if anyone wants to try it out. I haven't tried it yet since I have the Lourdes Machine but I think its definitely worth looking into. 

 

[rikelme]

I just finished taking 10 h2drinks sachets. Biggest benefits I felt is with sustained focus, especially toward the end of the long work day in Silicon Valley. H2 helped me a lot during the last few hours in the evening. Felt the benefits after first glass of water but wanted to make sure its not placebo or due to some other random event.

 

Great find lostfalco et al !

[lostfalco]

I just finished taking 10 h2drinks sachets. Biggest benefits I felt is with sustained focus, especially toward the end of the long work day in Silicon Valley. H2 helped me a lot during the last few hours in the evening. Felt the benefits after first glass of water but wanted to make sure its not placebo or due to some other random event.

 

Great find lostfalco et al !

Very cool, rikelme! Which product did you end up trying out?

[Groundhog Day]

My next experiment is to drink a bunch of hydrogen water and then jump in my hyperbaric chamber in an attempt to become Aquaman.

[Junk Master]

I wonder how much of the lack of muscular soreness Groundhog Day experienced is due to the extra magnesium in Glen's method?

 

For those of you who have taken Hydrogen water and a mitochondrial supplement like CoQ10, how do they compare?  Or even C60/OO?

[Junk Master]

Oh, I'm working on some interesting Beta-Cyclodextrin compounds as a way of increasing bioavailability (especially during intranasal usage) of certain compounds.  I'll keep you posted with my anecdotal results.

[lostfalco]

My next experiment is to drink a bunch of hydrogen water and then jump in my hyperbaric chamber in an attempt to become Aquaman.

haha Nice. 

I wonder how much of the lack of muscular soreness Groundhog Day experienced is due to the extra magnesium in Glen's method?

 

For those of you who have taken Hydrogen water and a mitochondrial supplement like CoQ10, how do they compare?  Or even C60/OO?

Yeah, there definitely could be multiple factors at play here. 

Oh, I'm working on some interesting Beta-Cyclodextrin compounds as a way of increasing bioavailability (especially during intranasal usage) of certain compounds.  I'll keep you posted with my anecdotal results.

Very cool, Junk Master. Looking forward to seeing what you come up with. I love me some intranasal compounds. 

[Amorphous]

 

What's up my friends?

 

Hope you're all doing well. 

 

As most of you know I really like to use The 20/10 Method when I study to enhance my ability to record memories. 

 

I'm always amazed at how many new things I notice during the second 20 minute study period and even more amazed at all the things I see during the third 20 minute study period. 

 

I just wrote up a little ditty discussing it here if you want to check it out. http://www.lostfalco...he-2010-method/

 

Here's the study where I got the idea. 

 

Enjoy!

 

http://www.ncbi.nlm....les/PMC3782739/

 

Front Hum Neurosci. 2013; 7: 589. 

Published online 2013 Sep 25. doi:

 

Making long-term memories in minutes: a spaced learning pattern from memory research in education

Paul Kelley1,* and  Terry Whatson2

 

Abstract

Memory systems select from environmental stimuli those to encode permanently. Repeated stimuli separated by timed spaces without stimuli can initiate Long-Term Potentiation (LTP) and long-term memory (LTM) encoding. These processes occur in time scales of minutes, and have been demonstrated in many species. This study reports on using a specific timed pattern of three repeated stimuli separated by 10 min spaces drawn from both behavioral and laboratory studies of LTP and LTM encoding. A technique was developed based on this pattern to test whether encoding complex information into LTM in students was possible using the pattern within a very short time scale. In an educational context, stimuli were periods of highly compressed instruction, and spaces were created through 10 min distractor activities. Spaced Learning in this form was used as the only means of instruction for a national curriculum Biology course, and led to very rapid LTM encoding as measured by the high-stakes test for the course. Remarkably, learning at a greatly increased speed and in a pattern that included deliberate distraction produced significantly higher scores than random answers (p < 0.00001) and scores were not significantly different for experimental groups (one hour spaced learning) and control groups (four months teaching). Thus learning per hour of instruction, as measured by the test, was significantly higher for the spaced learning groups (p < 0.00001). In a third condition, spaced learning was used to replace the end of course review for one of two examinations. Results showed significantly higher outcomes for the course using spaced learning (p < 0.0005). The implications of these findings and further areas for research are briefly considered.

 

 

4 months of materials to be learned in 1 hour? Amazing....in your lostfalco.com.... I mean the method works, but it doesn't seem like it works that well for me........Maybe I am not doing it correctly.

How do you read a whole book, e.g. principle of biochemistry or introduction to differential equations, in 1 hr? I don't think I can read that much in 20 minutes (even if I divide the whole book into 3 parts) and then repeat 2 times.

Please enlighten me. I really like to be able to learn a semester worth of material in 1 hr (I guess it would be 20(10) +20(10) +20 = 60 min with 2 x 10 min breaks).

[lostfalco]

4 months of materials to be learned in 1 hour? Amazing....in your lostfalco.com.... I mean the method works, but it doesn't seem like it works that well for me........Maybe I am not doing it correctly.

How do you read a whole book, e.g. principle of biochemistry or introduction to differential equations, in 1 hr? I don't think I can read that much in 20 minutes (even if I divide the whole book into 3 parts) and then repeat 2 times.

Please enlighten me. I really like to be able to learn a semester worth of material in 1 hr (I guess it would be 20(10) +20(10) +20 = 60 min with 2 x 10 min breaks).

 

Hey Amorphous, this is a good question. 

 

As I mentioned in the blog post, the semester's worth of material was for 13 to 15 year old biology students, "Using The 20/10 Method, 13 to 15 year old biology students were able to score just as well on standardized tests as their peers…" http://www.lostfalco...e-2010-method/ 

 

While it optimizes long term memory formation, it's still going to take numerous 20/10 study sessions to learn upper division college level content. 

 

For example, I always use it after lectures to help me retain the information. Right after the lecture I take a 10 minute break, then study the lecture content again for 20 minutes, 10 min break, study again for 20 minutes. 

 

I do this after each lecture and then I also study this way for the midterms. 

 

So, I am using The 20/10 Method over and over again to retain material. 

 

There is just A LOT more material in a difficult college course than a middle school biology course. 

[rikelme]

Very cool, rikelme! Which product did you end up trying out?

 

 

Great find lostfalco et al !

 

 

I bought sachets from h2drinks.us, for convenience.

[lostfalco]

I bought sachets from h2drinks.us, for convenience.

Cool. Thanks, for the info rikelme.

[Groundhog Day]

I wonder how much of the lack of muscular soreness Groundhog Day experienced is due to the extra magnesium in Glen's method?

 

For those of you who have taken Hydrogen water and a mitochondrial supplement like CoQ10, how do they compare?  Or even C60/OO?

 

I don't think it's the magnesium as I've done extensive testing with Mag Threonate, Citrate and Malate. Taken them individually and then all together for a while, moderate doses, then higher doses of Threonate and then the Malate.

[Junk Master]

Nice. Thanks for your input. I guess I will be ordering some mag rods and malic acid.

[streamlover]

Glad to see some of you trying out the H2 water...looking forward to feedback from nootrops as I think that is one of the major benefits of this protocol and I'd like to see it compared to some of the other protocols here. I have found though that I don't notice so much of this effect (clarity, optimism, joy, etc.) unless the concentrations of the brew are up in the 2.5-3.0ppm range. (I didn't really notice this much at all until I had improved the procedure enough to get this concentration.) Also, this effect doesn't seem to last that long...maybe around an hour or so, while the anti-inflammatory effects hold forever it seems as long as I'm getting 3 or 4 glasses per day.

 

I've refined the brewing parameters since making the video...here's what I'm doing now:

Mostly make it before going to bed and drink 3 or 4 up until around midday. Then I may make another 2 to drink later in the day if I have time and am inclined. Currently if I drink more than this, I'll get diarrhea...not too serious but probably not a good idea to keep pushing this envelope.

Recipe:

- 4-5 Mg rods (one guy said heating them improves the bubbling...haven't tried this yet)

- 1 gm malic acid

- boiling water, fill to overflow and cap immediately

- place in fridge (was putting it in freezer originally to try to cool as fast as possible but it doesn't seem to matter that much if you bypass the freezer step and it's much less stressful to not have to remember to move it over. I broke a few bottles before I decided to go this way.)

- leave for 3-8 hours (3 is probably optimal but leaving it overnight doesn't hurt that much. Even 12 or 15 hours is still OK if your seals on the container are decent.

- before opening, rotate bottle upside down to right side up for 15-20 secs. I saw this recommended in a Japanese paper and just took their word that it helps.

- open and drink right away (optimally) or put in a sport bottle with a good seal and drink over the next few hours. The concentration will diminish but I can still notice the effects, even the brain boost drinking this between pickleball games. Definitely improves stamina also.

 

I've measured the concentration of 3 or 4 brews over the past week with this recipe and they were all in the 3.0ppm range. This is 3 times what you get with any machine and 10 times what you get with one of the many pills on the market. You could always use multiple pills for greater concentrations but that gets expensive at $1 a pop. Not sure about the sachets mentioned above...haven't tested those.

 

A Japanese company, MIZ, has developed a method of brewing that separates the H2-generating reaction from the drinking water with a gas-permeable (but water-impermeable, I assume) membrane which allows the H2 to enter the water but nothing else. It's described in this paper. There's also a product from a different Japanese company that seems to use this technology, Aquela, which claims 5-7ppms concentration water. I couldn't figure out how to order it but I would really like to try it if anyone can work it out. This would eliminate the Mg overload problem.