6 replies to this topic

[treonsverdery]

When I read at the Costco magazine http://www.costcocon...ion/201302#pg66 that webmd.com says gingivitis might be linked to "half" of cardiovascular disease

 reducing gingivitis saves lives.png   13.81KB   3 downloads

I thought well curing that is pretty simple. Although I wondered if chronic gingivitis might have more to do with a minimally functional lifestyle that correlated with illness, online there is a metaanalysis online that says gingivitis is actually an authentic cardiovascular risk.

http://www.ncbi.nlm....pubmed/19322227 relative risk estimates for different categories of periodontal disease (including periodontitis, tooth loss, gingivitis and bone loss) ranged from 1.24 [95% confidence interval (CI), 1.01-1.51] to 1.34 (95% CI, 1.10-1.63). Risk estimates were similar in subgroup analyses by gender, outcome, study quality and method of periodontal disease assessment.
Periodontal disease is a risk factor or marker for CHD that is independent of traditional CHD risk factors, including socioeconomic status.

That is actually kind of pleasant to hear as it is easily prevented, as compared with say, "social functionality"

just creating a new kind of peptide antibiotic that stays outside the mucosa as well as instantly digests yet is producedat oral bacteria could possibly reduce all heart disease 20 pct to a third, representing hundreds of millions or billions of people having less cardiovascular disease Hundreds of peptide antibiotics have been described in the past half-century http://www.ncbi.nlm....icles/PMC89271/ Thus the dental well being new oral bacteria already being developed could be simply improved to reduce gingivitis, averting millions of heart attacks as well as saving vast amounts of money



Another approach to curing gingvitis is cheese oil I read eating cheese reduces tooth decay so there are likely some natural lipids or proteins that reduce gingivitis that could be added to foods, even possibly dentifrices, to leave a gingivitis reducing coating on the teeth. Also if cheese actually prevents gingivitis they could create milk that has more of the beneficial natural chemical

anyway here is a different costco reference suggesting gingivitis is strongly linked to a variety of diseases
http://www.costcocon...search_term=gum disease&doc_id=-1#pg45

Edited by treonsverdery, 01 May 2013 - 10:05 PM.

[nowayout]

Wasn't there a new analysis just this past year finding that gingivitis wasn't connected with heart disease? How are we supposed to keep all this straight?

[treonsverdery]

well there are a few approaches 1) prefer it is true, as http://www.ncbi.nlm....=gingivitis CHD the pubmed most recent publications, as well as the most recent review articles support the idea that gingivitis is a source of disease. Preferring it is true could also be linked to the way gingivitis is easy to prevent

2) cite a more recent source refuting the review articles as well as the linked metaanalysis.

I prefer that it be true as it makes curing about one third to a half of cardiovascular disease incredibly simple, which is actually worth trillions of US$ to public health. I strongly welcome links to higher quality references though. fortunately rather than preferences they can study nonhuman mammals to see if the effect is reproducible, as well as do studies on humans with gingivitis, then give some of them encouragement to cure it, then measure things like C reactive protein or arterial lumen thickness with sonography to see if physiology improves with reduced gingivitis.


more gingivitis curing technology
xylitol sweets reduce tooth decay, these could be made with cheese oil as well, to create a delicious candy that if you fell asleep with it would actually reduce illness. although I suppose it might be kind of risky to fall asleep eating candy

Edited by treonsverdery, 01 May 2013 - 10:38 PM.

[nowayout]

Unfortunately preferences have nothing to do with it.

The American Heart Association recently concluded, on the basis of more than 500 studies, that here is no evidence that gum disease causes heart disease after all.

http://healthland.ti...ease-after-all/

http://www.huffingto..._n_1438433.html

Of course, if someone has gum disease, it should be treated, but there is no evidence that treatment will refuce heart disease risk.

Edited by viveutvivas, 01 May 2013 - 11:58 PM.

[Mind]

Seems to me to be classic correlation does NOT equal causation in this case.

[nowayout]

Seems to me to be classic correlation does NOT equal causation in this case.

Yes, that is what the AHA found. There is correlation but it so far no evidence of causation. For example, it could just be that bad blood vessels make someone more prone to gum disease.

[treonsverdery]

I truly appreciate that reference. I also appreciate he support of scientifically gathered data over preference. The pubmed metaanalysis of 7 studies strongly suggested a link. I still think they should do a study outside the US on humans with gingivitis, then give some of them encouragement to cure it, then measure things like C reactive protein or arterial lumen thickness with sonography to see if physiology improves with reduced gingivitis.

the value of figuring this out is pretty high. preventing 2/10 of cardiovascular disease at the US has a value of a few trillion us$ (40 million chd @ 100k US$ is 4 trillion us$ ) I am not sure how much it is per person, here is some data though http://healthcarecos...ronic-diseases/

Also, remember the amount of back n forth that has occurred on the huge diet studies about lipids n heart disease. It is possible that a multimodal distribution is a source of the data variance. I read a reference that says some people are 6 times more likely to get gingivitis http://www.webmd.com...-disease?page=2 as a result of genetics. If they are separated out of the data, the most frequent genotype might be immune, or the genetically likely to get gingivitis could have been superconcentrated at some of the studies.

here is the metaanalysis description http://www.ncbi.nlm....pubmed/19322227 , there is some material here that could be improved
DATA SOURCES:

Relevant studies were identified using Medline and bibliographies of reviews, editorials, book chapters and letters discussing the relationship between periodontal disease and coronary heart disease (CHD).
STUDY SELECTION:

Studies were assessed for inclusion by two reviewers. Prospective studies with cohort or nested case-control design with CHD or cardiovascular disease (CVD) as an outcome were included. Study quality was rated.
DATA EXTRACTION AND SYNTHESIS:

Data were abstracted by one reviewer and reviewed for accuracy by another author: any discrepancies were adjudicated by a third author. Meta-analysis was conducted to evaluate heterogeneity and publication bias.
RESULTS:

Seven studies were included, some of which found that periodontal disease was independently associated with increased risk of CHD. Summary relative risk estimates for different categories of periodontal disease (including periodontitis, tooth loss, gingivitis and bone loss) ranged from 1.24 [95% confidence interval (CI), 1.01-1.51] to 1.34 (95% CI, 1.10-1.63). Risk estimates were similar in subgroup analyses by gender, outcome, study quality and method of periodontal disease assessment.
CONCLUSIONS:

Periodontal disease is a risk factor or marker for CHD that is independent of traditional CHD risk factors, including socioeconomic status. Further research is warranted in this important area of public health.


The first thing that could be improved is how the studies were gathered. It is likely the actual paper describes this, yet if researchers gathered studies on either quantity (high n), or recentness (multiple measured effects, with high quality data) they could get different grouped results.

Noting the study is English, from large databases of public wellness, I suggest they continue studies, using multiple measures from recent medical data. They could look at normal BP, circulating lipoproteins, normoglycemia, then see if there were gingivitis effects.

Edited by treonsverdery, 03 May 2013 - 05:21 PM.