36 replies to this topic

[Andey]

I see no reason to cycle it......it works very well for me. Any suggestions to cycle are not based on science but based on speculation. It's like creatine too....some claim it has to be cycled but there is no science behind that and it works continuously. I don't cycle my C60/EVOO either....most things don't need to be cycled and in most cases cycling is more detrimental than useful. Get your body tuned and keep it there.

Cycling is a way to go if body going to adjust hormones levels in response to supplement administration.
Retrospectively I could imagine that body could decrease LH to return T level in normal range, but its more relevant to bodybuilders that wants to increase T level way above normal range.
I ordered DAA week ago, waiting for delivery so your experience is highly appreciated.
Thanks )

[Hebbeh]

Realize that I'm 56 years old and being in my fifties, DAA makes me feel hormonally much younger.....it seems to keep my hormones not artificially elevated above normal but keeps them in a more youthful range for me. Will it work the same for a 20 or 30 year old guy already with youthful levels? Probably not. And no, I haven't had my levels tested as I see no reason to...I feel great now. And the few times I ran out of DAA and was forced to temporarily "cycle" off....I could tell the difference and was convinced to order more. But YMMV depending on your situation. Obviously not every single supp is beneficial for every single person or we would all have the same stack and same biology but we know that's not the case.

[HighDesertWizard]

Neuronal control of NF-kB and aging intersect in another way, founded in Settled Science, that sometimes also involves the Hypothalamus.

 

The Vagus Nerve, Heart Rate Variability, Cholinergic Antiinflammatory Pathway Nexus is, to my knowledge, our bodies' major, Innate mechanism for inflammation inhibition. A while back, I tried to summarize a bit of the literature about it at that Longecity link...

 

Kevin Tracey, the scientist most important to the research effort focused on this Innate Immunity Modulating Mechanism, is the lead author of a couple more recent study summaries that provide more significant insight. Links to the full articles follow...

 

Reflex Principles of Immunological Homeostasis

Neural reflexes in inflammation and immunity

 

If you believe that NF-kB is important and, yet, aren't familiar with the Vagus-HRV-CAIP Nexus, you're missing a big piece of the NF-kB puzzle...

---------------------------------

Please allow me to press you to pay attention to this Nexus in the following two ways...

• Vagus Nerve Stimulation results in High Heart Rate Variability (HRV) coincident with triggering of the Cholinergic Antiinflammatory Pathway (CAIP).

That Lower HRV is associated with increased Morbidity and Mortality is, by now, Settled Science. Meanwhile, Higher HRV is associated with increased healthy aging. No time to get at evidence about that point?

 

How about a Single Study Graphic Figure illustrating a fact-anomaly that the Vagus-HRV-CAIP Nexus and its impact on NF-kB can completely explain?

• And if that isn't enough to get your attention, how about a set of good old fashioned Population Survival Curves, in which a functioning Vagus Nerve is the Independent Variable? (From Reflex Principles of Immunological Homeostasis.)

• A third Study Snapshot about HRV, and, by implication, Vagus-CAIP-NF-kB, just for the fun of it...

Edited by HighDesertWizard, 01 February 2015 - 12:26 AM.

[HighDesertWizard]

About NF-kB science, notice the existence of profound discontinuity in the literature...
 
From the Opening Post, about a study published in 2013...
 

In the current study, Dr. Cai and his team demonstrated that activating the NF-κB pathway in the hypothalamus of mice significantly accelerated the development of aging, as shown by various physiological, cognitive, and behavioral tests. "The mice showed a decrease in muscle strength and size, in skin thickness, and in their ability to learn -- all indicators of aging. Activating this pathway systemic aging that shortened the lifespan," he said. Conversely, Dr. Cai and his group found that blocking the NF-κB pathway in the hypothalamus of mouse brains slowed aging and increased median longevity by about 20 percent, compared to controls.

 
Meanwhile, led by Karolinska Institute Honorary Doctorate, Kevin Tracey, dozens of others, in at least a hundred studies, with a first milestone study published in 2002, have been Settling the Science of our Innate Antiinflammatory process for Modulating Innate Immunity, the Cholinergic Antiinflammatory Pathway. It's Triggered by Vagus Nerve Stimulation, is Controlled by Neuronal Muscarinic M1 Receptors, Inhibits NF-kB, and its effect can be measured by a computed statistic, Heart Rate Variability. And that measure, HRV, has been shown, in innumerable studies to be profoundly associated with Morbidity and Mortality.

And, yet, the scientists quoted in the opening post, writing in 2013, are unfamiliar with the CAIP or didn't think it important enough to include a reference to it? And they are not alone in ignoring the CAIP... There are dozens, increasingly fewer, who are either ignorant of it or who choose to ignore it.
 
I believe we are close to new insight about the importance of NF-kB for aging and longevity as this discontinuity in the literature diminishes and new knowledge grows...

Edited by HighDesertWizard, 01 February 2015 - 04:51 PM.

[Logic]

Will supplementing Acetylcholine have an effect?

"...Acetylcholine inhibits cytokine production in macrophages via α7 nicotinic acetylcholine receptor (α7nAChR), and nicotine is a more stable agonist to control cytokine production..."
http://www.nature.co...cr2013128a.html
 

[HighDesertWizard]

Will supplementing Acetylcholine have an effect?

"...Acetylcholine inhibits cytokine production in macrophages via α7 nicotinic acetylcholine receptor (α7nAChR), and nicotine is a more stable agonist to control cytokine production..."
http://www.nature.co...cr2013128a.html
 

 

Logic... My purpose in posting to this thread was not to hijack it... But I did want to point out the discontinuity in the scientific literature about the importance of NF-kB...

 

I have just now created another Forum Thread to discuss specific means for Triggering the Vagus Nerve and/or the CAIP. It's entitled Triggering the Cholinergic Antiinflammatory Pathway to Inhibit NF-kB.

 

I answered your question above here... I suggest discussion of the science of the Vagus, HRV, and the CAIP take place here...

[Area-1255]

Maybe a key to the puzzle, but I suspect it is a whole lot more complicated than the headline proclaims.

Absolutely, it's a big key , especially in quality of life - and central energy production - and general aging factors..but it is not the ultimatum if other factors that in turn DECIDE the cellular volume or uptake are interrupted or destructed. Such as with the liver, which I would say is AT LEAST = HYPOTHALAMUS in importance, if not far more....no liver, no nothing...and let's not forget the liver manufactures vital enzymes that affect the breakdown of everything from neurotransmitters to neuropeptides hormones....

 

The hypothalamus may be a major player - but it's not central to every single replicate or poster-child of the aging spectrum.