54 replies to this topic

[marcobjj]

http://www.fasebj.or...c1-edff6332d1d1


What has become ubiquitous with age - gray hair - may soon become a thing of the past. Forget about trips to the hair salon, or buying box dye to cover up those roots, a team of European researchers say.
In a new research report published online in The FASEB Journal people who go gray develop massive oxidative stress via accumulation of hydrogen peroxide in the hair follicle, which causes hair to bleach itself from the inside out.
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The report notes that the enormous accumulation of hydrogen peroxide can be cured with a proprietary treatment developed by the researchers described as a topical, ultraviolet B-activated -- sunlight -- compound PC-KUS, a modified pseudocatalase.
What's more, the study also showed the same treatment works for the skin condition, vitiligo which is a condition that causes de-pigmentation of sections of skin. Although vitiligo isn't an agonizing, or dangerous condition, it can still be pretty distressing because it can change people's appearance so much, according to the American Academy of Dermatology. One to 2 million people in the U.S. have vitiligo, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
"For generations, numerous remedies have been concocted to hide gray hair," said Dr. Gerald Weissmann, the editor-in-chief of The FASEB Journal, "but now, for the first time, an actual treatment that gets to the root of the problem has been developed. While this is exciting news, what's even more exciting is that this also works for vitiligo. This condition, while technically cosmetic, can have serious socio-emotional effects of people. Developing an effective treatment for this condition has the potential to radically improve many people's lives."
In the current study, an international group of 2,411 patients with vitiligo, 2.4 percent were diagnosed with strictly segmental vitiligo and after treatment of the pseudocatalase activated via sunlight, the pigment of the skin and eyelashes returned.
The researchers did not specify when the treatment would become available for retail.

[cATsE]

Pretty cool, hope it won't take years and years before it hits the market.

[nowayout]

Am I the only one who finds that theory that grey hair is being cased by endogenous bleach a little hard to swallow?

[Mind]

Am I the only one who finds that theory that grey hair is being cased by endogenous bleach a little hard to swallow?

I am suspicious as well. Will follow this though. Wonder about side effects.

[marcobjj]

Am I the only one who finds that theory that grey hair is being cased by endogenous bleach a little hard to swallow?

why is that?

[niner]

Am I the only one who finds that theory that grey hair is being cased by endogenous bleach a little hard to swallow?

Are you aware that hydrogen peroxide is constantly formed in your cells? In the process of making ATP, mitochondria also create a radical anion called superoxide. Superoxide dismutase creates H2O2 as a byproduct of detoxifying superoxide. The H2O2 should ideally be taken care of by catalase, but not all of it is, and if catalase is insufficient, you will get a buildup of peroxide, the endogenous bleach.

[AgeVivo]

Am I the only one who finds that theory that grey hair is being cased by endogenous bleach a little hard to swallow?

That is not a new published discovery. This was published about one year ago (even twice I think by far apart teams, if I remember correctly) and had been discussed on LongeCity. In Japan there are now some topical applications for hair that counter the bleech, the tool looks like a topical deodorant (sorry I don't have the source; I had found it on google a few months ago)

Edited by AgeVivo, 08 May 2013 - 09:15 AM.

[Logic]

...That is not a new published discovery...

That's what I was thinking and wondering why everyone was only talking about it now.

There's also a way of increasing Catalase, which I cant now recall. Any ideas?

[marcobjj]

Am I the only one who finds that theory that grey hair is being cased by endogenous bleach a little hard to swallow?

That is not a new published discovery. This was published about one year ago (even twice I think by far apart teams, if I remember correctly) and had been discussed on LongeCity. In Japan there are now some topical applications for hair that counter the bleech, the tool looks like a topical deodorant (sorry I don't have the source; I had found it on google a few months ago)

really, I read a couple of years ago that Loreal was working on a pill to stop graying, but you'd have to take it for 10 years before you'd experience full effects. Never heard anything about reversing grey hair.

[Logic]

Some leads:

Oral supplements are available for SOD, catalase, and glutathione peroxidase; however, these substances may be digested in the intestine before they ever reach the bodily tissues. Giving the body extra amounts of the building blocks it requires to make these natural antioxidants, such as manganese, zinc, copper, and selenium, may be a more effective way to increasing their presence in the body.
http://www.vitaminst...m/catalase.html

Some scientists believe the hormone melatonin helps cells create catalase.
http://www.ehow.com/...production.html

Picrorhiza kurroa is a well-known herb in the Ayurvedic system of medicine in India. It is a small perennial herb found in the Himalayan region growing at elevations of 3,000-5,000 meters. One of the benefits of Picrorhiza is that it increases Catalase levels in the body and may contribute to reducing lipid peroxidation throughout the body.
http://www.invitehea...ts-supplements/

Glisodin
cocoa
resveratrol upregulates catalase gene activity
http://www.longecity...zyme-naturally/

[ta5]

Skinactives sells a gray hair serum with catalase:
http://www.skinactiv...uctase-MSR.html

I tried it on my beard for a few weeks. It gave me a strange bad headache at my temples.

[cATsE]

Has anyone tried this yet? I should have it in a week or two, will try it on my beard first, before I commit to shave my hair off. It should be added to a non-oily moisturizer and applied on the skin, after its absorbed one should go in the sun so the UV light can activate it.

By the way, these two products people have linked to above doesn't contain the specific PC-KUS compound talked about in the opening post.

[zorba990]

Has anyone tried this yet? I should have it in a week or two, will try it on my beard first, before I commit to shave my hair off. It should be added to a non-oily moisturizer and applied on the skin, after its absorbed one should go in the sun so the UV light can activate it.

By the way, these two products people have linked to above doesn't contain the specific PC-KUS compound talked about in the opening post.

From the study it looks like they just used Manganese and calcium. Manganese can be pretty toxic, though so I'm not sure you would want to use very much long term. Curious as to why they didn't add copper, which seemed to work for me (but Resveratrol oraly works better IMO).

[zorba990]

I wonder if it might make more sense to use probiotics topically:


Pseudocatalase from Lactobacillus plantarum: evidence for a homopentameric structure containing two atoms of manganese per subunit.

http://www.ncbi.nlm..../pubmed/4084532


Isolation and characterization of the pseudocatalase of Lactobacillus plantarum

http://www.ncbi.nlm..../pubmed/6853475

[marcobjj]

ha, I have L Plantarum on my Kefir culture, I'm thinking about feeding it some manganese and try to apply it on scalp

[zorba990]

ha, I have L Plantarum on my Kefir culture, I'm thinking about feeding it some manganese and try to apply it on scalp

Probably wouldn't take too much manganese or copper to kill a culture so start with just a tiny bit I would say.
DIY Manganese PseudoCatalase cream recipe is here: http://fightingvitil...o.com/The Cream
I haven't tried it.

[cATsE]

ha, I have L Plantarum on my Kefir culture, I'm thinking about feeding it some manganese and try to apply it on scalp

Probably wouldn't take too much manganese or copper to kill a culture so start with just a tiny bit I would say.
DIY Manganese PseudoCatalase cream recipe is here: http://fightingvitil...o.com/The Cream
I haven't tried it.

This is not PC-KUS, as someone also writes in the comment section on that board. Besides, PC-KUS is not that expensive, it's only $40 for 10grams, which is enough for 400ml of cream, so why go through all the hassle? And L Plantarum, really? Good luck with keeping a culture alive long enough once it's out of the fridge and in the sun.

[zorba990]

ha, I have L Plantarum on my Kefir culture, I'm thinking about feeding it some manganese and try to apply it on scalp

Probably wouldn't take too much manganese or copper to kill a culture so start with just a tiny bit I would say.
DIY Manganese PseudoCatalase cream recipe is here: http://fightingvitil...o.com/The Cream
I haven't tried it.

This is not PC-KUS, as someone also writes in the comment section on that board. Besides, PC-KUS is not that expensive, it's only $40 for 10grams, which is enough for 400ml of cream, so why go through all the hassle? And L Plantarum, really? Good luck with keeping a culture alive long enough once it's out of the fridge and in the sun.

I've read through the comments (http://fightingvitiligo.com/Comments) and not finding what you are talking about.

Perhaps you would like to supply a link to where your company is selling it so we can compare the formulae?

I believe the cream is simply supplying raw materials for the body to make catalase from.
Supplying exogenous catalase would not be as effective (molecule too big, not restarting the
natural biological process).

Edited by zorba990, 12 June 2013 - 06:44 PM.

[cATsE]

ha, I have L Plantarum on my Kefir culture, I'm thinking about feeding it some manganese and try to apply it on scalp

Probably wouldn't take too much manganese or copper to kill a culture so start with just a tiny bit I would say.
DIY Manganese PseudoCatalase cream recipe is here: http://fightingvitil...o.com/The Cream
I haven't tried it.

This is not PC-KUS, as someone also writes in the comment section on that board. Besides, PC-KUS is not that expensive, it's only $40 for 10grams, which is enough for 400ml of cream, so why go through all the hassle? And L Plantarum, really? Good luck with keeping a culture alive long enough once it's out of the fridge and in the sun.

I've read through the comments (http://fightingvitiligo.com/Comments) and not finding what you are talking about.

Richard (not verified)
Tue, 05/28/2013 - 17:41
Old ingredients not PC-KUS

Perhaps you would like to supply a link to where your company is selling it so we can compare the formulae?

I believe the cream is simply supplying raw materials for the body to make catalase from.
Supplying exogenous catalase would not be as effective (molecule too big, not restarting the
natural biological process).

LOL, I don't have a company, just do a search on eBay, that's where I found it myself.

Main reason I'm pretty sure that it isn't quite the same, is because of the time it takes to see results with this self-made cream, compared to what I read about PC-KUS.

But try it, we'll see who gets the best results, if any, because I'm not at all convinced it will actually work for grey hair, even if it may work well for vitiligo...

Edited by cATsE, 12 June 2013 - 07:32 PM.

[zorba990]

Since the ebay lister doesn't even list his ingredients, and the DIY cream reference does, what would lead you to believe it's more genuine than something which follows the patent's formula directly? BTW Peroxide will pretty much oxidize anything and foam in the process so producing a foam from it is really proof of nothing. In fact, lack of foaming would be more convincing.

As stated in the patent, pseudocatalase (a bit of a misnomer if you ask me), in this context, is:
"a transition metal bicarbonate complex". (from http://www.docstoc.c...-Patent-5895642 which enhances the formula by adding EDTA)

It may be important to note that in the above patent allowing the manganese carbonate to form through reaction and including the EDTA in that process maybe important (as opposed to simply using magnesium carbonate directly).

It has been observed that the addition of bicarbonate to manganese chloride in water leads to the precipitation of a white solid, mostly composed of manganese carbonate. It is thought that some manganese carbonate remains as solid when the cream
base is added, so that some manganese ions are unavailable for chelation with the EDTA. This may explain the higher activity of the composition of Example 3, since all of the manganese ions are available for chelation.

UV isn't required for hair color production so it's not necessarily relevant.

I feel like I should add again manganese is EXTREMELY TOXIC STUFF! Use caution and do not inhale!

Edited by zorba990, 12 June 2013 - 09:25 PM.

[ClarkSims]

This is the listing on Ebay that people are talking about. Does anyone have any ideas on how to verify the purity?

http://cgi.ebay.com/...mMakeTrack=true

[ClarkSims]

Does anyone have a link to the full text of the original article in FASEB?

[marcobjj]

http://www.fasebj.or...5.full.pdf html

[ClarkSims]

http://www.fasebj.or...5.full.pdf html

That is a great paper, but I was referring to their 2013 paper where they test PC-KUS to restore hair color.

Thanks,

Clark

[ClarkSims]

Curious as to why they didn't add copper, which seemed to work for me (but Resveratrol oraly works better IMO).

How do you take the Resveratrol? Do you do anything to increase the bioavailability?

[niner]

http://www.fasebj.or...5.full.pdf html

That is a great paper, but I was referring to their 2013 paper where they test PC-KUS to restore hair color.

They didn't use it to restore hair color. They were looking at vitiligo, and reported a restoration of pigment in skin and eyelashes. That's a pretty good sign, and it's certainly worth trying on ordinary grey hair, but it's not a sure thing. Grey hair and vitiligo are two different things, although there is hydrogen peroxide involved in both. Here's a very good article about the media hype on this, and what we can really say from Schallreuter's work. Have you been to www.pseudocatalase.com/ ? They are selling it, but you need a Doctor's prescription. I didn't see any mention there of use for grey hair, only for vitiligo.

Edited by niner, 28 July 2013 - 01:05 AM.

[marcobjj]

http://www.fasebj.or...5.full.pdf html

That is a great paper, but I was referring to their 2013 paper where they test PC-KUS to restore hair color.

Thanks,

Clark

sorry about that, I guess the only way to the full 2013 pdf is to get a paid subscription of the FASEB journal :

http://www.fasebj.or...9.full.pdf html

[Strangelove]

Quite interesting!

Anyone tried it? The seller on ebay has 100% positive feedback, so I hope what is selling is really pseudocatalase powder.

So, what is needed according to the study is a pseudocatalase cream?

If yes, a transdermal base might work even better, a microneedle roller might be a good idea also. The need or not of these additional products I guess depends on where the damage from the peroxide is in the anatomy of the hair.
-

[JohnD60]

It has been 3+ months, I would have expected some feedback on this by now from those that were going to try duplicating the study

[Stefanovic]

any updates by now? Some people seem to respond well.