65 replies to this topic

[mrkosh1]

It will be nice when there is a glucosepane breaking drug the equivalent of Product B that boosts telomerase.

 

Even if it only had a weak effect at first, if it would clear most of the glucosepane cross links in a couple years it would be worth it.

 

 

[Logic]

P. crispum, B. diffusa and T. chebula had the most potent antiglycation activity. These plant exerted noticeable antiglycation activity at different glycation modifications of albumin.

 

The average antiglycation potential was in the range from 32.35 to 61.14. P. crispum surpassed all the other plants as it obtained first ranking in overall performance (61.14). This was followed by B. diffusa (55.64) and T. chebula (51.26). B. diffusa showed great effect in protecting thiol group and T. chebula outperformed in inhibition to β-amyloid aggregation. S. chirayita and G. glabra obtained fourth and fifth ranking respectively by inhibiting fructosamine and AGEs. They moderately inhibited β-amyloid aggregation, but failed to protect thiol group from oxidation. Sixth and seventh position obtained by W. somnifera and Aloe barbadensis respectively, both of them moderately inhibited fructosamine, AGEs and β-amyloid formation, however A. barbadensis greatly inhibited the carbonyl formation.

 

http://www.tandfonli...09.2016.1228683

[YOLF]

 

Eugenol looks pretty interesting...

 

http://www.nature.co...icles/srep18798

 

Which is basically clove oil.  Any guesses as to what sort of dose a human would have to take to get a similar effect?

 

Anyone tried it? I've been thinking about it... I think it can be toxic and methyl-eugenol is safer?

 

Any information to suggest that it wouldn't make you lazy via lower dopamine as P5P, and B6 do? 

 

What about cocarboxylase? Can that break glucosepane? Swanson is making it. Maybe we can get RevGenetics to make a MetaCocarboxylase if it does?

Edited by YOLF, 01 March 2017 - 11:05 PM.

[YOLF]

Not plant derived, but what about palmitoyl pentapeptide-3 (Matrixyl)? It is touted as reducing fine lines over time and it's action appears to be through increasing collagen production by 117%, collagen IV by 327% and HA by 267%. Could it also be beneficial to kidney and brain diseases?

 

If we look at the parent product of the discovery (Replexion/ComplexionMD), it is combined with acetyl hexapeptide-3 and palmitoyl oligopeptide as well as some hyaluronic acid of unknown molecular weight. AH3 relaxes muscles which gives immediate effects, especially for caffeine junkies I'm thinking, but if this other stuff can keep collagen production stoked, I think that could be a method of displacing AGEs for removal if done along with stimulating the pathways for removal with the kidneys and liver. The kidneys lose EGFR with time, but this looks to be restorable with PEP-1192 (Klotho RH?) due to accumulation of of AGEs (in some part), so taking Matrixyl and perhaps palmitoyl oligopeptide-3 via injection or perhaps infusion, or perhaps making it into a slow release injection similar to some insulins, psoriasis therapies, or that cancer therapy for prostate cancer that outcompetes GnRH could lead to a long term solution to the problem of AGEs. I'm thinking Matrixyl could have similar action to klotho and structural fidelity seems to prevent most cancers, so something like Matrixyl should be very safe.

 

Oh note to use is that we don't know what an appropriate dose is for this stuff and if we look at GnRH, it basically castrates you if you use too much of it. So which brand gives an appropriate dose that won't stop your own synthesis of it? Or does taking it signal for increased production of it's precursors? How best to use it?

 

On a more botanical side note, what about Ellagic acid? It restores skin elasticity iirc. Has anyone discussed it?

[Nate-2004]

C16, a novel advanced glycation endproduct breaker, restores cardio-vascular dysfunction in experimental diabetic rats

...treatment for 4 weeks resulted in a dose-dependent and significant increase in cardiac output, a reduction of total periph-eral resistance, and an increase in systemic arterial compliance when comparedwith vehicle-treated diabetic rats.  Biochemical studies showed that C16 treatmentalso resulted in a significant decrease in immunoglobulin G-red blood cell surfacecrosslink content and an increase in collagen solubility.  Morphological and im-munohistochemical examinations indicated that C16 was able to prevent increasesof the collagen type III/I ratio in the aorta and decrease the accumulation of AGEin the aorta.  Conclusion: C16 has the ability to reduce AGE accumulation intissues in vivo, and can restore diabetes-associated cardiovascular disorders inrats.  This provides a potential therapeutic approach for cardiovascular diseaseassociated with diabetes and aging in humans...

 

Sci-hub =no paywall:

https://www.facebook.com/sci.hub.org/

 

The above paper:

http://sci-hub.bz/10...54.2005.00240.x

 

What became of this? Looks like this C16 has been around since 2005?

[normalizing]

im interested in c16, is this the one which prevents iron absorption or am i confused on this?