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The drug candidate, called J147, reversed memory loss in Alzheimer’s model mice, according to a study published online Monday in the journal Alzheimer’s Research and Therapy. The study builds on earlier research finding that the drug preserves brain function when given to Alzheimer’s model mice. That study was published on December 2011 in the journal PLoS One.
The study compared J147’s memory-enhancing effects with Aricept, generically known as donepezil. It found that while both improved short-term memory, only J147 improved spatial memory. Moreover, combining the drugs worked better than either alone.
“It looks like an interesting compound that will have therapeutic utility, whether in AD or not; they have done a good job of characterizing the pharmacokinetics and safety,” Walker said by email, referring to how the body reacts to the drug.
After six years of preclinical studies, J147 is ready for human clinical trials, said Dave Schubert, head of Salk’s cellular neurobiology laboratory. The compound, derived from the curry spice component curcumin, has low toxicity and actually reverses damage in neurons associated with Alzheimer’s, said Schubert, the study’s senior author. The lead author is Marguerite Prior, a research associate in Schubert’s laboratory.
Sounds like an interesting substance, I would certainly like to give it a try.
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