379 replies to this topic

[Hebbeh]

in

There can be no group buy without Hebbeh's fearless rat.

We will master the skills of the Jedi Knight to defeat the tyranny of the dark forces. Let the Force be with you.

[Reformed-Redan]

in

There can be no group buy without Hebbeh's fearless rat.

We will master the skills of the Jedi Knight to defeat the tyranny of the dark forces. Let the Force be with you.

Always.

[DamnedOwl]

Although I don't get why we're doing another headcount: I'm still interested.

This, but I'm still in also.

[Babychris]

Sounds tasty. i'm in

[Perception-Is-Reality]

I would like to be added to this group buy list.

[3AlarmLampscooter]

Count me in.

[Reformed-Redan]

Cool. Will try and keep a tab on things. So far I'd guess we have 80 people who have shown interest. When it comes to payment's I think half might actually contribute. Well, see. I'm almost done with the BPAP group buy and as soon as it's finished well see. Hope our European Custom Synthesis Supplier isn't too busy with all the other projects they're working on.

[ScienceGuy]

IDRA-21 USER FEEDBACK:

Hi Everyone,

I just took 5mg of IDRA-21 (RACEMATE FORM) via SUBLINGUAL administration

I will post and update soon regarding what (if any) noticable effects I experience, both POSITIVE and NEGATIVE


I should add that I have calculated the HUMAN EQUIVALENT DOSAGE (HED) range for IDRA-21 using the study on MONKEYS as the reference; wherein, the 'best dose' range for the MONKEYS was reported to be 0.15 - 3 MG / KG

Therefore, the HED = 0.15 x (12 / 37) to 3 x ( 12 / 37) = 0.049 to 0.973 MG / KG

I currently weigh 92kg and hence my HED would be = 4.5 to 89.5mg

Hence why I took 5mg as my first dose

Edited by ScienceGuy, 20 June 2013 - 04:43 AM.

[lostfalco]

IDRA-21 USER FEEDBACK:

Hi Everyone,

I just took 5mg of IDRA-21 (RACEMATE FORM) via SUBLINGUAL administration :)

I will post and update soon regarding what (if any) noticable effects I experience, both POSITIVE and NEGATIVE ;)


I should add that I have calculated the HUMAN EQUIVALENT DOSAGE (HED) range for IDRA-21 using the study on MONKEYS as the reference; wherein, the 'best dose' range for the MONKEYS was reported to be 0.15 - 3 MG / KG

Therefore, the HED = 0.15 x (12 / 37) to 3 x ( 12 / 37) = 0.049 to 0.973 MG / KG ;)

I currently weigh 92kg and hence my HED would be = 4.5 to 89.5mg

Hence why I took 5mg as my first dose :)

Thanks for posting ScienceGuy! I'm really looking forward to hearing your experiences.

[darksanity]

Is this still open? I'm totally in if so.

[Reformed-Redan]

Looking around for different suppliers. Will see how ScienceGuy's results come out.

[Reformed-Redan]

IDRA-21 USER FEEDBACK:

Hi Everyone,

I just took 5mg of IDRA-21 (RACEMATE FORM) via SUBLINGUAL administration

I will post and update soon regarding what (if any) noticable effects I experience, both POSITIVE and NEGATIVE


I should add that I have calculated the HUMAN EQUIVALENT DOSAGE (HED) range for IDRA-21 using the study on MONKEYS as the reference; wherein, the 'best dose' range for the MONKEYS was reported to be 0.15 - 3 MG / KG

Therefore, the HED = 0.15 x (12 / 37) to 3 x ( 12 / 37) = 0.049 to 0.973 MG / KG

I currently weigh 92kg and hence my HED would be = 4.5 to 89.5mg

Hence why I took 5mg as my first dose

Arrrgh, you got to the treasure cove first. Arrrr!

[trev.pol]

any update about effects?

[CLR]

Will they reveal the process to synthesize IDRA-21 so that some of us may be able to make it? Or is it going to be monopolized like other pharmaceuticals? The guns of the war against aging are always kept in the hands of the profit-hungry :(

Chlorinating molecules seems to be popular these days not only because it makes molecules more bioeffective, but also because its easy and it changes the structure to legitimize new patents. For example, clonazepam is a chlorinated benzodiazepine, much more potent than many other benzos; it also gave way to a new patent. Since IDRA-21 is a chlorinated, chiral derivative of aniracetam, all thats left to determine is what substances and equipment were used to synthesize it, and we should have all the info needed to design the multicomponent/cascade reaction to produce it.

Edited by CLR, 20 June 2013 - 09:19 PM.

[Reformed-Redan]

Well, this is a cliffhanger. On the next, "ScienceGuy and IDRA-21," will everything work out? Will it turn ScienceGuy into Mr. Hyde? Dum dum dum.

[3AlarmLampscooter]

[lostfalco]

Seriously, I hope he's ok. If ScienceGuy isn't around there will be like a 90% reduction in emoticons around here. Let's just assume he's REALLY busy with work.

[xsiv1]

^^^^ lol @ emoticon reduction

[ScienceGuy]

IDRA-21 USER FEEDBACK:

DAY ONE: I took 5mg SUBLINGUALLY upon waking. No adverse effects whatsoever. No significant noticeable beneficial effects, aside from a mild increase in alertness; although this was most welcome given I had a 4am start

DAY TWO: I took 5mg SUBLINGUALLY upon waking again. Given that IDRA-21 is reported to exert a 3-DAY EFFECT I did this deliberately, expecting this second dose to be cumulative. In short, it was. I experienced a stronger increase in alertness, but this time I also experienced a sharpening of focus and cognition; however, it seemed to be accompanied by a jittery restlessness and manifestation of mild anxiety, which is akin to what happens when I consume too much caffeine. This is not entirely pleasant and is a bit of a bummer because it essentially spoils the alertness increase.

I am going to take a break long enough to complete a washout period and then re-try IDRA-21 to ascertain whether both positive and negative effects are repeated. Of course, even if I personally find that I do not get along with IDRA-21 that does not mean you won't. It is probably worth mentioning that I do not respond well to ANIRACETAM either, which produces similar adverse effects when I take it, including increased anxiety.

Edited by ScienceGuy, 21 June 2013 - 06:24 PM.

[3AlarmLampscooter]

Interesting to hear, and glad you're alright!

I'd recommend trying Afobazole for the anxiety, as at least in me it was highly effective against anxiety of all etiologies. Of course I'm also someone with a strange tolerance for caffeine (I used to do in excess of 4g per day, don't do this)

So one anecdotal report of no serious adverse effects in an otherwise untested research chemical? Sign me up.

Edited by 3AlarmLampscooter, 21 June 2013 - 06:35 PM.

[Reformed-Redan]

Hey guys, I don't want to rule IDRA-21 out just yet; but, if ScienceGuy's report is shows weak effects I might shift the focus on more promising compounds. Don't want to waste your time and money and mine. Either that or increase the dose alongside taking ALCAR.

There are plenty of more interesting compounds out there with great nootorpic potential. Such as ISRIB, or PRL-8-53.

One compound that should produce immediate pronounced effects is Pitolisant. That awake feeling should be very apparent; like coffee 10x without the jitteriness or modafinil x2.

ISRIB, is something to be looked for sure.

Pitolisant seems like a great ADD med because it modulated dopa receptors through H3-inverse agonism, has little to no tolerance and is well tolerated. Might be a real winner and alongside ISRIB their structures do not seem too difficult to synthesize at reasonable costs.

[Izan]

yes yadayada, very much interested in pitolisant! isrib for supreme memory enhancement would also be great. thanks!

[Metagene]

yes yadayada, very much interested in pitolisant! isrib for supreme memory enhancement would also be great. thanks!

I also suggest we go for ISRIB then Pitolisant. Aniracetam agrees with me so IDRA-21 may still hold promise but let's keep it real here.

[empedocles]

Pardon my ignorance but ISRIB ?

[Metagene]

Integrated Stress Response Inhibitor

http://brainupdates....tified-in-mice/

[xsiv1]

Very interested in both compounds here and Aniracetam agrees with me very well. In fact, I find it anxiolytic without any mental fatigue...although it does 'feel' like a two-stage process whereby I almost 'feel' like I'm tired or foggy and then after about 45 minutes or so, I'm much more focused on the task at hand.

[megatron]

Is the washout period over? I would love to hear the continuation of what you wrote earlier

[Reformed-Redan]

Crazy busy with group buys. BPAP pretty much over, ISRIB in the works and pitolisant next. IDRA-21 seems like a dud for some reason. Might have to do with BBB permeability, pharmokinetics or just neurological differences between rhesus monkeys. Gonna go for pitolisant next. Fortunately pitolisant isn't that hard to synth and a large quantity can be made. But, will hold off for now as I'm just swamped with addresses and other daily routines.

[megatron]

Crazy busy with group buys. BPAP pretty much over, ISRIB in the works and pitolisant next. IDRA-21 seems like a dud for some reason. Might have to do with BBB permeability, pharmokinetics or just neurological differences between rhesus monkeys. Gonna go for pitolisant next. Fortunately pitolisant isn't that hard to synth and a large quantity can be made. But, will hold off for now as I'm just swamped with addresses and other daily routines.

Probably should have been more specific; I was referring to ScienceGuy's washout period and trial

[MasterHerb]

Crazy busy with group buys. BPAP pretty much over, ISRIB in the works and pitolisant next. IDRA-21 seems like a dud for some reason. Might have to do with BBB permeability, pharmokinetics or just neurological differences between rhesus monkeys. Gonna go for pitolisant next. Fortunately pitolisant isn't that hard to synth and a large quantity can be made. But, will hold off for now as I'm just swamped with addresses and other daily routines.

I will be actively waiting for the pitolisant group buy!