Nootropix.
When i took multi vit contain additional calcium ,those day i took normal my daily piracetam about 400mg ,i go party with my friends ,my brain just fried that day
i have lost friends and many thing .
My concentration never like before ,daily function is troublesome .
Anyone else can proof this ? try repeat my steps .
I think your brain must peak ,mean been on piracetam for a while and have massive of glutamate receptors up ,and repeat my step will see very effective how very little MSG can fry your brain while on piracetam .
With all due respect to Nootropix, I don't know if his story could be considered completely reliable or controlled. He lives in an area where food is heavily flavored with MSG and he has changed his mind about piracetam being harmful quite a few times. He also claims to have had a VERY positive initial reaction, so perhaps he was extremely sensitive to it, something that OP does not seem to be.
For the record, I have been on piracetam (every day~750mg/day) and oxiracetam (off and on, ~750mg/day) for the past 4 months and have eaten foods with massive amounts of MSG and been fine albeit a bit tired afterwards. I was on it for 6 months in a row and 4 months in a row last year and I eat American Chinese food (where the MSG is very noticeable) very often.
Piracetam is very neuroprotective. Although it is possible that he had an adverse reaction, it is very unlikely. There has never been a clinically recorded case of piractam being neurotoxic (except one with a patient with bipolar disorder, but it is unclear if the (mild) toxicity was due to the BP or the piracetam), and it has been used quite a bit in a clinical setting.
If his adverse reaction was to piracetam, it was an incredibly rare and unfortunate reaction.
Well I wasn't very convinced of his story in the beginning as well but when I read another member who got permanent brain fog from pramiracetam I could say that this isn't impossible.
Piracetam sure is neuroprotective for NMDA potentiation but it can turn rogue very easily if there is a glutamate flood. Piracetam + High dose of Calcium + High MSG intake is likely killer for a lot of people, if you add up exercise which increases glutamate levels you can very easily cause massive excitotoxicity.
The way he's talking corresponds to how victims of excitotoxicity express themselves (if that isn't the case then his english is totally wrecked) but the story is unclear as to drug use since it was a party he could have taken a drug that would have worsened the effects who knows...
But since I read that story with pramiracetam that isn't impossible, hopefully I personally never had that but I remember taking up to 10g and 10g at once was definetely too much as my brain felt really hot and exhausted.
I'm just saying that people shouldn't blindly believe in the definition of a nootropic coined by Dr. Corneliu Giurgea that says a nootropic has extremely low toxicity, from the reports even if it's not toxic for 99% of people it's not the kind of thing you can eat like sugar and be fine with it.
I have experienced similar twitching in both eyelids after a couple weeks of taking noopept (~10-100 mg/day) and lucidril (~100-500 mg/day). My eyelids would constantly twitch all day long. Not debilitative, actually rather amusing, but definitely abnormal. Also, joint aches, general muscle fatigue, dizziness, insomnia, and brain fuzziness.
After a couple more weeks (so, one full month of supplementation), each day of which I experienced these kinds of side effects, I decided to stop supplementing cold turkey, and this is the 5th day of my break. All the adverse symptoms have now gone away, so it does appear the noopept/lucidril were the culprits.
Nevertheless, I did enjoy other good effects from taking them, including clarity of mind, motivation boost, mental resolve, and improvements in memory and cognitive function.
In fact, even during my break, I'm still enjoying the positive afterglows, though somewhat attenuated. Strangely, I'm also experiencing a persistent, mild but quite noticeable medicinal taste / smell in my mouth / breath.
I'm looking forward to re-starting my regiment after a week break. Maybe smaller doses will help minimize the side effects. Hope to share more later. Any other helpful suggestions are appreciated. Thanks.
The fasciculations could have had happened due to that traumatic event and piracetam has probably unleashed brain damage caused by this trauma. A concussion can lead to dramatic changes in neurotransmission and therefore could cause fasciculations.
Do you have any other symptoms that began with fasciculations? Do you have any difficulty breathing?
No difficulties breathing nor any SLUDGE/DUMBBELLS symptoms except fasciculations.
The "trauma" incident that happened was three months after quitting Piracetam. I already had some of fasciculations at this time, but it seems to have unleashed the eye twitch that persisted for a week afterwards. I did not have a concussion (or any other significant physical injury), just a stressful experience.
Also, I'm not sure, but I think the fasciculations actually are more frequent and more intense now than they were when I was actually using Piracetam.
This leads me to ask the question: How long are the effects of Piracetam actually "active" in the system?
I know that the effect of Piracetam is cumulative, is this due to an 'upgrade' of the AMPA and NMDA receptors, or do I in fact have a buildup of Piracetam in my blood system?
Also reading this thread with interest, albeit brief: http://www.longecity...not-neurotoxic/
Well that could just be a mineral deficiency if you already had that even before the traumatic event, you say you take magnesium from time to time but how much exactly (elemental)?
Almost everyone is deficient in magnesium nowadays since most of it was filtered out from water and bread, we don't get as much as our ancestors did unless you supplement with it.
If that isn't magnesium it's probably potassium, eat 3-4 large bananas which contain 450 mg potassium each and if the symptoms subside then you know what's the problem, potassium is also something most people are deficient in. There's a few in bread, in french fries as well.
Where did you read that effects are cumulative? Don't you rather mean proportional? Usually everyone go back to baseline after piracetam clears out of your system, you might have long lasting changes if you learn a lot while using piracetam which could increase ability to form LTP but piracetam isn't active anymore once it leaves your system.
Piracetam doesn't touch to AMPA but to NMDA, it upregulates NMDA up to 20% then NMDA receptors are going back to baseline a few days after you quit.
Well that article does explain how piracetam acts, it stimulates calcium channels, that's a good thing for glutamate neurotransmission but this can cause severe excitotoxicity if you're magnesium deficient, take a calcium supplement (or a lot of milk) and take a lot of MSG.
Edited by YOLF, 04 June 2016 - 11:22 PM.
