709 replies to this topic

[formergenius]

Primarily the former. No, there are currently no KOR antagonists being used clinically. One recently released opioid antagonist shows greater affinity for KOR than others I believe, but still lacks the selectivity of JDTic. It's called Nalmefene; one guy with dissociative symptoms tried it and couldn't tolerate it, much like how naltrexone only becomes significantly KOR antagonist at a dose that's intolerable.

[Missjess]

I was interested in naltrexone as I read it completely abolished a few peoples dissociative symptoms and in that other patients showed marked improvement in symptoms. I have a question about jdtic, does it destroy ur kappa receptors completely? And if they grow back will they come back as normal not like changed like they were from drug use? What happens when u discontinue use of jdtic do u know the side effects etc

[formergenius]

You;re talking about Naloxone which needs to be administered intravenously.
I can't answer those questions; this is the element of risk I was talking about.

[Missjess]

Yes that must be the one...have u tried it?
Hmm yes I see well I would still be interested in trying jdtic

[neuroatypicow]

Hi, I'm a long-time sufferer of depression and anxiety, and have been failed by all the usual methods, and am interested in participating in this group buy, to add to my self-renovating regimen.(see my intro post). i have the $ available for my share of whatever amount/quantity you lads decide upon. i'll be ready to contribute funds whenever the word is given, please add me to the list?!
so excited to see how this endeavour pans out!
~NeuroatypiCow

[datrat]

SP a quick question. Do you have to have your name already on the payitsquare page in order to send funds, or does that happen after you go to checkout?

[formergenius]

missjess; no I haven't.

neuroatypicow; consider yourself on the list

datrat: I just filled in "formergenius" where you have to fill in your name, and put my real name in the address section.

Edited by formergenius, 24 January 2014 - 12:33 AM.

[datrat]

datrat: I just filled in "formergenius" where you have to fill in your name, and put my real name in the address section.


Thanks!

[penisbreath]

Has anyone here messed around with kappa agonism/antagonism on a short-term basis before? Considering we'd be getting a limited supply, is it possible the withdrawals might be kinda nasty? Or could the 2-week cycle mitigate that?

Edited by lucky.pierre, 24 January 2014 - 03:04 PM.

[formergenius]

Here's an updated list of people who are interested:

socialpiranha
lourdaud
Cosma
lucky.pierre
lammas2
JustAMan
hzwe
celebes
LetMusicRule
Strangelove
uralsky
meatsauce
addx
KieranA001
Here_Now
fanta2y
datrat
therein
alex921
synchronizing89
Puppeteer
AWATS
lost05
sweetniko
Missjess
neuroatypicow
formergenius (myself)

That's 27 people so far. 3 more and we can get $100/50mg prices.

Actually, considering 2 people have already put in $200, we only need 1 more participant, or 1 more participant buying for $200.
That's excluding shipping. Analysis may be hard to do due to the sample size required. I know NMR needs 1 gram sample size.
Can anyone with any knowledge about this whether A) Analysis would render said sample useless, and B) Which, if any, analysis method requires an acceptably small sample size?

Question is; is everyone O.K. with >95% purity? It is in stock by the way; no need for synthesis.
Also, we can't buy it until we have the full amount at hand (payment with this supplier was !00% upfront; perhaps this is negotiable. I'll try to find out. However, we'd still need the full amount at hand so as to not risk coming short of funds for payment, thus leaving the person buying in debt).

Please, if anyone decided to withdraw their interest, or finds these terms unacceptable, please post.

I've been busy with another noot project, but I've managed to get some more inquiries out, so with a bit of luck there's a superior option.
Cheers.

[Missjess]

I would be happy to pay $200 but I would prefer a pure quality especially because it's only a research chemical. Perhaps if others tried it first and reported back with positive reports then I would take the 95% quality..

[formergenius]

Well I've inquired about that, so we'll see. Alternatively it could be sent to another lab to purify it, but that would drive up the cost.

[Puppeteer]

Would it be possible to consult David Pierce regarding the purity? Do you think he'd have any insights? Also, Former, are you certain that the lab you're in contact with is genuine?

[Missjess]

Well I would insist on purity that is my preference. What about others? And yes is the person your in contact with genuine?

[formergenius]

I posted on the JDTic forum but it's dead. Perhaps socialpiranha can though.
No, I am not 100% certain, though suffice to say this will be confirmed before any payment is made.
However, for now I have no method to actually do so, besides travelling across the globe, so if you've any suggestions, please shoot
I would also prefer the highest purity possible, however I do think with such low doses that perhaps a slightly lower purity may be acceptable.

[KieranA001]

Well I would also want to buy another gram, but it won't let me login to change it !?

[Missjess]

I'm curious to know what are everyone's reasons for wanting to try this drug?

[KieranA001]

Also, I know this is irrelevant so I'm sorry but I would like to know how much Salvia one would have to smoke in order to down-regulate the KOR receptor. I couldn't fine the answer anywhere. Also, would the down-reguation be for life ?

Thanks.

[Missjess]

That's a good question!! But I do know that mine has been fuked from using iboga...it's like my consciousness has changed and I'm constantly spacey, lack of body awareness and I'm highly dissociated with a blank mind :( I also never have a mood it's always the same and anhedonia

[formergenius]

Kieran; if you press "Check-out", you should be able to edit the amount requested. Not sure this will update if you don't pay though.
Depends on the Salvinorin A content. I think the answer might be found within Salvinorin A binding assays and JDTic binding assays, then juxtaposing those.
Generally speaking, stress and anxiety is what perpetuates high Dynorphin levels, hence if you become significantly anxious/stressed for a prolonged period after using a KOR agonist, it may be that you perpetuate the downregulation induced, or so is my theory. But I just woke up; that may be mistaken. On second thought; I suppose you meant whether the KOR "destruction" of JDTic lasts for life? No, it doesn't. Seems to last about 2 weeks, hence its long duration of action.

edit; It may be interesting to note that most DP cases seem to be drug induced, wherein many drugs that induce DP activate the KOR (downregulation; may or may not lead to higher Dynorphin expression to compensate) or upregulate Dynorphin expression, such as Salvinorin A, THC, Cocaine, etc. Once this happens it becomes easier to be anxious/stressed, thus chances for perpetuating or aggravating the condition are higher. Note; semi-conjunction, might be wrong; again.. just woke up.

Edited by formergenius, 25 January 2014 - 02:24 PM.

[socialpiranha]

Missjess, did you use iboga for opiate detox ? That's what i used it for and i'm not sure if my dissociative symptoms are from the iboga itself or just the damage opiates did over the years. How long ago did you take iboga?

[Missjess]

No I used it for depersonalization disorder, I took 3.2 grams which is what Michelle from ibogaworld told me to take and it put me in hospital, it was way too much for me and I experienced really strong dissociative affects from the drug I ad to be put on a drip aswell. I took iboga 6 months ago and haven't felt the same since.

[KieranA001]

Kieran; if you press "Check-out", you should be able to edit the amount requested. Not sure this will update if you don't pay though.
Depends on the Salvinorin A content. I think the answer might be found within Salvinorin A binding assays and JDTic binding assays, then juxtaposing those.
Generally speaking, stress and anxiety is what perpetuates high Dynorphin levels, hence if you become significantly anxious/stressed for a prolonged period after using a KOR agonist, it may be that you perpetuate the downregulation induced, or so is my theory. But I just woke up; that may be mistaken. On second thought; I suppose you meant whether the KOR "destruction" of JDTic lasts for life? No, it doesn't. Seems to last about 2 weeks, hence its long duration of action.

edit; It may be interesting to note that most DP cases seem to be drug induced, wherein many drugs that induce DP activate the KOR (downregulation; may or may not lead to higher Dynorphin expression to compensate) or upregulate Dynorphin expression, such as Salvinorin A, THC, Cocaine, etc. Once this happens it becomes easier to be anxious/stressed, thus chances for perpetuating or aggravating the condition are higher. Note; semi-conjunction, might be wrong; again.. just woke up.

Thanks for that info! I took 5x Salvia just now and find that you get good after-effects for about 30 minutes but then I end up feeling depressed after a couple of hours. Looks like I'm not going to touch that stuff again. It's like, my thoughts end up changing into negative ones and everything. So from now on, Salvia is a no no! I hope JDTic gives better effects then that of Salvia. I presume it will be like the opposite to Salvia, so it might start of dysphoric and then the after effects are good, right ?

If you stop taking JDTic, will it cause me and all of you guys to feel like the after effects of Salvia. Seen as salvia is an agonist and the KOR receptor site grows back stronger after it's destroyed by JDTic, you'd think TDtic would cause a stronger KOR effect which will give the same results as salvia?

Edited by KieranA001, 25 January 2014 - 04:19 PM.

[Missjess]

Man I would never touch salvia I'm scared of that shit I've heard so many ppl getting dpdr from that shit.

[formergenius]

Well, generally Salvia is considered to be dysphoric immediately; people use it for the purported "afterglow". JDTIc on the other hand should be the opposite; KOR activation is lowered thus improving mood, perception and cognition. With Salvia, KOR activation leads to dysphoria and downregulation, the latter of which should then lead to the temporary "afterglow" by lowering the amount of receptors available for activation, before the KORs upregulate again.

With JDTic, as I understand it, receptors are "destroyed" (or whatever; antagonized/disabled) for two weeks, which can be considered as a form of downregulation, thus leading to immediate benefits. Whether the upregulation that would occur after the first dose, would raise receptor amount above initial amounts, I don't know. Though I'd be inclined to say that because of new-found lower stress/anxiety levels, dynorphin expression/production/signalling is indirectly reduced, thus leaving less endogenous ligands available for receptor activation, thus as it were leading to a normalizing of the KOR system over time. But maybe that's just optimism, and also it's more of a guess than anything. How it turns out in practice may be completely different

P.S. Socialpiranha, can you delete Kieran's $100 unpaid listing?

Edited by formergenius, 25 January 2014 - 04:43 PM.

[socialpiranha]

No I used it for depersonalization disorder, I took 3.2 grams which is what Michelle from ibogaworld told me to take and it put me in hospital, it was way too much for me and I experienced really strong dissociative affects from the drug I ad to be put on a drip aswell. I took iboga 6 months ago and haven't felt the same since.

Yeah i ended up in the hospital too, it's a fucked up drug. i took it a year ago this february and i still feel strange. It did stop my opiate addiction though. In hindsight i think it did some damage to my brain but i think it has reversed for the most part. The main thing i still notice is i find it hard to look at other people and not see them as animals as strange as that sounds.

P.S. Socialpiranha, can you delete Kieran's $100 unpaid listing?

done

[Missjess]

Oh shit!! That's fuked...yeah when I look around it's like my surroungdings look "dirty" and feel floaty. I had depersonalization disorder already but this state is just worse any the blank mind is extremelt strange it's like my entire brain has shut down and it feels empty. I'm going to see john of god in Brazil to see if he can help me for this. I know it deff changed my brain/neuro chemistry

Tell me more about ur flood...did u do it at home and we y dose did u take? I was in hospital for 2 and a half days after the first 9 hours of the experience and had to be put on a drip

[lammas2]

If I may ask, those of you who tried Ibogaine and had a negative experience, had you tried any psychedelics before Ibogaine?

[Missjess]

I had used iboga a few times before but not at a full flood dose so yes

[socialpiranha]

I didn't have a negative experience per se, i had an incredible experience that was extremely difficult at times. Yeah i have been bit of a psychonaut since i was like 12, I've done lsd, mescaline, mushrooms, salvia, 5meodalt, amt etc. Ibogaine is a whole different beast.